| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting FOXC1 in primary limbal stem cells cell (Study accession: SRP276213) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_15223_KD_FOXC1_SRP276213 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLRP10 | NLR family, pyrin domain containing 10 | 18.2676 |
| MAP2 | microtubule-associated protein 2 | 15.9934 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 15.7342 |
| RGS2 | regulator of G-protein signaling 2 | 14.5371 |
| MMP10 | matrix metallopeptidase 10 | 14.1944 |
| LAYN | layilin | 12.8344 |
| NRARP | NOTCH-regulated ankyrin repeat protein | 12.203 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 11.5239 |
| GJB6 | gap junction protein, beta 6, 30kDa | 11.4911 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 11.237 |
| CRCT1 | cysteine-rich C-terminal 1 | 10.9338 |
| KRTDAP | keratinocyte differentiation-associated protein | 10.679 |
| A2ML1 | alpha-2-macroglobulin-like 1 | 8.97854 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | 8.76599 |
| ULBP2 | UL16 binding protein 2 | 8.5995 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | 8.58186 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 8.16242 |
| EGF | epidermal growth factor | 8.11257 |
| VGLL3 | vestigial-like family member 3 | 7.94906 |
| WFDC5 | WAP four-disulfide core domain 5 | 7.82834 |
| DUSP16 | dual specificity phosphatase 16 | 7.71698 |
| PKP1 | plakophilin 1 | 7.63843 |
| SEMA5B | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 7.56265 |
| FAM83C | family with sequence similarity 83, member C | 7.2351 |
| IGFL2 | IGF-like family member 2 | 7.22462 |
| IL24 | interleukin 24 | 7.22462 |
| TMPRSS11F | transmembrane protease, serine 11F | 7.22462 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | 7.11734 |
| SBSN | suprabasin | 7.10584 |
| S100A2 | S100 calcium binding protein A2 | 6.92879 |
| LYPD3 | LY6/PLAUR domain containing 3 | 6.83123 |
| KRT17 | keratin 17, type I | 6.76232 |
| CALB1 | calbindin 1, 28kDa | 6.71053 |
| PI3 | peptidase inhibitor 3, skin-derived | 6.49427 |
| KRT6A | keratin 6A, type II | 6.43804 |
| DAPL1 | death associated protein-like 1 | 6.3727 |
| LIPG | lipase, endothelial | 6.34514 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 6.03004 |
| SPINK6 | serine peptidase inhibitor, Kazal type 6 | 5.96888 |
| SPRR2E | small proline-rich protein 2E | 5.92319 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 5.84244 |
| CSTA | cystatin A (stefin A) | 5.84244 |
| TMEM154 | transmembrane protein 154 | 5.81902 |
| DENND2C | DENN/MADD domain containing 2C | 5.73942 |
| VSIG10L | V-set and immunoglobulin domain containing 10 like | 5.73942 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 5.73942 |
| MYO16 | myosin XVI | 5.66892 |
| MMP1 | matrix metallopeptidase 1 | 5.55505 |
| KRT6B | keratin 6B, type II | 5.48794 |
| TNFAIP8L3 | tumor necrosis factor, alpha-induced protein 8-like 3 | 5.44568 |
| MUC15 | mucin 15, cell surface associated | 5.2879 |
| LYPD5 | LY6/PLAUR domain containing 5 | 5.22693 |
| SPRR2G | small proline-rich protein 2G | 5.21471 |
| DSG1 | desmoglein 1 | 5.17712 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 5.15206 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 5.06012 |
| RAET1E | retinoic acid early transcript 1E | 5.05848 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 5.03402 |
| GSDMA | gasdermin A | 5.02851 |
| CRABP2 | cellular retinoic acid binding protein 2 | 5.01786 |
| COL1A1 | collagen, type I, alpha 1 | 5.01786 |
| ADAMTS15 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | 5.01128 |
| CDHR1 | cadherin-related family member 1 | 5.01128 |
| ENDOD1 | endonuclease domain containing 1 | 5.01128 |
| METRNL | meteorin, glial cell differentiation regulator-like | 4.8645 |
