| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting WHSC1 in prostate cancer cell PC3(derived from metastatic site: bone) cell line (Study accession: SRP079918) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_15435_KD_WHSC1_SRP079918 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 20.0 |
| TNS3 | tensin 3 | 20.0 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 20.0 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 20.0 |
| BIRC5 | baculoviral IAP repeat containing 5 | 20.0 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 20.0 |
| TGFB2 | transforming growth factor, beta 2 | 20.0 |
| TNIP1 | TNFAIP3 interacting protein 1 | 20.0 |
| TNC | tenascin C | 20.0 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 20.0 |
| GANAB | glucosidase, alpha; neutral AB | 20.0 |
| NES | nestin | 20.0 |
| PDE8A | phosphodiesterase 8A | 20.0 |
| VEGFA | vascular endothelial growth factor A | 20.0 |
| TRIB3 | tribbles pseudokinase 3 | 20.0 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 20.0 |
| GYS1 | glycogen synthase 1 (muscle) | 20.0 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 20.0 |
| C15ORF52 | chromosome 15 open reading frame 52 | 20.0 |
| TFRC | transferrin receptor | 20.0 |
| STC1 | stanniocalcin 1 | 20.0 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 20.0 |
| ZNF664 | zinc finger protein 664 | 20.0 |
| COL1A1 | collagen, type I, alpha 1 | 20.0 |
| TBL1X | transducin (beta)-like 1X-linked | 20.0 |
| COL6A3 | collagen, type VI, alpha 3 | 20.0 |
| CDK6 | cyclin-dependent kinase 6 | 20.0 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 20.0 |
| PODXL | podocalyxin-like | 20.0 |
| C3 | complement component 3 | 20.0 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 20.0 |
| THBS1 | thrombospondin 1 | 20.0 |
| BICD2 | bicaudal D homolog 2 (Drosophila) | 20.0 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 20.0 |
| PRMT6 | protein arginine methyltransferase 6 | 20.0 |
| EPAS1 | endothelial PAS domain protein 1 | 20.0 |
| SCG5 | secretogranin V | 20.0 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 20.0 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 20.0 |
| COL4A2 | collagen, type IV, alpha 2 | 20.0 |
| COL4A1 | collagen, type IV, alpha 1 | 20.0 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 20.0 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 20.0 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 20.0 |
| SLIT2 | slit homolog 2 (Drosophila) | 20.0 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 20.0 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 20.0 |
| PPIF | peptidylprolyl isomerase F | 20.0 |
| HDGF | hepatoma-derived growth factor | 20.0 |
| FAM20C | family with sequence similarity 20, member C | 20.0 |
| ACO2 | aconitase 2, mitochondrial | 20.0 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 20.0 |
| NACC1 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | 20.0 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 20.0 |
| ERO1L | ERO1-like (S. cerevisiae) | 20.0 |
| YBX3 | Y box binding protein 3 | 20.0 |
| CALU | calumenin | 20.0 |
| OGFR | opioid growth factor receptor | 20.0 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 20.0 |
| ADAM15 | ADAM metallopeptidase domain 15 | 20.0 |
| CCNA2 | cyclin A2 | 20.0 |
| KLHDC3 | kelch domain containing 3 | 20.0 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | 20.0 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 20.0 |
| CALR | calreticulin | 20.0 |
| LCN2 | lipocalin 2 | 20.0 |
| PEG10 | paternally expressed 10 | 20.0 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 20.0 |
| KIF1C | kinesin family member 1C | 20.0 |
| LOXL2 | lysyl oxidase-like 2 | 20.0 |
| LONP1 | lon peptidase 1, mitochondrial | 20.0 |
| RCC2 | regulator of chromosome condensation 2 | 20.0 |
| TGM2 | transglutaminase 2 | 20.0 |
| HYOU1 | hypoxia up-regulated 1 | 20.0 |
| PXDN | peroxidasin | 20.0 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 20.0 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 20.0 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 20.0 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 20.0 |
| LAD1 | ladinin 1 | 20.0 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 20.0 |
| DMBT1 | deleted in malignant brain tumors 1 | 20.0 |
| CYCS | cytochrome c, somatic | 19.699 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 19.5229 |
| ACAT1 | acetyl-CoA acetyltransferase 1 | 18.7447 |
| STC2 | stanniocalcin 2 | 18.6021 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 18.6021 |
| TMEM30A | transmembrane protein 30A | 18.3979 |
| PRSS23 | protease, serine, 23 | 18.2924 |
| CTSC | cathepsin C | 18.2518 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | 18.2441 |
| DHX37 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 | 17.6421 |
| SAMD4A | sterile alpha motif domain containing 4A | 17.5623 |
| GRB10 | growth factor receptor-bound protein 10 | 17.4145 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 17.3526 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 17.2865 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 17.279 |
| RGS19 | regulator of G-protein signaling 19 | 17.1931 |
