Perturb_11947_KO_IRF4_SRP096865 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting IRF4 in Lymphoblastoid cell lines cell line (Study accession: SRP096865) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_11947_KO_IRF4_SRP096865 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
TREM1 triggering receptor expressed on myeloid cells 1 20.0
PLK2 polo-like kinase 2 20.0
ITK IL2-inducible T-cell kinase 20.0
UXT ubiquitously-expressed, prefoldin-like chaperone 20.0
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 20.0
CD44 CD44 molecule (Indian blood group) 20.0
DHRS3 dehydrogenase/reductase (SDR family) member 3 20.0
SESN1 sestrin 1 20.0
IFNG interferon, gamma 20.0
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 20.0
ZBED2 zinc finger, BED-type containing 2 20.0
DTX1 deltex 1, E3 ubiquitin ligase 20.0
WDFY1 WD repeat and FYVE domain containing 1 20.0
TMEM229B transmembrane protein 229B 20.0
ZDHHC14 zinc finger, DHHC-type containing 14 20.0
PARP9 poly (ADP-ribose) polymerase family, member 9 20.0
JAG1 jagged 1 20.0
C14ORF132 chromosome 14 open reading frame 132 20.0
NELL2 NEL-like 2 (chicken) 20.0
IPCEF1 interaction protein for cytohesin exchange factors 1 20.0
PTAFR platelet-activating factor receptor 20.0
CD6 CD6 molecule 20.0
LMO2 LIM domain only 2 (rhombotin-like 1) 20.0
GPR137B G protein-coupled receptor 137B 20.0
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 20.0
TFPI2 tissue factor pathway inhibitor 2 20.0
SCNN1G sodium channel, non voltage gated 1 gamma subunit 20.0
USH1G Usher syndrome 1G (autosomal recessive) 20.0
CSPG4 chondroitin sulfate proteoglycan 4 20.0
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 20.0
RNF144A ring finger protein 144A 20.0
RB1 retinoblastoma 1 20.0
GBP1 guanylate binding protein 1, interferon-inducible 20.0
SMIM14 small integral membrane protein 14 20.0
GPR82 G protein-coupled receptor 82 20.0
IL9R interleukin 9 receptor 20.0
AIM2 absent in melanoma 2 20.0
CD244 CD244 molecule, natural killer cell receptor 2B4 20.0
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 20.0
GBP4 guanylate binding protein 4 20.0
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 20.0
GADD45G growth arrest and DNA-damage-inducible, gamma 20.0
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 20.0
RIN3 Ras and Rab interactor 3 20.0
TSPAN11 tetraspanin 11 20.0
ACOXL acyl-CoA oxidase-like 20.0
RGS20 regulator of G-protein signaling 20 20.0
BCL2L11 BCL2-like 11 (apoptosis facilitator) 20.0
HHAT hedgehog acyltransferase 18.8861
NTNG1 netrin G1 18.7212
FAM118A family with sequence similarity 118, member A 18.6021
ADAMTSL2 ADAMTS-like 2 18.301
CAV2 caveolin 2 18.1024
PARP12 poly (ADP-ribose) polymerase family, member 12 17.6861
DTX3L deltex 3 like, E3 ubiquitin ligase 17.6234
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 17.4295
MYO3B myosin IIIB 17.2396
ITM2B integral membrane protein 2B 17.0487
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 16.9266
NR4A2 nuclear receptor subfamily 4, group A, member 2 16.7196
CD9 CD9 molecule 16.4476
TSPAN18 tetraspanin 18 16.4476
CD96 CD96 molecule 16.3263
TMEM37 transmembrane protein 37 15.9835
CCR1 chemokine (C-C motif) receptor 1 15.6586
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 15.3309
AFAP1L2 actin filament associated protein 1-like 2 15.1922
ACBD7 acyl-CoA binding domain containing 7 15.1691
GABARAPL1 GABA(A) receptor-associated protein like 1 15.0337
ABLIM1 actin binding LIM protein 1 15.0197
KIAA1324 KIAA1324 14.9716
EMX1 empty spiracles homeobox 1 14.8855
RGS13 regulator of G-protein signaling 13 14.7571
KIF13A kinesin family member 13A 14.681
LDLRAD4 low density lipoprotein receptor class A domain containing 4 14.6497
SGK223 homolog of rat pragma of Rnd2 14.581
WWTR1 WW domain containing transcription regulator 1 14.5702
FUCA1 fucosidase, alpha-L- 1, tissue 14.5585
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 14.4213
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 14.2625
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 14.1812
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 14.1707
GBP3 guanylate binding protein 3 13.5331
CTSW cathepsin W 13.4851
SYNJ2 synaptojanin 2 13.2817
MFGE8 milk fat globule-EGF factor 8 protein 13.2283
DACT3 dishevelled-binding antagonist of beta-catenin 3 13.213
GJB2 gap junction protein, beta 2, 26kDa 13.1961
GNG11 guanine nucleotide binding protein (G protein), gamma 11 12.9995
APELA apelin receptor early endogenous ligand 12.9836
SV2B synaptic vesicle glycoprotein 2B 12.9202
SCNN1B sodium channel, non voltage gated 1 beta subunit 12.5845
CCL1 chemokine (C-C motif) ligand 1 12.4738
HAPLN3 hyaluronan and proteoglycan link protein 3 12.4709
STAT1 signal transducer and activator of transcription 1, 91kDa 12.3767
CRTAM cytotoxic and regulatory T cell molecule 12.3491
ZMYM1 zinc finger, MYM-type 1 12.3304
PNKD paroxysmal nonkinesigenic dyskinesia 12.2658
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 12.2349
IRF1 interferon regulatory factor 1 12.2258

