| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting LNX2 in Lung fibroblast IMR90 cell line (Study accession: SRP113334) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_11645_KD_LNX2_SRP113334 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 20.0 |
| ZNF770 | zinc finger protein 770 | 20.0 |
| TTC14 | tetratricopeptide repeat domain 14 | 20.0 |
| SC5D | sterol-C5-desaturase | 20.0 |
| ARHGAP29 | Rho GTPase activating protein 29 | 20.0 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 20.0 |
| CLGN | calmegin | 20.0 |
| CD47 | CD47 molecule | 20.0 |
| BICC1 | BicC family RNA binding protein 1 | 20.0 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 20.0 |
| LY96 | lymphocyte antigen 96 | 20.0 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 20.0 |
| LYPLAL1 | lysophospholipase-like 1 | 20.0 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 20.0 |
| SCAF11 | SR-related CTD-associated factor 11 | 20.0 |
| MCFD2 | multiple coagulation factor deficiency 2 | 20.0 |
| AK5 | adenylate kinase 5 | 20.0 |
| GOLT1B | golgi transport 1B | 19.5229 |
| FAS | Fas cell surface death receptor | 19.3979 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 19.301 |
| MARCH7 | membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase | 18.8539 |
| SNRPE | small nuclear ribonucleoprotein polypeptide E | 18.7696 |
| KITLG | KIT ligand | 18.5528 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 18.4559 |
| AXL | AXL receptor tyrosine kinase | 18.301 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 18.0915 |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | 17.983 |
| DSEL | dermatan sulfate epimerase-like | 17.6882 |
| CUL5 | cullin 5 | 17.6778 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 17.6696 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 17.6108 |
| SLC38A6 | solute carrier family 38, member 6 | 17.2211 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 17.1261 |
| CCDC82 | coiled-coil domain containing 82 | 17.1186 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 17.091 |
| CD58 | CD58 molecule | 16.8389 |
| PUS7L | pseudouridylate synthase 7 homolog (S. cerevisiae)-like | 16.7932 |
| ELMOD2 | ELMO/CED-12 domain containing 2 | 16.7854 |
| SYPL1 | synaptophysin-like 1 | 16.7854 |
| NAE1 | NEDD8 activating enzyme E1 subunit 1 | 16.7854 |
| GINM1 | glycoprotein integral membrane 1 | 16.5715 |
| RMDN2 | regulator of microtubule dynamics 2 | 16.5418 |
| CD164 | CD164 molecule, sialomucin | 16.425 |
| UBLCP1 | ubiquitin-like domain containing CTD phosphatase 1 | 16.4244 |
| ORC4 | origin recognition complex, subunit 4 | 16.4244 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 16.3574 |
| GLMN | glomulin, FKBP associated protein | 16.3426 |
| ARMT1 | acidic residue methyltransferase 1 | 16.1732 |
| RIN2 | Ras and Rab interactor 2 | 16.0385 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 16.0356 |
| BCLAF1 | BCL2-associated transcription factor 1 | 15.734 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 15.5736 |
| SNX14 | sorting nexin 14 | 15.5078 |
| GMFB | glia maturation factor, beta | 15.4442 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 15.4442 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 15.4157 |
| SDCBP | syndecan binding protein (syntenin) | 15.3218 |
| FGF7 | fibroblast growth factor 7 | 15.2716 |
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 15.0732 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 14.9616 |
| GPR180 | G protein-coupled receptor 180 | 14.9256 |
| NUCB2 | nucleobindin 2 | 14.9256 |
| CCND2 | cyclin D2 | 14.6355 |
| WTAP | Wilms tumor 1 associated protein | 14.6165 |
| KIAA1033 | KIAA1033 | 14.4392 |
| RAD17 | RAD17 homolog (S. pombe) | 14.3088 |
| SMARCAD1 | SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 | 14.2687 |
| ACTR6 | ARP6 actin-related protein 6 homolog (yeast) | 14.1798 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 14.0886 |
| PERP | PERP, TP53 apoptosis effector | 14.0886 |
| ARL8B | ADP-ribosylation factor-like 8B | 14.0878 |
| FGF5 | fibroblast growth factor 5 | 14.0564 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 14.0185 |
| MSMO1 | methylsterol monooxygenase 1 | 14.0185 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 13.8897 |
| LIG4 | ligase IV, DNA, ATP-dependent | 13.6286 |
| ZUFSP | zinc finger with UFM1-specific peptidase domain | 13.4885 |
| ERLEC1 | endoplasmic reticulum lectin 1 | 13.457 |
| C1GALT1C1 | C1GALT1-specific chaperone 1 | 13.457 |
| CCBL2 | cysteine conjugate-beta lyase 2 | 13.4081 |
| TRNT1 | tRNA nucleotidyl transferase, CCA-adding, 1 | 13.3487 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 13.343 |
| RNF139 | ring finger protein 139 | 13.343 |
| INSL6 | insulin-like 6 | 13.343 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 13.3195 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 13.2347 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 13.2231 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 13.2204 |
| HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H') | 13.1992 |
| STXBP3 | syntaxin binding protein 3 | 13.1911 |
| PGF | placental growth factor | 13.1114 |
| TLK1 | tousled-like kinase 1 | 13.068 |
| IKBIP | IKBKB interacting protein | 13.068 |
| CFAP97 | cilia and flagella associated protein 97 | 13.0274 |
| TXNL1 | thioredoxin-like 1 | 13.0274 |
| TGDS | TDP-glucose 4,6-dehydratase | 12.9847 |
| PGRMC1 | progesterone receptor membrane component 1 | 12.9807 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 12.9506 |
| SMC3 | structural maintenance of chromosomes 3 | 12.9493 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 12.8918 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDLIM4 | PDZ and LIM domain 4 | -9.32334 |
