| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | Mut perturbation targeting ESR1 in breast cancer cell MCF7-Luc cell line (Study accession: SRP254635) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_2486_Mut_ESR1_SRP254635 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RHOD | ras homolog family member D | 20.0 |
| VARS | valyl-tRNA synthetase | 20.0 |
| TGFBRAP1 | transforming growth factor, beta receptor associated protein 1 | 20.0 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 20.0 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 20.0 |
| CACNA1H | calcium channel, voltage-dependent, T type, alpha 1H subunit | 20.0 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 20.0 |
| NCOR2 | nuclear receptor corepressor 2 | 20.0 |
| LRRC59 | leucine rich repeat containing 59 | 20.0 |
| LASP1 | LIM and SH3 protein 1 | 20.0 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 20.0 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 20.0 |
| G6PD | glucose-6-phosphate dehydrogenase | 20.0 |
| PKN1 | protein kinase N1 | 20.0 |
| DCTPP1 | dCTP pyrophosphatase 1 | 20.0 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 20.0 |
| FTSJ3 | FtsJ homolog 3 (E. coli) | 20.0 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 20.0 |
| CACYBP | calcyclin binding protein | 20.0 |
| MRPL28 | mitochondrial ribosomal protein L28 | 20.0 |
| BMP7 | bone morphogenetic protein 7 | 20.0 |
| REPIN1 | replication initiator 1 | 20.0 |
| STC2 | stanniocalcin 2 | 20.0 |
| CRIP2 | cysteine-rich protein 2 | 20.0 |
| USF2 | upstream transcription factor 2, c-fos interacting | 20.0 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 20.0 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 20.0 |
| TELO2 | telomere maintenance 2 | 20.0 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 20.0 |
| GSE1 | Gse1 coiled-coil protein | 20.0 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 20.0 |
| TUBB2A | tubulin, beta 2A class IIa | 20.0 |
| CS | citrate synthase | 20.0 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 20.0 |
| SEPHS2 | selenophosphate synthetase 2 | 20.0 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | 20.0 |
| TUFM | Tu translation elongation factor, mitochondrial | 20.0 |
| SLC2A4RG | SLC2A4 regulator | 20.0 |
| HTT | huntingtin | 20.0 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 20.0 |
| KPNB1 | karyopherin (importin) beta 1 | 20.0 |
| PKP3 | plakophilin 3 | 20.0 |
| GFRA1 | GDNF family receptor alpha 1 | 20.0 |
| ATXN2L | ataxin 2-like | 20.0 |
| C20ORF27 | chromosome 20 open reading frame 27 | 20.0 |
| H1F0 | H1 histone family, member 0 | 20.0 |
| ACTG1 | actin gamma 1 | 20.0 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 20.0 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 20.0 |
| EIF4H | eukaryotic translation initiation factor 4H | 20.0 |
| ABAT | 4-aminobutyrate aminotransferase | 20.0 |
| MAP4 | microtubule-associated protein 4 | 20.0 |
| TBX2 | T-box 2 | 20.0 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 20.0 |
| FAM168B | family with sequence similarity 168, member B | 20.0 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 20.0 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 20.0 |
| METRN | meteorin, glial cell differentiation regulator | 20.0 |
| RHOT2 | ras homolog family member T2 | 20.0 |
| GATAD2A | GATA zinc finger domain containing 2A | 20.0 |
| FLNA | filamin A, alpha | 20.0 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | 20.0 |
| ANKRD52 | ankyrin repeat domain 52 | 20.0 |
| RRP1 | ribosomal RNA processing 1 | 20.0 |
| NACC1 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | 20.0 |
| FTL | ferritin, light polypeptide | 20.0 |
| NOTCH3 | notch 3 | 20.0 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 20.0 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 20.0 |
| PLCD3 | phospholipase C, delta 3 | 20.0 |
| CTSB | cathepsin B | 20.0 |
| CTSD | cathepsin D | 20.0 |
| NUDC | nudC nuclear distribution protein | 20.0 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 20.0 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 20.0 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 20.0 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | 20.0 |
| NOP56 | NOP56 ribonucleoprotein | 20.0 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 20.0 |
| BCAS3 | breast carcinoma amplified sequence 3 | 20.0 |
| MAVS | mitochondrial antiviral signaling protein | 20.0 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 20.0 |
| CDC25B | cell division cycle 25B | 20.0 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 20.0 |
| XPO6 | exportin 6 | 20.0 |
| DBNDD1 | dysbindin (dystrobrevin binding protein 1) domain containing 1 | 20.0 |
| NRBP1 | nuclear receptor binding protein 1 | 20.0 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 20.0 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 20.0 |
| CUX1 | cut-like homeobox 1 | 20.0 |
| SULF2 | sulfatase 2 | 20.0 |
| KRT8 | keratin 8, type II | 20.0 |
| TRIP6 | thyroid hormone receptor interactor 6 | 20.0 |
| LMNB2 | lamin B2 | 20.0 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 20.0 |
| KRT19 | keratin 19, type I | 20.0 |
| KRT18 | keratin 18, type I | 20.0 |
| HSPB1 | heat shock 27kDa protein 1 | 20.0 |