| CLMN | calmin (calponin-like, transmembrane) | 4.73279 |
| THBD | thrombomodulin | 4.73172 |
| RAB7B | RAB7B, member RAS oncogene family | 4.70122 |
| CALB2 | calbindin 2 | 4.56839 |
| AGPAT9 | 1-acylglycerol-3-phosphate O-acyltransferase 9 | 4.542 |
| TMEM86A | transmembrane protein 86A | 4.4766 |
| FKBP5 | FK506 binding protein 5 | 4.4766 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 4.47441 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 4.41652 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 4.31299 |
| DSP | desmoplakin | 4.31299 |
| NGEF | neuronal guanine nucleotide exchange factor | 4.27274 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.25876 |
| PRNP | prion protein | 4.25394 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 4.22524 |
| FAM83B | family with sequence similarity 83, member B | 4.1981 |
| PKIB | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 4.19152 |
| SLC37A2 | solute carrier family 37 (glucose-6-phosphate transporter), member 2 | 4.1665 |
| PNLIPRP3 | pancreatic lipase-related protein 3 | 4.15049 |
| COL5A3 | collagen, type V, alpha 3 | 4.09806 |
| ANKRD22 | ankyrin repeat domain 22 | 4.07146 |
| CSRP2 | cysteine and glycine-rich protein 2 | 4.04831 |
| CSTB | cystatin B (stefin B) | 3.91342 |
| CLMP | CXADR-like membrane protein | 3.90794 |
| EPHB3 | EPH receptor B3 | 3.90206 |
| ATP12A | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | 3.84566 |
| FOXQ1 | forkhead box Q1 | 3.83092 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 3.82958 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 3.8099 |
| SPRR1A | small proline-rich protein 1A | 3.80507 |
| DUOXA1 | dual oxidase maturation factor 1 | 3.74211 |
| WNT7B | wingless-type MMTV integration site family, member 7B | 3.73323 |
| LIPK | lipase, family member K | 3.73323 |
| WFDC12 | WAP four-disulfide core domain 12 | 3.72101 |
| SLC13A5 | solute carrier family 13 (sodium-dependent citrate transporter), member 5 | 3.71969 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DIO2 | deiodinase, iodothyronine, type II | -15.1036 |
| ERICH5 | glutamate-rich 5 | -14.143 |
| FMO1 | flavin containing monooxygenase 1 | -13.6265 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -12.0749 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -11.9668 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -11.7976 |
| STC1 | stanniocalcin 1 | -11.5239 |
| ST6GALNAC1 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | -11.0891 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -10.6357 |
| FOXC1 | forkhead box C1 | -10.6357 |
| KRT3 | keratin 3, type II | -9.36471 |
| SMAD6 | SMAD family member 6 | -9.13943 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -9.02875 |
| CAPN5 | calpain 5 | -8.6768 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | -8.64117 |
| AP3B2 | adaptor-related protein complex 3, beta 2 subunit | -8.25295 |
| FAM46A | family with sequence similarity 46, member A | -8.22189 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | -7.94906 |
| FER1L6 | fer-1-like family member 6 | -7.83087 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -7.72478 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -7.51101 |
| CASKIN1 | CASK interacting protein 1 | -7.22462 |
| NCKAP5L | NCK-associated protein 5-like | -7.22462 |
| LYPD2 | LY6/PLAUR domain containing 2 | -7.16541 |
| DMRTA2 | DMRT-like family A2 | -7.13754 |
| SERPINB11 | serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) | -6.71053 |
| APOL2 | apolipoprotein L, 2 | -6.59517 |
| SYTL5 | synaptotagmin-like 5 | -5.98049 |
| ZFHX2 | zinc finger homeobox 2 | -5.91218 |
| LAMB4 | laminin, beta 4 | -5.89887 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -5.837 |
