| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting OVOL1 in MCF10A-M2(pre-malignant human breast cell line) cell line (Study accession: SRP352292) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_12163_KD_OVOL1_SRP352292 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAI2 | snail family zinc finger 2 | 20.0 |
| PLAU | plasminogen activator, urokinase | 20.0 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 20.0 |
| FAM110C | family with sequence similarity 110, member C | 20.0 |
| JUN | jun proto-oncogene | 20.0 |
| HBEGF | heparin-binding EGF-like growth factor | 20.0 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 20.0 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 20.0 |
| EPHB2 | EPH receptor B2 | 20.0 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 20.0 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 20.0 |
| FRMD6 | FERM domain containing 6 | 20.0 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 20.0 |
| PDGFB | platelet-derived growth factor beta polypeptide | 20.0 |
| ARID5A | AT rich interactive domain 5A (MRF1-like) | 20.0 |
| ANGPTL4 | angiopoietin-like 4 | 20.0 |
| C4ORF26 | chromosome 4 open reading frame 26 | 20.0 |
| HMGA2 | high mobility group AT-hook 2 | 20.0 |
| PLXNA4 | plexin A4 | 20.0 |
| VASN | vasorin | 20.0 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 20.0 |
| CTGF | connective tissue growth factor | 20.0 |
| C1ORF106 | chromosome 1 open reading frame 106 | 20.0 |
| ITGB6 | integrin, beta 6 | 20.0 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 20.0 |
| LBH | limb bud and heart development | 20.0 |
| STC1 | stanniocalcin 1 | 20.0 |
| IL11 | interleukin 11 | 20.0 |
| TUFT1 | tuftelin 1 | 20.0 |
| HCAR2 | hydroxycarboxylic acid receptor 2 | 20.0 |
| WNT7A | wingless-type MMTV integration site family, member 7A | 20.0 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 20.0 |
| GPR157 | G protein-coupled receptor 157 | 19.699 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | 19.2218 |
| ADAM19 | ADAM metallopeptidase domain 19 | 18.8539 |
| FAM83A | family with sequence similarity 83, member A | 18.7696 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 18.0969 |
| CD274 | CD274 molecule | 17.7986 |
| FERMT1 | fermitin family member 1 | 17.7986 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 17.2328 |
| TBX3 | T-box 3 | 16.2234 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 15.9302 |
| MOB3B | MOB kinase activator 3B | 15.6764 |
| RHOB | ras homolog family member B | 15.5233 |
| SMAD7 | SMAD family member 7 | 15.2865 |
| EPHA4 | EPH receptor A4 | 14.9662 |
| FAXDC2 | fatty acid hydroxylase domain containing 2 | 14.9103 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 14.8732 |
| VEGFA | vascular endothelial growth factor A | 14.7498 |
| FERMT2 | fermitin family member 2 | 14.578 |
| CCNA2 | cyclin A2 | 14.4478 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 14.4079 |
| SUSD6 | sushi domain containing 6 | 14.3991 |
| ARHGAP31 | Rho GTPase activating protein 31 | 14.3401 |
| PHLDB1 | pleckstrin homology-like domain, family B, member 1 | 14.3401 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 14.1684 |
| PDCD1LG2 | programmed cell death 1 ligand 2 | 14.0761 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 13.9933 |
| CYTH1 | cytohesin 1 | 13.8564 |
| RDH16 | retinol dehydrogenase 16 (all-trans) | 13.7911 |
| LIPG | lipase, endothelial | 13.7109 |
| LAMB3 | laminin, beta 3 | 12.9491 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 12.8787 |
| LPAR5 | lysophosphatidic acid receptor 5 | 12.7173 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 12.6938 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | 12.5222 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 12.156 |
| TGM2 | transglutaminase 2 | 12.0279 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 11.9205 |
| KLHL25 | kelch-like family member 25 | 11.8479 |
| P2RY6 | pyrimidinergic receptor P2Y, G-protein coupled, 6 | 11.7469 |
| PPARD | peroxisome proliferator-activated receptor delta | 11.7028 |
| COL4A1 | collagen, type IV, alpha 1 | 11.593 |
| SOX4 | SRY (sex determining region Y)-box 4 | 11.5588 |
| PRSS22 | protease, serine, 22 | 11.5588 |
| C3ORF52 | chromosome 3 open reading frame 52 | 11.5525 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 11.3777 |
| MMP2 | matrix metallopeptidase 2 | 11.2576 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 11.2506 |
| COL1A1 | collagen, type I, alpha 1 | 11.0631 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) | 11.0021 |
| SPOCD1 | SPOC domain containing 1 | 10.9819 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 10.7877 |
| PALLD | palladin, cytoskeletal associated protein | 10.6936 |
| KCTD11 | potassium channel tetramerization domain containing 11 | 10.3768 |
| SH2D2A | SH2 domain containing 2A | 10.3134 |
| HS3ST2 | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | 10.2329 |
| ULK1 | unc-51 like autophagy activating kinase 1 | 10.1979 |
| SMOX | spermine oxidase | 10.1567 |
| FOXC2 | forkhead box C2 | 9.98822 |
| PRICKLE2 | prickle homolog 2 (Drosophila) | 9.96786 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 9.90644 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 9.73968 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 9.70889 |
| ADAMTS15 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | 9.69818 |
| STK38L | serine/threonine kinase 38 like | 9.66281 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 9.65353 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 9.29761 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 9.14891 |
