| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting SMAD4 in pancreatic cancer cell PANC-1 cell line (Study accession: SRP255626) (PerturbAtlas) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Perturb_14607_KO_SMAD4_SRP255626 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 20.0 |
| ALPPL2 | alkaline phosphatase, placental-like 2 | 20.0 |
| GRHL3 | grainyhead-like 3 (Drosophila) | 20.0 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 20.0 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 20.0 |
| C14ORF132 | chromosome 14 open reading frame 132 | 20.0 |
| RET | ret proto-oncogene | 20.0 |
| AGR2 | anterior gradient 2 | 20.0 |
| TP53I11 | tumor protein p53 inducible protein 11 | 20.0 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | 20.0 |
| PPL | periplakin | 20.0 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 20.0 |
| PADI2 | peptidyl arginine deiminase, type II | 20.0 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | 20.0 |
| TMPRSS2 | transmembrane protease, serine 2 | 20.0 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | 20.0 |
| HTRA1 | HtrA serine peptidase 1 | 19.699 |
| BMP5 | bone morphogenetic protein 5 | 19.3979 |
| SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12 | 15.8777 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 15.6692 |
| ATP9A | ATPase, class II, type 9A | 15.2387 |
| SOX4 | SRY (sex determining region Y)-box 4 | 15.2293 |
| FAM101A | family with sequence similarity 101, member A | 14.5222 |
| MUC16 | mucin 16, cell surface associated | 14.3873 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 12.857 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 12.039 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 10.7261 |
| TFCP2L1 | transcription factor CP2-like 1 | 10.3583 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 10.1493 |
| TOX3 | TOX high mobility group box family member 3 | 9.86527 |
| INHBB | inhibin, beta B | 9.77677 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 9.68846 |
| TRIB1 | tribbles pseudokinase 1 | 9.28756 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | 9.13236 |
| GDF15 | growth differentiation factor 15 | 8.99005 |
| RIMKLA | ribosomal modification protein rimK-like family member A | 8.94776 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 8.94776 |
| PLXNA1 | plexin A1 | 8.70535 |
| FAM20C | family with sequence similarity 20, member C | 8.61625 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 8.49817 |
| WNT9A | wingless-type MMTV integration site family, member 9A | 8.18215 |
| KIFC3 | kinesin family member C3 | 8.10324 |
| ART5 | ADP-ribosyltransferase 5 | 8.10324 |
| COL3A1 | collagen, type III, alpha 1 | 7.96018 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | 7.64705 |
| FAM65C | family with sequence similarity 65, member C | 7.58081 |
| PCDH9 | protocadherin 9 | 7.5522 |
| NID1 | nidogen 1 | 7.39314 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | 7.33637 |
| ADM | adrenomedullin | 7.29318 |
| SESTD1 | SEC14 and spectrin domains 1 | 6.94271 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 6.93408 |
| BMP7 | bone morphogenetic protein 7 | 6.88428 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | 6.76904 |
| THSD7A | thrombospondin, type I, domain containing 7A | 6.57832 |
| PPP1R1B | protein phosphatase 1, regulatory (inhibitor) subunit 1B | 6.45829 |
| TRIM2 | tripartite motif containing 2 | 6.40798 |
| SORBS1 | sorbin and SH3 domain containing 1 | 6.2296 |
| KLF13 | Kruppel-like factor 13 | 6.20974 |
| HMGB3 | high mobility group box 3 | 6.12306 |
| ZNF608 | zinc finger protein 608 | 5.98603 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 5.93005 |
| EPB41 | erythrocyte membrane protein band 4.1 | 5.93005 |
| TMEM189 | transmembrane protein 189 | 5.91714 |
| GJB2 | gap junction protein, beta 2, 26kDa | 5.91714 |
| FOXA1 | forkhead box A1 | 5.8567 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 5.84675 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 5.82744 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 5.80542 |
| CABP7 | calcium binding protein 7 | 5.74077 |
| MLXIP | MLX interacting protein | 5.72065 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 5.72065 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 5.61882 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 5.49377 |
| NTN1 | netrin 1 | 5.48263 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 5.40882 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5.26592 |
| PTK7 | protein tyrosine kinase 7 (inactive) | 5.26543 |
| CLMN | calmin (calponin-like, transmembrane) | 5.16709 |
| KIAA1522 | KIAA1522 | 5.09328 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 4.94809 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 4.86083 |
| DACH1 | dachshund family transcription factor 1 | 4.83652 |
| COL12A1 | collagen, type XII, alpha 1 | 4.76412 |
| IGDCC4 | immunoglobulin superfamily, DCC subclass, member 4 | 4.64112 |
| TSPAN13 | tetraspanin 13 | 4.58988 |
| JUP | junction plakoglobin | 4.5549 |
| ZIC2 | Zic family member 2 | 4.49993 |
| CCDC85C | coiled-coil domain containing 85C | 4.4922 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 4.44628 |
| SKIL | SKI-like proto-oncogene | 4.34723 |
| LAMB1 | laminin, beta 1 | 4.31709 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 4.27819 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 4.20521 |
| CD99L2 | CD99 molecule-like 2 | 4.14446 |
| PARD6B | par-6 family cell polarity regulator beta | 4.1418 |
| PDGFB | platelet-derived growth factor beta polypeptide | 4.08591 |
