| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting EIF5A2 in ovarian cancer cell line SKOV3 cell line (Study accession: SRP294329) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_14324_KD_EIF5A2_SRP294329 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNX22 | sorting nexin 22 | 20.0 |
| NAV2 | neuron navigator 2 | 20.0 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 20.0 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 20.0 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | 20.0 |
| ZACN | zinc activated ligand-gated ion channel | 20.0 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | 20.0 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 20.0 |
| CDC14B | cell division cycle 14B | 20.0 |
| DOPEY1 | dopey family member 1 | 20.0 |
| TCP1 | t-complex 1 | 17.2782 |
| KCP | kielin/chordin-like protein | 17.1643 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 14.6839 |
| C12ORF73 | chromosome 12 open reading frame 73 | 14.5988 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | 13.9896 |
| GBA2 | glucosidase, beta (bile acid) 2 | 13.8779 |
| GPR132 | G protein-coupled receptor 132 | 13.6444 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 13.2375 |
| FAS | Fas cell surface death receptor | 13.0772 |
| PHPT1 | phosphohistidine phosphatase 1 | 12.8923 |
| MARS | methionyl-tRNA synthetase | 12.3981 |
| DPF3 | D4, zinc and double PHD fingers, family 3 | 11.9517 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 11.9183 |
| CENPP | centromere protein P | 11.9053 |
| EME1 | essential meiotic structure-specific endonuclease 1 | 11.8526 |
| TMEM50B | transmembrane protein 50B | 11.8091 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | 11.3791 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 11.1834 |
| TMEM97 | transmembrane protein 97 | 11.0514 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 10.978 |
| RHOBTB2 | Rho-related BTB domain containing 2 | 10.8719 |
| PCNXL4 | pecanex-like 4 (Drosophila) | 10.858 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | 10.3797 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 10.0066 |
| POLR3H | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 9.24457 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 8.58317 |
| ABI2 | abl-interactor 2 | 8.42952 |
| ARSG | arylsulfatase G | 8.3533 |
| NRDE2 | NRDE-2, necessary for RNA interference, domain containing | 8.3406 |
| SLC51A | solute carrier family 51, alpha subunit | 8.18181 |
| TXNDC17 | thioredoxin domain containing 17 | 7.96081 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 7.62909 |
| TUBB6 | tubulin, beta 6 class V | 7.54803 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 7.50062 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | 7.49001 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | 7.40955 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | 7.37673 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 7.15723 |
| BOP1 | block of proliferation 1 | 6.97803 |
| RWDD2A | RWD domain containing 2A | 6.87282 |
| PRPF40B | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | 6.86839 |
| FKBP15 | FK506 binding protein 15, 133kDa | 6.83021 |
| CARD9 | caspase recruitment domain family, member 9 | 6.61763 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | 6.60175 |
| CNTD1 | cyclin N-terminal domain containing 1 | 6.59984 |
| C1ORF122 | chromosome 1 open reading frame 122 | 6.2235 |
| LYPD1 | LY6/PLAUR domain containing 1 | 6.20212 |
| C18ORF8 | chromosome 18 open reading frame 8 | 6.15678 |
| GLIPR1 | GLI pathogenesis-related 1 | 6.14945 |
| VPRBP | Vpr (HIV-1) binding protein | 6.0233 |
| NOL7 | nucleolar protein 7, 27kDa | 5.9599 |
| GPRC5D | G protein-coupled receptor, class C, group 5, member D | 5.94522 |
| METTL20 | methyltransferase like 20 | 5.88368 |
| PLLP | plasmolipin | 5.87604 |
| WDR55 | WD repeat domain 55 | 5.8367 |
| ADGRA2 | adhesion G protein-coupled receptor A2 | 5.74526 |
| HOOK2 | hook microtubule-tethering protein 2 | 5.34086 |
| RYR3 | ryanodine receptor 3 | 5.33614 |
| LHFPL5 | lipoma HMGIC fusion partner-like 5 | 5.30582 |
| SNAP47 | synaptosomal-associated protein, 47kDa | 5.10511 |
| ACO2 | aconitase 2, mitochondrial | 4.90684 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 4.89937 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 4.86228 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | 4.81328 |
| CPM | carboxypeptidase M | 4.81328 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 4.7636 |
| SPTY2D1-AS1 | SPTY2D1 antisense RNA 1 | 4.6411 |
| TUBA1C | tubulin, alpha 1c | 4.64058 |
| PSMC3IP | PSMC3 interacting protein | 4.58897 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 4.51961 |
| CSNK1D | casein kinase 1, delta | 4.48968 |
| NKX6-2 | NK6 homeobox 2 | 4.48361 |
| C15ORF40 | chromosome 15 open reading frame 40 | 4.40409 |
| FAM227B | family with sequence similarity 227, member B | 4.40409 |
| COG8 | component of oligomeric golgi complex 8 | 4.30279 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 4.26725 |
| ZNF235 | zinc finger protein 235 | 4.26435 |
| SPATA7 | spermatogenesis associated 7 | 4.13728 |
| MPC2 | mitochondrial pyruvate carrier 2 | 4.11864 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 4.04914 |
| CIITA | class II, major histocompatibility complex, transactivator | 4.01525 |
| USP20 | ubiquitin specific peptidase 20 | 3.94968 |
| GPSM2 | G-protein signaling modulator 2 | 3.82221 |
| CCDC18 | coiled-coil domain containing 18 | 3.81796 |
| CCNE2 | cyclin E2 | 3.80942 |
| MEA1 | male-enhanced antigen 1 | 3.7614 |
| C12ORF76 | chromosome 12 open reading frame 76 | 3.56516 |
| MFSD6 | major facilitator superfamily domain containing 6 | 3.49648 |