decreased expression

Symbol Name Standardized Value
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -20.0
LTK leukocyte receptor tyrosine kinase -20.0
DDR2 discoidin domain receptor tyrosine kinase 2 -20.0
CTH cystathionine gamma-lyase -18.5086
DDN dendrin -15.3309
FAM129C family with sequence similarity 129, member C -14.8963
TERT telomerase reverse transcriptase -14.7913
LYPD6B LY6/PLAUR domain containing 6B -14.5609
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -14.5278
GAS2 growth arrest-specific 2 -14.3592
GPR160 G protein-coupled receptor 160 -13.9282
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -13.8247
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -13.2877
TMEM173 transmembrane protein 173 -12.8397
JCHAIN joining chain of multimeric IgA and IgM -12.1088
TRIB1 tribbles pseudokinase 1 -11.8995
PRDM1 PR domain containing 1, with ZNF domain -11.7917
FCHO1 FCH domain only 1 -11.646
GRAMD1B GRAM domain containing 1B -11.604
IGFBP3 insulin-like growth factor binding protein 3 -11.4147
CPED1 cadherin-like and PC-esterase domain containing 1 -11.17
ADAM23 ADAM metallopeptidase domain 23 -11.164
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -11.0658
SGSH N-sulfoglucosamine sulfohydrolase -10.8539
CNTNAP1 contactin associated protein 1 -10.6466
PXN paxillin -10.6229
HMX3 H6 family homeobox 3 -10.3358
BHLHE22 basic helix-loop-helix family, member e22 -10.2836
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -10.1788
SLC44A1 solute carrier family 44 (choline transporter), member 1 -10.1018
VAV3 vav 3 guanine nucleotide exchange factor -9.6863
SH3PXD2A SH3 and PX domains 2A -9.64859
CDC14B cell division cycle 14B -9.60124
IL12A interleukin 12A -9.52132
HMX2 H6 family homeobox 2 -9.49984
SLC35F3 solute carrier family 35, member F3 -9.01685
TCL1A T-cell leukemia/lymphoma 1A -8.76161
KLF2 Kruppel-like factor 2 -8.6458
FCRLA Fc receptor-like A -8.63026
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -8.58498
STARD13 StAR-related lipid transfer (START) domain containing 13 -8.56408
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -8.53728
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 -8.49928
ASCL1 achaete-scute family bHLH transcription factor 1 -8.48466
TNIK TRAF2 and NCK interacting kinase -8.07411
SELL selectin L -8.0283
ACKR2 atypical chemokine receptor 2 -7.84014
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -7.79716
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -7.58707
CMKLR1 chemerin chemokine-like receptor 1 -7.31671
COL24A1 collagen, type XXIV, alpha 1 -7.30634
SIRPB1 signal-regulatory protein beta 1 -7.26652
FKBP11 FK506 binding protein 11, 19 kDa -7.21666
CLMN calmin (calponin-like, transmembrane) -7.14752
NME8 NME/NM23 family member 8 -7.09334
MYOF myoferlin -6.87407
CCR8 chemokine (C-C motif) receptor 8 -6.80048
ZFAT zinc finger and AT hook domain containing -6.53811
HIST1H2BK histone cluster 1, H2bk -6.48819
OCLN occludin -6.44224
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -6.36876
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -6.21105
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -6.20612
EPN2 epsin 2 -6.18998
MYC v-myc avian myelocytomatosis viral oncogene homolog -6.11335
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -6.08624
FAM46C family with sequence similarity 46, member C -5.95578
DERL3 derlin 3 -5.78645
FBN2 fibrillin 2 -5.6727
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -5.64962
PSAT1 phosphoserine aminotransferase 1 -5.59426
CDON cell adhesion associated, oncogene regulated -5.47716
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -5.46232
HIST1H2BG histone cluster 1, H2bg -5.43883
MZB1 marginal zone B and B1 cell-specific protein -5.36522
SELPLG selectin P ligand -5.34479
CSF1R colony stimulating factor 1 receptor -5.31351
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -5.23764
CPNE2 copine II -5.19744
FAM102B family with sequence similarity 102, member B -5.19703
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -5.07556
SLC19A1 solute carrier family 19 (folate transporter), member 1 -5.05766
EZR ezrin -5.04398
HIST1H1C histone cluster 1, H1c -5.00431
SRM spermidine synthase -4.99384
HIST1H4I histone cluster 1, H4i -4.9712
CTNNA2 catenin (cadherin-associated protein), alpha 2 -4.94688
PECAM1 platelet/endothelial cell adhesion molecule 1 -4.92178
CD37 CD37 molecule -4.87343
DFNA5 deafness, autosomal dominant 5 -4.86972
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -4.83323
CPPED1 calcineurin-like phosphoesterase domain containing 1 -4.82797
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -4.80163
C15ORF39 chromosome 15 open reading frame 39 -4.7096
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -4.69844
MANF mesencephalic astrocyte-derived neurotrophic factor -4.56777
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -4.56777
ADAM8 ADAM metallopeptidase domain 8 -4.55456
LAMC1 laminin, gamma 1 (formerly LAMB2) -4.43736
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -4.38548