Perturb_2329_KD_SF3B5_SRP268983 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting SF3B5 in breast cancer cell BT-549 cell line (Study accession: SRP268983) (PerturbAtlas)
Similar Terms
Downloads & Tools

Genes

192 genes differentially expressed following the Perturb_2329_KD_SF3B5_SRP268983 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
MRPS14 mitochondrial ribosomal protein S14 13.6146
DONSON downstream neighbor of SON 12.2213
CYSTM1 cysteine-rich transmembrane module containing 1 10.3737
FOXK2 forkhead box K2 9.05204
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 8.67995
SLA2 Src-like-adaptor 2 8.52643
PLCD3 phospholipase C, delta 3 8.16993
EME1 essential meiotic structure-specific endonuclease 1 6.86543
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 6.19018
ERCC1 excision repair cross-complementation group 1 6.04251
MED31 mediator complex subunit 31 6.04251
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 6.03706
MCM9 minichromosome maintenance complex component 9 5.99077
ASB6 ankyrin repeat and SOCS box containing 6 5.80114
TP53BP1 tumor protein p53 binding protein 1 5.52974
TMEM184A transmembrane protein 184A 5.01942
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 5.01942
PTCD1 pentatricopeptide repeat domain 1 4.94172
FZD4 frizzled class receptor 4 4.85511
CNOT3 CCR4-NOT transcription complex, subunit 3 4.7181
NQO2 NAD(P)H dehydrogenase, quinone 2 4.61082
PPHLN1 periphilin 1 4.34127
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 3.80535
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 3.78819
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) 3.78724
CRBN cereblon 3.78687
LAMA5 laminin, alpha 5 3.7181
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 3.71766
CEBPZOS CEBPZ opposite strand 3.70109
METTL5 methyltransferase like 5 3.65812
MRPS7 mitochondrial ribosomal protein S7 3.43651
STKLD1 serine/threonine kinase-like domain containing 1 3.40454
MCMDC2 minichromosome maintenance domain containing 2 3.2806
RNASEH2C ribonuclease H2, subunit C 3.18842
ERN2 endoplasmic reticulum to nucleus signaling 2 3.16309
LPCAT3 lysophosphatidylcholine acyltransferase 3 3.09723
ESRRA estrogen-related receptor alpha 3.06927
C16ORF62 chromosome 16 open reading frame 62 3.05449
DNALI1 dynein, axonemal, light intermediate chain 1 3.01555
FAM175A family with sequence similarity 175, member A 2.98813
NKIRAS1 NFKB inhibitor interacting Ras-like 1 2.96577
RNF24 ring finger protein 24 2.95533
KRT17 keratin 17, type I 2.81278
SPATA21 spermatogenesis associated 21 2.80417
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.7879
CLN5 ceroid-lipofuscinosis, neuronal 5 2.75405
ERCC4 excision repair cross-complementation group 4 2.64546
TNFAIP8L1 tumor necrosis factor, alpha-induced protein 8-like 1 2.55202
RANBP9 RAN binding protein 9 2.54844
WDR38 WD repeat domain 38 2.52846
CEP295 centrosomal protein 295kDa 2.44114
THRSP thyroid hormone responsive 2.43774
MARS methionyl-tRNA synthetase 2.43774
PDAP1 PDGFA associated protein 1 2.40117
FBXO11 F-box protein 11 2.3131
IFT22 intraflagellar transport 22 2.27647
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 2.11621
PAQR4 progestin and adipoQ receptor family member IV 2.09718
ANKRD6 ankyrin repeat domain 6 2.07562
DDIT3 DNA-damage-inducible transcript 3 2.01171
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.9804
ACAT2 acetyl-CoA acetyltransferase 2 1.91447
NCAPH2 non-SMC condensin II complex, subunit H2 1.87853
TMOD1 tropomodulin 1 1.82678
ACTB actin, beta 1.81689
TM7SF2 transmembrane 7 superfamily member 2 1.81422
SKIDA1 SKI/DACH domain containing 1 1.79244
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 1.72454
SPG11 spastic paraplegia 11 (autosomal recessive) 1.71237
CRNKL1 crooked neck pre-mRNA splicing factor 1 1.70811
LRRC75A leucine rich repeat containing 75A 1.70797
C5ORF45 chromosome 5 open reading frame 45 1.6792
ILK integrin-linked kinase 1.67295
EFNA5 ephrin-A5 1.67295
SOX12 SRY (sex determining region Y)-box 12 1.5956
REEP5 receptor accessory protein 5 1.57693
HEATR1 HEAT repeat containing 1 1.55369
TATDN1 TatD DNase domain containing 1 1.55279
ATF5 activating transcription factor 5 1.55275
DCST2 DC-STAMP domain containing 2 1.55275
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.53962
CD151 CD151 molecule (Raph blood group) 1.51962
LRWD1 leucine-rich repeats and WD repeat domain containing 1 1.51151
DNM2 dynamin 2 1.50057
EPHA1 EPH receptor A1 1.4973
DLD dihydrolipoamide dehydrogenase 1.48872
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.48872
BAIAP3 BAI1-associated protein 3 1.46421
CTBP2 C-terminal binding protein 2 1.4389
RPL31 ribosomal protein L31 1.42441
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.36571
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.32304