| NELFCD | negative elongation factor complex member C/D | 3.46111 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 3.45087 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN31 | tetraspanin 31 | -20.0 |
| SNX32 | sorting nexin 32 | -20.0 |
| TRIM59 | tripartite motif containing 59 | -20.0 |
| WDR33 | WD repeat domain 33 | -20.0 |
| HIC1 | hypermethylated in cancer 1 | -20.0 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -20.0 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | -20.0 |
| RER1 | retention in endoplasmic reticulum sorting receptor 1 | -20.0 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -20.0 |
| ENOSF1 | enolase superfamily member 1 | -20.0 |
| FZD4 | frizzled class receptor 4 | -20.0 |
| DNASE1 | deoxyribonuclease I | -20.0 |
| ADCY3 | adenylate cyclase 3 | -20.0 |
| C11ORF68 | chromosome 11 open reading frame 68 | -20.0 |
| EXOSC9 | exosome component 9 | -18.6576 |
| FAM149B1 | family with sequence similarity 149, member B1 | -18.6021 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | -18.2076 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -18.1549 |
| KLC1 | kinesin light chain 1 | -17.5171 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -17.2596 |
| ATG9B | autophagy related 9B | -16.9255 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -16.7726 |
| LRRC41 | leucine rich repeat containing 41 | -16.1694 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -16.0065 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -16.0062 |
| RNASEH2C | ribonuclease H2, subunit C | -15.789 |
| MAX | MYC associated factor X | -15.7329 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -15.5476 |
| C19ORF54 | chromosome 19 open reading frame 54 | -14.5513 |
| GNGT2 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 | -14.1742 |
| TGFB1 | transforming growth factor, beta 1 | -13.7688 |
| NT5DC4 | 5'-nucleotidase domain containing 4 | -13.3953 |
| KIAA0895 | KIAA0895 | -13.292 |
| ARFRP1 | ADP-ribosylation factor related protein 1 | -12.9737 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -12.9334 |
| FAM166A | family with sequence similarity 166, member A | -12.6401 |
| BEST1 | bestrophin 1 | -12.3501 |
| UTP23 | UTP23, small subunit (SSU) processome component, homolog (yeast) | -12.0705 |
| POLG | polymerase (DNA directed), gamma | -11.9027 |
| ERCC1 | excision repair cross-complementation group 1 | -11.4824 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -10.9447 |
| FANCD2OS | FANCD2 opposite strand | -10.3164 |
| MLX | MLX, MAX dimerization protein | -10.2839 |
| ABCB9 | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | -10.2029 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -10.2002 |
| SRRM5 | serine/arginine repetitive matrix 5 | -10.0553 |
| FMNL3 | formin-like 3 | -9.7897 |
| TRAPPC4 | trafficking protein particle complex 4 | -9.7063 |
| FAM35A | family with sequence similarity 35, member A | -9.69754 |
| ORAOV1 | oral cancer overexpressed 1 | -9.51614 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | -9.17809 |
| SH3D21 | SH3 domain containing 21 | -8.98987 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -8.77339 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | -8.61941 |
| KHNYN | KH and NYN domain containing | -8.60676 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -8.57714 |
| SAMD14 | sterile alpha motif domain containing 14 | -8.42139 |
| CCDC85B | coiled-coil domain containing 85B | -8.31497 |
| ATXN2 | ataxin 2 | -8.15948 |
| MMEL1 | membrane metallo-endopeptidase-like 1 | -8.15942 |
| LRRC59 | leucine rich repeat containing 59 | -7.69254 |
| RPL27A | ribosomal protein L27a | -7.60614 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | -7.43235 |
| NRL | neural retina leucine zipper | -7.40256 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -7.36522 |
| PMCH | pro-melanin-concentrating hormone | -7.34919 |
| DLD | dihydrolipoamide dehydrogenase | -7.09978 |
| FAM134C | family with sequence similarity 134, member C | -7.02864 |
| COG1 | component of oligomeric golgi complex 1 | -7.00584 |
| CAPN12 | calpain 12 | -6.97535 |
| PAQR4 | progestin and adipoQ receptor family member IV | -6.84208 |
| C22ORF15 | chromosome 22 open reading frame 15 | -6.83423 |
| NR2C2AP | nuclear receptor 2C2-associated protein | -6.74279 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | -6.65495 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -6.60398 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -6.57756 |
| CLCC1 | chloride channel CLIC-like 1 | -6.55555 |
| ZNF276 | zinc finger protein 276 | -6.47335 |
| PRR29 | proline rich 29 | -6.37299 |
| WRAP53 | WD repeat containing, antisense to TP53 | -6.17868 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 | -6.08973 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -5.9176 |
| C19ORF44 | chromosome 19 open reading frame 44 | -5.86778 |
| STRADB | STE20-related kinase adaptor beta | -5.35715 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -5.30343 |
| PCBP2 | poly(rC) binding protein 2 | -5.24171 |
| FAM151A | family with sequence similarity 151, member A | -5.18474 |
| CISD3 | CDGSH iron sulfur domain 3 | -5.15001 |
| ADRM1 | adhesion regulating molecule 1 | -5.14841 |
| INTS8 | integrator complex subunit 8 | -5.13978 |
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta | -5.08859 |
| MTBP | MDM2 binding protein | -5.08318 |
| RPS29 | ribosomal protein S29 | -4.83957 |
| APOM | apolipoprotein M | -4.62674 |
| PLD4 | phospholipase D family, member 4 | -4.54289 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -4.51961 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -4.51616 |
| KRT18 | keratin 18, type I | -4.48745 |
| SLC25A34 | solute carrier family 25, member 34 | -4.33963 |
| TVP23A | trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) | -4.30279 |
