Perturb_10650_KO_KDSR_SRP308393 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting KDSR in Leukemia cell line MV4-11 cell line (Study accession: SRP308393) (PerturbAtlas)
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Genes

46 genes differentially expressed following the Perturb_10650_KO_KDSR_SRP308393 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 12.8365
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 8.77189
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 8.54314
LSP1 lymphocyte-specific protein 1 7.56159
SRGN serglycin 7.24872
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 7.24017
LMNA lamin A/C 7.14682
NCF1 neutrophil cytosolic factor 1 6.99612
RUNX3 runt-related transcription factor 3 5.31029
FTH1 ferritin, heavy polypeptide 1 4.04914
ZNF740 zinc finger protein 740 3.95018
IL4I1 interleukin 4 induced 1 3.932
CD44 CD44 molecule (Indian blood group) 3.28483
PRR33 proline rich 33 3.12172
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.10679
BARX1 BARX homeobox 1 3.05147
S100A10 S100 calcium binding protein A10 2.89119
PFKP phosphofructokinase, platelet 2.88873
MYBPH myosin binding protein H 2.86561
CES1 carboxylesterase 1 2.8564
TLDC2 TBC/LysM-associated domain containing 2 2.52179
ITGB7 integrin, beta 7 2.51013
PLEC plectin 2.35459
GPX1 glutathione peroxidase 1 2.34936
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.19477
CD276 CD276 molecule 2.12287
NOTCH1 notch 1 1.99886
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 1.98717
ADGRE5 adhesion G protein-coupled receptor E5 1.92483
FLNA filamin A, alpha 1.67682
ARHGAP26 Rho GTPase activating protein 26 1.67682
THBD thrombomodulin 1.59112
PTP4A3 protein tyrosine phosphatase type IVA, member 3 1.54909
PTPN6 protein tyrosine phosphatase, non-receptor type 6 1.54909
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.40885
ODF3B outer dense fiber of sperm tails 3B 1.34815
FADS3 fatty acid desaturase 3 1.33931
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 1.32111

decreased expression

Symbol Name Standardized Value
RAPSN receptor-associated protein of the synapse -3.12332
SREBF1 sterol regulatory element binding transcription factor 1 -3.06509
DNAH11 dynein, axonemal, heavy chain 11 -2.02436
WT1 Wilms tumor 1 -1.98014
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -1.95489
TTN titin -1.92483
FASN fatty acid synthase -1.35923
GLUL glutamate-ammonia ligase -1.34815