Perturb_2494_Mut_ESR1_SRP254635 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description Mut perturbation targeting ESR1 in breast cancer cell MCF7-Luc cell line (Study accession: SRP254635) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_2494_Mut_ESR1_SRP254635 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 20.0
REPIN1 replication initiator 1 20.0
DBN1 drebrin 1 20.0
CDK16 cyclin-dependent kinase 16 20.0
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 20.0
STC2 stanniocalcin 2 20.0
CRIP2 cysteine-rich protein 2 20.0
PKN1 protein kinase N1 20.0
G6PD glucose-6-phosphate dehydrogenase 20.0
CA12 carbonic anhydrase XII 20.0
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 20.0
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 20.0
DGKZ diacylglycerol kinase, zeta 20.0
PRSS23 protease, serine, 23 20.0
PIAS3 protein inhibitor of activated STAT, 3 20.0
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 20.0
ANXA2 annexin A2 20.0
PXDN peroxidasin 20.0
XPO6 exportin 6 20.0
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 20.0
AREG amphiregulin 20.0
CSTB cystatin B (stefin B) 20.0
RHOB ras homolog family member B 20.0
DHRS2 dehydrogenase/reductase (SDR family) member 2 20.0
SLC39A6 solute carrier family 39 (zinc transporter), member 6 20.0
STAU1 staufen double-stranded RNA binding protein 1 20.0
FOSL2 FOS-like antigen 2 20.0
GSE1 Gse1 coiled-coil protein 20.0
GREB1 growth regulation by estrogen in breast cancer 1 20.0
MYOF myoferlin 20.0
ZYX zyxin 20.0
TXNRD1 thioredoxin reductase 1 20.0
FAM127A family with sequence similarity 127, member A 20.0
THBS1 thrombospondin 1 20.0
GPX4 glutathione peroxidase 4 20.0
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 20.0
PTPRK protein tyrosine phosphatase, receptor type, K 20.0
SLC2A4RG SLC2A4 regulator 20.0
SOX4 SRY (sex determining region Y)-box 4 20.0
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 20.0
LAMC1 laminin, gamma 1 (formerly LAMB2) 20.0
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 20.0
RTN4 reticulon 4 20.0
GFRA1 GDNF family receptor alpha 1 20.0
PDIA4 protein disulfide isomerase family A, member 4 20.0
CXXC5 CXXC finger protein 5 20.0
WISP2 WNT1 inducible signaling pathway protein 2 20.0
INPPL1 inositol polyphosphate phosphatase-like 1 20.0
LDOC1 leucine zipper, down-regulated in cancer 1 20.0
SND1 staphylococcal nuclease and tudor domain containing 1 20.0
ABAT 4-aminobutyrate aminotransferase 20.0
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 20.0
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 20.0
SLC4A2 solute carrier family 4 (anion exchanger), member 2 20.0
MAP4 microtubule-associated protein 4 20.0
MTPN myotrophin 20.0
UGDH UDP-glucose 6-dehydrogenase 20.0
TMSB4X thymosin beta 4, X-linked 20.0
JAK1 Janus kinase 1 20.0
MKRN1 makorin ring finger protein 1 20.0
RARA retinoic acid receptor, alpha 20.0
CTSD cathepsin D 20.0
WWP1 WW domain containing E3 ubiquitin protein ligase 1 20.0
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 20.0
CHMP4A charged multivesicular body protein 4A 20.0
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 20.0
FTL ferritin, light polypeptide 20.0
TSPAN15 tetraspanin 15 20.0
NOTCH3 notch 3 20.0
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 20.0
FAM102A family with sequence similarity 102, member A 20.0
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 20.0
GPC1 glypican 1 20.0
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 20.0
METRN meteorin, glial cell differentiation regulator 20.0
UBE3C ubiquitin protein ligase E3C 20.0
ECE1 endothelin converting enzyme 1 20.0
HSPB1 heat shock 27kDa protein 1 20.0
TMSB10 thymosin beta 10 20.0
BAG3 BCL2-associated athanogene 3 20.0
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 20.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 20.0
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 20.0
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 20.0
JUP junction plakoglobin 20.0
ITPK1 inositol-tetrakisphosphate 1-kinase 20.0
TRIP6 thyroid hormone receptor interactor 6 20.0
MBOAT7 membrane bound O-acyltransferase domain containing 7 20.0
H2AFJ H2A histone family, member J 20.0
TBC1D16 TBC1 domain family, member 16 20.0
ESYT1 extended synaptotagmin-like protein 1 20.0
ULK1 unc-51 like autophagy activating kinase 1 20.0
FLNA filamin A, alpha 20.0
CERS2 ceramide synthase 2 20.0
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 20.0
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 20.0
IGFBP4 insulin-like growth factor binding protein 4 20.0
CUX1 cut-like homeobox 1 20.0
CRABP2 cellular retinoic acid binding protein 2 20.0
BCAS3 breast carcinoma amplified sequence 3 20.0

decreased expression

Symbol Name Standardized Value