| BAG3 | BCL2-associated athanogene 3 | 20.0 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 20.0 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MPG | N-methylpurine-DNA glycosylase | -20.0 |
| CNTNAP2 | contactin associated protein-like 2 | -20.0 |
| SYBU | syntabulin (syntaxin-interacting) | -20.0 |
| TMEM26 | transmembrane protein 26 | -20.0 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | -20.0 |
| UPK3A | uroplakin 3A | -20.0 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | -20.0 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | -20.0 |
| SOX21 | SRY (sex determining region Y)-box 21 | -20.0 |
| LIPC | lipase, hepatic | -20.0 |
| FOXD2 | forkhead box D2 | -20.0 |
| KRT20 | keratin 20, type I | -20.0 |
| AMTN | amelotin | -20.0 |
| CCDC68 | coiled-coil domain containing 68 | -20.0 |
| ATOH8 | atonal homolog 8 (Drosophila) | -20.0 |
| FAM189A1 | family with sequence similarity 189, member A1 | -20.0 |
| MCOLN3 | mucolipin 3 | -20.0 |
| MCOLN2 | mucolipin 2 | -20.0 |
| C8ORF4 | chromosome 8 open reading frame 4 | -20.0 |
| TNS4 | tensin 4 | -20.0 |
| TCAF2 | TRPM8 channel-associated factor 2 | -20.0 |
| VAMP5 | vesicle-associated membrane protein 5 | -20.0 |
| EML6 | echinoderm microtubule associated protein like 6 | -20.0 |
| XKR9 | XK, Kell blood group complex subunit-related family, member 9 | -20.0 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -20.0 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | -20.0 |
| TRIM31 | tripartite motif containing 31 | -20.0 |
| TFF2 | trefoil factor 2 | -20.0 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -20.0 |
| DUSP6 | dual specificity phosphatase 6 | -20.0 |
| HOXC11 | homeobox C11 | -20.0 |
| ZG16 | zymogen granule protein 16 | -20.0 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -20.0 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -20.0 |
| GPX2 | glutathione peroxidase 2 | -20.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -20.0 |
| TSPAN5 | tetraspanin 5 | -20.0 |
| KIAA0226L | KIAA0226-like | -20.0 |
| TNIK | TRAF2 and NCK interacting kinase | -20.0 |
| TLE6 | transducin-like enhancer of split 6 | -20.0 |
| TLE4 | transducin-like enhancer of split 4 | -20.0 |
| C3ORF80 | chromosome 3 open reading frame 80 | -20.0 |
| SLPI | secretory leukocyte peptidase inhibitor | -20.0 |
| CXCL17 | chemokine (C-X-C motif) ligand 17 | -20.0 |
| CGNL1 | cingulin-like 1 | -20.0 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -20.0 |
| APOLD1 | apolipoprotein L domain containing 1 | -20.0 |
| IL1R2 | interleukin 1 receptor, type II | -20.0 |
| FRY | furry homolog (Drosophila) | -20.0 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -20.0 |
| ART4 | ADP-ribosyltransferase 4 (Dombrock blood group) | -20.0 |
| CHSY3 | chondroitin sulfate synthase 3 | -20.0 |
| MAPK4 | mitogen-activated protein kinase 4 | -20.0 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -20.0 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -20.0 |
| TMEM139 | transmembrane protein 139 | -20.0 |
| C2CD4A | C2 calcium-dependent domain containing 4A | -20.0 |
| EMP1 | epithelial membrane protein 1 | -20.0 |
| CREG2 | cellular repressor of E1A-stimulated genes 2 | -20.0 |
| ERO1LB | ERO1-like beta (S. cerevisiae) | -20.0 |
| SLC52A3 | solute carrier family 52 (riboflavin transporter), member 3 | -20.0 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -20.0 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -20.0 |
| CXADR | coxsackie virus and adenovirus receptor | -20.0 |
| UPK1B | uroplakin 1B | -20.0 |
| CXORF57 | chromosome X open reading frame 57 | -20.0 |
| SDR42E1 | short chain dehydrogenase/reductase family 42E, member 1 | -20.0 |
| TM4SF18 | transmembrane 4 L six family member 18 | -20.0 |
| CDC42EP5 | CDC42 effector protein (Rho GTPase binding) 5 | -20.0 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -20.0 |
| RAPGEF3 | Rap guanine nucleotide exchange factor (GEF) 3 | -20.0 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -20.0 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -20.0 |
| EPHA7 | EPH receptor A7 | -20.0 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -20.0 |
| DAPK1 | death-associated protein kinase 1 | -20.0 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -20.0 |
| SSPN | sarcospan | -20.0 |
| AXIN2 | axin 2 | -20.0 |
| ZNF488 | zinc finger protein 488 | -20.0 |
| GPR78 | G protein-coupled receptor 78 | -20.0 |
| LHX6 | LIM homeobox 6 | -20.0 |
| COL2A1 | collagen, type II, alpha 1 | -20.0 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -20.0 |
| TENM4 | teneurin transmembrane protein 4 | -20.0 |
| C19ORF57 | chromosome 19 open reading frame 57 | -20.0 |
| HUNK | hormonally up-regulated Neu-associated kinase | -20.0 |
| AGR3 | anterior gradient 3 | -20.0 |
| RORC | RAR-related orphan receptor C | -20.0 |
| HDAC9 | histone deacetylase 9 | -20.0 |
| PLA2R1 | phospholipase A2 receptor 1, 180kDa | -20.0 |
| EPB41L4A | erythrocyte membrane protein band 4.1 like 4A | -20.0 |
| GNA14 | guanine nucleotide binding protein (G protein), alpha 14 | -20.0 |
| RINL | Ras and Rab interactor-like | -20.0 |
| ACOXL | acyl-CoA oxidase-like | -20.0 |
| GAL3ST1 | galactose-3-O-sulfotransferase 1 | -20.0 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | -20.0 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | -20.0 |
| HS3ST6 | heparan sulfate (glucosamine) 3-O-sulfotransferase 6 | -20.0 |
| HBEGF | heparin-binding EGF-like growth factor | -20.0 |
