Perturb_2442_KD_DDX5/DDX17_SRP098687 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting DDX5/DDX17 in breast cancer cell MCF-7 cell line (Study accession: SRP098687) (PerturbAtlas)
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Genes

169 genes differentially expressed following the Perturb_2442_KD_DDX5/DDX17_SRP098687 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
NARFL nuclear prelamin A recognition factor-like 20.0
HEMK1 HemK methyltransferase family member 1 20.0
YY1 YY1 transcription factor 20.0
BRAT1 BRCA1-associated ATM activator 1 20.0
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 20.0
L3MBTL2 l(3)mbt-like 2 (Drosophila) 20.0
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 19.3979
UBE2L3 ubiquitin-conjugating enzyme E2L 3 19.1549
RBM27 RNA binding motif protein 27 18.9586
MYO15B myosin XVB 16.5
FCHSD2 FCH and double SH3 domains 2 15.764
LONP1 lon peptidase 1, mitochondrial 15.1298
PTK6 protein tyrosine kinase 6 14.9988
C9ORF131 chromosome 9 open reading frame 131 14.8554
ZBTB44 zinc finger and BTB domain containing 44 14.8554
RUFY1 RUN and FYVE domain containing 1 14.2078
E4F1 E4F transcription factor 1 13.7694
C16ORF96 chromosome 16 open reading frame 96 13.5238
ARL3 ADP-ribosylation factor-like 3 13.2831
MST1 macrophage stimulating 1 12.5632
CDK10 cyclin-dependent kinase 10 12.2628
IL17REL interleukin 17 receptor E-like 12.0758
MAMDC4 MAM domain containing 4 11.8434
PHPT1 phosphohistidine phosphatase 1 11.6395
MAN1B1 mannosidase, alpha, class 1B, member 1 11.541
HEATR6 HEAT repeat containing 6 11.4596
NUP188 nucleoporin 188kDa 10.4355
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 10.2004
CCDC78 coiled-coil domain containing 78 9.96572
TRAPPC2L trafficking protein particle complex 2-like 9.96016
BAG5 BCL2-associated athanogene 5 9.93644
THBS4 thrombospondin 4 9.75406
CHGA chromogranin A 9.62093
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 9.60603
OAZ2 ornithine decarboxylase antizyme 2 9.39701
MYRF myelin regulatory factor 9.31964
C16ORF93 chromosome 16 open reading frame 93 9.14127
ZNF707 zinc finger protein 707 8.87947
STARD5 StAR-related lipid transfer (START) domain containing 5 8.87947
CDH4 cadherin 4, type 1, R-cadherin (retinal) 8.82444
RABL6 RAB, member RAS oncogene family-like 6 8.76161
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 8.58426
SYNGR2 synaptogyrin 2 8.58426
MTUS2 microtubule associated tumor suppressor candidate 2 8.39443
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 8.34886
PHB2 prohibitin 2 7.99543
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 7.95236
PRELID1 PRELI domain containing 1 7.93398
SCMH1 sex comb on midleg homolog 1 (Drosophila) 7.93398
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 7.75667
CDIP1 cell death-inducing p53 target 1 7.64561
JAM3 junctional adhesion molecule 3 7.59933
PTPRS protein tyrosine phosphatase, receptor type, S 7.45605
TBX1 T-box 1 7.45176
CSPG4 chondroitin sulfate proteoglycan 4 7.32324
TXLNA taxilin alpha 7.06281
GLIS2 GLIS family zinc finger 2 6.96641
FGFR3 fibroblast growth factor receptor 3 6.74309
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 6.72281
LARP1 La ribonucleoprotein domain family, member 1 6.59621
C12ORF65 chromosome 12 open reading frame 65 6.54713
PYGB phosphorylase, glycogen; brain 6.48754
C17ORF53 chromosome 17 open reading frame 53 6.28653
PITRM1 pitrilysin metallopeptidase 1 6.28653
TSPAN18 tetraspanin 18 6.26226
AGBL3 ATP/GTP binding protein-like 3 6.1799
FANCC Fanconi anemia, complementation group C 6.08919
P3H1 prolyl 3-hydroxylase 1 6.08899
SGSM2 small G protein signaling modulator 2 6.03555
ADRM1 adhesion regulating molecule 1 6.01342
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 5.90834
FAM178A family with sequence similarity 178, member A 5.88042
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 5.69859
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 5.67321
GSDMD gasdermin D 5.63099
PDCD11 programmed cell death 11 5.56046
YARS tyrosyl-tRNA synthetase 5.55984
GATSL2 GATS protein-like 2 5.52485
MAPK15 mitogen-activated protein kinase 15 5.51069
EHBP1L1 EH domain binding protein 1-like 1 5.50799
C16ORF71 chromosome 16 open reading frame 71 5.39884
TIGD7 tigger transposable element derived 7 5.35965
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 5.34833
FER1L5 fer-1-like family member 5 5.34833
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 5.16571
ZBED4 zinc finger, BED-type containing 4 5.14624
AEBP1 AE binding protein 1 5.14333
CPLX2 complexin 2 5.101
C7ORF43 chromosome 7 open reading frame 43 5.09637
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 5.08109
ACPT acid phosphatase, testicular 5.01343
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 4.99366
POLM polymerase (DNA directed), mu 4.99111
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 4.98692
SAMD1 sterile alpha motif domain containing 1 4.85207
KIRREL3 kin of IRRE like 3 (Drosophila) 4.83958
EIF4B eukaryotic translation initiation factor 4B 4.81524
UBE2S ubiquitin-conjugating enzyme E2S 4.79025
SPAG8 sperm associated antigen 8 4.71542
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 4.70472