| UTS2 | urotensin 2 | 9.14891 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD6 | SMAD family member 6 | -20.0 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -20.0 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -20.0 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -20.0 |
| SP8 | Sp8 transcription factor | -20.0 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -20.0 |
| HOXC13 | homeobox C13 | -18.6576 |
| PRR15L | proline rich 15-like | -14.7278 |
| FAM84A | family with sequence similarity 84, member A | -12.4458 |
| OSER1 | oxidative stress responsive serine-rich 1 | -11.4893 |
| TRIM31 | tripartite motif containing 31 | -11.3372 |
| IRX3 | iroquois homeobox 3 | -11.2665 |
| PLD6 | phospholipase D family, member 6 | -10.5098 |
| EREG | epiregulin | -10.4377 |
| DDIT4 | DNA-damage-inducible transcript 4 | -10.187 |
| SEH1L | SEH1-like (S. cerevisiae) | -10.1267 |
| CFDP1 | craniofacial development protein 1 | -9.99967 |
| AREG | amphiregulin | -9.5957 |
| TPRN | taperin | -9.53804 |
| IRX2 | iroquois homeobox 2 | -8.91063 |
| TP53 | tumor protein p53 | -8.90757 |
| EPN3 | epsin 3 | -8.4169 |
| LDLRAD3 | low density lipoprotein receptor class A domain containing 3 | -8.2821 |
| NRARP | NOTCH-regulated ankyrin repeat protein | -8.23986 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -8.23032 |
| RGS16 | regulator of G-protein signaling 16 | -8.11791 |
| ZNF488 | zinc finger protein 488 | -7.95464 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -7.52097 |
| OVOL1 | ovo-like zinc finger 1 | -7.51982 |
| SLC45A3 | solute carrier family 45, member 3 | -7.2919 |
| LMNB1 | lamin B1 | -7.06688 |
| SDPR | serum deprivation response | -7.03293 |
| TSKU | tsukushi, small leucine rich proteoglycan | -7.02109 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -6.91456 |
| IMPDH1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | -6.703 |
| KITLG | KIT ligand | -6.43329 |
| IRX5 | iroquois homeobox 5 | -6.39283 |
| HOXC11 | homeobox C11 | -6.38081 |
| EPGN | epithelial mitogen | -6.27219 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -6.19046 |
| DOK7 | docking protein 7 | -6.00506 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | -5.91159 |
| FAM198B | family with sequence similarity 198, member B | -5.77714 |
| ITGA6 | integrin, alpha 6 | -5.77714 |
| SMAD9 | SMAD family member 9 | -5.65914 |
| SYBU | syntabulin (syntaxin-interacting) | -5.63963 |
| NCOA7 | nuclear receptor coactivator 7 | -5.62759 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | -5.46696 |
| POC1B | POC1 centriolar protein B | -5.46162 |
| CNKSR3 | CNKSR family member 3 | -5.36474 |
| TWIST1 | twist family bHLH transcription factor 1 | -5.03237 |
| GTF2H1 | general transcription factor IIH, polypeptide 1, 62kDa | -5.02923 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -5.00684 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -4.97901 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -4.87133 |
| AVPI1 | arginine vasopressin-induced 1 | -4.85055 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -4.84922 |
| ZNF394 | zinc finger protein 394 | -4.77849 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -4.71859 |
| MED4 | mediator complex subunit 4 | -4.70078 |
| TGFB3 | transforming growth factor, beta 3 | -4.65855 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -4.54214 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -4.49784 |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 | -4.44948 |
| DIO2 | deiodinase, iodothyronine, type II | -4.44177 |
| ZNF750 | zinc finger protein 750 | -4.40165 |
| MBLAC2 | metallo-beta-lactamase domain containing 2 | -4.39681 |
| GDF15 | growth differentiation factor 15 | -4.3064 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -4.29678 |
| THEM6 | thioesterase superfamily member 6 | -4.2801 |
| FZD7 | frizzled class receptor 7 | -4.25444 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -4.25098 |
| THUMPD1 | THUMP domain containing 1 | -4.19948 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -4.16224 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -4.11667 |
| REPIN1 | replication initiator 1 | -4.07592 |
| CBX6 | chromobox homolog 6 | -4.04179 |
| ANKRD22 | ankyrin repeat domain 22 | -3.93016 |
| CANX | calnexin | -3.91818 |
| FST | follistatin | -3.91818 |
| LOC93622 | Morf4 family associated protein 1-like 1 pseudogene | -3.90478 |
| HMGB2 | high mobility group box 2 | -3.88539 |
| GRHL3 | grainyhead-like 3 (Drosophila) | -3.87786 |
| KRT23 | keratin 23, type I | -3.79622 |
| ARL14 | ADP-ribosylation factor-like 14 | -3.76147 |
| CDK20 | cyclin-dependent kinase 20 | -3.72899 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -3.48791 |
| RARG | retinoic acid receptor, gamma | -3.47929 |
| SCNN1G | sodium channel, non voltage gated 1 gamma subunit | -3.41136 |
| KRT13 | keratin 13, type I | -3.38281 |
| E2F2 | E2F transcription factor 2 | -3.37747 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -3.31368 |
| ZNF395 | zinc finger protein 395 | -3.29215 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -3.28955 |
| AARD | alanine and arginine rich domain containing protein | -3.27025 |
| IL12A | interleukin 12A | -3.2515 |
| PAX9 | paired box 9 | -3.21666 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | -3.18932 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | -3.14591 |
| SHB | Src homology 2 domain containing adaptor protein B | -3.14591 |
