| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting BRCA1 in neuroblastoma cell SH-EP-NMYCER cell line (Study accession: SRP135799) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_13890_KD_BRCA1_SRP135799 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TAGLN | transgelin | 20.0 |
| FST | follistatin | 20.0 |
| FOSL1 | FOS-like antigen 1 | 19.699 |
| CCND1 | cyclin D1 | 17.8153 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 17.1319 |
| PODXL | podocalyxin-like | 17.1024 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 17.0937 |
| CTGF | connective tissue growth factor | 17.0937 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 15.3707 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 14.0395 |
| CSRP1 | cysteine and glycine-rich protein 1 | 12.5057 |
| FAM196B | family with sequence similarity 196, member B | 12.2657 |
| CD274 | CD274 molecule | 12.1342 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 11.2241 |
| PPIF | peptidylprolyl isomerase F | 10.4939 |
| ANTXR2 | anthrax toxin receptor 2 | 10.4939 |
| RGS4 | regulator of G-protein signaling 4 | 10.4372 |
| HMGA2 | high mobility group AT-hook 2 | 9.98028 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 9.75788 |
| PSG4 | pregnancy specific beta-1-glycoprotein 4 | 9.41503 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 9.36632 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 8.50898 |
| DUSP5 | dual specificity phosphatase 5 | 8.42095 |
| RCAN1 | regulator of calcineurin 1 | 8.36706 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 8.25994 |
| SERPINB7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 8.20098 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 8.05216 |
| FGF1 | fibroblast growth factor 1 (acidic) | 7.96576 |
| FHL2 | four and a half LIM domains 2 | 7.89139 |
| AEN | apoptosis enhancing nuclease | 7.73243 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 7.61912 |
| CD44 | CD44 molecule (Indian blood group) | 7.44743 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 7.11608 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 7.08444 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 7.05286 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 6.86667 |
| CCNA2 | cyclin A2 | 6.65257 |
| DUSP1 | dual specificity phosphatase 1 | 6.29054 |
| MARCH4 | membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase | 6.2652 |
| LOX | lysyl oxidase | 6.20357 |
| JUN | jun proto-oncogene | 6.20357 |
| GATA2 | GATA binding protein 2 | 6.20357 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 6.18588 |
| USP53 | ubiquitin specific peptidase 53 | 6.17315 |
| ODC1 | ornithine decarboxylase 1 | 6.07902 |
| CLDN1 | claudin 1 | 6.06254 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 6.01596 |
| PALM2-AKAP2 | PALM2-AKAP2 readthrough | 6.00526 |
| DNMBP | dynamin binding protein | 5.96564 |
| EPHA2 | EPH receptor A2 | 5.7676 |
| RND3 | Rho family GTPase 3 | 5.72366 |
| BIRC2 | baculoviral IAP repeat containing 2 | 5.71412 |
| NOG | noggin | 5.70635 |
| BDNF | brain-derived neurotrophic factor | 5.69733 |
| FOXD1 | forkhead box D1 | 5.48189 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 5.45444 |
| PLAUR | plasminogen activator, urokinase receptor | 5.454 |
| NABP1 | nucleic acid binding protein 1 | 5.409 |
| MAP2K3 | mitogen-activated protein kinase kinase 3 | 5.36877 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 5.30702 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 5.30352 |
| CDC42SE1 | CDC42 small effector 1 | 5.26485 |
| FGF2 | fibroblast growth factor 2 (basic) | 5.10744 |
| HBEGF | heparin-binding EGF-like growth factor | 5.07701 |
| CALD1 | caldesmon 1 | 4.95464 |
| ESM1 | endothelial cell-specific molecule 1 | 4.86998 |
| S1PR1 | sphingosine-1-phosphate receptor 1 | 4.86998 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 4.76378 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 4.75638 |
| ITGA6 | integrin, alpha 6 | 4.68492 |
| NSUN2 | NOP2/Sun RNA methyltransferase family, member 2 | 4.6472 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | 4.64511 |
| MYO10 | myosin X | 4.64064 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 4.55326 |
| HDAC9 | histone deacetylase 9 | 4.53367 |
| SPRED3 | sprouty-related, EVH1 domain containing 3 | 4.49039 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 4.43685 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 4.40013 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 4.35845 |
| FGF5 | fibroblast growth factor 5 | 4.3328 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 4.33032 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 4.28682 |
| HAS2 | hyaluronan synthase 2 | 4.22903 |
| GPR176 | G protein-coupled receptor 176 | 4.22095 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 4.19856 |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 4.10077 |
| DAPK3 | death-associated protein kinase 3 | 4.08525 |
| ADAM19 | ADAM metallopeptidase domain 19 | 4.07727 |
| SBDS | Shwachman-Bodian-Diamond syndrome | 4.07727 |
| PTRF | polymerase I and transcript release factor | 4.02659 |
| THBS1 | thrombospondin 1 | 4.01853 |
| NAV2 | neuron navigator 2 | 3.92283 |
| CTPS1 | CTP synthase 1 | 3.88808 |
| SMTN | smoothelin | 3.76693 |
| BIRC3 | baculoviral IAP repeat containing 3 | 3.55617 |
| USP36 | ubiquitin specific peptidase 36 | 3.52336 |
| GMNN | geminin, DNA replication inhibitor | 3.52336 |
| DUSP7 | dual specificity phosphatase 7 | 3.52142 |
| BCL6 | B-cell CLL/lymphoma 6 | 3.50965 |
