Perturb_17620_KO_MLLT6_SRP245883 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting MLLT6 in U2OS cell line (Study accession: SRP245883) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_17620_KO_MLLT6_SRP245883 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
DNASE1 deoxyribonuclease I 20.0
SSFA2 sperm specific antigen 2 20.0
ZDHHC6 zinc finger, DHHC-type containing 6 20.0
KRT8 keratin 8, type II 20.0
GLRX2 glutaredoxin 2 20.0
GLOD4 glyoxalase domain containing 4 20.0
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 20.0
LHFPL5 lipoma HMGIC fusion partner-like 5 20.0
LOC122455342 testis-specific serine/proline-rich protein 20.0
UBN1 ubinuclein 1 20.0
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 20.0
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 20.0
VPS9D1 VPS9 domain containing 1 20.0
CDC14B cell division cycle 14B 20.0
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 20.0
SLC19A1 solute carrier family 19 (folate transporter), member 1 20.0
CSNK1D casein kinase 1, delta 20.0
METTL20 methyltransferase like 20 20.0
TTN titin 20.0
THAP3 THAP domain containing, apoptosis associated protein 3 20.0
SAMD11 sterile alpha motif domain containing 11 20.0
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 20.0
SPATA1 spermatogenesis associated 1 20.0
B9D1 B9 protein domain 1 20.0
RPAIN RPA interacting protein 20.0
NARFL nuclear prelamin A recognition factor-like 20.0
LRRC75A leucine rich repeat containing 75A 20.0
SRR serine racemase 20.0
GLIPR1 GLI pathogenesis-related 1 20.0
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 20.0
FAM151A family with sequence similarity 151, member A 20.0
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 20.0
MALSU1 mitochondrial assembly of ribosomal large subunit 1 20.0
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 20.0
HNRNPL heterogeneous nuclear ribonucleoprotein L 20.0
ERCC2 excision repair cross-complementation group 2 20.0
AKAP12 A kinase (PRKA) anchor protein 12 20.0
SCD stearoyl-CoA desaturase (delta-9-desaturase) 20.0
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 20.0
GPS2 G protein pathway suppressor 2 20.0
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 20.0
ARFRP1 ADP-ribosylation factor related protein 1 20.0
PTPRB protein tyrosine phosphatase, receptor type, B 19.699
PTMA prothymosin, alpha 19.699
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 19.5229
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 19.301
YIPF2 Yip1 domain family, member 2 18.8861
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 18.3565
SZT2 seizure threshold 2 homolog (mouse) 18.2441
OTUD4 OTU deubiquitinase 4 18.0655
LMNTD2 lamin tail domain containing 2 17.8239
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 17.8153
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 17.1163
EZR ezrin 17.0227
CINP cyclin-dependent kinase 2 interacting protein 16.8333
TMEM120B transmembrane protein 120B 16.5564
TSEN54 TSEN54 tRNA splicing endonuclease subunit 16.234
HOXA10 homeobox A10 15.8627
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 15.8244
CCNE2 cyclin E2 15.7519
HDDC2 HD domain containing 2 15.3556
ZNF771 zinc finger protein 771 15.1067
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 15.0199
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 14.9886
ERI2 ERI1 exoribonuclease family member 2 14.8711
SERBP1 SERPINE1 mRNA binding protein 1 14.8365
RPL7 ribosomal protein L7 14.7425
SH3D19 SH3 domain containing 19 14.7425
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 14.3305
CRYBG3 beta-gamma crystallin domain containing 3 14.1904
TBL3 transducin (beta)-like 3 14.1572
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 14.1457
RPS28 ribosomal protein S28 13.869
MYL5 myosin, light chain 5, regulatory 13.6739
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 13.4663
MRPL43 mitochondrial ribosomal protein L43 13.4295
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 13.3256
FMO1 flavin containing monooxygenase 1 13.2655
HSPD1 heat shock 60kDa protein 1 (chaperonin) 13.229
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 13.187
DDR2 discoidin domain receptor tyrosine kinase 2 13.1667
TOP1 topoisomerase (DNA) I 13.1138
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 12.8986
GYG1 glycogenin 1 12.7574
EPB41 erythrocyte membrane protein band 4.1 12.7075
C10ORF95 chromosome 10 open reading frame 95 12.6426
CCDC84 coiled-coil domain containing 84 12.6317
PDIA3 protein disulfide isomerase family A, member 3 12.4483
RAD9B RAD9 homolog B (S. pombe) 12.4291
TPT1 tumor protein, translationally-controlled 1 12.376
BRI3 brain protein I3 12.3023
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 12.2849
NCAPG non-SMC condensin I complex, subunit G 11.9456
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 11.9056