decreased expression

Symbol Name Standardized Value
LOC122455342 testis-specific serine/proline-rich protein -20.0
NR2C2AP nuclear receptor 2C2-associated protein -16.212
EMG1 EMG1 N1-specific pseudouridine methyltransferase -10.469
CCDC24 coiled-coil domain containing 24 -9.05204
ITFG2 integrin alpha FG-GAP repeat containing 2 -8.67995
RBBP4 retinoblastoma binding protein 4 -8.5925
TMEM97 transmembrane protein 97 -8.30611
PEX2 peroxisomal biogenesis factor 2 -8.30611
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -8.26261
MIEN1 migration and invasion enhancer 1 -6.94406
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -6.85973
TKFC triokinase/FMN cyclase -6.85973
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -6.85973
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -6.63067
C19ORF26 chromosome 19 open reading frame 26 -6.38696
C6ORF120 chromosome 6 open reading frame 120 -5.97749
NEMF nuclear export mediator factor -5.83941
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -5.83941
WWTR1 WW domain containing transcription regulator 1 -5.80114
ATRX alpha thalassemia/mental retardation syndrome X-linked -5.67281
PHC1 polyhomeotic homolog 1 (Drosophila) -5.10702
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -5.05158
ZACN zinc activated ligand-gated ion channel -4.99205
RELL2 RELT-like 2 -4.98954
DCTN2 dynactin 2 (p50) -4.95373
TREH trehalase (brush-border membrane glycoprotein) -4.90827
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -4.83785
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -4.41219
SLC7A6OS solute carrier family 7, member 6 opposite strand -4.36853
B9D1 B9 protein domain 1 -4.32132
FCHSD1 FCH and double SH3 domains 1 -4.25155
RBMS2 RNA binding motif, single stranded interacting protein 2 -4.21626
SREBF1 sterol regulatory element binding transcription factor 1 -4.10772
OGG1 8-oxoguanine DNA glycosylase -4.02721
C16ORF70 chromosome 16 open reading frame 70 -3.95881
PRG4 proteoglycan 4 -3.95824
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -3.95052
TOX4 TOX high mobility group box family member 4 -3.89413
TEX10 testis expressed 10 -3.85421
ZBTB46 zinc finger and BTB domain containing 46 -3.74103
CCNE2 cyclin E2 -3.71592
CFAP44 cilia and flagella associated protein 44 -3.69065
UNC45A unc-45 homolog A (C. elegans) -3.6503
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -3.6011
PLLP plasmolipin -3.5635
ZNHIT3 zinc finger, HIT-type containing 3 -3.55861
CDC23 cell division cycle 23 -3.53881
TELO2 telomere maintenance 2 -3.50061
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -3.47358
NCAPD3 non-SMC condensin II complex, subunit D3 -3.47214
SIK2 salt-inducible kinase 2 -3.46723
COL9A3 collagen, type IX, alpha 3 -3.43651
AP2A1 adaptor-related protein complex 2, alpha 1 subunit -3.40454
SSB Sjogren syndrome antigen B (autoantigen La) -3.34037
CCAR2 cell cycle and apoptosis regulator 2 -3.29629
C9ORF117 chromosome 9 open reading frame 117 -3.28916
KHNYN KH and NYN domain containing -3.16218
TUBGCP4 tubulin, gamma complex associated protein 4 -3.13407
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.09952
TMEM179B transmembrane protein 179B -3.09723
KIF2A kinesin heavy chain member 2A -3.09723
PRKCZ protein kinase C, zeta -2.952
CASKIN1 CASK interacting protein 1 -2.94414
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 -2.90798
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.87661
FANCL Fanconi anemia, complementation group L -2.86187
RIC3 RIC3 acetylcholine receptor chaperone -2.84827
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -2.84319
SBF1 SET binding factor 1 -2.74794
DXO decapping exoribonuclease -2.71001
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.6991
CDK4 cyclin-dependent kinase 4 -2.67538
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.57424
BMP6 bone morphogenetic protein 6 -2.55108
C1ORF56 chromosome 1 open reading frame 56 -2.48841
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.4882
ANKRD37 ankyrin repeat domain 37 -2.40117
GRIP2 glutamate receptor interacting protein 2 -2.39361
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -2.37908
PDZD7 PDZ domain containing 7 -2.35174
LRRC46 leucine rich repeat containing 46 -2.28266
FOXH1 forkhead box H1 -2.28266
CTNS cystinosin, lysosomal cystine transporter -2.26338
HIC1 hypermethylated in cancer 1 -2.26338
TICRR TOPBP1-interacting checkpoint and replication regulator -2.25895
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -2.22941
RPL10 ribosomal protein L10 -2.21624
TRIM59 tripartite motif containing 59 -2.19639
TMCO6 transmembrane and coiled-coil domains 6 -2.19279
NUDCD2 NudC domain containing 2 -2.1726
SETD6 SET domain containing 6 -2.13437
ELAC2 elaC ribonuclease Z 2 -2.11621
SLC35E4 solute carrier family 35, member E4 -2.04189
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.01917
CCNK cyclin K -1.98449
PCBP2 poly(rC) binding protein 2 -1.98338
B3GAT2 beta-1,3-glucuronyltransferase 2 -1.97502
RNF214 ring finger protein 214 -1.93615
VPRBP Vpr (HIV-1) binding protein -1.90467
TTC16 tetratricopeptide repeat domain 16 -1.89557