| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting HOXA1 in lung fibroblasts cell (Study accession: SRP012607) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_11705_KD_HOXA1_SRP012607 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | 20.0 |
| WLS | wntless Wnt ligand secretion mediator | 20.0 |
| TFPI2 | tissue factor pathway inhibitor 2 | 20.0 |
| COL8A1 | collagen, type VIII, alpha 1 | 20.0 |
| KTN1 | kinectin 1 (kinesin receptor) | 20.0 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 20.0 |
| SQSTM1 | sequestosome 1 | 20.0 |
| SCARB2 | scavenger receptor class B, member 2 | 20.0 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 20.0 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 20.0 |
| EGFR | epidermal growth factor receptor | 20.0 |
| PLXNB2 | plexin B2 | 20.0 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 20.0 |
| TGFB1 | transforming growth factor, beta 1 | 20.0 |
| SPON2 | spondin 2, extracellular matrix protein | 20.0 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 20.0 |
| NPTX1 | neuronal pentraxin I | 20.0 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 20.0 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 20.0 |
| STC1 | stanniocalcin 1 | 20.0 |
| CD63 | CD63 molecule | 20.0 |
| BSG | basigin (Ok blood group) | 20.0 |
| POSTN | periostin, osteoblast specific factor | 20.0 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 20.0 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 20.0 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 20.0 |
| EID1 | EP300 interacting inhibitor of differentiation 1 | 20.0 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 20.0 |
| TMEM30A | transmembrane protein 30A | 20.0 |
| MRC2 | mannose receptor, C type 2 | 20.0 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | 20.0 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 20.0 |
| COL3A1 | collagen, type III, alpha 1 | 20.0 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 20.0 |
| EIF4B | eukaryotic translation initiation factor 4B | 20.0 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | 20.0 |
| CHPF2 | chondroitin polymerizing factor 2 | 20.0 |
| SH3PXD2A | SH3 and PX domains 2A | 20.0 |
| CD44 | CD44 molecule (Indian blood group) | 20.0 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 20.0 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 20.0 |
| P3H1 | prolyl 3-hydroxylase 1 | 20.0 |
| INHBA | inhibin, beta A | 20.0 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 20.0 |
| COL4A2 | collagen, type IV, alpha 2 | 20.0 |
| COL4A1 | collagen, type IV, alpha 1 | 20.0 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 20.0 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 20.0 |
| ATP13A3 | ATPase type 13A3 | 20.0 |
| VCAN | versican | 20.0 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 20.0 |
| ITGB5 | integrin, beta 5 | 20.0 |
| HIPK2 | homeodomain interacting protein kinase 2 | 20.0 |
| SERINC1 | serine incorporator 1 | 20.0 |
| SERINC3 | serine incorporator 3 | 20.0 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 20.0 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 20.0 |
| COL18A1 | collagen, type XVIII, alpha 1 | 20.0 |
| PLAU | plasminogen activator, urokinase | 20.0 |
| PLAT | plasminogen activator, tissue | 20.0 |
| PSAP | prosaposin | 20.0 |
| MXRA8 | matrix-remodelling associated 8 | 20.0 |
| PLD3 | phospholipase D family, member 3 | 20.0 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | 20.0 |
| IGF2R | insulin-like growth factor 2 receptor | 20.0 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 20.0 |
| MCL1 | myeloid cell leukemia 1 | 20.0 |
| ADAM19 | ADAM metallopeptidase domain 19 | 20.0 |
| LAMB1 | laminin, beta 1 | 20.0 |
| FTL | ferritin, light polypeptide | 20.0 |
| SLC38A2 | solute carrier family 38, member 2 | 20.0 |
| NID2 | nidogen 2 (osteonidogen) | 20.0 |
| CTSB | cathepsin B | 20.0 |
| CTSC | cathepsin C | 20.0 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 20.0 |
| APP | amyloid beta (A4) precursor protein | 20.0 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 20.0 |
| COL5A2 | collagen, type V, alpha 2 | 20.0 |
| LAMP1 | lysosomal-associated membrane protein 1 | 20.0 |
| KIRREL | kin of IRRE like (Drosophila) | 20.0 |
| COL12A1 | collagen, type XII, alpha 1 | 20.0 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 20.0 |
| HYOU1 | hypoxia up-regulated 1 | 20.0 |
| PXDN | peroxidasin | 20.0 |
| RAB7A | RAB7A, member RAS oncogene family | 20.0 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 20.0 |
| MMP1 | matrix metallopeptidase 1 | 20.0 |
| MMP2 | matrix metallopeptidase 2 | 20.0 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 20.0 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 20.0 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 20.0 |
| RND3 | Rho family GTPase 3 | 20.0 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 20.0 |
| TTYH3 | tweety family member 3 | 20.0 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 20.0 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 20.0 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 20.0 |
| F2R | coagulation factor II (thrombin) receptor | 20.0 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 20.0 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 20.0 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BRCA2 | breast cancer 2, early onset | -20.0 |
