| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting SREBF2 in Primary Endothlelial Cell cell (Study accession: SRP385600) (PerturbAtlas) |
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122 genes differentially expressed following the Perturb_15102_KD_SREBF2_SRP385600 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FSCN1 | fascin actin-bundling protein 1 | 20.0 |
| MARCH7 | membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase | 12.1268 |
| SRFBP1 | serum response factor binding protein 1 | 9.25551 |
| SLC25A34 | solute carrier family 25, member 34 | 8.47118 |
| CTGF | connective tissue growth factor | 4.88529 |
| ATG9B | autophagy related 9B | 4.27932 |
| MAX | MYC associated factor X | 3.88636 |
| PROX2 | prospero homeobox 2 | 3.65551 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 3.59706 |
| TRIM59 | tripartite motif containing 59 | 3.58837 |
| PLCE1 | phospholipase C, epsilon 1 | 3.2445 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 3.20979 |
| TGM2 | transglutaminase 2 | 3.08864 |
| ZC2HC1C | zinc finger, C2HC-type containing 1C | 3.04363 |
| EFHC1 | EF-hand domain (C-terminal) containing 1 | 2.97584 |
| COPG2 | coatomer protein complex, subunit gamma 2 | 2.86477 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 2.7747 |
| NCAPG | non-SMC condensin I complex, subunit G | 2.76081 |
| RNF213 | ring finger protein 213 | 2.59284 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 2.57486 |
| JSRP1 | junctional sarcoplasmic reticulum protein 1 | 2.56088 |
| TBPL1 | TBP-like 1 | 2.44945 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 2.43021 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 2.35467 |
| FSIP1 | fibrous sheath interacting protein 1 | 2.25849 |
| BGN | biglycan | 2.24922 |
| TM6SF1 | transmembrane 6 superfamily member 1 | 2.17306 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 2.16759 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 2.03402 |
| APC2 | adenomatosis polyposis coli 2 | 1.97017 |
| SIK2 | salt-inducible kinase 2 | 1.93226 |
| GLRX2 | glutaredoxin 2 | 1.89931 |
| MLF2 | myeloid leukemia factor 2 | 1.89719 |
| IFT80 | intraflagellar transport 80 | 1.79426 |
| FAM120AOS | family with sequence similarity 120A opposite strand | 1.79261 |
| KRT8 | keratin 8, type II | 1.76902 |
| CCDC176 | coiled-coil domain containing 176 | 1.73034 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | 1.70303 |
| BMP4 | bone morphogenetic protein 4 | 1.68596 |
| PCNT | pericentrin | 1.67185 |
| RHOC | ras homolog family member C | 1.64594 |
| COL8A1 | collagen, type VIII, alpha 1 | 1.64441 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1.63065 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 1.63065 |
| SDPR | serum deprivation response | 1.59501 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 1.59501 |
| NUDCD1 | NudC domain containing 1 | 1.56147 |
| TEX10 | testis expressed 10 | 1.55762 |
| TBRG1 | transforming growth factor beta regulator 1 | 1.50758 |
| CCDC66 | coiled-coil domain containing 66 | 1.45188 |
| ZNF575 | zinc finger protein 575 | 1.42541 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | 1.42541 |
| LIG3 | ligase III, DNA, ATP-dependent | 1.42479 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 1.37886 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | 1.34883 |
| PHKG1 | phosphorylase kinase, gamma 1 (muscle) | 1.3452 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 1.34469 |
| FAM219B | family with sequence similarity 219, member B | 1.33099 |
| PAQR3 | progestin and adipoQ receptor family member III | 1.3161 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FGF14 | fibroblast growth factor 14 | -7.89453 |
| RAB43 | RAB43, member RAS oncogene family | -6.69179 |
| ABI2 | abl-interactor 2 | -6.43327 |
| SGSM1 | small G protein signaling modulator 1 | -6.23315 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | -5.90117 |
| MTBP | MDM2 binding protein | -5.30186 |
| AGK | acylglycerol kinase | -4.97779 |
| CHKA | choline kinase alpha | -4.81753 |
| C21ORF2 | chromosome 21 open reading frame 2 | -4.76066 |
| C7ORF49 | chromosome 7 open reading frame 49 | -4.07107 |
| RELL2 | RELT-like 2 | -3.94438 |
| MMP1 | matrix metallopeptidase 1 | -3.80039 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | -3.59706 |
| GFM1 | G elongation factor, mitochondrial 1 | -3.59706 |
| KRT17 | keratin 17, type I | -3.37774 |
| MS4A2 | membrane-spanning 4-domains, subfamily A, member 2 | -3.37703 |
| EVA1B | eva-1 homolog B (C. elegans) | -3.00439 |
| PDK2 | pyruvate dehydrogenase kinase, isozyme 2 | -2.91411 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -2.83421 |
| UBE2N | ubiquitin-conjugating enzyme E2N | -2.54328 |
| GJD3 | gap junction protein, delta 3, 31.9kDa | -2.53537 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -2.44945 |
| PNCK | pregnancy up-regulated nonubiquitous CaM kinase | -2.38289 |
| C14ORF166 | chromosome 14 open reading frame 166 | -2.20919 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | -2.15471 |
| LOC122455342 | testis-specific serine/proline-rich protein | -2.04429 |
| CBR4 | carbonyl reductase 4 | -2.04126 |
| DXO | decapping exoribonuclease | -2.02042 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -1.98811 |
| ACSM1 | acyl-CoA synthetase medium-chain family member 1 | -1.91019 |
| WDR90 | WD repeat domain 90 | -1.89931 |
| GCA | grancalcin, EF-hand calcium binding protein | -1.89775 |
| SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | -1.89131 |
| CPM | carboxypeptidase M | -1.89045 |
| LYRM2 | LYR motif containing 2 | -1.84052 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -1.81561 |
| SQSTM1 | sequestosome 1 | -1.79759 |
| CDCA3 | cell division cycle associated 3 | -1.79426 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -1.76881 |
| TBC1D22B | TBC1 domain family, member 22B | -1.75648 |
| NPB | neuropeptide B | -1.69425 |
| RGL4 | ral guanine nucleotide dissociation stimulator-like 4 | -1.68596 |
| MUS81 | MUS81 structure-specific endonuclease subunit | -1.68596 |
| MMP24 | matrix metallopeptidase 24 (membrane-inserted) | -1.67785 |
| TUBA1C | tubulin, alpha 1c | -1.63065 |
| CIRBP | cold inducible RNA binding protein | -1.62019 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -1.60003 |
| BOP1 | block of proliferation 1 | -1.5922 |
| EPHX4 | epoxide hydrolase 4 | -1.5871 |
| TRABD2A | TraB domain containing 2A | -1.51837 |
| L3MBTL2 | l(3)mbt-like 2 (Drosophila) | -1.50286 |
| ZNF627 | zinc finger protein 627 | -1.48574 |
| C22ORF23 | chromosome 22 open reading frame 23 | -1.44867 |
| CRABP1 | cellular retinoic acid binding protein 1 | -1.44867 |
| FAS | Fas cell surface death receptor | -1.44867 |
| FAM228B | family with sequence similarity 228, member B | -1.4482 |
| NCOA3 | nuclear receptor coactivator 3 | -1.40835 |
| KRI1 | KRI1 homolog (S. cerevisiae) | -1.38223 |
| TSC2 | tuberous sclerosis 2 | -1.36456 |
| TSPAN18 | tetraspanin 18 | -1.3452 |
| COL4A1 | collagen, type IV, alpha 1 | -1.3452 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | -1.3421 |
| PCBP2 | poly(rC) binding protein 2 | -1.30361 |
