Perturb_14621_KO_SMAD4_SRP255626 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting SMAD4 in pancreatic cancer cell PATU8902 cell line (Study accession: SRP255626) (PerturbAtlas)
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Genes

120 genes differentially expressed following the Perturb_14621_KO_SMAD4_SRP255626 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
SULF2 sulfatase 2 20.0
CCND2 cyclin D2 20.0
FGFBP1 fibroblast growth factor binding protein 1 20.0
C6ORF15 chromosome 6 open reading frame 15 20.0
SPNS2 spinster homolog 2 (Drosophila) 20.0
GPRC5B G protein-coupled receptor, class C, group 5, member B 11.5093
S100A4 S100 calcium binding protein A4 10.6303
PDLIM1 PDZ and LIM domain 1 9.47781
CLDN1 claudin 1 8.56207
ADGRG1 adhesion G protein-coupled receptor G1 7.49683
S100A6 S100 calcium binding protein A6 6.62323
GSN gelsolin 6.62323
APOL2 apolipoprotein L, 2 5.42706
EFNB1 ephrin-B1 5.14467
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 5.00968
COBL cordon-bleu WH2 repeat protein 4.35149
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 4.04736
PXDN peroxidasin 3.73173
KLK6 kallikrein-related peptidase 6 3.73173
UNC5A unc-5 homolog A (C. elegans) 3.73173
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.64391
IRF1 interferon regulatory factor 1 3.43113
SAMD9 sterile alpha motif domain containing 9 3.42271
KRT19 keratin 19, type I 3.2176
C3 complement component 3 2.89206
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.83077
CRIP2 cysteine-rich protein 2 2.82695
CRNN cornulin 2.80956
UNC5B unc-5 homolog B (C. elegans) 2.79294
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.73116
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.71551
PTK6 protein tyrosine kinase 6 2.71551
ZBED2 zinc finger, BED-type containing 2 2.64792
CALB2 calbindin 2 2.61438
TAPBPL TAP binding protein-like 2.58866
C1ORF116 chromosome 1 open reading frame 116 2.5458
SERINC2 serine incorporator 2 2.5458
KRT4 keratin 4, type II 2.46886
KLK10 kallikrein-related peptidase 10 2.40366
TH tyrosine hydroxylase 2.36388
APOL1 apolipoprotein L, 1 2.32003
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.28981
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 2.22791
PARD6B par-6 family cell polarity regulator beta 2.21555
C9ORF16 chromosome 9 open reading frame 16 2.21555
ERAP1 endoplasmic reticulum aminopeptidase 1 2.16947
KRT7 keratin 7, type II 2.1412
MISP mitotic spindle positioning 2.1412
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.11968
KIAA1211L KIAA1211-like 2.08615
KLC4 kinesin light chain 4 2.08299
UNC93A unc-93 homolog A (C. elegans) 2.078
IL20RA interleukin 20 receptor, alpha 2.0718
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.07074
KRT80 keratin 80, type II 2.07074
LYRM1 LYR motif containing 1 2.07074
PARP14 poly (ADP-ribose) polymerase family, member 14 2.07074
PARP9 poly (ADP-ribose) polymerase family, member 9 2.07074
MEGF9 multiple EGF-like-domains 9 2.0564
CCDC114 coiled-coil domain containing 114 2.0564
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.0564
DTX3L deltex 3 like, E3 ubiquitin ligase 1.98408
SLCO3A1 solute carrier organic anion transporter family, member 3A1 1.97599
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 1.92194
APOL6 apolipoprotein L, 6 1.90289
BMP4 bone morphogenetic protein 4 1.88455
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 1.82507
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.81784
RPGR retinitis pigmentosa GTPase regulator 1.79155
HLA-DRA major histocompatibility complex, class II, DR alpha 1.7504
NEK11 NIMA-related kinase 11 1.70411
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.69665
CCDC40 coiled-coil domain containing 40 1.67236
CSRP1 cysteine and glycine-rich protein 1 1.67236
UST uronyl-2-sulfotransferase 1.65733
DENND6B DENN/MADD domain containing 6B 1.63707
MYO1C myosin IC 1.6365
PRDX5 peroxiredoxin 5 1.62935
CCDC113 coiled-coil domain containing 113 1.61983
CD9 CD9 molecule 1.61839
LY6E lymphocyte antigen 6 complex, locus E 1.57296
CAPN8 calpain 8 1.54694
TAPBP TAP binding protein (tapasin) 1.50664
KRT18 keratin 18, type I 1.50662
SDCBP syndecan binding protein (syntenin) 1.496
FAM102A family with sequence similarity 102, member A 1.4741
TMCC3 transmembrane and coiled-coil domain family 3 1.4741
UBXN11 UBX domain protein 11 1.47395
FTH1 ferritin, heavy polypeptide 1 1.44957
PADI1 peptidyl arginine deiminase, type I 1.37256
AFAP1L2 actin filament associated protein 1-like 2 1.36971
PDGFA platelet-derived growth factor alpha polypeptide 1.3234
SLIT2 slit homolog 2 (Drosophila) 1.3145

decreased expression

Symbol Name Standardized Value
XYLT1 xylosyltransferase I -20.0
COL13A1 collagen, type XIII, alpha 1 -5.36694
BIRC2 baculoviral IAP repeat containing 2 -4.87255
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -4.35149
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -3.7717
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -3.7717
PLXND1 plexin D1 -3.59096
RHOBTB3 Rho-related BTB domain containing 3 -3.54175
CD44 CD44 molecule (Indian blood group) -3.33676
HSPG2 heparan sulfate proteoglycan 2 -3.0825
KIAA1462 KIAA1462 -3.0821
SMAD4 SMAD family member 4 -2.81467
JAG1 jagged 1 -2.52372
ANTXR2 anthrax toxin receptor 2 -2.45119
MYO10 myosin X -2.34361
KCNIP3 Kv channel interacting protein 3, calsenilin -2.26493
ZAK sterile alpha motif and leucine zipper containing kinase AZK -2.17242
PLXNA2 plexin A2 -2.02276
DAB2IP DAB2 interacting protein -1.63707
FZD7 frizzled class receptor 7 -1.63707
CSF1 colony stimulating factor 1 (macrophage) -1.63707
ERRFI1 ERBB receptor feedback inhibitor 1 -1.60495
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -1.55309
PODXL podocalyxin-like -1.53669
ENO2 enolase 2 (gamma, neuronal) -1.53669
RCAN3 RCAN family member 3 -1.52431
PTTG1IP pituitary tumor-transforming 1 interacting protein -1.42737