| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting DEDD in triple-negative breast cancer cell MDA-MB-468 cell line (Study accession: SRP198555) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_17561_KD_DEDD_SRP198555 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | 11.8753 |
| KLHDC3 | kelch domain containing 3 | 10.9466 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 10.8241 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 | 9.95621 |
| ANPEP | alanyl (membrane) aminopeptidase | 8.899 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 7.24292 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 6.61615 |
| BARX2 | BARX homeobox 2 | 6.48922 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 6.47159 |
| KRT17 | keratin 17, type I | 6.38485 |
| KRT80 | keratin 80, type II | 6.27411 |
| LBH | limb bud and heart development | 5.93655 |
| SET | SET nuclear proto-oncogene | 5.86786 |
| TNRC18 | trinucleotide repeat containing 18 | 5.67504 |
| CRISP3 | cysteine-rich secretory protein 3 | 5.19818 |
| IER3 | immediate early response 3 | 5.04447 |
| EVI5L | ecotropic viral integration site 5-like | 4.67356 |
| SRPR | signal recognition particle receptor (docking protein) | 4.58788 |
| TMED4 | transmembrane emp24 protein transport domain containing 4 | 4.45646 |
| EHD1 | EH-domain containing 1 | 4.22863 |
| PVRL1 | poliovirus receptor-related 1 (herpesvirus entry mediator C) | 3.46495 |
| S100A2 | S100 calcium binding protein A2 | 3.46173 |
| NRK | Nik related kinase | 3.46115 |
| USF2 | upstream transcription factor 2, c-fos interacting | 3.35087 |
| RPSA | ribosomal protein SA | 3.30695 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 3.30302 |
| HIP1R | huntingtin interacting protein 1 related | 3.21353 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | 3.14913 |
| EIF3G | eukaryotic translation initiation factor 3, subunit G | 3.05427 |
| RPS27 | ribosomal protein S27 | 3.0495 |
| DDA1 | DET1 and DDB1 associated 1 | 3.03504 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 3.00865 |
| NEURL1B | neuralized E3 ubiquitin protein ligase 1B | 3.00697 |
| IFFO2 | intermediate filament family orphan 2 | 2.83529 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 2.82487 |
| CNN3 | calponin 3, acidic | 2.73651 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2.73379 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 2.60909 |
| ACTN1 | actinin, alpha 1 | 2.60847 |
| RPL27 | ribosomal protein L27 | 2.60463 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | 2.50919 |
| TMEM55B | transmembrane protein 55B | 2.40109 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | 2.39121 |
| GCAT | glycine C-acetyltransferase | 2.39121 |
| TNKS1BP1 | tankyrase 1 binding protein 1, 182kDa | 2.34279 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 2.33707 |
| RPL8 | ribosomal protein L8 | 2.32012 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 2.31527 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 2.28906 |
| RPS25 | ribosomal protein S25 | 2.28804 |
| FKBP4 | FK506 binding protein 4, 59kDa | 2.25356 |
| JUND | jun D proto-oncogene | 2.24629 |
| DUSP16 | dual specificity phosphatase 16 | 2.19457 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 2.16822 |
| CLU | clusterin | 2.16685 |
| RPL4 | ribosomal protein L4 | 2.16254 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.16254 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 2.16254 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.13557 |
| KRT5 | keratin 5, type II | 2.13557 |
| MARCKSL1 | MARCKS-like 1 | 2.09827 |
| RPL15 | ribosomal protein L15 | 2.09488 |
| RAI14 | retinoic acid induced 14 | 2.09488 |
| INHBA | inhibin, beta A | 2.09243 |
| CD24 | CD24 molecule | 2.08896 |
| SYT7 | synaptotagmin VII | 2.08896 |
| CPTP | ceramide-1-phosphate transfer protein | 2.06779 |
| TCP1 | t-complex 1 | 2.06779 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 1.95556 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 1.95458 |
| RPL17 | ribosomal protein L17 | 1.93111 |
| MAF1 | MAF1 homolog (S. cerevisiae) | 1.9217 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 1.90059 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 1.88259 |
| GLA | galactosidase, alpha | 1.87431 |
| ZNF703 | zinc finger protein 703 | 1.84095 |
| RPL27A | ribosomal protein L27a | 1.82919 |
| ATG4D | autophagy related 4D, cysteine peptidase | 1.82919 |
| DNM3 | dynamin 3 | 1.82383 |
| CHPF | chondroitin polymerizing factor | 1.82383 |
| RPLP0 | ribosomal protein, large, P0 | 1.81588 |
| MBOAT1 | membrane bound O-acyltransferase domain containing 1 | 1.81588 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | 1.79693 |
| STIP1 | stress-induced phosphoprotein 1 | 1.79024 |
| AKIRIN1 | akirin 1 | 1.77894 |
| RPS3 | ribosomal protein S3 | 1.72345 |
| SLC45A3 | solute carrier family 45, member 3 | 1.72005 |
| HIST3H2A | histone cluster 3, H2a | 1.67426 |
| C2ORF54 | chromosome 2 open reading frame 54 | 1.62127 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 1.59998 |
| SCRIB | scribbled planar cell polarity protein | 1.59581 |
| RPL14 | ribosomal protein L14 | 1.56112 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 1.56112 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 1.50604 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 1.50024 |
| LAGE3 | L antigen family, member 3 | 1.497 |
| RPS8 | ribosomal protein S8 | 1.47716 |
