| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting STAT3 in MDA-MB-468 cell line (Study accession: SRP081918) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_12529_KD_STAT3_SRP081918 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 20.0 |
| PXDC1 | PX domain containing 1 | 20.0 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 20.0 |
| C1ORF116 | chromosome 1 open reading frame 116 | 20.0 |
| RRM2 | ribonucleotide reductase M2 | 20.0 |
| CLIC5 | chloride intracellular channel 5 | 20.0 |
| MYH15 | myosin, heavy chain 15 | 20.0 |
| GJA5 | gap junction protein, alpha 5, 40kDa | 20.0 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 20.0 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 20.0 |
| CST6 | cystatin E/M | 20.0 |
| ANKRD13A | ankyrin repeat domain 13A | 20.0 |
| HBEGF | heparin-binding EGF-like growth factor | 20.0 |
| CTGF | connective tissue growth factor | 20.0 |
| OXSR1 | oxidative stress responsive 1 | 20.0 |
| KRTAP2-4 | keratin associated protein 2-4 | 20.0 |
| GM2A | GM2 ganglioside activator | 20.0 |
| SCEL | sciellin | 20.0 |
| CCNA2 | cyclin A2 | 20.0 |
| PSG6 | pregnancy specific beta-1-glycoprotein 6 | 20.0 |
| RAPGEF3 | Rap guanine nucleotide exchange factor (GEF) 3 | 20.0 |
| NLRP10 | NLR family, pyrin domain containing 10 | 20.0 |
| SERPINB7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 20.0 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 19.3979 |
| CALB2 | calbindin 2 | 19.1549 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 18.1611 |
| TMEM40 | transmembrane protein 40 | 18.0177 |
| ABHD4 | abhydrolase domain containing 4 | 17.757 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 17.5623 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 17.0395 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 16.8614 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | 16.7324 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 16.44 |
| RGS2 | regulator of G-protein signaling 2 | 16.2423 |
| PLCXD2 | phosphatidylinositol-specific phospholipase C, X domain containing 2 | 16.126 |
| TCHH | trichohyalin | 16.0292 |
| USP2 | ubiquitin specific peptidase 2 | 15.9566 |
| PSG1 | pregnancy specific beta-1-glycoprotein 1 | 15.644 |
| ZBED2 | zinc finger, BED-type containing 2 | 15.3325 |
| CAB39 | calcium binding protein 39 | 15.2951 |
| ADM | adrenomedullin | 15.2951 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 14.786 |
| TMPRSS11E | transmembrane protease, serine 11E | 14.4572 |
| USP53 | ubiquitin specific peptidase 53 | 14.3717 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 14.1196 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 13.9164 |
| NUAK2 | NUAK family, SNF1-like kinase, 2 | 13.772 |
| SMIM13 | small integral membrane protein 13 | 13.7004 |
| BCL2L1 | BCL2-like 1 | 13.3494 |
| MT2A | metallothionein 2A | 13.1349 |
| PDLIM1 | PDZ and LIM domain 1 | 13.1259 |
| KLF6 | Kruppel-like factor 6 | 12.724 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 12.6595 |
| MYPN | myopalladin | 12.6505 |
| MITF | microphthalmia-associated transcription factor | 12.5562 |
| TUBA4A | tubulin, alpha 4a | 12.4956 |
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 | 12.3251 |
| PSG4 | pregnancy specific beta-1-glycoprotein 4 | 12.2681 |
| BCL10 | B-cell CLL/lymphoma 10 | 12.2568 |
| STMN1 | stathmin 1 | 11.9263 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 11.9031 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 11.8774 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 11.7117 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 11.7101 |
| SASH1 | SAM and SH3 domain containing 1 | 11.6796 |
| SMPD3 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 11.5939 |
| COTL1 | coactosin-like F-actin binding protein 1 | 11.5509 |
| XIRP1 | xin actin binding repeat containing 1 | 11.4374 |
| KRT34 | keratin 34, type I | 11.2518 |
| OXTR | oxytocin receptor | 11.1635 |
| SYT14 | synaptotagmin XIV | 10.9405 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 10.935 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 10.921 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 10.9091 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 10.6756 |
| FAM198B | family with sequence similarity 198, member B | 10.6682 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 10.6638 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 10.6402 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 10.6012 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 10.5401 |
| TUFT1 | tuftelin 1 | 10.4734 |
| LMCD1 | LIM and cysteine-rich domains 1 | 10.4604 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 10.3928 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 10.2669 |
| CSRP1 | cysteine and glycine-rich protein 1 | 10.2305 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 10.2067 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 10.1217 |
| TCF19 | transcription factor 19 | 10.1217 |
| ATP6V0D2 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 10.1106 |
| GPX1 | glutathione peroxidase 1 | 10.094 |
| PSG2 | pregnancy specific beta-1-glycoprotein 2 | 9.93668 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 9.93253 |
| SLC36A1 | solute carrier family 36 (proton/amino acid symporter), member 1 | 9.91361 |
| RAB3B | RAB3B, member RAS oncogene family | 9.84131 |
| WEE1 | WEE1 G2 checkpoint kinase | 9.8313 |
| PSKH1 | protein serine kinase H1 | 9.80514 |
| C1QTNF6 | C1q and tumor necrosis factor related protein 6 | 9.78027 |
