| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting ERCC6L2 in primary mesenchymal stem cells isolated from bone marrow cell (Study accession: SRP349996) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_15239_KD_ERCC6L2_SRP349996 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 12.9686 |
| STAC2 | SH3 and cysteine rich domain 2 | 9.22459 |
| WIPF3 | WAS/WASL interacting protein family, member 3 | 8.17051 |
| ARFGEF3 | ARFGEF family member 3 | 7.68517 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7.24994 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 6.94691 |
| HAS3 | hyaluronan synthase 3 | 6.81419 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 6.59517 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 6.53711 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 6.45851 |
| TSPAN13 | tetraspanin 13 | 6.18235 |
| KISS1 | KiSS-1 metastasis-suppressor | 5.78108 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 5.69854 |
| TTC9 | tetratricopeptide repeat domain 9 | 5.38912 |
| TTBK1 | tau tubulin kinase 1 | 5.37169 |
| CDH8 | cadherin 8, type 2 | 5.35685 |
| NGF | nerve growth factor (beta polypeptide) | 5.15724 |
| AARD | alanine and arginine rich domain containing protein | 5.13038 |
| DUSP26 | dual specificity phosphatase 26 (putative) | 5.13038 |
| CPNE4 | copine IV | 5.06514 |
| CNN1 | calponin 1, basic, smooth muscle | 5.02133 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 4.79681 |
| FILIP1L | filamin A interacting protein 1-like | 4.74414 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 4.64313 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 4.60119 |
| GATA6 | GATA binding protein 6 | 4.4678 |
| ADRB2 | adrenoceptor beta 2, surface | 4.25837 |
| GRB14 | growth factor receptor-bound protein 14 | 4.23954 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 4.21475 |
| PLXNC1 | plexin C1 | 4.13304 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 4.05946 |
| TSPAN2 | tetraspanin 2 | 4.01361 |
| MKX | mohawk homeobox | 3.97139 |
| CELF2 | CUGBP, Elav-like family member 2 | 3.88423 |
| RAVER2 | ribonucleoprotein, PTB-binding 2 | 3.82682 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | 3.76221 |
| EDNRA | endothelin receptor type A | 3.75873 |
| L1CAM | L1 cell adhesion molecule | 3.68503 |
| RBM24 | RNA binding motif protein 24 | 3.64166 |
| SOX11 | SRY (sex determining region Y)-box 11 | 3.55316 |
| TPD52 | tumor protein D52 | 3.54576 |
| CREB5 | cAMP responsive element binding protein 5 | 3.47738 |
| STAC | SH3 and cysteine rich domain | 3.47498 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | 3.44332 |
| PRKCH | protein kinase C, eta | 3.42343 |
| SLITRK4 | SLIT and NTRK-like family, member 4 | 3.41176 |
| CDK15 | cyclin-dependent kinase 15 | 3.40183 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 3.3812 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 3.22173 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.20546 |
| IGSF9B | immunoglobulin superfamily, member 9B | 3.08435 |
| DUSP8 | dual specificity phosphatase 8 | 3.07031 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 2.98848 |
| COL4A1 | collagen, type IV, alpha 1 | 2.90832 |
| FAM129A | family with sequence similarity 129, member A | 2.87289 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 | 2.8584 |
| STK32B | serine/threonine kinase 32B | 2.85661 |
| BDNF | brain-derived neurotrophic factor | 2.84192 |
| GPR63 | G protein-coupled receptor 63 | 2.84151 |
| AFF3 | AF4/FMR2 family, member 3 | 2.79913 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 2.76762 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 2.7537 |
| SYNPO2L | synaptopodin 2-like | 2.71316 |
| TM4SF20 | transmembrane 4 L six family member 20 | 2.6576 |
| ZNF704 | zinc finger protein 704 | 2.6159 |
| SGCD | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | 2.56654 |
| C11ORF87 | chromosome 11 open reading frame 87 | 2.47453 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 2.46183 |
| MAP3K7CL | MAP3K7 C-terminal like | 2.41574 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | 2.34193 |
| NAP1L2 | nucleosome assembly protein 1-like 2 | 2.34102 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 2.29735 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 2.29323 |
| FAM107B | family with sequence similarity 107, member B | 2.2821 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | 2.2821 |
| SH3RF2 | SH3 domain containing ring finger 2 | 2.28043 |
| MRGPRE | MAS-related GPR, member E | 2.28043 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 2.19704 |
| DIAPH3 | diaphanous-related formin 3 | 2.17984 |
| BTG3 | BTG family, member 3 | 2.16296 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 2.15697 |
| SYNGR3 | synaptogyrin 3 | 2.13807 |
| NOVA2 | neuro-oncological ventral antigen 2 | 2.09993 |
| HES2 | hes family bHLH transcription factor 2 | 2.09788 |
| LOC728392 | uncharacterized LOC728392 | 2.07993 |
| EFNB2 | ephrin-B2 | 2.07313 |
| INA | internexin neuronal intermediate filament protein, alpha | 2.07029 |
| FGF1 | fibroblast growth factor 1 (acidic) | 2.06034 |
| IL11 | interleukin 11 | 2.03407 |
| KIF1A | kinesin family member 1A | 2.02513 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 1.99309 |
| TTLL7 | tubulin tyrosine ligase-like family member 7 | 1.97766 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 1.97432 |
| KCNQ4 | potassium channel, voltage gated KQT-like subfamily Q, member 4 | 1.96279 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 1.96279 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 1.92753 |
