Perturb_14246_KO_FOXM1_SRP328179 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting FOXM1 in OPM2 human myeloma cell line cell line (Study accession: SRP328179) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_14246_KO_FOXM1_SRP328179 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 20.0
KMT2A lysine (K)-specific methyltransferase 2A 20.0
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 20.0
RCSD1 RCSD domain containing 1 20.0
MCM4 minichromosome maintenance complex component 4 20.0
SCARB1 scavenger receptor class B, member 1 20.0
HES6 hes family bHLH transcription factor 6 20.0
MYRF myelin regulatory factor 20.0
PDIA2 protein disulfide isomerase family A, member 2 20.0
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 20.0
CD276 CD276 molecule 20.0
HSPH1 heat shock 105kDa/110kDa protein 1 20.0
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 20.0
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 20.0
CCDC86 coiled-coil domain containing 86 20.0
COTL1 coactosin-like F-actin binding protein 1 20.0
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 20.0
EPHB2 EPH receptor B2 20.0
NBEAL2 neurobeachin-like 2 20.0
MYL1 myosin, light chain 1, alkali; skeletal, fast 20.0
ZNF692 zinc finger protein 692 20.0
TFRC transferrin receptor 20.0
WDR90 WD repeat domain 90 20.0
RHPN2 rhophilin, Rho GTPase binding protein 2 20.0
ADGRE5 adhesion G protein-coupled receptor E5 20.0
JAG2 jagged 2 20.0
BEST3 bestrophin 3 20.0
TNPO2 transportin 2 20.0
MYO18A myosin XVIIIA 20.0
LAMA5 laminin, alpha 5 20.0
ABR active BCR-related 20.0
CSK c-src tyrosine kinase 20.0
GOLM1 golgi membrane protein 1 20.0
HSPA8 heat shock 70kDa protein 8 20.0
HIP1R huntingtin interacting protein 1 related 20.0
EDRF1 erythroid differentiation regulatory factor 1 20.0
RAI14 retinoic acid induced 14 20.0
TRIP10 thyroid hormone receptor interactor 10 20.0
ZNF121 zinc finger protein 121 20.0
MEGF6 multiple EGF-like-domains 6 20.0
SEPT3 septin 3 20.0
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 20.0
CD44 CD44 molecule (Indian blood group) 20.0
SACS sacsin molecular chaperone 20.0
RERG RAS-like, estrogen-regulated, growth inhibitor 20.0
GSE1 Gse1 coiled-coil protein 20.0
SH3TC1 SH3 domain and tetratricopeptide repeats 1 20.0
PODXL podocalyxin-like 20.0
TAGLN2 transgelin 2 20.0
FKBP4 FK506 binding protein 4, 59kDa 20.0
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 20.0
INF2 inverted formin, FH2 and WH2 domain containing 20.0
MYADM myeloid-associated differentiation marker 20.0
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 20.0
CREG1 cellular repressor of E1A-stimulated genes 1 20.0
AFAP1L2 actin filament associated protein 1-like 2 20.0
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 20.0
SCML2 sex comb on midleg-like 2 (Drosophila) 20.0
ZMIZ1 zinc finger, MIZ-type containing 1 20.0
SYNE3 spectrin repeat containing, nuclear envelope family member 3 20.0
IGFBP7 insulin-like growth factor binding protein 7 20.0
ITGB7 integrin, beta 7 20.0
TPCN1 two pore segment channel 1 20.0
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 20.0
LPCAT1 lysophosphatidylcholine acyltransferase 1 20.0
FHOD1 formin homology 2 domain containing 1 20.0
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 20.0
EPB41L2 erythrocyte membrane protein band 4.1-like 2 20.0
ADAM15 ADAM metallopeptidase domain 15 20.0
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 20.0
SDCCAG3 serologically defined colon cancer antigen 3 20.0
PAGE5 P antigen family, member 5 (prostate associated) 20.0
LYN LYN proto-oncogene, Src family tyrosine kinase 20.0
VAV1 vav 1 guanine nucleotide exchange factor 20.0
ARHGAP21 Rho GTPase activating protein 21 20.0
IL4R interleukin 4 receptor 20.0
ANXA4 annexin A4 20.0
PUS7 pseudouridylate synthase 7 (putative) 20.0
SLC19A1 solute carrier family 19 (folate transporter), member 1 20.0
MED9 mediator complex subunit 9 20.0
MNX1 motor neuron and pancreas homeobox 1 20.0
PRDX2 peroxiredoxin 2 20.0
KAT2A K(lysine) acetyltransferase 2A 20.0
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 20.0
NCS1 neuronal calcium sensor 1 20.0
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 20.0
ADAM23 ADAM metallopeptidase domain 23 20.0
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 20.0
CD81 CD81 molecule 20.0
SLC25A53 solute carrier family 25, member 53 20.0
PPDPF pancreatic progenitor cell differentiation and proliferation factor 20.0
RAP1GAP2 RAP1 GTPase activating protein 2 20.0
ENDOD1 endonuclease domain containing 1 20.0
TIMP2 TIMP metallopeptidase inhibitor 2 20.0
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 20.0
SMG5 SMG5 nonsense mediated mRNA decay factor 20.0
NOP56 NOP56 ribonucleoprotein 20.0
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 20.0