| ASF1B | anti-silencing function 1B histone chaperone | -20.0 |
| TGFBR3 | transforming growth factor, beta receptor III | -20.0 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -20.0 |
| MCM10 | minichromosome maintenance complex component 10 | -20.0 |
| E2F1 | E2F transcription factor 1 | -20.0 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -20.0 |
| CDC6 | cell division cycle 6 | -20.0 |
| AMPH | amphiphysin | -20.0 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | -20.0 |
| CENPA | centromere protein A | -20.0 |
| EXO1 | exonuclease 1 | -20.0 |
| KIAA0101 | KIAA0101 | -20.0 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -20.0 |
| PLK4 | polo-like kinase 4 | -20.0 |
| POLQ | polymerase (DNA directed), theta | -20.0 |
| NLRP10 | NLR family, pyrin domain containing 10 | -20.0 |
| UBE2T | ubiquitin-conjugating enzyme E2T | -20.0 |
| BIRC3 | baculoviral IAP repeat containing 3 | -20.0 |
| FANCD2 | Fanconi anemia, complementation group D2 | -20.0 |
| EML5 | echinoderm microtubule associated protein like 5 | -20.0 |
| CDC45 | cell division cycle 45 | -20.0 |
| EPB41 | erythrocyte membrane protein band 4.1 | -20.0 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -20.0 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -20.0 |
| RPL39L | ribosomal protein L39-like | -20.0 |
| NDC80 | NDC80 kinetochore complex component | -20.0 |
| WDR62 | WD repeat domain 62 | -20.0 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -20.0 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -20.0 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -20.0 |
| RBL1 | retinoblastoma-like 1 | -20.0 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -20.0 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -20.0 |
| SAPCD2 | suppressor APC domain containing 2 | -20.0 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -20.0 |
| DDIAS | DNA damage-induced apoptosis suppressor | -20.0 |
| ABHD14B | abhydrolase domain containing 14B | -20.0 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -20.0 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -20.0 |
| ORC1 | origin recognition complex, subunit 1 | -20.0 |
| CEP57L1 | centrosomal protein 57kDa-like 1 | -20.0 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -20.0 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -20.0 |
| STPG1 | sperm-tail PG-rich repeat containing 1 | -20.0 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -20.0 |
| TMEM117 | transmembrane protein 117 | -20.0 |
| GPSM2 | G-protein signaling modulator 2 | -20.0 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -20.0 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -20.0 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -20.0 |
| TROAP | trophinin associated protein | -20.0 |
| ARL4A | ADP-ribosylation factor-like 4A | -20.0 |
| MAMDC2 | MAM domain containing 2 | -20.0 |
| RAD51AP1 | RAD51 associated protein 1 | -20.0 |
| HDAC9 | histone deacetylase 9 | -20.0 |
| EXTL1 | exostosin-like glycosyltransferase 1 | -20.0 |
| CCDC53 | coiled-coil domain containing 53 | -20.0 |
| SDPR | serum deprivation response | -20.0 |
| FICD | FIC domain containing | -20.0 |
| NEK2 | NIMA-related kinase 2 | -20.0 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -20.0 |
| CLSPN | claspin | -20.0 |
| CDCA7 | cell division cycle associated 7 | -20.0 |
| SKA1 | spindle and kinetochore associated complex subunit 1 | -20.0 |
| POC1A | POC1 centriolar protein A | -20.0 |
| CEP128 | centrosomal protein 128kDa | -20.0 |
| SLC38A5 | solute carrier family 38, member 5 | -20.0 |
| TRAIP | TRAF interacting protein | -20.0 |
| HOXA5 | homeobox A5 | -20.0 |
| TYMS | thymidylate synthetase | -20.0 |
| PRUNE2 | prune homolog 2 (Drosophila) | -20.0 |
| SLC4A8 | solute carrier family 4, sodium bicarbonate cotransporter, member 8 | -20.0 |
| TEAD4 | TEA domain family member 4 | -20.0 |
| WDR76 | WD repeat domain 76 | -20.0 |
| NEURL1B | neuralized E3 ubiquitin protein ligase 1B | -20.0 |
| TRAF1 | TNF receptor-associated factor 1 | -20.0 |
| CENPM | centromere protein M | -20.0 |
| CENPI | centromere protein I | -20.0 |
| CENPH | centromere protein H | -20.0 |
| CENPW | centromere protein W | -20.0 |
| CENPU | centromere protein U | -20.0 |
| VLDLR | very low density lipoprotein receptor | -20.0 |
| RAD51 | RAD51 recombinase | -20.0 |
| GRPR | gastrin-releasing peptide receptor | -20.0 |
| CAND2 | cullin-associated and neddylation-dissociated 2 (putative) | -20.0 |
| SELENBP1 | selenium binding protein 1 | -20.0 |
| KIF15 | kinesin family member 15 | -20.0 |
| C10ORF10 | chromosome 10 open reading frame 10 | -20.0 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -20.0 |
| NCAPH | non-SMC condensin I complex, subunit H | -20.0 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -20.0 |
| CDC25C | cell division cycle 25C | -20.0 |
| KIF18A | kinesin family member 18A | -20.0 |
| KIF18B | kinesin family member 18B | -20.0 |
| BARD1 | BRCA1 associated RING domain 1 | -20.0 |
| DBF4B | DBF4 zinc finger B | -20.0 |
| ERCC6L | excision repair cross-complementation group 6-like | -20.0 |
| IL32 | interleukin 32 | -20.0 |
| WWC1 | WW and C2 domain containing 1 | -20.0 |
