| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting STAT3/HMGN5 in triple-negative breast cancer cell MDA-MB-231 cell line (Study accession: SRP354633) (PerturbAtlas) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Perturb_17547_KD_STAT3/HMGN5_SRP354633 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 20.0 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog | 20.0 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 20.0 |
| GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 | 20.0 |
| KPNB1 | karyopherin (importin) beta 1 | 20.0 |
| SON | SON DNA binding protein | 20.0 |
| EHD1 | EH-domain containing 1 | 20.0 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 20.0 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 20.0 |
| PRMT1 | protein arginine methyltransferase 1 | 20.0 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 20.0 |
| SQSTM1 | sequestosome 1 | 20.0 |
| LRRC59 | leucine rich repeat containing 59 | 20.0 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 20.0 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 20.0 |
| ATF4 | activating transcription factor 4 | 20.0 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 20.0 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 20.0 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 20.0 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 20.0 |
| SEC13 | SEC13 homolog (S. cerevisiae) | 20.0 |
| FLII | flightless I homolog (Drosophila) | 20.0 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 20.0 |
| EIF5A | eukaryotic translation initiation factor 5A | 20.0 |
| MTDH | metadherin | 20.0 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | 20.0 |
| GDF15 | growth differentiation factor 15 | 20.0 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 20.0 |
| XRN2 | 5'-3' exoribonuclease 2 | 20.0 |
| SRPR | signal recognition particle receptor (docking protein) | 20.0 |
| TXNRD1 | thioredoxin reductase 1 | 20.0 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 20.0 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 20.0 |
| HSPA8 | heat shock 70kDa protein 8 | 20.0 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 20.0 |
| DUSP5 | dual specificity phosphatase 5 | 20.0 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 20.0 |
| ARF4 | ADP-ribosylation factor 4 | 20.0 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 20.0 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 20.0 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 20.0 |
| GOLGA2 | golgin A2 | 20.0 |
| GOLGA3 | golgin A3 | 20.0 |
| STK40 | serine/threonine kinase 40 | 20.0 |
| NCL | nucleolin | 20.0 |
| FRMD6 | FERM domain containing 6 | 20.0 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 20.0 |
| CLTC | clathrin, heavy chain (Hc) | 20.0 |
| FOSL1 | FOS-like antigen 1 | 20.0 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 20.0 |
| IGF2R | insulin-like growth factor 2 receptor | 20.0 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 20.0 |
| RANGAP1 | Ran GTPase activating protein 1 | 20.0 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | 20.0 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 20.0 |
| HM13 | histocompatibility (minor) 13 | 20.0 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | 20.0 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 20.0 |
| FASN | fatty acid synthase | 20.0 |
| RPL5 | ribosomal protein L5 | 20.0 |
| KLF6 | Kruppel-like factor 6 | 20.0 |
| TUG1 | taurine up-regulated 1 (non-protein coding) | 20.0 |
| XBP1 | X-box binding protein 1 | 20.0 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 20.0 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 20.0 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 20.0 |
| ILF2 | interleukin enhancer binding factor 2 | 20.0 |
| CDC37 | cell division cycle 37 | 20.0 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 20.0 |
| FTL | ferritin, light polypeptide | 20.0 |
| CALR | calreticulin | 20.0 |
| SLC38A2 | solute carrier family 38, member 2 | 20.0 |
| KIAA0100 | KIAA0100 | 20.0 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 20.0 |
| KLHL5 | kelch-like family member 5 | 20.0 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 20.0 |
| HYOU1 | hypoxia up-regulated 1 | 20.0 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 20.0 |
| COPB1 | coatomer protein complex, subunit beta 1 | 20.0 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 20.0 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 20.0 |
| SETD5 | SET domain containing 5 | 20.0 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 20.0 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 20.0 |
| VCP | valosin containing protein | 20.0 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 20.0 |
| GCN1L1 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 20.0 |
| CCNI | cyclin I | 20.0 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 20.0 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 20.0 |
| TXNIP | thioredoxin interacting protein | 20.0 |
| BRD2 | bromodomain containing 2 | 20.0 |
| PEG10 | paternally expressed 10 | 20.0 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 20.0 |
| HDLBP | high density lipoprotein binding protein | 20.0 |
| KARS | lysyl-tRNA synthetase | 20.0 |
| UBAP2L | ubiquitin associated protein 2-like | 20.0 |
| C1ORF43 | chromosome 1 open reading frame 43 | 20.0 |
