| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting MDMX in uveal melanoma MEL202 cell line (Study accession: SRP393452) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_17690_KD_MDMX_SRP393452 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBE2N | ubiquitin-conjugating enzyme E2N | 20.0 |
| DLEU7 | deleted in lymphocytic leukemia, 7 | 20.0 |
| DOK6 | docking protein 6 | 20.0 |
| PIGC | phosphatidylinositol glycan anchor biosynthesis, class C | 16.7317 |
| TTN | titin | 14.8512 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 12.0824 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 10.8686 |
| TUBA1C | tubulin, alpha 1c | 10.2218 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 7.84467 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | 7.40682 |
| C7ORF62 | chromosome 7 open reading frame 62 | 7.08888 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | 6.23601 |
| HIST1H4I | histone cluster 1, H4i | 6.11982 |
| C12ORF60 | chromosome 12 open reading frame 60 | 5.98495 |
| SESN3 | sestrin 3 | 5.89398 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 5.57191 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 5.55651 |
| FSIP2 | fibrous sheath interacting protein 2 | 5.54048 |
| STAG3 | stromal antigen 3 | 5.5121 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 5.50603 |
| LRRTM3 | leucine rich repeat transmembrane neuronal 3 | 5.3499 |
| FMO5 | flavin containing monooxygenase 5 | 5.24638 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 5.16467 |
| RPL10 | ribosomal protein L10 | 5.1441 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 5.09622 |
| CPM | carboxypeptidase M | 4.97078 |
| ATP10B | ATPase, class V, type 10B | 4.97078 |
| TSHR | thyroid stimulating hormone receptor | 4.97078 |
| TNK1 | tyrosine kinase, non-receptor, 1 | 4.8749 |
| OR2H2 | olfactory receptor, family 2, subfamily H, member 2 | 4.74721 |
| COG5 | component of oligomeric golgi complex 5 | 4.68248 |
| C7ORF49 | chromosome 7 open reading frame 49 | 4.66585 |
| AASS | aminoadipate-semialdehyde synthase | 4.62808 |
| PHIP | pleckstrin homology domain interacting protein | 4.53761 |
| ATG7 | autophagy related 7 | 4.5029 |
| SOCS2 | suppressor of cytokine signaling 2 | 4.50088 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 4.41993 |
| KIAA2026 | KIAA2026 | 4.35301 |
| CD36 | CD36 molecule (thrombospondin receptor) | 4.2447 |
| C19ORF71 | chromosome 19 open reading frame 71 | 4.06436 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 4.04046 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 4.02793 |
| FAS | Fas cell surface death receptor | 3.96736 |
| CALB1 | calbindin 1, 28kDa | 3.92091 |
| SCAMP1 | secretory carrier membrane protein 1 | 3.73864 |
| ATP5S | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) | 3.71839 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 3.55628 |
| HOXA7 | homeobox A7 | 3.54517 |
| TRAFD1 | TRAF-type zinc finger domain containing 1 | 3.44026 |
| STK25 | serine/threonine kinase 25 | 3.32614 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 3.28161 |
| THBS1 | thrombospondin 1 | 3.1902 |
| ARSG | arylsulfatase G | 3.17253 |
| SYCP2 | synaptonemal complex protein 2 | 3.09262 |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | 3.05557 |
| PAQR3 | progestin and adipoQ receptor family member III | 3.02095 |
| C2ORF16 | chromosome 2 open reading frame 16 | 3.01299 |
| ACAP1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 3.00971 |
| FAM189A2 | family with sequence similarity 189, member A2 | 2.99875 |
| PODXL | podocalyxin-like | 2.99875 |
| TMSB4X | thymosin beta 4, X-linked | 2.95063 |
| CTNS | cystinosin, lysosomal cystine transporter | 2.93198 |
