Perturb_16455_KO_CHUK_SRP229998 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting CHUK in skin xenograft tumor (lung cancer cell H1299) tissue (Study accession: SRP229998) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_16455_KO_CHUK_SRP229998 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
TGFB1 transforming growth factor, beta 1 20.0
LDHA lactate dehydrogenase A 20.0
EEF2 eukaryotic translation elongation factor 2 20.0
RPS11 ribosomal protein S11 20.0
RPS16 ribosomal protein S16 20.0
RPS15 ribosomal protein S15 20.0
RPS14 ribosomal protein S14 20.0
RPS19 ribosomal protein S19 20.0
RPS18 ribosomal protein S18 20.0
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 20.0
RPL14 ribosomal protein L14 20.0
PTMS parathymosin 20.0
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 20.0
ACTG1 actin gamma 1 20.0
FLII flightless I homolog (Drosophila) 20.0
RPL27A ribosomal protein L27a 20.0
RPL13A ribosomal protein L13a 20.0
RPLP2 ribosomal protein, large, P2 20.0
RPLP1 ribosomal protein, large, P1 20.0
RPLP0 ribosomal protein, large, P0 20.0
PHB2 prohibitin 2 20.0
LUC7L3 LUC7-like 3 (S. cerevisiae) 20.0
TM4SF1 transmembrane 4 L six family member 1 20.0
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 20.0
RPL15 ribosomal protein L15 20.0
RPL17 ribosomal protein L17 20.0
RPS9 ribosomal protein S9 20.0
RPS8 ribosomal protein S8 20.0
RPSA ribosomal protein SA 20.0
RPL29 ribosomal protein L29 20.0
RPL28 ribosomal protein L28 20.0
RPL24 ribosomal protein L24 20.0
RPL27 ribosomal protein L27 20.0
SF3B1 splicing factor 3b, subunit 1, 155kDa 20.0
TPT1 tumor protein, translationally-controlled 1 20.0
MYH9 myosin, heavy chain 9, non-muscle 20.0
RPS2 ribosomal protein S2 20.0
RPS3 ribosomal protein S3 20.0
RPS5 ribosomal protein S5 20.0
RPL10 ribosomal protein L10 20.0
RPL13 ribosomal protein L13 20.0
RPL18 ribosomal protein L18 20.0
RPL19 ribosomal protein L19 20.0
RPS27A ribosomal protein S27a 20.0
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 20.0
HSPA9 heat shock 70kDa protein 9 (mortalin) 20.0
HSPA8 heat shock 70kDa protein 8 20.0
RPS7 ribosomal protein S7 20.0
RPS6 ribosomal protein S6 20.0
RPL10A ribosomal protein L10a 20.0
RPL12 ribosomal protein L12 20.0
RPS25 ribosomal protein S25 20.0
RPS20 ribosomal protein S20 20.0
MRPS12 mitochondrial ribosomal protein S12 20.0
FASN fatty acid synthase 20.0
RPL8 ribosomal protein L8 20.0
RPL9 ribosomal protein L9 20.0
RPL6 ribosomal protein L6 20.0
RPL4 ribosomal protein L4 20.0
RPL3 ribosomal protein L3 20.0
SCD stearoyl-CoA desaturase (delta-9-desaturase) 20.0
RPS24 ribosomal protein S24 20.0
RPS27 ribosomal protein S27 20.0
RPL37A ribosomal protein L37a 20.0
RPL18A ribosomal protein L18a 20.0
CCNA2 cyclin A2 20.0
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 20.0
SLC38A2 solute carrier family 38, member 2 20.0
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 20.0
HSPD1 heat shock 60kDa protein 1 (chaperonin) 20.0
TPI1 triosephosphate isomerase 1 20.0
RPL7A ribosomal protein L7a 20.0
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 20.0
COL6A2 collagen, type VI, alpha 2 20.0
RPL7 ribosomal protein L7 20.0
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 20.0
P4HB prolyl 4-hydroxylase, beta polypeptide 20.0
LGALS1 lectin, galactoside-binding, soluble, 1 20.0
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 20.0
GNAS GNAS complex locus 20.0
GAPDH glyceraldehyde-3-phosphate dehydrogenase 20.0
RPL36 ribosomal protein L36 20.0
RPL34 ribosomal protein L34 20.0
RPL35 ribosomal protein L35 20.0
RPL32 ribosomal protein L32 20.0
RPL30 ribosomal protein L30 20.0
RPL31 ribosomal protein L31 20.0
RPL37 ribosomal protein L37 20.0
RHOA ras homolog family member A 20.0
FLNA filamin A, alpha 20.0
B2M beta-2-microglobulin 20.0
APP amyloid beta (A4) precursor protein 20.0
LMNA lamin A/C 20.0
CANX calnexin 20.0
BTF3 basic transcription factor 3 20.0
EIF3E eukaryotic translation initiation factor 3, subunit E 20.0
RPL35A ribosomal protein L35a 20.0
FLNC filamin C, gamma 20.0
EEF1B2 eukaryotic translation elongation factor 1 beta 2 20.0
BSG basigin (Ok blood group) 20.0

decreased expression

Symbol Name Standardized Value
SPEG SPEG complex locus -20.0
TNC tenascin C -20.0
CDC42 cell division cycle 42 -20.0
TNNT3 troponin T type 3 (skeletal, fast) -20.0
TNNI2 troponin I type 2 (skeletal, fast) -20.0
MOV10 Mov10 RISC complex RNA helicase -20.0
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -20.0
