Perturb_2098_KD_NFKB2_SRP256232 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting NFKB2 in bone osteosarcoma epithelial cells U2OS cell line (Study accession: SRP256232) (PerturbAtlas)
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Genes

102 genes differentially expressed following the Perturb_2098_KD_NFKB2_SRP256232 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
FCMR Fc fragment of IgM receptor 20.0
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 11.2958
ZNF444 zinc finger protein 444 8.00266
C5ORF45 chromosome 5 open reading frame 45 7.48057
DPF3 D4, zinc and double PHD fingers, family 3 5.56649
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 3.97115
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.73499
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 3.61995
IQGAP2 IQ motif containing GTPase activating protein 2 3.58145
TMEM120B transmembrane protein 120B 2.98725
LGALS8 lectin, galactoside-binding, soluble, 8 2.36101
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.34335
IGFL2 IGF-like family member 2 2.31966
HIST1H4I histone cluster 1, H4i 2.2642
CCDC85B coiled-coil domain containing 85B 2.22941
ZNF224 zinc finger protein 224 2.12741
HRNR hornerin 1.92738
NQO2 NAD(P)H dehydrogenase, quinone 2 1.76317
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 1.76172
NKX6-2 NK6 homeobox 2 1.70612
TP53TG5 TP53 target 5 1.70375
MMP3 matrix metallopeptidase 3 1.70045
GANC glucosidase, alpha; neutral C 1.67697
TNK1 tyrosine kinase, non-receptor, 1 1.67671
ARRDC1 arrestin domain containing 1 1.67671
ATXN2 ataxin 2 1.64896
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 1.623
RFX5 regulatory factor X, 5 (influences HLA class II expression) 1.59193
PAQR3 progestin and adipoQ receptor family member III 1.58003
CDC42SE1 CDC42 small effector 1 1.56357
MALSU1 mitochondrial assembly of ribosomal large subunit 1 1.47776
ARSG arylsulfatase G 1.47776
DEPDC1 DEP domain containing 1 1.39347
C1ORF56 chromosome 1 open reading frame 56 1.36362
LRRC17 leucine rich repeat containing 17 1.34949
ZSCAN5A zinc finger and SCAN domain containing 5A 1.31952
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 1.31619

decreased expression

Symbol Name Standardized Value
RFC5 replication factor C (activator 1) 5, 36.5kDa -4.78156
CLVS1 clavesin 1 -4.13327
CCDC107 coiled-coil domain containing 107 -3.68982
H1F0 H1 histone family, member 0 -3.61995
CERKL ceramide kinase-like -3.58145
POLG polymerase (DNA directed), gamma -3.21109
MMP24-AS1 MMP24 antisense RNA 1 -3.11629
THOC6 THO complex 6 -2.98725
PCGF2 polycomb group ring finger 2 -2.98725
TRAPPC4 trafficking protein particle complex 4 -2.96857
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.93835
AFG3L2 AFG3-like AAA ATPase 2 -2.85075
TNPO1 transportin 1 -2.73658
DNAH11 dynein, axonemal, heavy chain 11 -2.73658
TMEM79 transmembrane protein 79 -2.73331
FIZ1 FLT3-interacting zinc finger 1 -2.5835
ABHD14A abhydrolase domain containing 14A -2.50023
CNPY2 canopy FGF signaling regulator 2 -2.35312
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.31168
DEK DEK proto-oncogene -2.31168
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.31168
ST5 suppression of tumorigenicity 5 -2.30531
PDHX pyruvate dehydrogenase complex, component X -2.24354
SRPX2 sushi-repeat containing protein, X-linked 2 -2.20011
ZNHIT3 zinc finger, HIT-type containing 3 -2.10467
CGREF1 cell growth regulator with EF-hand domain 1 -2.0788
PDGFRL platelet-derived growth factor receptor-like -1.98814
EFHC1 EF-hand domain (C-terminal) containing 1 -1.98049
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -1.96752
TSPAN31 tetraspanin 31 -1.95219
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -1.92738
PINK1 PTEN induced putative kinase 1 -1.90834
MOCS1 molybdenum cofactor synthesis 1 -1.89237
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -1.8844
VIL1 villin 1 -1.88424
ZBTB46 zinc finger and BTB domain containing 46 -1.86504
RAD23A RAD23 homolog A (S. cerevisiae) -1.81134
ACOT8 acyl-CoA thioesterase 8 -1.76626
PIAS1 protein inhibitor of activated STAT, 1 -1.75846
MLX MLX, MAX dimerization protein -1.74041
FAS Fas cell surface death receptor -1.72759
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -1.7124
PRIMPOL primase and polymerase (DNA-directed) -1.69729
FAM71E1 family with sequence similarity 71, member E1 -1.67782
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.67697
PCED1B PC-esterase domain containing 1B -1.67671
GYG1 glycogenin 1 -1.65547
C1ORF35 chromosome 1 open reading frame 35 -1.65456
NASP nuclear autoantigenic sperm protein (histone-binding) -1.60873
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -1.60873
ACSM3 acyl-CoA synthetase medium-chain family member 3 -1.60234
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -1.59386
MYH11 myosin, heavy chain 11, smooth muscle -1.56573
ANLN anillin, actin binding protein -1.56357
ENOSF1 enolase superfamily member 1 -1.53268
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -1.51916
SARNP SAP domain containing ribonucleoprotein -1.51661
MAP4 microtubule-associated protein 4 -1.48073
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -1.4806
NPB neuropeptide B -1.47776
RER1 retention in endoplasmic reticulum sorting receptor 1 -1.39347
KIAA1257 KIAA1257 -1.3702
RBM7 RNA binding motif protein 7 -1.36094
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -1.35369
ZFP36L2 ZFP36 ring finger protein-like 2 -1.32467