| ELFN2 | extracellular leucine-rich repeat and fibronectin type III domain containing 2 | 17.1445 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 16.9263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -20.0 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -20.0 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -20.0 |
| KRT19 | keratin 19, type I | -20.0 |
| KRT7 | keratin 7, type II | -20.0 |
| ARHGAP29 | Rho GTPase activating protein 29 | -20.0 |
| LAMC2 | laminin, gamma 2 | -20.0 |
| PLAU | plasminogen activator, urokinase | -20.0 |
| FTH1 | ferritin, heavy polypeptide 1 | -20.0 |
| TWF1 | twinfilin actin binding protein 1 | -20.0 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -20.0 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -20.0 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | -20.0 |
| CDCP1 | CUB domain containing protein 1 | -20.0 |
| IL23A | interleukin 23, alpha subunit p19 | -20.0 |
| CSTB | cystatin B (stefin B) | -20.0 |
| HIPK3 | homeodomain interacting protein kinase 3 | -20.0 |
| MMP9 | matrix metallopeptidase 9 | -20.0 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -20.0 |
| TBCB | tubulin folding cofactor B | -20.0 |
| PKP1 | plakophilin 1 | -20.0 |
| CCND1 | cyclin D1 | -20.0 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -20.0 |
| CAPN2 | calpain 2, (m/II) large subunit | -20.0 |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 | -20.0 |
| KRT81 | keratin 81, type II | -20.0 |
| LAMA3 | laminin, alpha 3 | -20.0 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -20.0 |
| TXNRD1 | thioredoxin reductase 1 | -20.0 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -20.0 |
| ANTXR2 | anthrax toxin receptor 2 | -20.0 |
| CLDN4 | claudin 4 | -20.0 |
| RAB15 | RAB15, member RAS oncogene family | -20.0 |
| FOSL1 | FOS-like antigen 1 | -20.0 |
| FAM43A | family with sequence similarity 43, member A | -20.0 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -20.0 |
| TAGLN2 | transgelin 2 | -20.0 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -20.0 |
| AHNAK2 | AHNAK nucleoprotein 2 | -20.0 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -18.7696 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -18.7696 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -18.5528 |
| SNX7 | sorting nexin 7 | -17.9172 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -17.5867 |
| NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit | -17.3904 |
| RAD21 | RAD21 homolog (S. pombe) | -17.3788 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -17.0334 |
| MKRN1 | makorin ring finger protein 1 | -16.7929 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -16.787 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -16.7324 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -16.6778 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -16.659 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -16.5243 |
| FST | follistatin | -16.5053 |
| DNAJC11 | DnaJ (Hsp40) homolog, subfamily C, member 11 | -16.3884 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -16.2436 |
| FNBP1L | formin binding protein 1-like | -16.2436 |
| TMED4 | transmembrane emp24 protein transport domain containing 4 | -16.119 |
| SLC6A2 | solute carrier family 6 (neurotransmitter transporter), member 2 | -15.6343 |
| UNG | uracil-DNA glycosylase | -15.5965 |
| SMAD3 | SMAD family member 3 | -15.4873 |
| PI3 | peptidase inhibitor 3, skin-derived | -15.3372 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -15.2974 |
| CCNA1 | cyclin A1 | -15.1319 |
| PLEKHG3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 | -14.9733 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | -14.492 |
| SNX9 | sorting nexin 9 | -14.3872 |
| HIP1 | huntingtin interacting protein 1 | -14.2336 |
| DOCK4 | dedicator of cytokinesis 4 | -14.0882 |
| FIBP | fibroblast growth factor (acidic) intracellular binding protein | -14.0775 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -14.0311 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -13.959 |
| SFT2D2 | SFT2 domain containing 2 | -13.7005 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -13.6944 |
| PLS3 | plastin 3 | -13.6754 |
| EFNB1 | ephrin-B1 | -13.4384 |
| PTBP3 | polypyrimidine tract binding protein 3 | -13.1743 |
| PRSS8 | protease, serine, 8 | -12.9866 |
| MYH15 | myosin, heavy chain 15 | -12.8819 |
| FBLIM1 | filamin binding LIM protein 1 | -12.7246 |
| RC3H2 | ring finger and CCCH-type domains 2 | -12.5601 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -12.4295 |
| AGO2 | argonaute RISC catalytic component 2 | -12.425 |
| FRMD6 | FERM domain containing 6 | -12.3309 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -12.2318 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -12.1458 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -12.0833 |
| PLEC | plectin | -12.0198 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -12.0132 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -11.9929 |
| EPHA2 | EPH receptor A2 | -11.8691 |
| ANXA2 | annexin A2 | -11.839 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -11.8356 |
| NEFL | neurofilament, light polypeptide | -11.6642 |
| LPXN | leupaxin | -11.6259 |
| EPGN | epithelial mitogen | -11.6144 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -11.5747 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -11.3814 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -11.3706 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | -11.3278 |