decreased expression

Symbol Name Standardized Value
RORA RAR-related orphan receptor A -7.57936
PATE4 prostate and testis expressed 4 -7.51441
MX2 MX dynamin-like GTPase 2 -7.06281
ACO1 aconitase 1, soluble -5.81786
STXBP5L syntaxin binding protein 5-like -4.92146
RAB23 RAB23, member RAS oncogene family -4.64278
FRMD4A FERM domain containing 4A -4.2394
GLS glutaminase -4.05883
TLDC2 TBC/LysM-associated domain containing 2 -4.00318
MAP1B microtubule-associated protein 1B -3.70792
SPRYD4 SPRY domain containing 4 -3.51756
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -3.43353
CEL carboxyl ester lipase -3.38792
FAM184A family with sequence similarity 184, member A -3.38397
FN1 fibronectin 1 -3.13107
BBS4 Bardet-Biedl syndrome 4 -3.07902
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -3.04677
PATE3 prostate and testis expressed 3 -2.73287
EMCN endomucin -2.62761
RNFT1 ring finger protein, transmembrane 1 -2.5608
OGN osteoglycin -2.42198
ASIC2 acid sensing (proton gated) ion channel 2 -2.19103
RNF212B ring finger protein 212B -2.15105
ZNHIT3 zinc finger, HIT-type containing 3 -2.15013
SBF2 SET binding factor 2 -2.10131
C7ORF49 chromosome 7 open reading frame 49 -2.07787
SPON1 spondin 1, extracellular matrix protein -2.06749
ASB18 ankyrin repeat and SOCS box containing 18 -2.03048
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.03036
TRIM13 tripartite motif containing 13 -1.98734
CTHRC1 collagen triple helix repeat containing 1 -1.97785
NRG4 neuregulin 4 -1.97785
ZC3H14 zinc finger CCCH-type containing 14 -1.97443
ANGPTL6 angiopoietin-like 6 -1.96241
LMO3 LIM domain only 3 (rhombotin-like 2) -1.88938
HVCN1 hydrogen voltage gated channel 1 -1.83258
OR8D1 olfactory receptor, family 8, subfamily D, member 1 -1.83258
SP140 SP140 nuclear body protein -1.82332
MTIF3 mitochondrial translational initiation factor 3 -1.78895
TUBA8 tubulin, alpha 8 -1.76424
ASPN asporin -1.74525
CISD3 CDGSH iron sulfur domain 3 -1.73322
OSBPL10 oxysterol binding protein-like 10 -1.72392
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -1.72115
APLP2 amyloid beta (A4) precursor-like protein 2 -1.6982
CENPO centromere protein O -1.69594
CAPN12 calpain 12 -1.68953
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -1.64938
MATN2 matrilin 2 -1.64938
PM20D1 peptidase M20 domain containing 1 -1.64314
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -1.62915
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -1.62411
AKT3 v-akt murine thymoma viral oncogene homolog 3 -1.61729
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -1.56449
STK24 serine/threonine kinase 24 -1.55989
GLRX2 glutaredoxin 2 -1.49961
CLUL1 clusterin-like 1 (retinal) -1.4973
OR8B8 olfactory receptor, family 8, subfamily B, member 8 -1.48463
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -1.42791
SFT2D3 SFT2 domain containing 3 -1.42617
TSHZ2 teashirt zinc finger homeobox 2 -1.42281
REEP5 receptor accessory protein 5 -1.37424
PRIMPOL primase and polymerase (DNA-directed) -1.37113
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) -1.37113
NECAB1 N-terminal EF-hand calcium binding protein 1 -1.35447
CHRND cholinergic receptor, nicotinic, delta (muscle) -1.34722
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -1.33754
LOX lysyl oxidase -1.32789
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -1.3129