Perturb_17218_KD_OCT4_ERP128142 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting OCT4 in TE03 (I3) human embryonic stem cells (hESCs) cell line (Study accession: ERP128142) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_17218_KD_OCT4_ERP128142 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PRDX6 peroxiredoxin 6 20.0
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 20.0
FSCN1 fascin actin-bundling protein 1 20.0
RAPSN receptor-associated protein of the synapse 20.0
FGFR1 fibroblast growth factor receptor 1 20.0
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 20.0
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 20.0
WNK1 WNK lysine deficient protein kinase 1 20.0
MACF1 microtubule-actin crosslinking factor 1 20.0
KTN1 kinectin 1 (kinesin receptor) 20.0
DSG2 desmoglein 2 20.0
TPM1 tropomyosin 1 (alpha) 20.0
TPM3 tropomyosin 3 20.0
TPM4 tropomyosin 4 20.0
TLN1 talin 1 20.0
COL2A1 collagen, type II, alpha 1 20.0
P4HB prolyl 4-hydroxylase, beta polypeptide 20.0
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 20.0
SURF4 surfeit 4 20.0
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 20.0
FN1 fibronectin 1 20.0
GNAS GNAS complex locus 20.0
MAGED2 melanoma antigen family D2 20.0
CD63 CD63 molecule 20.0
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 20.0
LAMC1 laminin, gamma 1 (formerly LAMB2) 20.0
PODXL podocalyxin-like 20.0
TAGLN2 transgelin 2 20.0
IQGAP1 IQ motif containing GTPase activating protein 1 20.0
THBS1 thrombospondin 1 20.0
RPN2 ribophorin II 20.0
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 20.0
STMN1 stathmin 1 20.0
MYH9 myosin, heavy chain 9, non-muscle 20.0
APLP2 amyloid beta (A4) precursor-like protein 2 20.0
SPTAN1 spectrin, alpha, non-erythrocytic 1 20.0
TMEM2 transmembrane protein 2 20.0
MORF4L2 mortality factor 4 like 2 20.0
HAPLN1 hyaluronan and proteoglycan link protein 1 20.0
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 20.0
ACTG1 actin gamma 1 20.0
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 20.0
ENAH enabled homolog (Drosophila) 20.0
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 20.0
COL4A2 collagen, type IV, alpha 2 20.0
COL4A1 collagen, type IV, alpha 1 20.0
PTPRF protein tyrosine phosphatase, receptor type, F 20.0
COL1A1 collagen, type I, alpha 1 20.0
ARF1 ADP-ribosylation factor 1 20.0
VCAN versican 20.0
ITGAV integrin, alpha V 20.0
LRP1 low density lipoprotein receptor-related protein 1 20.0
COL1A2 collagen, type I, alpha 2 20.0
DSP desmoplakin 20.0
AP2B1 adaptor-related protein complex 2, beta 1 subunit 20.0
TMBIM6 transmembrane BAX inhibitor motif containing 6 20.0
TMSB4X thymosin beta 4, X-linked 20.0
FASN fatty acid synthase 20.0
SCD stearoyl-CoA desaturase (delta-9-desaturase) 20.0
LAPTM4B lysosomal protein transmembrane 4 beta 20.0
ACTC1 actin, alpha, cardiac muscle 1 20.0
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 20.0
FAT1 FAT atypical cadherin 1 20.0
CALU calumenin 20.0
CALM3 calmodulin 3 (phosphorylase kinase, delta) 20.0
TAGLN transgelin 20.0
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 20.0
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 20.0
ADAM19 ADAM metallopeptidase domain 19 20.0
LAMB1 laminin, beta 1 20.0
ACTN1 actinin, alpha 1 20.0
ACTN4 actinin, alpha 4 20.0
ADGRL2 adhesion G protein-coupled receptor L2 20.0
CALR calreticulin 20.0
FLNA filamin A, alpha 20.0
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 20.0
FSTL1 follistatin-like 1 20.0
PKM pyruvate kinase, muscle 20.0
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 20.0
ANXA5 annexin A5 20.0
MMP14 matrix metallopeptidase 14 (membrane-inserted) 20.0
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 20.0
CALD1 caldesmon 1 20.0
FLNB filamin B, beta 20.0
PXDN peroxidasin 20.0
PLS3 plastin 3 20.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 20.0
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 20.0
FZD7 frizzled class receptor 7 20.0
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 20.0
COL18A1 collagen, type XVIII, alpha 1 20.0
PSAP prosaposin 20.0
APP amyloid beta (A4) precursor protein 20.0
IGFBP5 insulin-like growth factor binding protein 5 20.0
PEG10 paternally expressed 10 20.0
KRT8 keratin 8, type II 20.0
KRT18 keratin 18, type I 20.0
HDLBP high density lipoprotein binding protein 20.0
TMSB10 thymosin beta 10 20.0
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 20.0

decreased expression

Symbol Name Standardized Value
RYR2 ryanodine receptor 2 (cardiac) -20.0
CSMD2 CUB and Sushi multiple domains 2 -20.0
