Perturb_13600_KD_DDIT3_SRP337871 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting DDIT3 in Myxoid liposarcoma tissue (Study accession: SRP337871) (PerturbAtlas)
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Genes

175 genes differentially expressed following the Perturb_13600_KD_DDIT3_SRP337871 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
MMP24-AS1 MMP24 antisense RNA 1 17.1561
LYPD1 LY6/PLAUR domain containing 1 10.6236
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 8.79107
TUBA1C tubulin, alpha 1c 8.491
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 7.8802
KRT8 keratin 8, type II 7.51168
ATP8B4 ATPase, class I, type 8B, member 4 7.22364
SGCE sarcoglycan, epsilon 6.26429
CDC42SE1 CDC42 small effector 1 6.12019
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 5.87011
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 5.7001
LAYN layilin 5.43406
BRD7 bromodomain containing 7 5.43206
SPC24 SPC24, NDC80 kinetochore complex component 5.07934
EMG1 EMG1 N1-specific pseudouridine methyltransferase 4.99358
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 4.71311
C7ORF49 chromosome 7 open reading frame 49 4.4019
ACKR2 atypical chemokine receptor 2 4.38429
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 4.14362
PANK2 pantothenate kinase 2 3.98958
COL5A1 collagen, type V, alpha 1 3.87929
PCNXL4 pecanex-like 4 (Drosophila) 3.66252
C1ORF167 chromosome 1 open reading frame 167 3.55052
PLTP phospholipid transfer protein 3.55052
CXCR5 chemokine (C-X-C motif) receptor 5 3.50054
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 3.42591
CCDC159 coiled-coil domain containing 159 3.40945
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 3.38609
KDM1A lysine (K)-specific demethylase 1A 3.37183
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 3.31268
IQGAP2 IQ motif containing GTPase activating protein 2 3.18498
CCDC18 coiled-coil domain containing 18 3.18498
RPL27A ribosomal protein L27a 3.11776
EXOSC9 exosome component 9 3.11776
CLSTN1 calsyntenin 1 3.11596
CDC14B cell division cycle 14B 3.07051
SPTB spectrin, beta, erythrocytic 3.01805
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.98623
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.94528
ANKRD13C ankyrin repeat domain 13C 2.84466
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.73923
H1F0 H1 histone family, member 0 2.72084
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 2.70035
HEATR1 HEAT repeat containing 1 2.63524
THRA thyroid hormone receptor, alpha 2.61177
ADGRA2 adhesion G protein-coupled receptor A2 2.55747
YY1AP1 YY1 associated protein 1 2.55138
ADRM1 adhesion regulating molecule 1 2.44946
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 2.36328
FKRP fukutin related protein 2.34656
CLCC1 chloride channel CLIC-like 1 2.30153
ARSG arylsulfatase G 2.29885
RPL10 ribosomal protein L10 2.24592
MYH9 myosin, heavy chain 9, non-muscle 2.23639
SNAI3 snail family zinc finger 3 2.22343
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.21706
MTMR10 myotubularin related protein 10 2.21367
GANC glucosidase, alpha; neutral C 2.17519
F8 coagulation factor VIII, procoagulant component 2.11131
ARL5C ADP-ribosylation factor-like 5C 2.11131
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.07377
ZFP36L2 ZFP36 ring finger protein-like 2 2.02122
PAX6 paired box 6 1.99369
TMED1 transmembrane emp24 protein transport domain containing 1 1.98741
ERAP1 endoplasmic reticulum aminopeptidase 1 1.81156
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.80071
BHLHE40 basic helix-loop-helix family, member e40 1.7978
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 1.7978
GPR39 G protein-coupled receptor 39 1.7978
RAG2 recombination activating gene 2 1.7978
VTI1B vesicle transport through interaction with t-SNAREs 1B 1.78068
TBX10 T-box 10 1.75832
PKN3 protein kinase N3 1.75798
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 1.75705
ZBTB46 zinc finger and BTB domain containing 46 1.74577
RUVBL1 RuvB-like AAA ATPase 1 1.74004
MAT2A methionine adenosyltransferase II, alpha 1.73351
TSC2 tuberous sclerosis 2 1.71551
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.70643
GPX3 glutathione peroxidase 3 1.69498
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 1.66413
KHNYN KH and NYN domain containing 1.63399
MAPK10 mitogen-activated protein kinase 10 1.62191
PPP6R2 protein phosphatase 6, regulatory subunit 2 1.61926
C11ORF48 1.61888
STRADB STE20-related kinase adaptor beta 1.60228
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 1.5976
MCC mutated in colorectal cancers 1.59438
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 1.55558
PRICKLE3 prickle homolog 3 (Drosophila) 1.52349
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.48004
PP2D1 protein phosphatase 2C-like domain containing 1 1.47001
EZR ezrin 1.4614
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 1.45597
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.44616
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.44572
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 1.4168
NKX6-2 NK6 homeobox 2 1.4168
RNF123 ring finger protein 123 1.4168
SULF2 sulfatase 2 1.39695