| TGM2 | transglutaminase 2 | -8.93424 |
| NDUFAF3 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | -8.86899 |
| IFITM3 | interferon induced transmembrane protein 3 | -8.65783 |
| ATP5G1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) | -8.58201 |
| CCND1 | cyclin D1 | -8.3181 |
| C19ORF53 | chromosome 19 open reading frame 53 | -8.26981 |
| GNAS | GNAS complex locus | -8.0668 |
| RPL10A | ribosomal protein L10a | -8.0668 |
| RPL13 | ribosomal protein L13 | -7.93069 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -7.89844 |
| DAXX | death-domain associated protein | -7.87189 |
| RPLP0 | ribosomal protein, large, P0 | -7.86695 |
| PFDN2 | prefoldin subunit 2 | -7.84593 |
| PTTG1 | pituitary tumor-transforming 1 | -7.61604 |
| HSPB1 | heat shock 27kDa protein 1 | -7.55079 |
| IFITM2 | interferon induced transmembrane protein 2 | -7.50514 |
| C9ORF16 | chromosome 9 open reading frame 16 | -7.44717 |
| TPM2 | tropomyosin 2 (beta) | -7.43889 |
| C16ORF13 | chromosome 16 open reading frame 13 | -7.40335 |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F | -7.37548 |
| PDLIM1 | PDZ and LIM domain 1 | -7.33519 |
| C1ORF122 | chromosome 1 open reading frame 122 | -7.3068 |
| RPL7A | ribosomal protein L7a | -7.30395 |
| S100A13 | S100 calcium binding protein A13 | -7.30387 |
| MEA1 | male-enhanced antigen 1 | -7.24751 |
| GAL | galanin/GMAP prepropeptide | -7.23296 |
| SERF2 | small EDRK-rich factor 2 | -7.22133 |
| TCEB2 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) | -7.20765 |
| SPON2 | spondin 2, extracellular matrix protein | -7.20227 |
| CMTM3 | CKLF-like MARVEL transmembrane domain containing 3 | -7.18043 |
| GYPC | glycophorin C (Gerbich blood group) | -7.14992 |
| RPL3 | ribosomal protein L3 | -6.98433 |
| ANAPC11 | anaphase promoting complex subunit 11 | -6.97581 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -6.94964 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -6.93216 |
| PHPT1 | phosphohistidine phosphatase 1 | -6.85742 |
| PSMB4 | proteasome (prosome, macropain) subunit, beta type, 4 | -6.84686 |
| RNASEH2C | ribonuclease H2, subunit C | -6.78787 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -6.77473 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -6.74563 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -6.72623 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -6.70265 |
| C12ORF10 | chromosome 12 open reading frame 10 | -6.66852 |
| LAMTOR2 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | -6.62995 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -6.61493 |
| RPS2 | ribosomal protein S2 | -6.60173 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -6.59471 |
| RPS11 | ribosomal protein S11 | -6.5749 |
| RRAS | related RAS viral (r-ras) oncogene homolog | -6.51426 |
| RPS14 | ribosomal protein S14 | -6.49513 |
| ATP5G2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) | -6.45992 |
| RPS8 | ribosomal protein S8 | -6.44321 |
| ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | -6.42788 |
| ROMO1 | reactive oxygen species modulator 1 | -6.42411 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -6.41071 |
| RPL23A | ribosomal protein L23a | -6.40691 |
| CDK16 | cyclin-dependent kinase 16 | -6.39662 |
| MRPL27 | mitochondrial ribosomal protein L27 | -6.38058 |
| FAM96B | family with sequence similarity 96, member B | -6.36888 |
| RPS6 | ribosomal protein S6 | -6.35741 |
| TMSB10 | thymosin beta 10 | -6.35577 |
| PRAF2 | PRA1 domain family, member 2 | -6.31275 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -6.31153 |
| DESI1 | desumoylating isopeptidase 1 | -6.29573 |
| CRIP2 | cysteine-rich protein 2 | -6.28184 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -6.27156 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -6.26442 |
| RPL13A | ribosomal protein L13a | -6.25472 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -6.24625 |
| C12ORF57 | chromosome 12 open reading frame 57 | -6.23932 |
| GPX4 | glutathione peroxidase 4 | -6.22458 |
| DPCD | deleted in primary ciliary dyskinesia homolog (mouse) | -6.22182 |
| OST4 | oligosaccharyltransferase 4 homolog (S. cerevisiae) | -6.2186 |
| TBCB | tubulin folding cofactor B | -6.21478 |
| FAM162A | family with sequence similarity 162, member A | -6.18651 |
| RPS15A | ribosomal protein S15a | -6.18503 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | -6.15176 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -6.15046 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -6.14414 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -6.14237 |
| DDA1 | DET1 and DDB1 associated 1 | -6.1324 |
| RPL32 | ribosomal protein L32 | -6.11049 |
| MRPS15 | mitochondrial ribosomal protein S15 | -6.09644 |
| RPL29 | ribosomal protein L29 | -6.06682 |
| SELM | selenoprotein M | -6.06682 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -6.06518 |
| RPL18 | ribosomal protein L18 | -6.03633 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | -6.02832 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -6.02538 |
| TADA3 | transcriptional adaptor 3 | -6.02357 |
| POLR2G | polymerase (RNA) II (DNA directed) polypeptide G | -5.98742 |
| RPL8 | ribosomal protein L8 | -5.98742 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -5.97129 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | -5.97129 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | -5.94924 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | -5.94415 |
| NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | -5.93706 |
| RPL36 | ribosomal protein L36 | -5.93155 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 | -5.91104 |