| PTBP1 | polypyrimidine tract binding protein 1 | 20.0 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 20.0 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -20.0 |
| FBLN7 | fibulin 7 | -20.0 |
| GJB2 | gap junction protein, beta 2, 26kDa | -20.0 |
| RUNDC3B | RUN domain containing 3B | -20.0 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -20.0 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -20.0 |
| TNFRSF13C | tumor necrosis factor receptor superfamily, member 13C | -20.0 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -20.0 |
| CDA | cytidine deaminase | -20.0 |
| LDHD | lactate dehydrogenase D | -20.0 |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV | -20.0 |
| FGFR3 | fibroblast growth factor receptor 3 | -20.0 |
| TRPV2 | transient receptor potential cation channel, subfamily V, member 2 | -20.0 |
| HAS2 | hyaluronan synthase 2 | -20.0 |
| BMP6 | bone morphogenetic protein 6 | -20.0 |
| GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D | -20.0 |
| IL2RB | interleukin 2 receptor, beta | -20.0 |
| NT5M | 5',3'-nucleotidase, mitochondrial | -20.0 |
| C1R | complement component 1, r subcomponent | -20.0 |
| SHH | sonic hedgehog | -20.0 |
| TTLL1 | tubulin tyrosine ligase-like family member 1 | -20.0 |
| PSCA | prostate stem cell antigen | -20.0 |
| CA11 | carbonic anhydrase XI | -20.0 |
| PER3 | period circadian clock 3 | -20.0 |
| RTKN2 | rhotekin 2 | -20.0 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -20.0 |
| SPA17 | sperm autoantigenic protein 17 | -20.0 |
| PTK2B | protein tyrosine kinase 2 beta | -20.0 |
| AMOT | angiomotin | -20.0 |
| LAMA3 | laminin, alpha 3 | -20.0 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -20.0 |
| RASD2 | RASD family, member 2 | -20.0 |
| HR | hair growth associated | -20.0 |
| GIPR | gastric inhibitory polypeptide receptor | -20.0 |
| SH2D2A | SH2 domain containing 2A | -20.0 |
| PTH1R | parathyroid hormone 1 receptor | -20.0 |
| C5 | complement component 5 | -20.0 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | -20.0 |
| TMEM178A | transmembrane protein 178A | -20.0 |
| SECTM1 | secreted and transmembrane 1 | -20.0 |
| GGT7 | gamma-glutamyltransferase 7 | -20.0 |
| TLE2 | transducin-like enhancer of split 2 | -20.0 |
| SCN4A | sodium channel, voltage gated, type IV alpha subunit | -20.0 |
| COL6A3 | collagen, type VI, alpha 3 | -20.0 |
| L1CAM | L1 cell adhesion molecule | -20.0 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -20.0 |
| C1QL1 | complement component 1, q subcomponent-like 1 | -20.0 |
| UTS2 | urotensin 2 | -20.0 |
| PLB1 | phospholipase B1 | -20.0 |
| STAT4 | signal transducer and activator of transcription 4 | -20.0 |
| ITGAX | integrin, alpha X (complement component 3 receptor 4 subunit) | -20.0 |
| OSCAR | osteoclast associated, immunoglobulin-like receptor | -20.0 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -20.0 |
| TNFRSF25 | tumor necrosis factor receptor superfamily, member 25 | -20.0 |
| POU6F1 | POU class 6 homeobox 1 | -20.0 |
| NEGR1 | neuronal growth regulator 1 | -20.0 |
| CALB2 | calbindin 2 | -20.0 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -20.0 |
| CALHM3 | calcium homeostasis modulator 3 | -20.0 |
| JAK3 | Janus kinase 3 | -20.0 |
| ADGRA2 | adhesion G protein-coupled receptor A2 | -20.0 |
| CHSY3 | chondroitin sulfate synthase 3 | -20.0 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -20.0 |
| MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 | -20.0 |
| FHOD3 | formin homology 2 domain containing 3 | -20.0 |
| PDE11A | phosphodiesterase 11A | -20.0 |
| TRNP1 | TMF1-regulated nuclear protein 1 | -20.0 |
| ADAM11 | ADAM metallopeptidase domain 11 | -20.0 |
| CCNA1 | cyclin A1 | -20.0 |
| ADAP1 | ArfGAP with dual PH domains 1 | -20.0 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -20.0 |
| TRIM9 | tripartite motif containing 9 | -20.0 |
| SLC22A31 | solute carrier family 22, member 31 | -20.0 |
| SCNN1D | sodium channel, non voltage gated 1 delta subunit | -20.0 |
| CST7 | cystatin F (leukocystatin) | -20.0 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -20.0 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | -20.0 |
| NRG2 | neuregulin 2 | -20.0 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | -20.0 |
| FAM72B | family with sequence similarity 72, member B | -20.0 |
| FAM72A | family with sequence similarity 72, member A | -20.0 |
| SNAI2 | snail family zinc finger 2 | -20.0 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | -20.0 |
| OLFML2A | olfactomedin-like 2A | -20.0 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | -20.0 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -20.0 |
| PRCD | progressive rod-cone degeneration | -20.0 |
| NTNG2 | netrin G2 | -20.0 |
| VPS37D | vacuolar protein sorting 37 homolog D (S. cerevisiae) | -20.0 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -20.0 |
| CRABP2 | cellular retinoic acid binding protein 2 | -20.0 |
| CCDC88B | coiled-coil domain containing 88B | -20.0 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -20.0 |
| MPZL2 | myelin protein zero-like 2 | -20.0 |
| FEZF1 | FEZ family zinc finger 1 | -20.0 |
| RORB | RAR-related orphan receptor B | -20.0 |
| SNN | stannin | -20.0 |
| ZNF385B | zinc finger protein 385B | -20.0 |
| TBXAS1 | thromboxane A synthase 1 (platelet) | -20.0 |
| ZC4H2 | zinc finger, C4H2 domain containing | -20.0 |
