| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | OE perturbation targeting PDE5 in breast cancer cell MCF-7 cell line (Study accession: ERP011301) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_2418_OE_PDE5_ERP011301 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DTNA | dystrobrevin, alpha | 20.0 |
| RAB12 | RAB12, member RAS oncogene family | 20.0 |
| PON2 | paraoxonase 2 | 20.0 |
| MUC1 | mucin 1, cell surface associated | 20.0 |
| MOCS2 | molybdenum cofactor synthesis 2 | 20.0 |
| CLU | clusterin | 20.0 |
| AJUBA | ajuba LIM protein | 20.0 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 20.0 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 20.0 |
| CSRP1 | cysteine and glycine-rich protein 1 | 20.0 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 20.0 |
| PDLIM5 | PDZ and LIM domain 5 | 20.0 |
| UNC13D | unc-13 homolog D (C. elegans) | 20.0 |
| C9ORF3 | chromosome 9 open reading frame 3 | 20.0 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 20.0 |
| G6PD | glucose-6-phosphate dehydrogenase | 20.0 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 20.0 |
| RAPSN | receptor-associated protein of the synapse | 20.0 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 20.0 |
| MED15 | mediator complex subunit 15 | 20.0 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 20.0 |
| LMO7 | LIM domain 7 | 20.0 |
| DUSP16 | dual specificity phosphatase 16 | 20.0 |
| LASP1 | LIM and SH3 protein 1 | 20.0 |
| INHBB | inhibin, beta B | 20.0 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 20.0 |
| IGF1R | insulin-like growth factor 1 receptor | 20.0 |
| SYT10 | synaptotagmin X | 20.0 |
| MDK | midkine (neurite growth-promoting factor 2) | 20.0 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 20.0 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 20.0 |
| KRT80 | keratin 80, type II | 20.0 |
| KRT81 | keratin 81, type II | 20.0 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | 20.0 |
| YIPF6 | Yip1 domain family, member 6 | 20.0 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | 20.0 |
| ABHD11 | abhydrolase domain containing 11 | 20.0 |
| GSN | gelsolin | 20.0 |
| CLSTN3 | calsyntenin 3 | 20.0 |
| LDHA | lactate dehydrogenase A | 20.0 |
| QPRT | quinolinate phosphoribosyltransferase | 20.0 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 20.0 |
| CRLF1 | cytokine receptor-like factor 1 | 20.0 |
| RHOBTB2 | Rho-related BTB domain containing 2 | 20.0 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 20.0 |
| L1CAM | L1 cell adhesion molecule | 20.0 |
| TMEM2 | transmembrane protein 2 | 20.0 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 20.0 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 20.0 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 20.0 |
| CADPS2 | Ca++-dependent secretion activator 2 | 20.0 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 20.0 |
| MAPK4 | mitogen-activated protein kinase 4 | 20.0 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 20.0 |
| CD59 | CD59 molecule, complement regulatory protein | 20.0 |
| KIAA1324 | KIAA1324 | 20.0 |
| AMOTL2 | angiomotin like 2 | 20.0 |
| EME2 | essential meiotic structure-specific endonuclease subunit 2 | 20.0 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | 20.0 |
| S100A10 | S100 calcium binding protein A10 | 20.0 |
| S100A14 | S100 calcium binding protein A14 | 20.0 |
| KIAA1217 | KIAA1217 | 20.0 |
| DALRD3 | DALR anticodon binding domain containing 3 | 20.0 |
| XBP1 | X-box binding protein 1 | 20.0 |
| ABAT | 4-aminobutyrate aminotransferase | 20.0 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 20.0 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 20.0 |
| ODC1 | ornithine decarboxylase 1 | 20.0 |
| LAMB1 | laminin, beta 1 | 20.0 |
| ACACB | acetyl-CoA carboxylase beta | 20.0 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 20.0 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 20.0 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 20.0 |
| MAOA | monoamine oxidase A | 20.0 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 20.0 |
| PEG10 | paternally expressed 10 | 20.0 |
| NELL1 | NEL-like 1 (chicken) | 20.0 |
| UAP1L1 | UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 | 20.0 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 20.0 |
| ALG10 | ALG10, alpha-1,2-glucosyltransferase | 20.0 |
| OSBPL10 | oxysterol binding protein-like 10 | 20.0 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 20.0 |
| SGCE | sarcoglycan, epsilon | 20.0 |
| MACC1 | metastasis associated in colon cancer 1 | 20.0 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 20.0 |
| WWC3 | WWC family member 3 | 20.0 |
| PM20D1 | peptidase M20 domain containing 1 | 20.0 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 20.0 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | 20.0 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 20.0 |
| FLVCR2 | feline leukemia virus subgroup C cellular receptor family, member 2 | 20.0 |
| HIP1 | huntingtin interacting protein 1 | 20.0 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 20.0 |
| HSPB8 | heat shock 22kDa protein 8 | 20.0 |
| SSFA2 | sperm specific antigen 2 | 20.0 |
| KIAA1467 | KIAA1467 | 20.0 |
| DLG3 | discs, large homolog 3 (Drosophila) | 20.0 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 20.0 |