decreased expression

Symbol Name Standardized Value
MARS methionyl-tRNA synthetase -20.0
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -9.73706
CCDC85B coiled-coil domain containing 85B -8.41514
VEPH1 ventricular zone expressed PH domain-containing 1 -8.09879
SYNC syncoilin, intermediate filament protein -7.69339
TTI2 TELO2 interacting protein 2 -6.73433
FAM57A family with sequence similarity 57, member A -6.58366
CD37 CD37 molecule -5.25051
LGALS8 lectin, galactoside-binding, soluble, 8 -3.45124
CCNK cyclin K -3.3741
C12ORF76 chromosome 12 open reading frame 76 -3.22769
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 -3.2034
C22ORF23 chromosome 22 open reading frame 23 -3.11848
ZMAT5 zinc finger, matrin-type 5 -3.07051
MCM2 minichromosome maintenance complex component 2 -2.77652
DNM1L dynamin 1-like -2.72084
INO80E INO80 complex subunit E -2.6608
DENND1A DENN/MADD domain containing 1A -2.66012
AVIL advillin -2.65324
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.55187
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.35179
ZFHX3 zinc finger homeobox 3 -2.26486
TBCE tubulin folding cofactor E -2.26147
PEX10 peroxisomal biogenesis factor 10 -2.23341
C11ORF58 chromosome 11 open reading frame 58 -2.15033
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.11131
BACE1 beta-site APP-cleaving enzyme 1 -2.02352
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.01446
RPL11 ribosomal protein L11 -1.98372
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -1.91418
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -1.90978
SLMAP sarcolemma associated protein -1.90906
TMEM80 transmembrane protein 80 -1.86408
CCDC157 coiled-coil domain containing 157 -1.85451
PITX3 paired-like homeodomain 3 -1.8313
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.82932
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -1.82932
SFPQ splicing factor proline/glutamine-rich -1.78068
RPL7 ribosomal protein L7 -1.7512
CBR4 carbonyl reductase 4 -1.75011
FGF14 fibroblast growth factor 14 -1.71494
TRIM44 tripartite motif containing 44 -1.67927
LPIN3 lipin 3 -1.66413
GABPB1 GA binding protein transcription factor, beta subunit 1 -1.66165
BAZ1A bromodomain adjacent to zinc finger domain, 1A -1.66165
TSPAN31 tetraspanin 31 -1.6606
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 -1.65042
PARP1 poly (ADP-ribose) polymerase 1 -1.62709
ZSWIM7 zinc finger, SWIM-type containing 7 -1.62449
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -1.61888
IL24 interleukin 24 -1.61352
PHF10 PHD finger protein 10 -1.58631
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -1.55086
ZIC4 Zic family member 4 -1.52686
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -1.49327
NCAPD3 non-SMC condensin II complex, subunit D3 -1.49327
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -1.47001
MRPS22 mitochondrial ribosomal protein S22 -1.47001
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -1.46489
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -1.45657
L3MBTL2 l(3)mbt-like 2 (Drosophila) -1.42755
C11ORF68 chromosome 11 open reading frame 68 -1.36996
ZNF814 zinc finger protein 814 -1.35733
MTA2 metastasis associated 1 family, member 2 -1.35593
TUBA1B tubulin, alpha 1b -1.35324
TP53I13 tumor protein p53 inducible protein 13 -1.34369
IL17RC interleukin 17 receptor C -1.34318
PRKCZ protein kinase C, zeta -1.34164
C12ORF65 chromosome 12 open reading frame 65 -1.33494
SET SET nuclear proto-oncogene -1.3337
GPS2 G protein pathway suppressor 2 -1.33232
ISYNA1 inositol-3-phosphate synthase 1 -1.32777
KLK2 kallikrein-related peptidase 2 -1.32183
NR2F2 nuclear receptor subfamily 2, group F, member 2 -1.30268
WDR6 WD repeat domain 6 -1.30268