Perturb_13978_OE_RNU11_SRP178463 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting RNU11 in neuron cell (Study accession: SRP178463) (PerturbAtlas)
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Genes

190 genes differentially expressed following the Perturb_13978_OE_RNU11_SRP178463 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
SCUBE3 signal peptide, CUB domain, EGF-like 3 10.7747
FLT1 fms-related tyrosine kinase 1 10.2762
ADAM19 ADAM metallopeptidase domain 19 9.68813
ADGRG1 adhesion G protein-coupled receptor G1 8.50923
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 8.08863
NTSR1 neurotensin receptor 1 (high affinity) 7.41627
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 7.11916
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 6.35757
LTBP1 latent transforming growth factor beta binding protein 1 6.02831
MEDAG mesenteric estrogen-dependent adipogenesis 5.97838
LOX lysyl oxidase 5.6798
MFAP2 microfibrillar-associated protein 2 5.039
NOTCH3 notch 3 4.8024
TAGLN2 transgelin 2 4.57731
NEK7 NIMA-related kinase 7 4.50568
SOX9 SRY (sex determining region Y)-box 9 4.44288
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 4.42202
MFAP5 microfibrillar associated protein 5 4.35152
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 4.00056
ANPEP alanyl (membrane) aminopeptidase 3.7767
CD44 CD44 molecule (Indian blood group) 3.77165
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 3.77165
GPR68 G protein-coupled receptor 68 3.53271
ENC1 ectodermal-neural cortex 1 (with BTB domain) 3.32495
LAMB3 laminin, beta 3 3.24812
PEAR1 platelet endothelial aggregation receptor 1 3.18308
GPER1 G protein-coupled estrogen receptor 1 3.16345
ANGPT2 angiopoietin 2 3.00579
ADAMTSL1 ADAMTS-like 1 2.97169
PRELP proline/arginine-rich end leucine-rich repeat protein 2.96827
SMTN smoothelin 2.9524
KIAA1549L KIAA1549-like 2.9524
ENG endoglin 2.85902
SH2D3C SH2 domain containing 3C 2.83208
ZNF703 zinc finger protein 703 2.66323
TAGLN transgelin 2.637
OSMR oncostatin M receptor 2.58955
PLXNA4 plexin A4 2.56519
WISP1 WNT1 inducible signaling pathway protein 1 2.5467
SLC35E4 solute carrier family 35, member E4 2.54115
GLIPR1 GLI pathogenesis-related 1 2.51517
NOTCH1 notch 1 2.50654
MMP16 matrix metallopeptidase 16 (membrane-inserted) 2.46589
MARCKSL1 MARCKS-like 1 2.46589
MMP28 matrix metallopeptidase 28 2.43769
HMGA2 high mobility group AT-hook 2 2.42428
PROCR protein C receptor, endothelial 2.37401
KIFC3 kinesin family member C3 2.31348
SPHK1 sphingosine kinase 1 2.28006
NDRG1 N-myc downstream regulated 1 2.13734
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.05329
NAV1 neuron navigator 1 2.02517
STX1B syntaxin 1B 1.9862
XYLT1 xylosyltransferase I 1.9442
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.92601
HES1 hes family bHLH transcription factor 1 1.88505
VEGFC vascular endothelial growth factor C 1.88428
FZD7 frizzled class receptor 7 1.88428
PLAT plasminogen activator, tissue 1.85618
GMNN geminin, DNA replication inhibitor 1.83464
CCDC80 coiled-coil domain containing 80 1.82477
ARSI arylsulfatase family, member I 1.79664
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.76703
ITGA1 integrin, alpha 1 1.76456
FOXC2 forkhead box C2 1.76163
POSTN periostin, osteoblast specific factor 1.75873
KIF21B kinesin family member 21B 1.74301
FZD8 frizzled class receptor 8 1.74124
TEK TEK tyrosine kinase, endothelial 1.73612
LRRC17 leucine rich repeat containing 17 1.67084
LDHA lactate dehydrogenase A 1.66373
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 1.58649
RAB17 RAB17, member RAS oncogene family 1.5637
DIAPH1 diaphanous-related formin 1 1.53578
QPCT glutaminyl-peptide cyclotransferase 1.53578
SREBF1 sterol regulatory element binding transcription factor 1 1.53342
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.46963
GRIP2 glutamate receptor interacting protein 2 1.46495
TUBA1A tubulin, alpha 1a 1.44809
SYNPO synaptopodin 1.44399
TINAGL1 tubulointerstitial nephritis antigen-like 1 1.44399
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1.44399
COTL1 coactosin-like F-actin binding protein 1 1.40835
SGK223 homolog of rat pragma of Rnd2 1.37041
C6ORF132 chromosome 6 open reading frame 132 1.37041
SULF1 sulfatase 1 1.36366
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 1.36366
EFR3B EFR3 homolog B (S. cerevisiae) 1.3552
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 1.35103
LXN latexin 1.34304
PTGES prostaglandin E synthase 1.33401
KLHL4 kelch-like family member 4 1.31521
FXYD5 FXYD domain containing ion transport regulator 5 1.3151
LPPR4 lipid phosphate phosphatase-related protein type 4 1.3151
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 1.30696
SOD3 superoxide dismutase 3, extracellular 1.30346
ALCAM activated leukocyte cell adhesion molecule 1.30263