| LIMK2 | LIM domain kinase 2 | 20.0 |
| IFI6 | interferon, alpha-inducible protein 6 | 20.0 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -20.0 |
| PCDH1 | protocadherin 1 | -20.0 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -20.0 |
| IRS1 | insulin receptor substrate 1 | -20.0 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | -20.0 |
| RNF43 | ring finger protein 43 | -20.0 |
| CLSTN2 | calsyntenin 2 | -20.0 |
| CRISP3 | cysteine-rich secretory protein 3 | -20.0 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -20.0 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -20.0 |
| PLXDC2 | plexin domain containing 2 | -20.0 |
| RPL39 | ribosomal protein L39 | -20.0 |
| MKI67 | marker of proliferation Ki-67 | -20.0 |
| PRLR | prolactin receptor | -20.0 |
| TENM3 | teneurin transmembrane protein 3 | -20.0 |
| DSCAM | Down syndrome cell adhesion molecule | -20.0 |
| TCEAL1 | transcription elongation factor A (SII)-like 1 | -20.0 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -20.0 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | -20.0 |
| SDK1 | sidekick cell adhesion molecule 1 | -20.0 |
| KYNU | kynureninase | -20.0 |
| PLK2 | polo-like kinase 2 | -20.0 |
| TRIM45 | tripartite motif containing 45 | -20.0 |
| TNS3 | tensin 3 | -20.0 |
| GFRA1 | GDNF family receptor alpha 1 | -20.0 |
| RAB9B | RAB9B, member RAS oncogene family | -20.0 |
| ZNF28 | zinc finger protein 28 | -20.0 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -20.0 |
| RBM47 | RNA binding motif protein 47 | -20.0 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -20.0 |
| PMP22 | peripheral myelin protein 22 | -20.0 |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 | -20.0 |
| FBXO27 | F-box protein 27 | -20.0 |
| AIM1 | absent in melanoma 1 | -20.0 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -20.0 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -20.0 |
| MORF4L2 | mortality factor 4 like 2 | -20.0 |
| CDK6 | cyclin-dependent kinase 6 | -20.0 |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 | -20.0 |
| ATP11C | ATPase, class VI, type 11C | -20.0 |
| FAM83B | family with sequence similarity 83, member B | -20.0 |
| SLC5A8 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | -20.0 |
| CUL4B | cullin 4B | -20.0 |
| NECAB1 | N-terminal EF-hand calcium binding protein 1 | -20.0 |
| PCLO | piccolo presynaptic cytomatrix protein | -20.0 |
| RNF152 | ring finger protein 152 | -20.0 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -20.0 |
| ISOC1 | isochorismatase domain containing 1 | -20.0 |
| HMCN1 | hemicentin 1 | -20.0 |
| C6ORF141 | chromosome 6 open reading frame 141 | -20.0 |
| FBL | fibrillarin | -20.0 |
| DRD1 | dopamine receptor D1 | -20.0 |
| TMEM64 | transmembrane protein 64 | -20.0 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -20.0 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -20.0 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -20.0 |
| ZNF704 | zinc finger protein 704 | -20.0 |
| SMAD3 | SMAD family member 3 | -20.0 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -20.0 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -20.0 |
| CRABP2 | cellular retinoic acid binding protein 2 | -20.0 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -20.0 |
| MAP2 | microtubule-associated protein 2 | -20.0 |
| RRM2 | ribonucleotide reductase M2 | -20.0 |
| SAGE1 | sarcoma antigen 1 | -20.0 |
| CCDC170 | coiled-coil domain containing 170 | -20.0 |
| ACSS1 | acyl-CoA synthetase short-chain family member 1 | -20.0 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -20.0 |
| ADCY1 | adenylate cyclase 1 (brain) | -20.0 |
| FTL | ferritin, light polypeptide | -20.0 |
| BCL2 | B-cell CLL/lymphoma 2 | -20.0 |
| FAM102B | family with sequence similarity 102, member B | -20.0 |
| FAM122B | family with sequence similarity 122B | -20.0 |
| CTSF | cathepsin F | -20.0 |
| CDCA7L | cell division cycle associated 7-like | -20.0 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -20.0 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -20.0 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | -20.0 |
| HMGB2 | high mobility group box 2 | -20.0 |
| BAMBI | BMP and activin membrane-bound inhibitor | -20.0 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -20.0 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -20.0 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | -20.0 |
| STAG2 | stromal antigen 2 | -20.0 |
| SESN3 | sestrin 3 | -20.0 |
| ADAMTS19 | ADAM metallopeptidase with thrombospondin type 1 motif, 19 | -20.0 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -20.0 |
| BCAS3 | breast carcinoma amplified sequence 3 | -20.0 |
| LAMP2 | lysosomal-associated membrane protein 2 | -20.0 |
| TMEM150C | transmembrane protein 150C | -20.0 |
| LIG1 | ligase I, DNA, ATP-dependent | -20.0 |
| HCAR1 | hydroxycarboxylic acid receptor 1 | -20.0 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -20.0 |
| SLC27A6 | solute carrier family 27 (fatty acid transporter), member 6 | -20.0 |
| MME | membrane metallo-endopeptidase | -20.0 |
| ACKR3 | atypical chemokine receptor 3 | -20.0 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -20.0 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -20.0 |
| XYLT1 | xylosyltransferase I | -20.0 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -20.0 |
