Perturb_11419_KD_CD95L_SRP302700 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting CD95L in LNCaP cell line (Study accession: SRP302700) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_11419_KD_CD95L_SRP302700 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
TMEM184C transmembrane protein 184C 20.0
KDM6B lysine (K)-specific demethylase 6B 20.0
WNK2 WNK lysine deficient protein kinase 2 20.0
MED16 mediator complex subunit 16 20.0
RNF44 ring finger protein 44 20.0
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 20.0
NCOR2 nuclear receptor corepressor 2 20.0
MCM2 minichromosome maintenance complex component 2 20.0
USF2 upstream transcription factor 2, c-fos interacting 20.0
SOX12 SRY (sex determining region Y)-box 12 20.0
ZDHHC5 zinc finger, DHHC-type containing 5 20.0
MIDN midnolin 20.0
RPUSD1 RNA pseudouridylate synthase domain containing 1 20.0
ALCAM activated leukocyte cell adhesion molecule 20.0
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 20.0
SET SET nuclear proto-oncogene 20.0
MARVELD1 MARVEL domain containing 1 20.0
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 20.0
DNAAF5 dynein, axonemal, assembly factor 5 20.0
FAM155B family with sequence similarity 155, member B 20.0
REPIN1 replication initiator 1 20.0
FN1 fibronectin 1 20.0
RNF4 ring finger protein 4 20.0
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 20.0
JUND jun D proto-oncogene 20.0
POM121C POM121 transmembrane nucleoporin C 20.0
ARHGAP1 Rho GTPase activating protein 1 20.0
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 20.0
ITFG3 integrin alpha FG-GAP repeat containing 3 20.0
MORF4L1 mortality factor 4 like 1 20.0
ADGRG1 adhesion G protein-coupled receptor G1 20.0
RNF187 ring finger protein 187 20.0
ABR active BCR-related 20.0
TAPBP TAP binding protein (tapasin) 20.0
NAT8L N-acetyltransferase 8-like (GCN5-related, putative) 20.0
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 20.0
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 20.0
DAP death-associated protein 20.0
BCL9L B-cell CLL/lymphoma 9-like 20.0
NR1H2 nuclear receptor subfamily 1, group H, member 2 20.0
ENAH enabled homolog (Drosophila) 20.0
MED22 mediator complex subunit 22 20.0
STK40 serine/threonine kinase 40 20.0
SRM spermidine synthase 20.0
LPPR2 lipid phosphate phosphatase-related protein type 2 20.0
DOT1L DOT1-like histone H3K79 methyltransferase 20.0
SZRD1 SUZ RNA binding domain containing 1 20.0
CAPN15 calpain 15 20.0
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 20.0
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 20.0
TCOF1 Treacher Collins-Franceschetti syndrome 1 20.0
MKNK2 MAP kinase interacting serine/threonine kinase 2 20.0
MAP4 microtubule-associated protein 4 20.0
TOM1L2 target of myb1-like 2 (chicken) 20.0
ZNF598 zinc finger protein 598 20.0
WNT7B wingless-type MMTV integration site family, member 7B 20.0
SGPL1 sphingosine-1-phosphate lyase 1 20.0
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 20.0
PROSER1 proline and serine rich 1 20.0
CBX6 chromobox homolog 6 20.0
CKAP5 cytoskeleton associated protein 5 20.0
ANKRD52 ankyrin repeat domain 52 20.0
SCNN1A sodium channel, non voltage gated 1 alpha subunit 20.0
FOXP4 forkhead box P4 20.0
MAP1B microtubule-associated protein 1B 20.0
ZBTB7A zinc finger and BTB domain containing 7A 20.0
KLHDC3 kelch domain containing 3 20.0
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 20.0
NOTCH1 notch 1 20.0
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 20.0
PRAC1 prostate cancer susceptibility candidate 1 20.0
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 20.0
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 20.0
USP10 ubiquitin specific peptidase 10 20.0
NIPAL3 NIPA-like domain containing 3 20.0
NUP210 nucleoporin 210kDa 20.0
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 20.0
CPTP ceramide-1-phosphate transfer protein 20.0
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 20.0
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 20.0
PPP6R1 protein phosphatase 6, regulatory subunit 1 20.0
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 20.0
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 20.0
RBM15B RNA binding motif protein 15B 20.0
SPINT1 serine peptidase inhibitor, Kunitz type 1 20.0
SEC16A SEC16 homolog A (S. cerevisiae) 20.0
DSEL dermatan sulfate epimerase-like 20.0
LONP1 lon peptidase 1, mitochondrial 20.0
NONO non-POU domain containing, octamer-binding 20.0
POM121 POM121 transmembrane nucleoporin 20.0
GATAD2A GATA zinc finger domain containing 2A 20.0
PKD1 polycystic kidney disease 1 (autosomal dominant) 20.0
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 20.0
H2AFX H2A histone family, member X 20.0
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 20.0
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 20.0
FAM83F family with sequence similarity 83, member F 20.0
