Perturb_13709_KD_RNF2_SRP351230 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting RNF2 in NCI-H1963 cell line (Study accession: SRP351230) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_13709_KD_RNF2_SRP351230 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
CRIP2 cysteine-rich protein 2 20.0
IRAK1 interleukin-1 receptor-associated kinase 1 20.0
HES6 hes family bHLH transcription factor 6 20.0
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 20.0
AKR1C2 aldo-keto reductase family 1, member C2 20.0
SOX1 SRY (sex determining region Y)-box 1 20.0
PTMA prothymosin, alpha 20.0
PTMS parathymosin 20.0
LDHA lactate dehydrogenase A 20.0
CFL1 cofilin 1 (non-muscle) 20.0
RBBP8 retinoblastoma binding protein 8 20.0
MAP7D1 MAP7 domain containing 1 20.0
TCP1 t-complex 1 20.0
RPLP0 ribosomal protein, large, P0 20.0
PKN1 protein kinase N1 20.0
TPM3 tropomyosin 3 20.0
MARCKSL1 MARCKS-like 1 20.0
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 20.0
RPL27A ribosomal protein L27a 20.0
KHSRP KH-type splicing regulatory protein 20.0
HMGA1 high mobility group AT-hook 1 20.0
RPL13A ribosomal protein L13a 20.0
RPLP2 ribosomal protein, large, P2 20.0
RPLP1 ribosomal protein, large, P1 20.0
RPS16 ribosomal protein S16 20.0
RPS15 ribosomal protein S15 20.0
HSPA8 heat shock 70kDa protein 8 20.0
RPS6 ribosomal protein S6 20.0
RPS5 ribosomal protein S5 20.0
RPS3 ribosomal protein S3 20.0
RPS2 ribosomal protein S2 20.0
RPSA ribosomal protein SA 20.0
RPL28 ribosomal protein L28 20.0
RPL27 ribosomal protein L27 20.0
STMN3 stathmin-like 3 20.0
PRRC2A proline-rich coiled-coil 2A 20.0
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 20.0
CYC1 cytochrome c-1 20.0
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 20.0
RPS19 ribosomal protein S19 20.0
WDR34 WD repeat domain 34 20.0
MRFAP1 Morf4 family associated protein 1 20.0
PANX2 pannexin 2 20.0
ARF3 ADP-ribosylation factor 3 20.0
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 20.0
RPL11 ribosomal protein L11 20.0
RPL13 ribosomal protein L13 20.0
PABPC1 poly(A) binding protein, cytoplasmic 1 20.0
HSDL1 hydroxysteroid dehydrogenase like 1 20.0
BLCAP bladder cancer associated protein 20.0
IGF2R insulin-like growth factor 2 receptor 20.0
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 20.0
HDGF hepatoma-derived growth factor 20.0
DYNLL2 dynein, light chain, LC8-type 2 20.0
CHKB choline kinase beta 20.0
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 20.0
RANGAP1 Ran GTPase activating protein 1 20.0
RPS27 ribosomal protein S27 20.0
RPS20 ribosomal protein S20 20.0
RPS28 ribosomal protein S28 20.0
MRPS12 mitochondrial ribosomal protein S12 20.0
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 20.0
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 20.0
INSM1 insulinoma-associated 1 20.0
LPCAT1 lysophosphatidylcholine acyltransferase 1 20.0
ENO1 enolase 1, (alpha) 20.0
ODC1 ornithine decarboxylase 1 20.0
RPL18A ribosomal protein L18a 20.0
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 20.0
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 20.0
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 20.0
YBX1 Y box binding protein 1 20.0
STIP1 stress-induced phosphoprotein 1 20.0
TPI1 triosephosphate isomerase 1 20.0
RPL4 ribosomal protein L4 20.0
TPGS2 tubulin polyglutamylase complex subunit 2 20.0
TFDP1 transcription factor Dp-1 20.0
BCAP31 B-cell receptor-associated protein 31 20.0
PFN1 profilin 1 20.0
SET SET nuclear proto-oncogene 20.0
COTL1 coactosin-like F-actin binding protein 1 20.0
TRIB3 tribbles pseudokinase 3 20.0
DPYSL5 dihydropyrimidinase-like 5 20.0
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 20.0
SBF1 SET binding factor 1 20.0
STC1 stanniocalcin 1 20.0
PARP1 poly (ADP-ribose) polymerase 1 20.0
PKM pyruvate kinase, muscle 20.0
C1ORF43 chromosome 1 open reading frame 43 20.0
LAPTM4B lysosomal protein transmembrane 4 beta 20.0
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 20.0
TXNIP thioredoxin interacting protein 20.0
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 20.0
MARCKS myristoylated alanine-rich protein kinase C substrate 20.0
ADRBK1 adrenergic, beta, receptor kinase 1 20.0
LMNB2 lamin B2 20.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 20.0
IPO7 importin 7 20.0
ACTB actin, beta 20.0
HMGN2 high mobility group nucleosomal binding domain 2 20.0

decreased expression

Symbol Name Standardized Value
RNF2 ring finger protein 2 -20.0
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -20.0
DDR2 discoidin domain receptor tyrosine kinase 2 -20.0
