| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting AS3MT in neuroblastoma cell SH-SY5Y cell line (Study accession: SRP332674) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_13902_KO_AS3MT_SRP332674 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAPK7 | mitogen-activated protein kinase 7 | 20.0 |
| FAM228B | family with sequence similarity 228, member B | 20.0 |
| EPB41 | erythrocyte membrane protein band 4.1 | 14.6492 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 12.0586 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 10.7738 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 10.1144 |
| DQX1 | DEAQ box RNA-dependent ATPase 1 | 9.19671 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 6.07127 |
| CFAP44 | cilia and flagella associated protein 44 | 5.90132 |
| COX20 | COX20 cytochrome c oxidase assembly factor | 5.70461 |
| TRIM59 | tripartite motif containing 59 | 5.39637 |
| SARDH | sarcosine dehydrogenase | 5.21485 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | 5.16596 |
| TCP1 | t-complex 1 | 5.02057 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 4.7173 |
| FERMT2 | fermitin family member 2 | 4.64558 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 4.28412 |
| TEFM | transcription elongation factor, mitochondrial | 4.16957 |
| STRADA | STE20-related kinase adaptor alpha | 3.94855 |
| IER3 | immediate early response 3 | 3.72615 |
| ENOSF1 | enolase superfamily member 1 | 3.6321 |
| RAF1 | Raf-1 proto-oncogene, serine/threonine kinase | 3.60826 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 3.5973 |
| PTMA | prothymosin, alpha | 3.59325 |
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 3.36006 |
| PPHLN1 | periphilin 1 | 3.31502 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 3.2449 |
| GLOD4 | glyoxalase domain containing 4 | 3.19412 |
| PRSS23 | protease, serine, 23 | 3.10057 |
| SAMD11 | sterile alpha motif domain containing 11 | 3.03896 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 3.02805 |
| TFB1M | transcription factor B1, mitochondrial | 3.01428 |
| PDGFRL | platelet-derived growth factor receptor-like | 2.98215 |
| KLC1 | kinesin light chain 1 | 2.97666 |
| ZNF571 | zinc finger protein 571 | 2.96078 |
| TMOD1 | tropomodulin 1 | 2.9559 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 2.89699 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 2.88209 |
| POLR2C | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa | 2.86571 |
| RNF213 | ring finger protein 213 | 2.84244 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 2.82528 |
| ZNF517 | zinc finger protein 517 | 2.7679 |
| CCL15 | chemokine (C-C motif) ligand 15 | 2.75079 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 2.70109 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 2.66666 |
| DDTL | D-dopachrome tautomerase-like | 2.65901 |
| GLRX2 | glutaredoxin 2 | 2.64417 |
| AKIRIN2 | akirin 2 | 2.62483 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 2.62266 |
| TPT1 | tumor protein, translationally-controlled 1 | 2.59623 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 2.58303 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | 2.5348 |
| STKLD1 | serine/threonine kinase-like domain containing 1 | 2.51516 |
| PMPCB | peptidase (mitochondrial processing) beta | 2.45796 |
| C12ORF65 | chromosome 12 open reading frame 65 | 2.42986 |
| CCDC73 | coiled-coil domain containing 73 | 2.37738 |
| NRDE2 | NRDE-2, necessary for RNA interference, domain containing | 2.37135 |
| LOC338667 | V-set and immunoglobulin domain-containing protein 10-like | 2.35957 |
| CP | ceruloplasmin (ferroxidase) | 2.34069 |
| TMEM41A | transmembrane protein 41A | 2.34052 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 2.27637 |
| C3ORF17 | chromosome 3 open reading frame 17 | 2.26122 |
| ATG10 | autophagy related 10 | 2.21868 |
| MFI2 | antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 | 2.20544 |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter), member 2 | 2.20446 |
| SUN2 | Sad1 and UNC84 domain containing 2 | 2.18776 |
| TAF6 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | 2.16955 |
| DOC2A | double C2-like domains, alpha | 2.14923 |
| MED9 | mediator complex subunit 9 | 2.13428 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 2.13235 |
| RIC3 | RIC3 acetylcholine receptor chaperone | 2.13067 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 2.13067 |
| C19ORF44 | chromosome 19 open reading frame 44 | 2.11332 |
| CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase | 2.10079 |
| PRIMPOL | primase and polymerase (DNA-directed) | 2.09337 |
| CCDC107 | coiled-coil domain containing 107 | 2.08983 |
| RFPL1 | ret finger protein-like 1 | 2.08641 |
| POLG | polymerase (DNA directed), gamma | 2.07897 |
| MFAP4 | microfibrillar-associated protein 4 | 2.07753 |
| GYG1 | glycogenin 1 | 2.05348 |
| IFT20 | intraflagellar transport 20 | 2.03306 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 2.02253 |
| ZNF771 | zinc finger protein 771 | 2.02223 |
| LRRC41 | leucine rich repeat containing 41 | 2.01477 |
| RPL32 | ribosomal protein L32 | 1.96434 |
| MFSD11 | major facilitator superfamily domain containing 11 | 1.95689 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | 1.95686 |
| C21ORF2 | chromosome 21 open reading frame 2 | 1.94814 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 1.94025 |
| ZNF3 | zinc finger protein 3 | 1.93923 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 1.93637 |
| PTCD1 | pentatricopeptide repeat domain 1 | 1.93237 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 1.8971 |
| LHFPL5 | lipoma HMGIC fusion partner-like 5 | 1.87588 |
| PMEL | premelanosome protein | 1.8752 |
| BOC | BOC cell adhesion associated, oncogene regulated | 1.86838 |
| MRPS14 | mitochondrial ribosomal protein S14 | 1.84881 |
| PAQR4 | progestin and adipoQ receptor family member IV | 1.84802 |