| CORO1C | coronin, actin binding protein, 1C | 3.48466 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BRCA1 | breast cancer 1, early onset | -20.0 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | -20.0 |
| FASN | fatty acid synthase | -20.0 |
| MME | membrane metallo-endopeptidase | -20.0 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -20.0 |
| COL1A1 | collagen, type I, alpha 1 | -20.0 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | -20.0 |
| COL3A1 | collagen, type III, alpha 1 | -20.0 |
| LUM | lumican | -20.0 |
| INSIG1 | insulin induced gene 1 | -20.0 |
| SDCBP | syndecan binding protein (syntenin) | -18.1427 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -17.2048 |
| COL5A1 | collagen, type V, alpha 1 | -17.0575 |
| PLXND1 | plexin D1 | -15.7867 |
| PCDH18 | protocadherin 18 | -14.9113 |
| SDC2 | syndecan 2 | -14.809 |
| COL1A2 | collagen, type I, alpha 2 | -14.5492 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -12.5756 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -12.4863 |
| TNS3 | tensin 3 | -12.0974 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -11.6936 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -11.2614 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -10.9781 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -10.9073 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -10.8437 |
| FADS1 | fatty acid desaturase 1 | -10.578 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | -10.3373 |
| PCOLCE | procollagen C-endopeptidase enhancer | -9.98028 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -9.92877 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -9.91582 |
| COL5A2 | collagen, type V, alpha 2 | -9.7755 |
| APOL6 | apolipoprotein L, 6 | -9.76272 |
| MMP2 | matrix metallopeptidase 2 | -9.73979 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -9.5408 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | -9.39913 |
| SLIT1 | slit homolog 1 (Drosophila) | -9.20847 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -9.09639 |
| BGN | biglycan | -8.95004 |
| S100A4 | S100 calcium binding protein A4 | -8.93588 |
| RAB11A | RAB11A, member RAS oncogene family | -8.63508 |
| PGM3 | phosphoglucomutase 3 | -8.61611 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -8.42095 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -8.38201 |
| COL4A2 | collagen, type IV, alpha 2 | -8.38201 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -8.25487 |
| SORBS2 | sorbin and SH3 domain containing 2 | -8.20098 |
| LDLR | low density lipoprotein receptor | -8.13761 |
| BCHE | butyrylcholinesterase | -8.01147 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -7.92219 |
| BMP1 | bone morphogenetic protein 1 | -7.84628 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -7.69724 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -7.14633 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | -6.88622 |
| FSTL1 | follistatin-like 1 | -6.77531 |
| ADGRA2 | adhesion G protein-coupled receptor A2 | -6.76574 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -6.711 |
| DDIT4 | DNA-damage-inducible transcript 4 | -6.68304 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -6.67119 |
| MAGEC2 | melanoma antigen family C2 | -6.52626 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -6.4695 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -6.40723 |
| CAV2 | caveolin 2 | -6.35098 |
| HMCN1 | hemicentin 1 | -6.24172 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -6.21097 |
| FAM198B | family with sequence similarity 198, member B | -6.21097 |
| SYNPO | synaptopodin | -6.04724 |
| AFAP1L2 | actin filament associated protein 1-like 2 | -6.03929 |
| TNS2 | tensin 2 | -5.85912 |
| PRSS23 | protease, serine, 23 | -5.79709 |
| LINC00998 | long intergenic non-protein coding RNA 998 | -5.75721 |
| ARHGAP42 | Rho GTPase activating protein 42 | -5.75721 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | -5.56614 |
| FAM96A | family with sequence similarity 96, member A | -5.55558 |
| SOX4 | SRY (sex determining region Y)-box 4 | -5.55558 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -5.51643 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | -5.49222 |
| COL6A1 | collagen, type VI, alpha 1 | -5.30352 |
| TMEM135 | transmembrane protein 135 | -5.27271 |
| SEC23IP | SEC23 interacting protein | -5.15641 |
| GBAS | glioblastoma amplified sequence | -5.15641 |
| PM20D2 | peptidase M20 domain containing 2 | -5.1422 |
| COL4A1 | collagen, type IV, alpha 1 | -4.9582 |
| MRC2 | mannose receptor, C type 2 | -4.94473 |
| CRABP2 | cellular retinoic acid binding protein 2 | -4.92884 |
| E2F4 | E2F transcription factor 4, p107/p130-binding | -4.87297 |
| CCNG2 | cyclin G2 | -4.85427 |
| RARG | retinoic acid receptor, gamma | -4.78202 |
| B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 | -4.76378 |
| YPEL2 | yippee-like 2 (Drosophila) | -4.71361 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -4.70508 |
| MPLKIP | M-phase specific PLK1 interacting protein | -4.681 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -4.64778 |
| LPIN1 | lipin 1 | -4.61408 |
| TMEM178B | transmembrane protein 178B | -4.56158 |
| TRPM8 | transient receptor potential cation channel, subfamily M, member 8 | -4.55924 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -4.46126 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -4.44787 |
| CXXC5 | CXXC finger protein 5 | -4.17885 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -4.15826 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -4.07217 |