TFDP1 transcription factor Dp-1 20.0
SUGP2 SURP and G patch domain containing 2 20.0

decreased expression

Symbol Name Standardized Value
RHOH ras homolog family member H -20.0
CUBN cubilin (intrinsic factor-cobalamin receptor) -20.0
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -20.0
TJP1 tight junction protein 1 -20.0
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -20.0
SNAP29 synaptosomal-associated protein, 29kDa -20.0
DENND5B DENN/MADD domain containing 5B -20.0
MEI1 meiosis inhibitor 1 -20.0
PLCH1 phospholipase C, eta 1 -20.0
CCL3 chemokine (C-C motif) ligand 3 -20.0
GSTM1 glutathione S-transferase mu 1 -20.0
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -20.0
TTLL1 tubulin tyrosine ligase-like family member 1 -20.0
MAGED1 melanoma antigen family D1 -20.0
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -20.0
HRK harakiri, BCL2 interacting protein -20.0
TXNDC15 thioredoxin domain containing 15 -20.0
TP53INP2 tumor protein p53 inducible nuclear protein 2 -20.0
STEAP1 six transmembrane epithelial antigen of the prostate 1 -20.0
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -20.0
DPYSL2 dihydropyrimidinase-like 2 -20.0
CFLAR CASP8 and FADD-like apoptosis regulator -20.0
STX5 syntaxin 5 -20.0
TMEM143 transmembrane protein 143 -20.0
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -20.0
PLXDC2 plexin domain containing 2 -20.0
WIPF1 WAS/WASL interacting protein family, member 1 -20.0
FRY furry homolog (Drosophila) -20.0
PNPLA8 patatin-like phospholipase domain containing 8 -20.0
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 -20.0
TRIOBP TRIO and F-actin binding protein -20.0
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -20.0
SELL selectin L -20.0
RAB30 RAB30, member RAS oncogene family -20.0
PELI1 pellino E3 ubiquitin protein ligase 1 -20.0
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -20.0
FANCF Fanconi anemia, complementation group F -20.0
ACP2 acid phosphatase 2, lysosomal -20.0
ARHGAP9 Rho GTPase activating protein 9 -20.0
CYTIP cytohesin 1 interacting protein -20.0
H1FX H1 histone family, member X -20.0
FAM167A family with sequence similarity 167, member A -20.0
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -20.0
MBNL2 muscleblind-like splicing regulator 2 -20.0
MLH1 mutL homolog 1 -20.0
CPED1 cadherin-like and PC-esterase domain containing 1 -20.0
WSCD1 WSC domain containing 1 -20.0
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -20.0
CTH cystathionine gamma-lyase -20.0
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -20.0
ITGA8 integrin, alpha 8 -20.0
FBXO40 F-box protein 40 -20.0
EMP3 epithelial membrane protein 3 -20.0
SDF2L1 stromal cell-derived factor 2-like 1 -20.0
TROAP trophinin associated protein -20.0
ACVR1 activin A receptor, type I -20.0
NMRAL1 NmrA-like family domain containing 1 -20.0
IL21R interleukin 21 receptor -20.0
PHF21A PHD finger protein 21A -20.0
ADNP2 ADNP homeobox 2 -20.0
RGS16 regulator of G-protein signaling 16 -20.0
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -20.0
SMIM14 small integral membrane protein 14 -20.0
NDE1 nudE neurodevelopment protein 1 -20.0
CPEB3 cytoplasmic polyadenylation element binding protein 3 -20.0
DDIT3 DNA-damage-inducible transcript 3 -20.0
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -20.0
DKK1 dickkopf WNT signaling pathway inhibitor 1 -20.0
SLC35F1 solute carrier family 35, member F1 -20.0
TUBA1A tubulin, alpha 1a -20.0
DCC DCC netrin 1 receptor -20.0
FLRT1 fibronectin leucine rich transmembrane protein 1 -20.0
LY9 lymphocyte antigen 9 -20.0
RHBDD2 rhomboid domain containing 2 -20.0
GTSE1 G-2 and S-phase expressed 1 -20.0
ARHGAP28 Rho GTPase activating protein 28 -20.0
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 -20.0
DSEL dermatan sulfate epimerase-like -20.0
IL10RA interleukin 10 receptor, alpha -20.0
OTOGL otogelin-like -20.0
SHISA3 shisa family member 3 -20.0
CRELD2 cysteine-rich with EGF-like domains 2 -20.0
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -20.0
NLRP11 NLR family, pyrin domain containing 11 -20.0
AMPD3 adenosine monophosphate deaminase 3 -20.0
AMPD1 adenosine monophosphate deaminase 1 -20.0
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -20.0
NEURL1B neuralized E3 ubiquitin protein ligase 1B -20.0
SCPEP1 serine carboxypeptidase 1 -20.0
SULF1 sulfatase 1 -20.0
HLTF helicase-like transcription factor -20.0
FICD FIC domain containing -20.0
STBD1 starch binding domain 1 -20.0
CLEC7A C-type lectin domain family 7, member A -20.0
MRPS21 mitochondrial ribosomal protein S21 -20.0
ACAA2 acetyl-CoA acyltransferase 2 -20.0
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -20.0
SH2D3C SH2 domain containing 3C -20.0
HMP19 HMP19 protein -20.0
GALC galactosylceramidase -20.0