UNC13A unc-13 homolog A (C. elegans) -20.0
SS18 synovial sarcoma translocation, chromosome 18 -20.0
EPB41 erythrocyte membrane protein band 4.1 -20.0
FAM129A family with sequence similarity 129, member A -20.0
AKT3 v-akt murine thymoma viral oncogene homolog 3 -20.0
PNMA2 paraneoplastic Ma antigen 2 -20.0
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -20.0
KHNYN KH and NYN domain containing -20.0
TTL tubulin tyrosine ligase -20.0
MEF2A myocyte enhancer factor 2A -20.0
LARS leucyl-tRNA synthetase -20.0
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -20.0
SHISA5 shisa family member 5 -20.0
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -20.0
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -20.0
MFAP4 microfibrillar-associated protein 4 -20.0
MED13 mediator complex subunit 13 -20.0
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -20.0
ZNF714 zinc finger protein 714 -20.0
NNT nicotinamide nucleotide transhydrogenase -20.0
FOPNL FGFR1OP N-terminal like -20.0
RBPJ recombination signal binding protein for immunoglobulin kappa J region -20.0
PCYOX1 prenylcysteine oxidase 1 -20.0
LZTS3 leucine zipper, putative tumor suppressor family member 3 -20.0
SPARCL1 SPARC-like 1 (hevin) -20.0
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -20.0
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -20.0
SCP2 sterol carrier protein 2 -20.0
KIF5B kinesin family member 5B -20.0
COMMD6 COMM domain containing 6 -20.0
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -20.0
GPX8 glutathione peroxidase 8 (putative) -20.0
TMOD3 tropomodulin 3 (ubiquitous) -20.0
MTMR4 myotubularin related protein 4 -20.0
TMCO1 transmembrane and coiled-coil domains 1 -20.0
CLGN calmegin -20.0
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -20.0
CUL4B cullin 4B -20.0
SEPT9 septin 9 -20.0
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -20.0
CFL2 cofilin 2 (muscle) -20.0
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -20.0
RNF152 ring finger protein 152 -20.0
PTPRJ protein tyrosine phosphatase, receptor type, J -20.0
LTBP4 latent transforming growth factor beta binding protein 4 -20.0
TRIM66 tripartite motif containing 66 -20.0
TMOD2 tropomodulin 2 (neuronal) -20.0
CHMP3 charged multivesicular body protein 3 -20.0
PHF21A PHD finger protein 21A -20.0
KLHL8 kelch-like family member 8 -20.0
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -20.0
DKK3 dickkopf WNT signaling pathway inhibitor 3 -20.0
HDAC9 histone deacetylase 9 -20.0
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -20.0
CLIC1 chloride intracellular channel 1 -20.0
CRABP2 cellular retinoic acid binding protein 2 -20.0
NEK9 NIMA-related kinase 9 -20.0
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -20.0
SSR1 signal sequence receptor, alpha -20.0
PHF1 PHD finger protein 1 -20.0
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -20.0
KDM1B lysine (K)-specific demethylase 1B -20.0
SAFB scaffold attachment factor B -20.0
HSPA4L heat shock 70kDa protein 4-like -20.0
FMR1 fragile X mental retardation 1 -20.0
CALCOCO2 calcium binding and coiled-coil domain 2 -20.0
PYGO2 pygopus family PHD finger 2 -20.0
TAPT1 transmembrane anterior posterior transformation 1 -20.0
GDAP1 ganglioside induced differentiation associated protein 1 -20.0
COPS2 COP9 signalosome subunit 2 -20.0
ZCCHC11 zinc finger, CCHC domain containing 11 -20.0
ABHD3 abhydrolase domain containing 3 -20.0
TIMP2 TIMP metallopeptidase inhibitor 2 -20.0
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -20.0
RCN2 reticulocalbin 2, EF-hand calcium binding domain -20.0
PITRM1 pitrilysin metallopeptidase 1 -20.0
SDC2 syndecan 2 -20.0
SDC3 syndecan 3 -20.0
STRBP spermatid perinuclear RNA binding protein -20.0
HACD3 3-hydroxyacyl-CoA dehydratase 3 -20.0
FNDC3A fibronectin type III domain containing 3A -20.0
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -20.0
FN1 fibronectin 1 -20.0
SLIT1 slit homolog 1 (Drosophila) -20.0
SESN3 sestrin 3 -20.0
PLS1 plastin 1 -20.0
KIAA1598 -20.0
USP34 ubiquitin specific peptidase 34 -20.0
LAMP3 lysosomal-associated membrane protein 3 -20.0
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -20.0
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -20.0
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -20.0
ADAM22 ADAM metallopeptidase domain 22 -20.0
EPS15 epidermal growth factor receptor pathway substrate 15 -20.0
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -20.0
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -20.0
STOML2 stomatin (EPB72)-like 2 -20.0