FAM81A family with sequence similarity 81, member A 11.8589
CBR4 carbonyl reductase 4 11.8171
RPL11 ribosomal protein L11 11.7777
EIF3G eukaryotic translation initiation factor 3, subunit G 11.7768
EME1 essential meiotic structure-specific endonuclease 1 11.5106
CD44 CD44 molecule (Indian blood group) 11.4963

decreased expression

Symbol Name Standardized Value
ZNF263 zinc finger protein 263 -20.0
TFB1M transcription factor B1, mitochondrial -20.0
GFAP glial fibrillary acidic protein -20.0
DLD dihydrolipoamide dehydrogenase -20.0
WTAP Wilms tumor 1 associated protein -20.0
ZDHHC8 zinc finger, DHHC-type containing 8 -20.0
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -20.0
NOXO1 NADPH oxidase organizer 1 -20.0
PGAM2 phosphoglycerate mutase 2 (muscle) -20.0
PRPF39 pre-mRNA processing factor 39 -20.0
HEXB hexosaminidase B (beta polypeptide) -20.0
KAT5 K(lysine) acetyltransferase 5 -20.0
ARRDC1 arrestin domain containing 1 -20.0
SPTB spectrin, beta, erythrocytic -20.0
PLXNA4 plexin A4 -20.0
SPHK2 sphingosine kinase 2 -20.0
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -20.0
ERC1 ELKS/RAB6-interacting/CAST family member 1 -20.0
FN1 fibronectin 1 -20.0
MMP24-AS1 MMP24 antisense RNA 1 -20.0
GTPBP1 GTP binding protein 1 -20.0
ZWILCH zwilch kinetochore protein -20.0
NECAB1 N-terminal EF-hand calcium binding protein 1 -20.0
ZACN zinc activated ligand-gated ion channel -20.0
PGF placental growth factor -20.0
CDSN corneodesmosin -20.0
UTS2 urotensin 2 -20.0
NCAPD3 non-SMC condensin II complex, subunit D3 -20.0
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -20.0
FAM228B family with sequence similarity 228, member B -20.0
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -20.0
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -20.0
USP47 ubiquitin specific peptidase 47 -20.0
LCTL lactase-like -20.0
RPL10 ribosomal protein L10 -20.0
ITFG2 integrin alpha FG-GAP repeat containing 2 -20.0
CCDC115 coiled-coil domain containing 115 -20.0
PTOV1 prostate tumor overexpressed 1 -20.0
PANK2 pantothenate kinase 2 -20.0
FSIP1 fibrous sheath interacting protein 1 -20.0
HYI hydroxypyruvate isomerase (putative) -20.0
APC2 adenomatosis polyposis coli 2 -20.0
SNX22 sorting nexin 22 -20.0
VIM vimentin -20.0
ENOSF1 enolase superfamily member 1 -20.0
FAM149B1 family with sequence similarity 149, member B1 -20.0
B3GAT2 beta-1,3-glucuronyltransferase 2 -20.0
RNF123 ring finger protein 123 -20.0
PTGR2 prostaglandin reductase 2 -20.0
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -20.0
TREH trehalase (brush-border membrane glycoprotein) -20.0
ARG2 arginase 2 -20.0
HIST1H4I histone cluster 1, H4i -20.0
ACO2 aconitase 2, mitochondrial -20.0
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -20.0
CCAR2 cell cycle and apoptosis regulator 2 -20.0
C2ORF16 chromosome 2 open reading frame 16 -20.0
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -20.0
TICRR TOPBP1-interacting checkpoint and replication regulator -20.0
SRRD SRR1 domain containing -20.0
PCSK7 proprotein convertase subtilisin/kexin type 7 -20.0
ADCY3 adenylate cyclase 3 -20.0
KLHDC4 kelch domain containing 4 -20.0
TUBA1C tubulin, alpha 1c -20.0
ZNF497 zinc finger protein 497 -20.0
VPRBP Vpr (HIV-1) binding protein -20.0
UBXN11 UBX domain protein 11 -20.0
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -20.0
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -20.0
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -20.0
FADS1 fatty acid desaturase 1 -20.0
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -20.0
IL17D interleukin 17D -20.0
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -20.0
TMEM184A transmembrane protein 184A -20.0
CDC42SE1 CDC42 small effector 1 -20.0
MICA MHC class I polypeptide-related sequence A -20.0
C12ORF65 chromosome 12 open reading frame 65 -20.0
SSPN sarcospan -20.0
FAM161B family with sequence similarity 161, member B -20.0
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -20.0
TBPL1 TBP-like 1 -20.0
C21ORF2 chromosome 21 open reading frame 2 -20.0
TFIP11 tuftelin interacting protein 11 -20.0
SARNP SAP domain containing ribonucleoprotein -20.0
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -20.0
JMJD4 jumonji domain containing 4 -20.0
ZNF517 zinc finger protein 517 -19.2218
SPAG1 sperm associated antigen 1 -19.1549
RAB15 RAB15, member RAS oncogene family -19.0458
EFHC1 EF-hand domain (C-terminal) containing 1 -18.7959
PDZD8 PDZ domain containing 8 -18.7212
FBXO11 F-box protein 11 -18.699
ATG7 autophagy related 7 -18.585
TEX9 testis expressed 9 -18.0605
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -17.821
SYTL4 synaptotagmin-like 4 -17.6799
COG5 component of oligomeric golgi complex 5 -17.5607
GBA2 glucosidase, beta (bile acid) 2 -17.5186
SUMF1 sulfatase modifying factor 1 -17.4868