| EPHA7 | EPH receptor A7 | 4.05656 |
| COL5A2 | collagen, type V, alpha 2 | 3.97227 |
| ZNF704 | zinc finger protein 704 | 3.97196 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NT5E | 5'-nucleotidase, ecto (CD73) | -20.0 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -20.0 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -20.0 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -20.0 |
| EPAS1 | endothelial PAS domain protein 1 | -17.6799 |
| CDCP1 | CUB domain containing protein 1 | -16.9523 |
| MT2A | metallothionein 2A | -15.6692 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -15.4029 |
| CD59 | CD59 molecule, complement regulatory protein | -15.0134 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -14.5222 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -13.1703 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -12.3617 |
| CTSD | cathepsin D | -11.6169 |
| RNF182 | ring finger protein 182 | -10.9697 |
| KRT19 | keratin 19, type I | -10.5135 |
| ASPH | aspartate beta-hydroxylase | -10.1493 |
| AGPAT9 | 1-acylglycerol-3-phosphate O-acyltransferase 9 | -10.0375 |
| ARSK | arylsulfatase family, member K | -9.84864 |
| BIRC3 | baculoviral IAP repeat containing 3 | -9.77141 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | -9.72762 |
| FZD7 | frizzled class receptor 7 | -9.68575 |
| CES1 | carboxylesterase 1 | -8.8995 |
| FOXF2 | forkhead box F2 | -8.8189 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -8.77723 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -8.68064 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -8.09646 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -8.09351 |
| FOSL1 | FOS-like antigen 1 | -7.97589 |
| FBXO27 | F-box protein 27 | -7.92955 |
| AFAP1L1 | actin filament associated protein 1-like 1 | -7.66865 |
| PYGB | phosphorylase, glycogen; brain | -7.58081 |
| PAPL | iron/zinc purple acid phosphatase-like protein | -7.51671 |
| ABLIM3 | actin binding LIM protein family, member 3 | -7.51671 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -7.46677 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -7.21411 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -7.06632 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -6.99645 |
| EHD2 | EH-domain containing 2 | -6.95526 |
| MT1E | metallothionein 1E | -6.86573 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -6.76591 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -6.6964 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -6.67091 |
| CD70 | CD70 molecule | -6.63365 |
| MLPH | melanophilin | -6.54758 |
| FOXQ1 | forkhead box Q1 | -6.30778 |
| SAMD11 | sterile alpha motif domain containing 11 | -6.28767 |
| PLCE1 | phospholipase C, epsilon 1 | -6.26305 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -6.24928 |
| BEGAIN | brain-enriched guanylate kinase-associated | -6.12775 |
| LMNA | lamin A/C | -6.12576 |
| SMOX | spermine oxidase | -6.12306 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | -6.05404 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -5.98778 |
| NAV1 | neuron navigator 1 | -5.94284 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -5.91714 |
| KIAA1549L | KIAA1549-like | -5.91572 |
| SFRP1 | secreted frizzled-related protein 1 | -5.80978 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -5.76477 |
| LONRF2 | LON peptidase N-terminal domain and ring finger 2 | -5.71696 |
| ARHGAP26 | Rho GTPase activating protein 26 | -5.70297 |
| TSPAN15 | tetraspanin 15 | -5.6346 |
| FGFRL1 | fibroblast growth factor receptor-like 1 | -5.58765 |
| VIM | vimentin | -5.54321 |
| ANTXR2 | anthrax toxin receptor 2 | -5.52504 |
| RAP1B | RAP1B, member of RAS oncogene family | -5.42573 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -5.29431 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | -5.24519 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -5.20881 |
| PEAR1 | platelet endothelial aggregation receptor 1 | -5.06828 |
| P3H2 | prolyl 3-hydroxylase 2 | -4.98958 |
| CEL | carboxyl ester lipase | -4.96314 |
| ANPEP | alanyl (membrane) aminopeptidase | -4.92507 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -4.87206 |
| HSPB1 | heat shock 27kDa protein 1 | -4.82289 |
| LPIN1 | lipin 1 | -4.80859 |
| STMN3 | stathmin-like 3 | -4.63555 |
| ZNF365 | zinc finger protein 365 | -4.58988 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -4.51841 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -4.51814 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | -4.51214 |
| WT1 | Wilms tumor 1 | -4.51214 |
| MYADM | myeloid-associated differentiation marker | -4.49286 |
| UPK1B | uroplakin 1B | -4.3968 |
| CLTB | clathrin, light chain B | -4.39401 |
| EREG | epiregulin | -4.35582 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -4.31789 |
| GALE | UDP-galactose-4-epimerase | -4.31789 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -4.31636 |
| B3GNT7 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 | -4.30632 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -4.30632 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -4.3047 |
| DSTN | destrin (actin depolymerizing factor) | -4.23564 |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | -4.19004 |
| BMP6 | bone morphogenetic protein 6 | -4.17632 |
| C11ORF68 | chromosome 11 open reading frame 68 | -4.15964 |
| KIAA1462 | KIAA1462 | -4.08516 |
| ANXA1 | annexin A1 | -4.07716 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -4.07716 |
| CSF1 | colony stimulating factor 1 (macrophage) | -4.05656 |
| CYB561 | cytochrome b561 | -4.0022 |
