| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting BRCA1 in breast cancer cell MCF-7 cell line (Study accession: SRP367511) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_2470_KD_BRCA1_SRP367511 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLK11 | kallikrein-related peptidase 11 | 20.0 |
| SYTL4 | synaptotagmin-like 4 | 20.0 |
| KIAA1324 | KIAA1324 | 20.0 |
| ANO7 | anoctamin 7 | 20.0 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 20.0 |
| SFXN2 | sideroflexin 2 | 20.0 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 20.0 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 20.0 |
| CA2 | carbonic anhydrase II | 19.0969 |
| CBX5 | chromobox homolog 5 | 16.1087 |
| AGR2 | anterior gradient 2 | 15.8754 |
| PLK2 | polo-like kinase 2 | 14.4503 |
| AGR3 | anterior gradient 3 | 12.6394 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | 12.4725 |
| ACO1 | aconitase 1, soluble | 11.9874 |
| SMIM14 | small integral membrane protein 14 | 11.9061 |
| ABHD2 | abhydrolase domain containing 2 | 10.6891 |
| SCIN | scinderin | 10.2905 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 10.2687 |
| ATL3 | atlastin GTPase 3 | 10.2197 |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 | 10.0348 |
| CLSTN2 | calsyntenin 2 | 9.67504 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 9.25691 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 9.23158 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 8.90572 |
| ADI1 | acireductone dioxygenase 1 | 8.753 |
| CPD | carboxypeptidase D | 8.59711 |
| FREM2 | FRAS1 related extracellular matrix protein 2 | 8.4751 |
| MPPED2 | metallophosphoesterase domain containing 2 | 8.31413 |
| C9ORF152 | chromosome 9 open reading frame 152 | 8.25147 |
| BRI3BP | BRI3 binding protein | 7.98611 |
| ZMAT3 | zinc finger, matrin-type 3 | 7.94413 |
| GOLM1 | golgi membrane protein 1 | 7.58605 |
| C1ORF226 | chromosome 1 open reading frame 226 | 7.5764 |
| RPL22 | ribosomal protein L22 | 7.50413 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 7.42958 |
| PGR | progesterone receptor | 7.34464 |
| FGFR4 | fibroblast growth factor receptor 4 | 7.32489 |
| TFF3 | trefoil factor 3 (intestinal) | 7.3063 |
| RPS3A | ribosomal protein S3A | 7.27109 |
| DHFR | dihydrofolate reductase | 7.13924 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 7.1338 |
| NPY1R | neuropeptide Y receptor Y1 | 7.07367 |
| RPLP0 | ribosomal protein, large, P0 | 7.07342 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 7.05507 |
| GAN | gigaxonin | 7.00523 |
| SLC9A2 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 | 7.00192 |
| SNRPD3 | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 6.99945 |
| XBP1 | X-box binding protein 1 | 6.94938 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 6.92109 |
| TMEM164 | transmembrane protein 164 | 6.88539 |
| CAPN9 | calpain 9 | 6.80024 |
| RRM2 | ribonucleotide reductase M2 | 6.75637 |
| BCAS1 | breast carcinoma amplified sequence 1 | 6.46577 |
| SYCP2 | synaptonemal complex protein 2 | 6.42213 |
| PLCB4 | phospholipase C, beta 4 | 6.27838 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 6.25425 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 6.21456 |
| ADCY1 | adenylate cyclase 1 (brain) | 6.20866 |
| RPL9 | ribosomal protein L9 | 6.12982 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | 6.11429 |
| FGG | fibrinogen gamma chain | 6.11425 |
| ISOC1 | isochorismatase domain containing 1 | 6.10874 |
| HIPK3 | homeodomain interacting protein kinase 3 | 6.06664 |
| RPSA | ribosomal protein SA | 6.00669 |
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | 6.00447 |
| SPTLC3 | serine palmitoyltransferase, long chain base subunit 3 | 6.00326 |
| CREB3L4 | cAMP responsive element binding protein 3-like 4 | 5.97733 |
| PARVA | parvin, alpha | 5.82529 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 5.82261 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 5.67573 |
| TPT1 | tumor protein, translationally-controlled 1 | 5.6743 |
| C3ORF14 | chromosome 3 open reading frame 14 | 5.63457 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 5.61953 |
| SLC38A1 | solute carrier family 38, member 1 | 5.37625 |
| C5ORF24 | chromosome 5 open reading frame 24 | 5.36738 |
| RPL7 | ribosomal protein L7 | 5.35749 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 5.35749 |
| KLF2 | Kruppel-like factor 2 | 5.35749 |
| STMN1 | stathmin 1 | 5.33318 |
| NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | 5.30173 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | 5.24191 |
| RPS6 | ribosomal protein S6 | 5.21169 |
| SOX3 | SRY (sex determining region Y)-box 3 | 5.1914 |
| TSPAN1 | tetraspanin 1 | 5.09745 |
| NIPAL2 | NIPA-like domain containing 2 | 5.07887 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 5.0359 |
| TTC39A | tetratricopeptide repeat domain 39A | 4.96376 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | 4.92261 |
| SOCS2 | suppressor of cytokine signaling 2 | 4.88362 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 4.8345 |
| ANLN | anillin, actin binding protein | 4.83393 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | 4.82625 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 4.8067 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 4.79965 |
| GNA14 | guanine nucleotide binding protein (G protein), alpha 14 | 4.78324 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 4.76499 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | 4.73392 |
