Perturb_17201_OE_GATA3|JUN_SRP188712 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting GATA3|JUN in T47D cell line (Study accession: SRP188712) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_17201_OE_GATA3|JUN_SRP188712 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
UBN1 ubinuclein 1 20.0
C12ORF73 chromosome 12 open reading frame 73 20.0
ANGPTL6 angiopoietin-like 6 20.0
C5ORF45 chromosome 5 open reading frame 45 20.0
TMEM184A transmembrane protein 184A 20.0
CXCR5 chemokine (C-X-C motif) receptor 5 20.0
TLDC2 TBC/LysM-associated domain containing 2 20.0
WDR86 WD repeat domain 86 20.0
C7ORF49 chromosome 7 open reading frame 49 20.0
TSNAXIP1 translin-associated factor X interacting protein 1 20.0
THAP11 THAP domain containing 11 20.0
ABI2 abl-interactor 2 20.0
ACO1 aconitase 1, soluble 20.0
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 18.699
BEST1 bestrophin 1 18.2366
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 18.2147
GPR137 G protein-coupled receptor 137 14.6505
SUN2 Sad1 and UNC84 domain containing 2 13.7183
RIC8A RIC8 guanine nucleotide exchange factor A 12.0543
CDH13 cadherin 13 11.1317
RRBP1 ribosome binding protein 1 11.0243
GPR39 G protein-coupled receptor 39 10.9702
SLC7A6OS solute carrier family 7, member 6 opposite strand 10.7526
RFC5 replication factor C (activator 1) 5, 36.5kDa 9.84405
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 8.88615
GPR132 G protein-coupled receptor 132 8.8784
JUN jun proto-oncogene 8.76239
TRRAP transformation/transcription domain-associated protein 8.69055
GLS glutaminase 8.57375
NKIRAS1 NFKB inhibitor interacting Ras-like 1 8.03257
COG5 component of oligomeric golgi complex 5 7.99176
MARS methionyl-tRNA synthetase 7.7747
PAQR3 progestin and adipoQ receptor family member III 7.01996
CLVS1 clavesin 1 6.39578
IFIH1 interferon induced with helicase C domain 1 6.07641
MYCBP MYC binding protein 5.93756
RPS27A ribosomal protein S27a 5.87404
OGFR opioid growth factor receptor 5.70278
PARP9 poly (ADP-ribose) polymerase family, member 9 5.29496
WBSCR22 Williams Beuren syndrome chromosome region 22 5.29404
CTNS cystinosin, lysosomal cystine transporter 5.10338
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 5.07057
TRIM31 tripartite motif containing 31 5.04497
TRABD2A TraB domain containing 2A 4.90005
TPBG trophoblast glycoprotein 4.87445
NANS N-acetylneuraminic acid synthase 4.76019
ACOT13 acyl-CoA thioesterase 13 4.65294
HEATR1 HEAT repeat containing 1 4.51476
CAST calpastatin 4.32009
LOXL3 lysyl oxidase-like 3 4.21248
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 4.06681
C18ORF8 chromosome 18 open reading frame 8 4.04376
RHOC ras homolog family member C 4.00165
MIEN1 migration and invasion enhancer 1 3.99406
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 3.94111
XRRA1 X-ray radiation resistance associated 1 3.86545
TCP11L1 t-complex 11, testis-specific-like 1 3.65275
EMC9 ER membrane protein complex subunit 9 3.5452
TTC6 tetratricopeptide repeat domain 6 3.51127
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 3.50891
BRI3 brain protein I3 3.45251
TRIM56 tripartite motif containing 56 3.42436
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.2735
THRA thyroid hormone receptor, alpha 3.24505
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 3.20586
EPHA1 EPH receptor A1 3.19063
PARP14 poly (ADP-ribose) polymerase family, member 14 3.16754
KRT80 keratin 80, type II 3.1515
OTUD7B OTU deubiquitinase 7B 3.13399
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 3.09211
UPK2 uroplakin 2 2.98441
NUP62 nucleoporin 62kDa 2.95206
SAMHD1 SAM domain and HD domain 1 2.84228
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.82923
MYBBP1A MYB binding protein (P160) 1a 2.82834
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 2.82633
AFG3L2 AFG3-like AAA ATPase 2 2.82218
KRTAP5-8 keratin associated protein 5-8 2.78401
SPAG1 sperm associated antigen 1 2.78401
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.78024
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.71566
PARP8 poly (ADP-ribose) polymerase family, member 8 2.69655
SREBF1 sterol regulatory element binding transcription factor 1 2.68419
PKM pyruvate kinase, muscle 2.67953
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.62279
MROH8 maestro heat-like repeat family member 8 2.50244
C1ORF54 chromosome 1 open reading frame 54 2.50026
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.43833
RAB43 RAB43, member RAS oncogene family 2.38318
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.37671
ADAM9 ADAM metallopeptidase domain 9 2.34168
DSP desmoplakin 2.23749
IL16 interleukin 16 2.233
SDC4 syndecan 4 2.233
ERAP1 endoplasmic reticulum aminopeptidase 1 2.22448
KIAA2018 KIAA2018 2.22423
FSIP1 fibrous sheath interacting protein 1 2.1689
TMEM132A transmembrane protein 132A 2.05531
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 2.0317
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.0244