C9ORF152 chromosome 9 open reading frame 152 -20.0
NELL2 NEL-like 2 (chicken) -20.0
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -20.0
SOX2 SRY (sex determining region Y)-box 2 -20.0
UPK3A uroplakin 3A -20.0
C2ORF54 chromosome 2 open reading frame 54 -20.0
CETN3 centrin, EF-hand protein, 3 -20.0
SYCP2 synaptonemal complex protein 2 -20.0
KLF13 Kruppel-like factor 13 -20.0
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 -20.0
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -20.0
FMNL3 formin-like 3 -20.0
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -20.0
FAM46C family with sequence similarity 46, member C -20.0
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -20.0
MDFIC MyoD family inhibitor domain containing -20.0
PARM1 prostate androgen-regulated mucin-like protein 1 -20.0
SUSD2 sushi domain containing 2 -20.0
CEPT1 choline/ethanolamine phosphotransferase 1 -20.0
TGFB3 transforming growth factor, beta 3 -20.0
MEF2C myocyte enhancer factor 2C -20.0
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -20.0
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) -20.0
TM4SF1 transmembrane 4 L six family member 1 -20.0
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 -20.0
LTBP4 latent transforming growth factor beta binding protein 4 -20.0
VAT1L vesicle amine transport 1-like -20.0
ACSL4 acyl-CoA synthetase long-chain family member 4 -20.0
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -20.0
VGLL1 vestigial-like family member 1 -20.0
ADPRHL1 ADP-ribosylhydrolase like 1 -20.0
CAPN5 calpain 5 -20.0
SEPT10 septin 10 -20.0
CAPN9 calpain 9 -20.0
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -20.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -20.0
SHROOM1 shroom family member 1 -20.0
TSPAN1 tetraspanin 1 -20.0
PCCA propionyl CoA carboxylase, alpha polypeptide -20.0
GCAT glycine C-acetyltransferase -20.0
ZBTB10 zinc finger and BTB domain containing 10 -20.0
RTKN rhotekin -20.0
SLPI secretory leukocyte peptidase inhibitor -20.0
TMEM194B transmembrane protein 194B -20.0
CCDC125 coiled-coil domain containing 125 -20.0
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -20.0
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -20.0
CAPN8 calpain 8 -20.0
MPPED2 metallophosphoesterase domain containing 2 -20.0
PDE4D phosphodiesterase 4D, cAMP-specific -20.0
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -20.0
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -20.0
LIN7A lin-7 homolog A (C. elegans) -20.0
PCDH10 protocadherin 10 -20.0
SORCS2 sortilin-related VPS10 domain containing receptor 2 -20.0
MAPK4 mitogen-activated protein kinase 4 -20.0
SLAIN1 SLAIN motif family, member 1 -20.0
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -20.0
HEG1 heart development protein with EGF-like domains 1 -20.0
ARHGAP42 Rho GTPase activating protein 42 -20.0
DAPK1 death-associated protein kinase 1 -20.0
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -20.0
CKMT1B creatine kinase, mitochondrial 1B -20.0
CKMT1A creatine kinase, mitochondrial 1A -20.0
UPK2 uroplakin 2 -20.0
MSMB microseminoprotein, beta- -20.0
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -20.0
WNT10B wingless-type MMTV integration site family, member 10B -20.0
ASTN2 astrotactin 2 -20.0
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -20.0
MPC1 mitochondrial pyruvate carrier 1 -20.0
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -20.0
DHRS13 dehydrogenase/reductase (SDR family) member 13 -20.0
KCTD12 potassium channel tetramerization domain containing 12 -20.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -20.0
PLBD1 phospholipase B domain containing 1 -20.0
ADGRV1 adhesion G protein-coupled receptor V1 -20.0
ASCL2 achaete-scute family bHLH transcription factor 2 -20.0
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -20.0
APCDD1 adenomatosis polyposis coli down-regulated 1 -20.0
RIOK2 RIO kinase 2 -20.0
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -20.0
SGCE sarcoglycan, epsilon -20.0
EPHB6 EPH receptor B6 -20.0
PBX3 pre-B-cell leukemia homeobox 3 -20.0
SLC44A3 solute carrier family 44, member 3 -20.0
RNF145 ring finger protein 145 -20.0
CCNO cyclin O -20.0
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -20.0
ACOX2 acyl-CoA oxidase 2, branched chain -20.0
KRT4 keratin 4, type II -20.0
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -20.0
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -20.0
HCAR1 hydroxycarboxylic acid receptor 1 -20.0
WDR72 WD repeat domain 72 -20.0
TRIM29 tripartite motif containing 29 -20.0
STARD4 StAR-related lipid transfer (START) domain containing 4 -20.0
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -20.0
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -20.0
SHH sonic hedgehog -20.0