| HMGB1 | high mobility group box 1 | 1.79718 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 1.79469 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPATA1 | spermatogenesis associated 1 | -20.0 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -20.0 |
| ORAOV1 | oral cancer overexpressed 1 | -20.0 |
| PGF | placental growth factor | -20.0 |
| C12ORF73 | chromosome 12 open reading frame 73 | -18.7212 |
| HIST1H4I | histone cluster 1, H4i | -17.9508 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -16.3114 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | -13.7355 |
| PDK2 | pyruvate dehydrogenase kinase, isozyme 2 | -13.2943 |
| TMEM79 | transmembrane protein 79 | -12.9192 |
| CDC42SE1 | CDC42 small effector 1 | -12.901 |
| STX18 | syntaxin 18 | -12.8639 |
| ATXN2 | ataxin 2 | -11.4068 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | -11.0023 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -10.9843 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -10.416 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | -10.3272 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -9.82308 |
| WDR6 | WD repeat domain 6 | -9.70638 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | -9.61825 |
| ACKR4 | atypical chemokine receptor 4 | -9.51995 |
| SNX22 | sorting nexin 22 | -9.42033 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -9.35968 |
| ATG7 | autophagy related 7 | -8.73013 |
| MSH6 | mutS homolog 6 | -8.71468 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | -8.68578 |
| DALRD3 | DALR anticodon binding domain containing 3 | -8.61144 |
| RHOQ | ras homolog family member Q | -8.34479 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | -8.1254 |
| ERAP1 | endoplasmic reticulum aminopeptidase 1 | -8.06992 |
| SNX24 | sorting nexin 24 | -7.8822 |
| MROH8 | maestro heat-like repeat family member 8 | -7.10777 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | -7.04965 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -6.87695 |
| IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) | -6.80007 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | -6.02626 |
| RBBP4 | retinoblastoma binding protein 4 | -5.87949 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -5.80076 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -5.56888 |
| CGREF1 | cell growth regulator with EF-hand domain 1 | -5.55682 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | -5.55289 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -5.3421 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | -5.25783 |
| DOPEY1 | dopey family member 1 | -5.25302 |
| C16ORF70 | chromosome 16 open reading frame 70 | -5.05413 |
| LRRC55 | leucine rich repeat containing 55 | -4.9631 |
| NDUFAF7 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 | -4.9631 |
| FAM13C | family with sequence similarity 13, member C | -4.86795 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -4.86513 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -4.79433 |
| SPRYD4 | SPRY domain containing 4 | -4.79389 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -4.77504 |
| PRCD | progressive rod-cone degeneration | -4.76503 |
| DNAH10 | dynein, axonemal, heavy chain 10 | -4.64352 |
| ADAM17 | ADAM metallopeptidase domain 17 | -4.64352 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -4.44975 |
| C12ORF60 | chromosome 12 open reading frame 60 | -4.44975 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -4.38219 |
| KCNH1 | potassium channel, voltage gated eag related subfamily H, member 1 | -4.29591 |
| TFPI2 | tissue factor pathway inhibitor 2 | -4.2438 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -4.20799 |
| GANC | glucosidase, alpha; neutral C | -4.17685 |
| MOCS2 | molybdenum cofactor synthesis 2 | -4.127 |
| FAM151A | family with sequence similarity 151, member A | -4.06966 |
| GFM2 | G elongation factor, mitochondrial 2 | -3.94373 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | -3.94373 |
| PLLP | plasmolipin | -3.65269 |
| SARM1 | sterile alpha and TIR motif containing 1 | -3.53872 |
| FAM120AOS | family with sequence similarity 120A opposite strand | -3.49372 |
| CAST | calpastatin | -3.31955 |
| GPN1 | GPN-loop GTPase 1 | -3.22653 |
| SLC46A1 | solute carrier family 46 (folate transporter), member 1 | -3.18642 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.16781 |
| HDAC9 | histone deacetylase 9 | -3.16085 |
| BRD7 | bromodomain containing 7 | -3.10812 |
| RNF123 | ring finger protein 123 | -3.0733 |
| C7 | complement component 7 | -3.07137 |
| MSMP | microseminoprotein, prostate associated | -3.06184 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -3.03896 |
| RPL10 | ribosomal protein L10 | -3.01463 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | -3.00067 |
| MRPL43 | mitochondrial ribosomal protein L43 | -2.99782 |
| TCHP | trichoplein, keratin filament binding | -2.99092 |
| ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | -2.98282 |
| MROH2B | maestro heat-like repeat family member 2B | -2.92998 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -2.92087 |
| DDIT3 | DNA-damage-inducible transcript 3 | -2.89699 |
| TUB | tubby bipartite transcription factor | -2.87365 |
| ANGPTL6 | angiopoietin-like 6 | -2.85767 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -2.78956 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.76502 |
| PLD4 | phospholipase D family, member 4 | -2.74337 |
| KHK | ketohexokinase (fructokinase) | -2.70109 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -2.62375 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -2.61997 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | -2.53355 |
| HERPUD2 | HERPUD family member 2 | -2.50882 |
| NME7 | NME/NM23 family member 7 | -2.5013 |
| JAKMIP3 | Janus kinase and microtubule interacting protein 3 | -2.49429 |
| PINK1 | PTEN induced putative kinase 1 | -2.49429 |