decreased expression

Symbol Name Standardized Value
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -20.0
BBIP1 BBSome interacting protein 1 -20.0
LRRC75A leucine rich repeat containing 75A -20.0
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -15.5142
FAM120AOS family with sequence similarity 120A opposite strand -14.5241
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -13.946
ZNHIT2 zinc finger, HIT-type containing 2 -11.2784
ZFYVE16 zinc finger, FYVE domain containing 16 -10.3997
ARG2 arginase 2 -8.52975
TAPBP TAP binding protein (tapasin) -8.39399
PAH phenylalanine hydroxylase -8.26405
ATG10 autophagy related 10 -7.93645
CFAP126 cilia and flagella associated protein 126 -7.84701
ZNF497 zinc finger protein 497 -7.6502
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -7.51539
FOXH1 forkhead box H1 -7.2446
TMPRSS4 transmembrane protease, serine 4 -7.20036
RABL6 RAB, member RAS oncogene family-like 6 -6.82585
CLCC1 chloride channel CLIC-like 1 -6.68042
TRIM59 tripartite motif containing 59 -6.60228
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -6.44966
EIF4B eukaryotic translation initiation factor 4B -6.17471
ZBTB45 zinc finger and BTB domain containing 45 -6.0054
STK24 serine/threonine kinase 24 -5.96736
IL18BP interleukin 18 binding protein -5.59587
ACBD6 acyl-CoA binding domain containing 6 -5.29774
ITFG2 integrin alpha FG-GAP repeat containing 2 -5.0763
HDDC2 HD domain containing 2 -4.54123
C9ORF172 chromosome 9 open reading frame 172 -4.04271
LOC122455342 testis-specific serine/proline-rich protein -4.00954
USP3 ubiquitin specific peptidase 3 -3.6971
WBSCR16 Williams-Beuren syndrome chromosome region 16 -3.67537
ADCY3 adenylate cyclase 3 -3.64396
GOLM1 golgi membrane protein 1 -3.48702
TSPAN31 tetraspanin 31 -3.41868
EME1 essential meiotic structure-specific endonuclease 1 -3.25701
PEX10 peroxisomal biogenesis factor 10 -3.224
SGCE sarcoglycan, epsilon -3.18381
TMEM263 transmembrane protein 263 -3.07831
TOB1 transducer of ERBB2, 1 -3.03642
MRPS34 mitochondrial ribosomal protein S34 -3.00755
IL24 interleukin 24 -2.98441
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.86898
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -2.82584
TCP1 t-complex 1 -2.76968
TNS2 tensin 2 -2.75527
MLX MLX, MAX dimerization protein -2.71566
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing -2.68947
FCMR Fc fragment of IgM receptor -2.68341
KMT2E lysine (K)-specific methyltransferase 2E -2.66258
CCDC176 coiled-coil domain containing 176 -2.65407
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.64806
LRRC24 leucine rich repeat containing 24 -2.64806
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -2.63221
BCAS3 breast carcinoma amplified sequence 3 -2.63145
POLG polymerase (DNA directed), gamma -2.62279
SRPX2 sushi-repeat containing protein, X-linked 2 -2.60062
PROB1 proline-rich basic protein 1 -2.5547
TRIM14 tripartite motif containing 14 -2.54561
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.51953
AATK apoptosis-associated tyrosine kinase -2.51953
C12ORF60 chromosome 12 open reading frame 60 -2.50244
PRSS23 protease, serine, 23 -2.49966
MED31 mediator complex subunit 31 -2.44634
SAMD14 sterile alpha motif domain containing 14 -2.43833
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.42787
BCL7A B-cell CLL/lymphoma 7A -2.41991
VIM vimentin -2.40231
SARNP SAP domain containing ribonucleoprotein -2.2572
CD37 CD37 molecule -2.23967
HBP1 HMG-box transcription factor 1 -2.23318
TSEN54 TSEN54 tRNA splicing endonuclease subunit -2.18686
TMEM140 transmembrane protein 140 -2.1705
RAD9A RAD9 homolog A (S. pombe) -2.16954
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.10359
SLC35F4 solute carrier family 35, member F4 -2.03874
ZBTB46 zinc finger and BTB domain containing 46 -2.02174
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.00038
ASCL1 achaete-scute family bHLH transcription factor 1 -1.97025
RHOF ras homolog family member F (in filopodia) -1.96138
WDR33 WD repeat domain 33 -1.92538
FANCD2OS FANCD2 opposite strand -1.88998
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -1.86262
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -1.83101
COX11 COX11 cytochrome c oxidase copper chaperone -1.82544
JTB jumping translocation breakpoint -1.8216
KLLN killin, p53-regulated DNA replication inhibitor -1.81254
PMCH pro-melanin-concentrating hormone -1.80863
MPI mannose phosphate isomerase -1.8055
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -1.80158
STAB1 stabilin 1 -1.78698
CCNK cyclin K -1.72762
RECQL4 RecQ protein-like 4 -1.72702
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -1.71754
FAM184B family with sequence similarity 184, member B -1.70652
PLLP plasmolipin -1.70143
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -1.68342
RAB23 RAB23, member RAS oncogene family -1.66409
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -1.64664
FAM92A1 family with sequence similarity 92, member A1 -1.64664