| RPL21 | ribosomal protein L21 | 4.71755 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 4.66656 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ICAM1 | intercellular adhesion molecule 1 | -20.0 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -20.0 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -20.0 |
| ODF3B | outer dense fiber of sperm tails 3B | -20.0 |
| PML | promyelocytic leukemia | -20.0 |
| CCL5 | chemokine (C-C motif) ligand 5 | -20.0 |
| IFI44L | interferon-induced protein 44-like | -20.0 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -20.0 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -20.0 |
| TRIM14 | tripartite motif containing 14 | -20.0 |
| DHX58 | DEXH (Asp-Glu-X-His) box polypeptide 58 | -20.0 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -20.0 |
| CA9 | carbonic anhydrase IX | -20.0 |
| UBA7 | ubiquitin-like modifier activating enzyme 7 | -20.0 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -20.0 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -20.0 |
| VEGFA | vascular endothelial growth factor A | -20.0 |
| MYO1C | myosin IC | -20.0 |
| LGALS9 | lectin, galactoside-binding, soluble, 9 | -20.0 |
| CDK18 | cyclin-dependent kinase 18 | -20.0 |
| MX2 | MX dynamin-like GTPase 2 | -20.0 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -20.0 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -20.0 |
| PARP10 | poly (ADP-ribose) polymerase family, member 10 | -20.0 |
| KREMEN2 | kringle containing transmembrane protein 2 | -20.0 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | -20.0 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -20.0 |
| IRF1 | interferon regulatory factor 1 | -20.0 |
| IRF7 | interferon regulatory factor 7 | -20.0 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -20.0 |
| IFNL2 | interferon, lambda 2 | -20.0 |
| IFNL3 | interferon, lambda 3 | -20.0 |
| PMP22 | peripheral myelin protein 22 | -20.0 |
| BST2 | bone marrow stromal cell antigen 2 | -20.0 |
| KLHDC7B | kelch domain containing 7B | -20.0 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -20.0 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -20.0 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -20.0 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | -20.0 |
| XAF1 | XIAP associated factor 1 | -20.0 |
| IFITM1 | interferon induced transmembrane protein 1 | -20.0 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -20.0 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -20.0 |
| PLAUR | plasminogen activator, urokinase receptor | -20.0 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | -20.0 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -20.0 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -20.0 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -20.0 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -20.0 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -20.0 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -20.0 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -20.0 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -20.0 |
| C19ORF66 | chromosome 19 open reading frame 66 | -20.0 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -20.0 |
| SAMD9 | sterile alpha motif domain containing 9 | -20.0 |
| ENO2 | enolase 2 (gamma, neuronal) | -20.0 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | -20.0 |
| TRIM56 | tripartite motif containing 56 | -20.0 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -20.0 |
| IFI44 | interferon-induced protein 44 | -20.0 |
| USP18 | ubiquitin specific peptidase 18 | -20.0 |
| TYMP | thymidine phosphorylase | -20.0 |
| IFI35 | interferon-induced protein 35 | -20.0 |
| OGFR | opioid growth factor receptor | -20.0 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -20.0 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | -20.0 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -20.0 |
| TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | -20.0 |
| LIF | leukemia inhibitory factor | -20.0 |
| LAMB3 | laminin, beta 3 | -20.0 |
| HLA-B | major histocompatibility complex, class I, B | -20.0 |
| HLA-A | major histocompatibility complex, class I, A | -20.0 |
| HLA-F | major histocompatibility complex, class I, F | -20.0 |
| TNF | tumor necrosis factor | -20.0 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -20.0 |
| SP100 | SP100 nuclear antigen | -20.0 |
| HLA-C | major histocompatibility complex, class I, C | -20.0 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | -20.0 |
| APOL1 | apolipoprotein L, 1 | -20.0 |
| LAMP3 | lysosomal-associated membrane protein 3 | -20.0 |
| MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | -20.0 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -20.0 |
| ANGPTL4 | angiopoietin-like 4 | -20.0 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -20.0 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -20.0 |
| BATF2 | basic leucine zipper transcription factor, ATF-like 2 | -20.0 |
| TRIM21 | tripartite motif containing 21 | -20.0 |
| IFIH1 | interferon induced with helicase C domain 1 | -20.0 |
| NLRC5 | NLR family, CARD domain containing 5 | -20.0 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -20.0 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -20.0 |
| HILPDA | hypoxia inducible lipid droplet-associated | -20.0 |
| PLSCR1 | phospholipid scramblase 1 | -20.0 |
| RND1 | Rho family GTPase 1 | -20.0 |
| SAMHD1 | SAM domain and HD domain 1 | -20.0 |
| REC8 | REC8 meiotic recombination protein | -20.0 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -20.0 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | -20.0 |
| LOXL2 | lysyl oxidase-like 2 | -20.0 |