| CAPN13 | calpain 13 | -5.74044 |
| FAM189B | family with sequence similarity 189, member B | -5.64191 |
| CROT | carnitine O-octanoyltransferase | -5.64049 |
| TNS3 | tensin 3 | -5.62185 |
| GDF15 | growth differentiation factor 15 | -5.56017 |
| MAP1A | microtubule-associated protein 1A | -5.49301 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -5.45086 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -5.36952 |
| MAP6 | microtubule-associated protein 6 | -5.33926 |
| TMPRSS2 | transmembrane protease, serine 2 | -5.2879 |
| RAB15 | RAB15, member RAS oncogene family | -5.22693 |
| SDPR | serum deprivation response | -5.21548 |
| ECHDC1 | ethylmalonyl-CoA decarboxylase 1 | -5.21471 |
| HSPA1A | heat shock 70kDa protein 1A | -5.01786 |
| DPYSL4 | dihydropyrimidinase-like 4 | -4.9316 |
| FAM214A | family with sequence similarity 214, member A | -4.83465 |
| PARP10 | poly (ADP-ribose) polymerase family, member 10 | -4.72602 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | -4.64718 |
| TRIM14 | tripartite motif containing 14 | -4.62331 |
| COA6 | cytochrome c oxidase assembly factor 6 | -4.59602 |
| FNIP2 | folliculin interacting protein 2 | -4.52248 |
| ZNF503 | zinc finger protein 503 | -4.50442 |
| INSR | insulin receptor | -4.42115 |
| PLIN2 | perilipin 2 | -4.37453 |
| FBXO41 | F-box protein 41 | -4.2239 |
| CERK | ceramide kinase | -4.20058 |
| EMX2 | empty spiracles homeobox 2 | -4.0778 |
| B3GNT7 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 | -4.01647 |
| ZNF213 | zinc finger protein 213 | -3.9481 |
| OTX1 | orthodenticle homeobox 1 | -3.94092 |
| SULT4A1 | sulfotransferase family 4A, member 1 | -3.90794 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | -3.73323 |
| CLDN11 | claudin 11 | -3.6805 |
| KIAA1549 | KIAA1549 | -3.64162 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -3.58964 |
| DTX4 | deltex 4, E3 ubiquitin ligase | -3.54254 |
| GRAMD1B | GRAM domain containing 1B | -3.48449 |
| TSPAN13 | tetraspanin 13 | -3.4765 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -3.46041 |
| CLU | clusterin | -3.43097 |
| MYLIP | myosin regulatory light chain interacting protein | -3.41586 |
| C17ORF96 | chromosome 17 open reading frame 96 | -3.40928 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -3.37313 |
| MFSD4 | major facilitator superfamily domain containing 4 | -3.36555 |
| C19ORF12 | chromosome 19 open reading frame 12 | -3.3547 |
| SP140 | SP140 nuclear body protein | -3.33338 |
| UTRN | utrophin | -3.32311 |
| TNFRSF10C | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | -3.31667 |
| GLUL | glutamate-ammonia ligase | -3.3165 |
| TTC28 | tetratricopeptide repeat domain 28 | -3.2782 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -3.24712 |
| BAG2 | BCL2-associated athanogene 2 | -3.24025 |
| SLC26A4 | solute carrier family 26 (anion exchanger), member 4 | -3.20269 |
| KCNE3 | potassium channel, voltage gated subfamily E regulatory beta subunit 3 | -3.19758 |
| CCND2 | cyclin D2 | -3.18942 |
| APOL1 | apolipoprotein L, 1 | -3.18424 |
| PAX6 | paired box 6 | -3.17671 |
| CAPNS1 | calpain, small subunit 1 | -3.13829 |
| DOK3 | docking protein 3 | -3.13829 |
| FAM174B | family with sequence similarity 174, member B | -3.13829 |
| ACP2 | acid phosphatase 2, lysosomal | -3.12603 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -3.09285 |
| CP | ceruloplasmin (ferroxidase) | -3.08075 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -3.07829 |
| MERTK | MER proto-oncogene, tyrosine kinase | -3.03721 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -3.03437 |
| TMC5 | transmembrane channel-like 5 | -3.0079 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -2.98266 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -2.9699 |