| CCDC80 | coiled-coil domain containing 80 | 9.70501 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | 9.66711 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 9.63702 |
| Symbol | Name | Standardized Value |
|---|---|---|
| S100A7A | S100 calcium binding protein A7A | -20.0 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -20.0 |
| PDLIM5 | PDZ and LIM domain 5 | -20.0 |
| IL22RA2 | interleukin 22 receptor, alpha 2 | -20.0 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -20.0 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | -20.0 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -20.0 |
| CD46 | CD46 molecule, complement regulatory protein | -20.0 |
| CDK6 | cyclin-dependent kinase 6 | -20.0 |
| CBFB | core-binding factor, beta subunit | -20.0 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -20.0 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | -20.0 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -20.0 |
| TTC3 | tetratricopeptide repeat domain 3 | -20.0 |
| S100A9 | S100 calcium binding protein A9 | -20.0 |
| SLC35E1 | solute carrier family 35, member E1 | -20.0 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -20.0 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -20.0 |
| S100A8 | S100 calcium binding protein A8 | -20.0 |
| S100A7 | S100 calcium binding protein A7 | -20.0 |
| HMGN1 | high mobility group nucleosome binding domain 1 | -20.0 |
| ADRBK2 | adrenergic, beta, receptor kinase 2 | -20.0 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -20.0 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | -20.0 |
| COPS3 | COP9 signalosome subunit 3 | -20.0 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | -20.0 |
| KIFAP3 | kinesin-associated protein 3 | -20.0 |
| STAC2 | SH3 and cysteine rich domain 2 | -20.0 |
| SFT2D2 | SFT2 domain containing 2 | -20.0 |
| F11R | F11 receptor | -20.0 |
| NOTCH3 | notch 3 | -20.0 |
| SEP15 | 15 kDa selenoprotein | -20.0 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -20.0 |
| PROM1 | prominin 1 | -20.0 |
| A2M | alpha-2-macroglobulin | -20.0 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -20.0 |
| CNOT6 | CCR4-NOT transcription complex, subunit 6 | -20.0 |
| KLHL5 | kelch-like family member 5 | -20.0 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -20.0 |
| KIAA1324 | KIAA1324 | -20.0 |
| SSR1 | signal sequence receptor, alpha | -20.0 |
| HIF1AN | hypoxia inducible factor 1, alpha subunit inhibitor | -20.0 |
| CP | ceruloplasmin (ferroxidase) | -20.0 |
| ABI2 | abl-interactor 2 | -19.301 |
| CDC42SE2 | CDC42 small effector 2 | -19.2218 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -19.2218 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -18.4949 |
| SLC28A3 | solute carrier family 28 (concentrative nucleoside transporter), member 3 | -18.1611 |
| ATP13A5 | ATPase type 13A5 | -18.0706 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -18.0177 |
| FAM91A1 | family with sequence similarity 91, member A1 | -17.9281 |
| STRA6 | stimulated by retinoic acid 6 | -17.8761 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -17.6968 |
| C3 | complement component 3 | -17.6904 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -17.2757 |
| CDV3 | CDV3 homolog (mouse) | -17.032 |
| PLXDC2 | plexin domain containing 2 | -16.3571 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | -16.2354 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -15.9664 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -15.847 |
| TTC39B | tetratricopeptide repeat domain 39B | -15.2652 |
| PRLR | prolactin receptor | -15.2534 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | -15.1998 |
| PLAGL2 | pleiomorphic adenoma gene-like 2 | -15.1721 |
| APCDD1 | adenomatosis polyposis coli down-regulated 1 | -15.1495 |
| ATXN1L | ataxin 1-like | -15.1165 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -15.1093 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -15.0378 |
| PGLYRP4 | peptidoglycan recognition protein 4 | -14.8232 |
| GATSL2 | GATS protein-like 2 | -14.7773 |
| CLDN8 | claudin 8 | -14.7233 |
| ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | -14.6872 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -14.6423 |
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | -14.6238 |
| UNC45A | unc-45 homolog A (C. elegans) | -13.9164 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | -13.82 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | -13.7554 |
| NXPE3 | neurexophilin and PC-esterase domain family, member 3 | -13.7554 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -13.7554 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | -13.2602 |
| CPD | carboxypeptidase D | -13.2495 |
| CADPS2 | Ca++-dependent secretion activator 2 | -13.1928 |
| MAGED2 | melanoma antigen family D2 | -13.1928 |
| MMP7 | matrix metallopeptidase 7 | -12.9519 |
| CASP14 | caspase 14, apoptosis-related cysteine peptidase | -12.7247 |
| TP53 | tumor protein p53 | -12.613 |
| AP4E1 | adaptor-related protein complex 4, epsilon 1 subunit | -12.5174 |
| SLFN11 | schlafen family member 11 | -12.4192 |
| PLXND1 | plexin D1 | -12.3678 |
| TMEM184C | transmembrane protein 184C | -12.3502 |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | -12.2194 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -12.1849 |
| AXIN2 | axin 2 | -12.1785 |
| IL1R1 | interleukin 1 receptor, type I | -12.1339 |
| SMIM14 | small integral membrane protein 14 | -12.0337 |
| ANXA8L1 | annexin A8-like 1 | -12.0265 |
| TGFB2 | transforming growth factor, beta 2 | -11.9206 |
| LYPD6 | LY6/PLAUR domain containing 6 | -11.9082 |
| CBX5 | chromobox homolog 5 | -11.8783 |
| HR | hair growth associated | -11.868 |