| GPI | glucose-6-phosphate isomerase | 1.47716 |
| H2AFX | H2A histone family, member X | 1.47716 |
| PFKP | phosphofructokinase, platelet | 1.47626 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -20.0 |
| CLDN1 | claudin 1 | -20.0 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -18.4437 |
| C3 | complement component 3 | -18.1079 |
| MSN | moesin | -18.1079 |
| MUC16 | mucin 16, cell surface associated | -17.1331 |
| CP | ceruloplasmin (ferroxidase) | -15.3065 |
| MSMO1 | methylsterol monooxygenase 1 | -14.5793 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -13.2183 |
| CD46 | CD46 molecule, complement regulatory protein | -13.2183 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -11.8321 |
| LPIN1 | lipin 1 | -9.85787 |
| DEDD | death effector domain containing | -9.15225 |
| A2M | alpha-2-macroglobulin | -8.48275 |
| ASS1 | argininosuccinate synthase 1 | -8.26455 |
| ENOPH1 | enolase-phosphatase 1 | -8.26455 |
| S100A7 | S100 calcium binding protein A7 | -7.77432 |
| ATP9A | ATPase, class II, type 9A | -7.77432 |
| CASP14 | caspase 14, apoptosis-related cysteine peptidase | -7.54615 |
| TMPRSS4 | transmembrane protease, serine 4 | -7.38215 |
| KIAA1549L | KIAA1549-like | -7.32845 |
| PXDN | peroxidasin | -7.22074 |
| S100A7A | S100 calcium binding protein A7A | -6.71537 |
| FAM65B | family with sequence similarity 65, member B | -6.71199 |
| NCOA7 | nuclear receptor coactivator 7 | -6.45226 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -6.26897 |
| HLA-B | major histocompatibility complex, class I, B | -6.25257 |
| NNMT | nicotinamide N-methyltransferase | -6.1835 |
| TLE3 | transducin-like enhancer of split 3 | -6.16859 |
| ICAM1 | intercellular adhesion molecule 1 | -5.99431 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -5.67477 |
| FASN | fatty acid synthase | -5.66095 |
| RAB31 | RAB31, member RAS oncogene family | -5.66095 |
| PEG10 | paternally expressed 10 | -5.61688 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -5.52754 |
| PGM2L1 | phosphoglucomutase 2-like 1 | -5.39441 |
| ASPH | aspartate beta-hydroxylase | -5.3868 |
| DST | dystonin | -4.77202 |
| SSR1 | signal sequence receptor, alpha | -4.68506 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -4.63089 |
| ITGB8 | integrin, beta 8 | -4.63089 |
| PRR5L | proline rich 5 like | -4.40815 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -4.4035 |
| LAMB1 | laminin, beta 1 | -4.39423 |
| KITLG | KIT ligand | -4.23111 |
| NELL2 | NEL-like 2 (chicken) | -4.22863 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -3.92205 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -3.92205 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -3.87326 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -3.57652 |
| CLIC5 | chloride intracellular channel 5 | -3.56064 |
| PPM1E | protein phosphatase, Mg2+/Mn2+ dependent, 1E | -3.37023 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -3.30695 |
| TNS1 | tensin 1 | -3.24508 |
| FDPS | farnesyl diphosphate synthase | -3.13665 |
| KRT6A | keratin 6A, type II | -3.10438 |
| CUEDC1 | CUE domain containing 1 | -3.06084 |
| CUL4B | cullin 4B | -3.0495 |
| CNOT6 | CCR4-NOT transcription complex, subunit 6 | -3.03633 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -3.03504 |
| COL5A2 | collagen, type V, alpha 2 | -3.01391 |
| MUC1 | mucin 1, cell surface associated | -3.00914 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -2.90772 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -2.8477 |
| IGSF3 | immunoglobulin superfamily, member 3 | -2.83529 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | -2.83529 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -2.83529 |
| TMEM87B | transmembrane protein 87B | -2.82487 |
| GPC4 | glypican 4 | -2.82411 |
| AHNAK2 | AHNAK nucleoprotein 2 | -2.76366 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -2.74076 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -2.71088 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -2.63766 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | -2.62761 |
| ALS2CL | ALS2 C-terminal like | -2.62179 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -2.50919 |
| TUBB6 | tubulin, beta 6 class V | -2.48059 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | -2.47558 |
| SON | SON DNA binding protein | -2.46619 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -2.46619 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.46488 |
| MAPK8 | mitogen-activated protein kinase 8 | -2.46377 |
| TNPO1 | transportin 1 | -2.43702 |
| FAM73A | family with sequence similarity 73, member A | -2.40109 |
| SC5D | sterol-C5-desaturase | -2.3691 |
| ITGAV | integrin, alpha V | -2.36511 |
| PSAT1 | phosphoserine aminotransferase 1 | -2.32733 |
| CAPN13 | calpain 13 | -2.2113 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | -2.17001 |
| ATP11A | ATPase, class VI, type 11A | -2.16822 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -2.16795 |
| LIMA1 | LIM domain and actin binding 1 | -2.16685 |
| HIPK1 | homeodomain interacting protein kinase 1 | -2.16685 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | -2.16254 |
| VEGFA | vascular endothelial growth factor A | -2.16254 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -2.16254 |
| MMP7 | matrix metallopeptidase 7 | -2.16254 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -2.16254 |
| ANXA8 | annexin A8 | -2.15751 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -2.14436 |