decreased expression

Symbol Name Standardized Value
ADA adenosine deaminase -9.87738
FTH1 ferritin, heavy polypeptide 1 -8.74595
L1CAM L1 cell adhesion molecule -7.41627
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -7.15227
KLF9 Kruppel-like factor 9 -6.02831
MAN1C1 mannosidase, alpha, class 1C, member 1 -5.97838
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -5.937
DDIT4 DNA-damage-inducible transcript 4 -5.6798
TP53I11 tumor protein p53 inducible protein 11 -5.42997
TM7SF2 transmembrane 7 superfamily member 2 -5.34536
DUSP27 dual specificity phosphatase 27 (putative) -5.24886
MMP11 matrix metallopeptidase 11 -5.24886
LCNL1 lipocalin-like 1 -4.86271
ACKR3 atypical chemokine receptor 3 -4.68871
ACVR1C activin A receptor, type IC -4.60967
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -4.51157
FTL ferritin, light polypeptide -4.50568
CTSH cathepsin H -3.31315
TFRC transferrin receptor -3.04234
GPNMB glycoprotein (transmembrane) nmb -2.91132
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.87065
TAPBPL TAP binding protein-like -2.76797
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -2.75165
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.71063
PELI2 pellino E3 ubiquitin protein ligase family member 2 -2.637
ANGPT1 angiopoietin 1 -2.62915
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.61135
SHISA9 shisa family member 9 -2.60125
NHLRC3 NHL repeat containing 3 -2.59682
CLEC3B C-type lectin domain family 3, member B -2.58955
TENM2 teneurin transmembrane protein 2 -2.5886
MEGF9 multiple EGF-like-domains 9 -2.43048
CTSL cathepsin L -2.40674
UNC5D unc-5 homolog D (C. elegans) -2.37318
CASP1 caspase 1, apoptosis-related cysteine peptidase -2.28276
ALOX5 arachidonate 5-lipoxygenase -2.28006
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.2553
IL34 interleukin 34 -2.22277
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.13199
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.09005
HAVCR2 hepatitis A virus cellular receptor 2 -2.06023
MOSPD2 motile sperm domain containing 2 -2.02194
DBP D site of albumin promoter (albumin D-box) binding protein -1.98987
SLC16A14 solute carrier family 16, member 14 -1.98411
MYBPC2 myosin binding protein C, fast type -1.9536
CTSK cathepsin K -1.9442
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -1.9442
TNFAIP8L3 tumor necrosis factor, alpha-induced protein 8-like 3 -1.88428
TRIM9 tripartite motif containing 9 -1.87723
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -1.80849
IGFBP5 insulin-like growth factor binding protein 5 -1.79033
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -1.74301
CCND3 cyclin D3 -1.74301
KLHL41 kelch-like family member 41 -1.74301
KLF13 Kruppel-like factor 13 -1.74301
SLC16A6 solute carrier family 16, member 6 -1.71611
WISP2 WNT1 inducible signaling pathway protein 2 -1.69866
AMDHD2 amidohydrolase domain containing 2 -1.6748
ANTXR1 anthrax toxin receptor 1 -1.66759
UBA7 ubiquitin-like modifier activating enzyme 7 -1.65933
TCN2 transcobalamin II -1.65054
KLHL24 kelch-like family member 24 -1.64965
STEAP4 STEAP family member 4 -1.63449
DPP7 dipeptidyl-peptidase 7 -1.61181
CXCL14 chemokine (C-X-C motif) ligand 14 -1.59143
RAB39B RAB39B, member RAS oncogene family -1.58662
FZD5 frizzled class receptor 5 -1.58649
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -1.564
FAM111A family with sequence similarity 111, member A -1.564
SCN5A sodium channel, voltage gated, type V alpha subunit -1.56007
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -1.55936
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -1.55469
PAPLN papilin, proteoglycan-like sulfated glycoprotein -1.53578
WSB1 WD repeat and SOCS box containing 1 -1.52827
WEE1 WEE1 G2 checkpoint kinase -1.50316
RGS11 regulator of G-protein signaling 11 -1.48373
OLFML2A olfactomedin-like 2A -1.48361
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -1.47927
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -1.4522
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 -1.4481
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -1.43971
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -1.43674
FLCN folliculin -1.41064
KCNK15 potassium channel, two pore domain subfamily K, member 15 -1.40835
ASS1 argininosuccinate synthase 1 -1.39243
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -1.37041
CD34 CD34 molecule -1.37041
S100A3 S100 calcium binding protein A3 -1.3552
TMEM194A transmembrane protein 194A -1.35103
FAM107A family with sequence similarity 107, member A -1.31365
SERINC5 serine incorporator 5 -1.31365
ACVR2A activin A receptor, type IIA -1.30696
RFTN1 raftlin, lipid raft linker 1 -1.30696