CPT1A carnitine palmitoyltransferase 1A (liver) -20.0
CABLES1 Cdk5 and Abl enzyme substrate 1 -20.0
TERT telomerase reverse transcriptase -20.0
ATXN7L1 ataxin 7-like 1 -20.0
TRIM14 tripartite motif containing 14 -20.0
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -20.0
HIST1H2AC histone cluster 1, H2ac -20.0
CUTC cutC copper transporter -20.0
OGDHL oxoglutarate dehydrogenase-like -20.0
CHGA chromogranin A -20.0
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -20.0
GPR27 G protein-coupled receptor 27 -20.0
STEAP3 STEAP family member 3, metalloreductase -20.0
SCN8A sodium channel, voltage gated, type VIII alpha subunit -20.0
MAP2K6 mitogen-activated protein kinase kinase 6 -20.0
ATP2A3 ATPase, Ca++ transporting, ubiquitous -20.0
PIPOX pipecolic acid oxidase -20.0
PGBD5 piggyBac transposable element derived 5 -20.0
FAM216A family with sequence similarity 216, member A -20.0
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -20.0
CA14 carbonic anhydrase XIV -20.0
IRS4 insulin receptor substrate 4 -20.0
C14ORF132 chromosome 14 open reading frame 132 -20.0
PCOLCE2 procollagen C-endopeptidase enhancer 2 -20.0
SYT14 synaptotagmin XIV -20.0
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -20.0
NTHL1 nth endonuclease III-like 1 (E. coli) -20.0
KIF5A kinesin family member 5A -20.0
GRID2 glutamate receptor, ionotropic, delta 2 -20.0
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -20.0
LDB2 LIM domain binding 2 -20.0
ADGRG2 adhesion G protein-coupled receptor G2 -20.0
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -20.0
BEND4 BEN domain containing 4 -20.0
TOX3 TOX high mobility group box family member 3 -20.0
MUC3A mucin 3A, cell surface associated -20.0
SOCS1 suppressor of cytokine signaling 1 -20.0
RYR1 ryanodine receptor 1 (skeletal) -20.0
HRASLS5 HRAS-like suppressor family, member 5 -20.0
WSCD1 WSC domain containing 1 -20.0
STAC SH3 and cysteine rich domain -20.0
KIZ kizuna centrosomal protein -20.0
FAR2 fatty acyl CoA reductase 2 -20.0
BRSK2 BR serine/threonine kinase 2 -20.0
PTCHD1 patched domain containing 1 -20.0
WIPF3 WAS/WASL interacting protein family, member 3 -20.0
AP3B2 adaptor-related protein complex 3, beta 2 subunit -20.0
PDE4B phosphodiesterase 4B, cAMP-specific -20.0
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 -20.0
HLA-DOA major histocompatibility complex, class II, DO alpha -20.0
FOXM1 forkhead box M1 -20.0
RHBDL3 rhomboid, veinlet-like 3 (Drosophila) -20.0
TEX15 testis expressed 15 -20.0
FBXO41 F-box protein 41 -20.0
ZDHHC22 zinc finger, DHHC-type containing 22 -20.0
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -20.0
FAM101B family with sequence similarity 101, member B -20.0
KRTCAP3 keratinocyte associated protein 3 -20.0
FAM20A family with sequence similarity 20, member A -20.0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -20.0
TMEM178B transmembrane protein 178B -20.0
EPHA7 EPH receptor A7 -20.0
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -20.0
B3GAT1 beta-1,3-glucuronyltransferase 1 -20.0
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 -20.0
COL14A1 collagen, type XIV, alpha 1 -20.0
SYT2 synaptotagmin II -20.0
NKAIN1 Na+/K+ transporting ATPase interacting 1 -20.0
ADCY5 adenylate cyclase 5 -20.0
MTM1 myotubularin 1 -20.0
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -20.0
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -20.0
RIMS4 regulating synaptic membrane exocytosis 4 -20.0
CDHR1 cadherin-related family member 1 -20.0
MT1X metallothionein 1X -20.0
MT1F metallothionein 1F -20.0
ZBTB3 zinc finger and BTB domain containing 3 -20.0
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -20.0
ZNF829 zinc finger protein 829 -20.0
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -20.0
NEFH neurofilament, heavy polypeptide -20.0
TFCP2L1 transcription factor CP2-like 1 -20.0
FLT4 fms-related tyrosine kinase 4 -20.0
LCK LCK proto-oncogene, Src family tyrosine kinase -20.0
TIMP4 TIMP metallopeptidase inhibitor 4 -20.0
NAP1L3 nucleosome assembly protein 1-like 3 -20.0
NAP1L2 nucleosome assembly protein 1-like 2 -20.0
GPR19 G protein-coupled receptor 19 -20.0
MT2A metallothionein 2A -20.0
RGS16 regulator of G-protein signaling 16 -20.0
TMEM132B transmembrane protein 132B -20.0
PODXL2 podocalyxin-like 2 -20.0
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -20.0
NGFR nerve growth factor receptor -20.0
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -20.0
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 -20.0
PRKG1 protein kinase, cGMP-dependent, type I -20.0
RPP25 ribonuclease P/MRP 25kDa subunit -20.0