TGFBR3 transforming growth factor, beta receptor III -20.0
DNM1 dynamin 1 -20.0
NDRG1 N-myc downstream regulated 1 -20.0
PCOLCE procollagen C-endopeptidase enhancer -20.0
CLEC11A C-type lectin domain family 11, member A -20.0
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -20.0
POSTN periostin, osteoblast specific factor -20.0
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -20.0
IGFBP6 insulin-like growth factor binding protein 6 -20.0
GMNN geminin, DNA replication inhibitor -20.0
WWTR1 WW domain containing transcription regulator 1 -20.0
PAEP progestagen-associated endometrial protein -20.0
SMIM3 small integral membrane protein 3 -20.0
PERP PERP, TP53 apoptosis effector -20.0
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -20.0
TSC22D1 TSC22 domain family, member 1 -20.0
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -20.0
LTBP1 latent transforming growth factor beta binding protein 1 -20.0
DAP death-associated protein -20.0
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -20.0
TOP1 topoisomerase (DNA) I -20.0
CHUK conserved helix-loop-helix ubiquitous kinase -20.0
STX1A syntaxin 1A (brain) -20.0
DUSP6 dual specificity phosphatase 6 -20.0
TNNC2 troponin C type 2 (fast) -20.0
MYH2 myosin, heavy chain 2, skeletal muscle, adult -20.0
MYH1 myosin, heavy chain 1, skeletal muscle, adult -20.0
MYH4 myosin, heavy chain 4, skeletal muscle -20.0
BGN biglycan -20.0
NGEF neuronal guanine nucleotide exchange factor -20.0
RNF182 ring finger protein 182 -20.0
PHTF1 putative homeodomain transcription factor 1 -20.0
ACTA1 actin, alpha 1, skeletal muscle -20.0
SH3PXD2A SH3 and PX domains 2A -20.0
CKM creatine kinase, muscle -20.0
CXCL14 chemokine (C-X-C motif) ligand 14 -20.0
ADGRG1 adhesion G protein-coupled receptor G1 -20.0
SSBP3 single stranded DNA binding protein 3 -20.0
BCL10 B-cell CLL/lymphoma 10 -20.0
ADGRB1 adhesion G protein-coupled receptor B1 -20.0
SASH1 SAM and SH3 domain containing 1 -20.0
PLEK2 pleckstrin 2 -20.0
SPATS2 spermatogenesis associated, serine-rich 2 -20.0
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -20.0
SFRP1 secreted frizzled-related protein 1 -20.0
SGK223 homolog of rat pragma of Rnd2 -20.0
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -20.0
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -20.0
F2RL1 coagulation factor II (thrombin) receptor-like 1 -20.0
FHL2 four and a half LIM domains 2 -20.0
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -20.0
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -20.0
IGFBP7 insulin-like growth factor binding protein 7 -20.0
AKIRIN1 akirin 1 -20.0
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -20.0
GADD45A growth arrest and DNA-damage-inducible, alpha -20.0
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -20.0
LPCAT1 lysophosphatidylcholine acyltransferase 1 -20.0
VGF VGF nerve growth factor inducible -20.0
TRNP1 TMF1-regulated nuclear protein 1 -20.0
SHANK1 SH3 and multiple ankyrin repeat domains 1 -20.0
RIN1 Ras and Rab interactor 1 -20.0
SIPA1L1 signal-induced proliferation-associated 1 like 1 -20.0
CTSZ cathepsin Z -20.0
CTSS cathepsin S -20.0
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) -20.0
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -20.0
RHPN1 rhophilin, Rho GTPase binding protein 1 -20.0
IL4R interleukin 4 receptor -20.0
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 -20.0
PXDN peroxidasin -20.0
ARL4C ADP-ribosylation factor-like 4C -20.0
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -20.0
LOXL1 lysyl oxidase-like 1 -20.0
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -20.0
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -20.0
SDC1 syndecan 1 -20.0
EPHB2 EPH receptor B2 -20.0
CORO2B coronin, actin binding protein, 2B -20.0
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -20.0
COL5A1 collagen, type V, alpha 1 -20.0
COL5A2 collagen, type V, alpha 2 -20.0
TMCC3 transmembrane and coiled-coil domain family 3 -20.0
IL13RA2 interleukin 13 receptor, alpha 2 -20.0
DES desmin -20.0
CPM carboxypeptidase M -20.0
HMOX1 heme oxygenase 1 -20.0
NTSR1 neurotensin receptor 1 (high affinity) -20.0
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -20.0
MMP1 matrix metallopeptidase 1 -20.0
IRF2BPL interferon regulatory factor 2 binding protein-like -20.0
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -20.0
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -20.0