ABHD2 abhydrolase domain containing 2 20.0
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 20.0
NCS1 neuronal calcium sensor 1 20.0

decreased expression

Symbol Name Standardized Value
SPTSSA serine palmitoyltransferase, small subunit A -20.0
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -20.0
TEF thyrotrophic embryonic factor -20.0
ERMP1 endoplasmic reticulum metallopeptidase 1 -20.0
GSKIP GSK3B interacting protein -20.0
LIMA1 LIM domain and actin binding 1 -20.0
RAB12 RAB12, member RAS oncogene family -20.0
TMTC4 transmembrane and tetratricopeptide repeat containing 4 -20.0
UGP2 UDP-glucose pyrophosphorylase 2 -20.0
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -20.0
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -20.0
FOPNL FGFR1OP N-terminal like -20.0
ARMC1 armadillo repeat containing 1 -20.0
TSEN15 TSEN15 tRNA splicing endonuclease subunit -20.0
FNDC3A fibronectin type III domain containing 3A -20.0
STK38 serine/threonine kinase 38 -20.0
KLHDC8B kelch domain containing 8B -20.0
TUFT1 tuftelin 1 -20.0
SEC24A SEC24 family member A -20.0
JKAMP JNK1/MAPK8-associated membrane protein -20.0
KLHL28 kelch-like family member 28 -20.0
GPD1L glycerol-3-phosphate dehydrogenase 1-like -20.0
HIST1H2BG histone cluster 1, H2bg -20.0
VAMP7 vesicle-associated membrane protein 7 -20.0
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 -20.0
SORT1 sortilin 1 -20.0
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -20.0
ZNF350 zinc finger protein 350 -20.0
XXYLT1 xyloside xylosyltransferase 1 -20.0
SCAMP5 secretory carrier membrane protein 5 -20.0
TMEM43 transmembrane protein 43 -20.0
SNAPIN SNAP-associated protein -20.0
USP46 ubiquitin specific peptidase 46 -20.0
C9ORF41 chromosome 9 open reading frame 41 -20.0
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -20.0
ACER2 alkaline ceramidase 2 -20.0
FRK fyn-related Src family tyrosine kinase -20.0
STARD3 StAR-related lipid transfer (START) domain containing 3 -20.0
FAM217B family with sequence similarity 217, member B -20.0
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -20.0
E2F3 E2F transcription factor 3 -20.0
PTPRG protein tyrosine phosphatase, receptor type, G -20.0
WDR37 WD repeat domain 37 -20.0
RAB11FIP4 RAB11 family interacting protein 4 (class II) -20.0
STXBP4 syntaxin binding protein 4 -20.0
TMEM2 transmembrane protein 2 -20.0
CCNT2 cyclin T2 -20.0
DESI1 desumoylating isopeptidase 1 -20.0
GNPDA1 glucosamine-6-phosphate deaminase 1 -20.0
BTBD7 BTB (POZ) domain containing 7 -20.0
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -20.0
CEL carboxyl ester lipase -20.0
ZYG11B zyg-11 family member B, cell cycle regulator -20.0
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -20.0
CAMLG calcium modulating ligand -20.0
FBXO45 F-box protein 45 -20.0
LIN7C lin-7 homolog C (C. elegans) -20.0
SNW1 SNW domain containing 1 -20.0
CLDND1 claudin domain containing 1 -20.0
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -20.0
KLHL42 kelch-like family member 42 -20.0
CASD1 CAS1 domain containing 1 -20.0
IGSF3 immunoglobulin superfamily, member 3 -20.0
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -20.0
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -20.0
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -20.0
KLHL15 kelch-like family member 15 -20.0
PCID2 PCI domain containing 2 -20.0
PFN2 profilin 2 -20.0
RYK receptor-like tyrosine kinase -20.0
CHIC1 cysteine-rich hydrophobic domain 1 -20.0
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -20.0
UBA3 ubiquitin-like modifier activating enzyme 3 -20.0
USP12 ubiquitin specific peptidase 12 -20.0
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -20.0
SCML2 sex comb on midleg-like 2 (Drosophila) -20.0
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -20.0
FAM35A family with sequence similarity 35, member A -20.0
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -20.0
MXD1 MAX dimerization protein 1 -20.0
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -20.0
CBR1 carbonyl reductase 1 -20.0
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -20.0
KLHL20 kelch-like family member 20 -20.0
NLRP6 NLR family, pyrin domain containing 6 -20.0
EFR3A EFR3 homolog A (S. cerevisiae) -20.0
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -20.0
TBCC tubulin folding cofactor C -20.0
ABHD3 abhydrolase domain containing 3 -20.0
MXI1 MAX interactor 1, dimerization protein -20.0
VANGL1 VANGL planar cell polarity protein 1 -20.0
NSL1 NSL1, MIS12 kinetochore complex component -20.0
KIAA0513 KIAA0513 -20.0
NEK7 NIMA-related kinase 7 -20.0
FBXL5 F-box and leucine-rich repeat protein 5 -20.0
MPZL3 myelin protein zero-like 3 -20.0
KPNA3 karyopherin alpha 3 (importin alpha 4) -20.0
TIGAR TP53 induced glycolysis regulatory phosphatase -20.0
TRIM23 tripartite motif containing 23 -20.0
ANKRD46 ankyrin repeat domain 46 -20.0