| C10ORF10 | chromosome 10 open reading frame 10 | 2.92638 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | 2.85893 |
| MPI | mannose phosphate isomerase | 2.80251 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | 2.7618 |
| FRMD4A | FERM domain containing 4A | 2.75799 |
| RBBP4 | retinoblastoma binding protein 4 | 2.74522 |
| ADH6 | alcohol dehydrogenase 6 (class V) | 2.69667 |
| C9ORF131 | chromosome 9 open reading frame 131 | 2.6672 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 2.64767 |
| MGST2 | microsomal glutathione S-transferase 2 | 2.60747 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.59979 |
| BCL7A | B-cell CLL/lymphoma 7A | 2.56565 |
| FAM13A | family with sequence similarity 13, member A | 2.55324 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.53088 |
| KLC4 | kinesin light chain 4 | 2.52473 |
| TMEM198 | transmembrane protein 198 | 2.45696 |
| PGAM2 | phosphoglycerate mutase 2 (muscle) | 2.44327 |
| CDK13 | cyclin-dependent kinase 13 | 2.43204 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | 2.43007 |
| ETNK2 | ethanolamine kinase 2 | 2.42084 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 2.36936 |
| SERINC4 | serine incorporator 4 | 2.35347 |
| C16ORF71 | chromosome 16 open reading frame 71 | 2.33317 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | 2.3331 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 2.32238 |
| TBPL1 | TBP-like 1 | 2.24184 |
| ZNF546 | zinc finger protein 546 | 2.23077 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 2.20504 |
| C14ORF93 | chromosome 14 open reading frame 93 | 2.20504 |
| HTRA2 | HtrA serine peptidase 2 | 2.17633 |
| ATXN1 | ataxin 1 | 2.17633 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 2.17491 |
| TRPM3 | transient receptor potential cation channel, subfamily M, member 3 | 2.17491 |
| RGS13 | regulator of G-protein signaling 13 | 2.12202 |
| DNAH10 | dynein, axonemal, heavy chain 10 | 2.09986 |
| BDNF | brain-derived neurotrophic factor | 2.08953 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | 2.08124 |
| LMO7 | LIM domain 7 | 2.06346 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIM59 | tripartite motif containing 59 | -20.0 |
| INTS8 | integrator complex subunit 8 | -20.0 |
| PMEL | premelanosome protein | -20.0 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -20.0 |
| TTI2 | TELO2 interacting protein 2 | -17.757 |
| ENOSF1 | enolase superfamily member 1 | -17.1024 |
| EXOSC9 | exosome component 9 | -15.6581 |
| POLG | polymerase (DNA directed), gamma | -14.9198 |
| BOLA1 | bolA family member 1 | -14.0711 |
| FANCD2OS | FANCD2 opposite strand | -13.5318 |
| LRRC41 | leucine rich repeat containing 41 | -12.31 |
| SPATA21 | spermatogenesis associated 21 | -12.2292 |
| MLX | MLX, MAX dimerization protein | -12.2292 |
| PMCH | pro-melanin-concentrating hormone | -11.9888 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -11.8788 |
| SNX32 | sorting nexin 32 | -11.5691 |
| PAQR4 | progestin and adipoQ receptor family member IV | -10.8554 |
| KIF7 | kinesin family member 7 | -9.86395 |
| DCLRE1C | DNA cross-link repair 1C | -9.41796 |
| ADCY3 | adenylate cyclase 3 | -9.3577 |
| KLC1 | kinesin light chain 1 | -8.93064 |
| LCTL | lactase-like | -8.70687 |
| LRRC59 | leucine rich repeat containing 59 | -8.65938 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -8.62972 |
| GSE1 | Gse1 coiled-coil protein | -8.56937 |
| CCL15 | chemokine (C-C motif) ligand 15 | -8.35641 |
| OTUD4 | OTU deubiquitinase 4 | -8.2396 |
| FAM166A | family with sequence similarity 166, member A | -7.85962 |
| NOSTRIN | nitric oxide synthase trafficking | -7.80204 |
| CLCC1 | chloride channel CLIC-like 1 | -7.80204 |
| VIL1 | villin 1 | -7.65796 |
| TMEM55B | transmembrane protein 55B | -7.40682 |
