Perturb_12293_OE_RORC_SRP066204 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting RORC in MDA-MB-231 cell line (Study accession: SRP066204) (PerturbAtlas)
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Genes

117 genes differentially expressed following the Perturb_12293_OE_RORC_SRP066204 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 6.91926
GPR39 G protein-coupled receptor 39 6.15508
ERCC1 excision repair cross-complementation group 1 6.13812
HIST1H2BN histone cluster 1, H2bn 5.84683
DNASE1 deoxyribonuclease I 5.58678
FAM149B1 family with sequence similarity 149, member B1 5.46448
ESRRA estrogen-related receptor alpha 4.53013
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 4.49815
LSMEM2 leucine-rich single-pass membrane protein 2 4.27228
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 3.79349
TUBB6 tubulin, beta 6 class V 3.75848
CPSF3L cleavage and polyadenylation specific factor 3-like 3.75848
MXD3 MAX dimerization protein 3 3.74151
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 3.71031
LPCAT3 lysophosphatidylcholine acyltransferase 3 3.63777
RPS29 ribosomal protein S29 3.61449
WDR38 WD repeat domain 38 3.5037
ATG10 autophagy related 10 3.5037
FBXL6 F-box and leucine-rich repeat protein 6 3.48442
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 3.48222
NDRG4 NDRG family member 4 3.43574
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 3.37886
BMP6 bone morphogenetic protein 6 3.31873
FSIP1 fibrous sheath interacting protein 1 3.29921
ENO3 enolase 3 (beta, muscle) 3.29571
ACO2 aconitase 2, mitochondrial 3.16534
KLC1 kinesin light chain 1 3.01832
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.92398
GLOD4 glyoxalase domain containing 4 2.83387
JMJD8 jumonji domain containing 8 2.83387
TBCE tubulin folding cofactor E 2.83387
TSPAN31 tetraspanin 31 2.79434
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.73248
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 2.72614
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 2.696
DOC2A double C2-like domains, alpha 2.67252
SRR serine racemase 2.67252
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.61924
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.55912
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.55912
LAMA5 laminin, alpha 5 2.54974
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.54612
LOC122455342 testis-specific serine/proline-rich protein 2.53359
PSMC3IP PSMC3 interacting protein 2.48542
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.44942
MFSD11 major facilitator superfamily domain containing 11 2.44667
WDR55 WD repeat domain 55 2.42032
KIF2A kinesin heavy chain member 2A 2.36517
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.34315
LCORL ligand dependent nuclear receptor corepressor-like 2.30936
SNAP47 synaptosomal-associated protein, 47kDa 2.25259
FAM175A family with sequence similarity 175, member A 2.24084
DCLRE1C DNA cross-link repair 1C 2.23231
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 2.21067
KAT5 K(lysine) acetyltransferase 5 2.17797
SAMD11 sterile alpha motif domain containing 11 2.16047
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2.1329
EME1 essential meiotic structure-specific endonuclease 1 2.06486
SARM1 sterile alpha and TIR motif containing 1 2.06189
OTUD4 OTU deubiquitinase 4 2.01863
LYPD1 LY6/PLAUR domain containing 1 1.99382
ACAT2 acetyl-CoA acetyltransferase 2 1.97361
RNF123 ring finger protein 123 1.86668
THAP3 THAP domain containing, apoptosis associated protein 3 1.85219
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.85037
ASB6 ankyrin repeat and SOCS box containing 6 1.83667
TRIM14 tripartite motif containing 14 1.78432
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.78432
NCAPH2 non-SMC condensin II complex, subunit H2 1.78432
DDTL D-dopachrome tautomerase-like 1.78325
ARL10 ADP-ribosylation factor-like 10 1.77465
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 1.76725
ANAPC10 anaphase promoting complex subunit 10 1.76725
ZBTB25 zinc finger and BTB domain containing 25 1.74521
RPAIN RPA interacting protein 1.71806
FANCD2OS FANCD2 opposite strand 1.68568
RUVBL1 RuvB-like AAA ATPase 1 1.67829
TESK2 testis-specific kinase 2 1.67829
CCDC73 coiled-coil domain containing 73 1.67329
FANCI Fanconi anemia, complementation group I 1.64788
RAD9A RAD9 homolog A (S. pombe) 1.60649
SZT2 seizure threshold 2 homolog (mouse) 1.5925
POLG polymerase (DNA directed), gamma 1.58538
CRYBG3 beta-gamma crystallin domain containing 3 1.57623
MLX MLX, MAX dimerization protein 1.55382
ACSBG1 acyl-CoA synthetase bubblegum family member 1 1.50848
SPAG17 sperm associated antigen 17 1.50848
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.50321
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 1.50321
C17ORF104 chromosome 17 open reading frame 104 1.47176
CCNK cyclin K 1.46579
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 1.45459
CRLF1 cytokine receptor-like factor 1 1.45277
C12ORF76 chromosome 12 open reading frame 76 1.43488
FAM166A family with sequence similarity 166, member A 1.40642
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1.40317
SUGP2 SURP and G patch domain containing 2 1.38859
ENDOG endonuclease G 1.38485
CCDC64B coiled-coil domain containing 64B 1.38351
WNT2B wingless-type MMTV integration site family, member 2B 1.37319

decreased expression

Symbol Name Standardized Value
KIF23 kinesin family member 23 -20.0
TMEM218 transmembrane protein 218 -6.38135
CTR9 CTR9, Paf1/RNA polymerase II complex component -3.63378
RBBP4 retinoblastoma binding protein 4 -3.39661
BEND3 BEN domain containing 3 -3.0834
COG5 component of oligomeric golgi complex 5 -2.61953
SPATA1 spermatogenesis associated 1 -2.61442
C5ORF45 chromosome 5 open reading frame 45 -2.30462
TPT1 tumor protein, translationally-controlled 1 -2.06189
ELMOD3 ELMO/CED-12 domain containing 3 -2.05078
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.91072
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -1.78432
BBIP1 BBSome interacting protein 1 -1.74521
TMEM79 transmembrane protein 79 -1.43488
TPM4 tropomyosin 4 -1.43488
BOP1 block of proliferation 1 -1.31816
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -1.31816