| MRPL36 | mitochondrial ribosomal protein L36 | 1.92059 |
| NF2 | neurofibromin 2 (merlin) | 1.91855 |
| ABLIM1 | actin binding LIM protein 1 | 1.86556 |
| SOD3 | superoxide dismutase 3, extracellular | 1.86123 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLIN4 | perilipin 4 | -19.0 |
| APOE | apolipoprotein E | -18.5686 |
| C3 | complement component 3 | -13.3182 |
| CHI3L2 | chitinase 3-like 2 | -13.1178 |
| RASD1 | RAS, dexamethasone-induced 1 | -12.9686 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -12.6531 |
| CIDEC | cell death-inducing DFFA-like effector c | -12.4782 |
| HEPH | hephaestin | -12.3779 |
| APOL4 | apolipoprotein L, 4 | -12.3779 |
| TNC | tenascin C | -10.3798 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -10.2877 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -10.2285 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | -10.1488 |
| WISP1 | WNT1 inducible signaling pathway protein 1 | -9.53289 |
| CPNE7 | copine VII | -9.29487 |
| ADRA2A | adrenoceptor alpha 2A | -9.05102 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -9.04988 |
| APOD | apolipoprotein D | -8.87411 |
| COL6A3 | collagen, type VI, alpha 3 | -8.87411 |
| AOC3 | amine oxidase, copper containing 3 | -8.17051 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | -8.14645 |
| MTSS1 | metastasis suppressor 1 | -8.06133 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -7.94339 |
| MMP13 | matrix metallopeptidase 13 | -7.86478 |
| DPEP1 | dipeptidase 1 (renal) | -7.65785 |
| G0S2 | G0/G1 switch 2 | -7.53692 |
| NOTUM | notum pectinacetylesterase homolog (Drosophila) | -7.41487 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -7.20925 |
| LSP1 | lymphocyte-specific protein 1 | -6.87896 |
| FBLN2 | fibulin 2 | -6.31934 |
| ACKR3 | atypical chemokine receptor 3 | -6.13814 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -6.10407 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -5.78108 |
| SBSN | suprabasin | -5.48831 |
| TMEM119 | transmembrane protein 119 | -5.48544 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -5.48062 |
| DGAT2 | diacylglycerol O-acyltransferase 2 | -5.38303 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -5.31125 |
| CLCA2 | chloride channel accessory 2 | -5.15739 |
| PITX3 | paired-like homeodomain 3 | -4.79877 |
| PCOLCE | procollagen C-endopeptidase enhancer | -4.65949 |
| FIBIN | fin bud initiation factor homolog (zebrafish) | -4.62266 |
| IL1RL1 | interleukin 1 receptor-like 1 | -4.33043 |
| PF4 | platelet factor 4 | -4.27489 |
| SPARCL1 | SPARC-like 1 (hevin) | -4.21357 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -4.11659 |
| TGFBR3 | transforming growth factor, beta receptor III | -4.01361 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -3.94424 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -3.9148 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -3.82011 |
| SRPX | sushi-repeat containing protein, X-linked | -3.79996 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | -3.79768 |
| PRR33 | proline rich 33 | -3.76221 |
| LCNL1 | lipocalin-like 1 | -3.7149 |
| IGF2 | insulin-like growth factor 2 | -3.36752 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -3.25247 |
| OLFML2B | olfactomedin-like 2B | -3.2178 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.21295 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -3.2087 |
| VIT | vitrin | -3.13514 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -3.08733 |
| HMOX1 | heme oxygenase 1 | -3.07458 |
| SOCS1 | suppressor of cytokine signaling 1 | -3.05201 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -2.94871 |
| MMP3 | matrix metallopeptidase 3 | -2.90461 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -2.89439 |
| SUSD2 | sushi domain containing 2 | -2.87739 |
| MMP28 | matrix metallopeptidase 28 | -2.84151 |
| CTHRC1 | collagen triple helix repeat containing 1 | -2.79733 |
| OLFML3 | olfactomedin-like 3 | -2.78961 |
| RGS2 | regulator of G-protein signaling 2 | -2.76762 |
| NID1 | nidogen 1 | -2.73405 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -2.71455 |
| GRM4 | glutamate receptor, metabotropic 4 | -2.71242 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -2.71242 |
| C1QTNF1 | C1q and tumor necrosis factor related protein 1 | -2.70453 |
| TECPR2 | tectonin beta-propeller repeat containing 2 | -2.69983 |
| SLC38A3 | solute carrier family 38, member 3 | -2.692 |
| COL7A1 | collagen, type VII, alpha 1 | -2.68998 |
| SYT6 | synaptotagmin VI | -2.64978 |
| CFD | complement factor D (adipsin) | -2.59858 |
| KRT5 | keratin 5, type II | -2.5727 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -2.55607 |
| FTH1 | ferritin, heavy polypeptide 1 | -2.55306 |
| MMP7 | matrix metallopeptidase 7 | -2.46183 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -2.40037 |
| SYNDIG1 | synapse differentiation inducing 1 | -2.37928 |
| VMO1 | vitelline membrane outer layer 1 homolog (chicken) | -2.35505 |
| SFRP5 | secreted frizzled-related protein 5 | -2.33986 |
| IL1R1 | interleukin 1 receptor, type I | -2.30109 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -2.2821 |
| APOL2 | apolipoprotein L, 2 | -2.2821 |
| GGT5 | gamma-glutamyltransferase 5 | -2.28043 |
| GAL | galanin/GMAP prepropeptide | -2.26423 |
| P4HA3 | prolyl 4-hydroxylase, alpha polypeptide III | -2.2612 |
| CLEC2D | C-type lectin domain family 2, member D | -2.26003 |
| LAMB1 | laminin, beta 1 | -2.25091 |
| NMB | neuromedin B | -2.22744 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -2.17475 |
| WDR86 | WD repeat domain 86 | -2.17475 |