| HIST1H2BN | histone cluster 1, H2bn | -7.33249 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -7.2023 |
| DNASE1 | deoxyribonuclease I | -7.02181 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -6.84086 |
| KIAA0895 | KIAA0895 | -6.76279 |
| TEFM | transcription elongation factor, mitochondrial | -6.74879 |
| HIST1H1E | histone cluster 1, H1e | -6.40389 |
| FBXO11 | F-box protein 11 | -6.35803 |
| FAM149B1 | family with sequence similarity 149, member B1 | -6.28268 |
| IFT80 | intraflagellar transport 80 | -6.1188 |
| STXBP5L | syntaxin binding protein 5-like | -5.84333 |
| ZNF771 | zinc finger protein 771 | -5.71701 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | -5.56554 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | -5.46612 |
| ZFHX3 | zinc finger homeobox 3 | -5.45733 |
| SRR | serine racemase | -5.40715 |
| TEX2 | testis expressed 2 | -5.22752 |
| PDZD11 | PDZ domain containing 11 | -5.19014 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -5.18758 |
| LHFPL5 | lipoma HMGIC fusion partner-like 5 | -5.01442 |
| MFSD11 | major facilitator superfamily domain containing 11 | -4.95094 |
| MTMR2 | myotubularin related protein 2 | -4.94278 |
| ZNHIT3 | zinc finger, HIT-type containing 3 | -4.72821 |
| IQCK | IQ motif containing K | -4.64909 |
| ORAOV1 | oral cancer overexpressed 1 | -4.57246 |
| IGSF6 | immunoglobulin superfamily, member 6 | -4.53761 |
| ERCC1 | excision repair cross-complementation group 1 | -4.49475 |
| SLC25A35 | solute carrier family 25, member 35 | -4.46664 |
| MYEF2 | myelin expression factor 2 | -4.35332 |
| IFT20 | intraflagellar transport 20 | -4.18182 |
| TRIM14 | tripartite motif containing 14 | -4.16176 |
| NT5DC4 | 5'-nucleotidase domain containing 4 | -4.09024 |
| NECAB1 | N-terminal EF-hand calcium binding protein 1 | -3.98347 |
| EME1 | essential meiotic structure-specific endonuclease 1 | -3.97759 |
| ZNF276 | zinc finger protein 276 | -3.97118 |
| CCNA2 | cyclin A2 | -3.96736 |
| IFT22 | intraflagellar transport 22 | -3.9134 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | -3.91312 |
| UTS2 | urotensin 2 | -3.87547 |
| C14ORF79 | chromosome 14 open reading frame 79 | -3.8657 |
| FRMD5 | FERM domain containing 5 | -3.86267 |
| ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | -3.86195 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 | -3.81578 |
| TMPO | thymopoietin | -3.79955 |
| FADS1 | fatty acid desaturase 1 | -3.76317 |
| SLC39A9 | solute carrier family 39, member 9 | -3.76132 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -3.7448 |
| MYO1E | myosin IE | -3.74185 |
| ERCC4 | excision repair cross-complementation group 4 | -3.62336 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -3.62035 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -3.59374 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.57223 |
| SUPT20H | suppressor of Ty 20 homolog (S. cerevisiae) | -3.54517 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -3.4924 |
| ANAPC10 | anaphase promoting complex subunit 10 | -3.42665 |
| OGN | osteoglycin | -3.35982 |
| SYNGR2 | synaptogyrin 2 | -3.31022 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | -3.28257 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -3.24143 |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | -3.23085 |
| ETFDH | electron-transferring-flavoprotein dehydrogenase | -3.14266 |
| UBXN6 | UBX domain protein 6 | -3.10044 |
| UTP23 | UTP23, small subunit (SSU) processome component, homolog (yeast) | -3.06642 |
| PBK | PDZ binding kinase | -3.05238 |
| RMDN3 | regulator of microtubule dynamics 3 | -3.02326 |
| ATF5 | activating transcription factor 5 | -3.02326 |
| ARL10 | ADP-ribosylation factor-like 10 | -3.02273 |
| CENPP | centromere protein P | -2.93172 |
