Perturb_2690_KD_BMOR_SRP344304 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting BMOR in breast cancer cell MDA-MB-231 brain metastasis tissue (Study accession: SRP344304) (PerturbAtlas)
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Genes

165 genes differentially expressed following the Perturb_2690_KD_BMOR_SRP344304 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
KRT19 keratin 19, type I 7.30909
FOS FBJ murine osteosarcoma viral oncogene homolog 5.42601
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 5.36501
ESAM endothelial cell adhesion molecule 4.88547
COL18A1 collagen, type XVIII, alpha 1 4.80045
KRT7 keratin 7, type II 4.33352
IL1A interleukin 1, alpha 3.4669
HCLS1 hematopoietic cell-specific Lyn substrate 1 3.39811
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 3.16728
MXRA8 matrix-remodelling associated 8 3.09632
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.93396
JUP junction plakoglobin 2.90929
BAHCC1 BAH domain and coiled-coil containing 1 2.90797
NELL2 NEL-like 2 (chicken) 2.90125
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.81668
CARD11 caspase recruitment domain family, member 11 2.77523
HTRA1 HtrA serine peptidase 1 2.68058
FAM20C family with sequence similarity 20, member C 2.63195
HMHA1 histocompatibility (minor) HA-1 2.61154
C10ORF10 chromosome 10 open reading frame 10 2.58361
MST1R macrophage stimulating 1 receptor 2.5495
PLXNB3 plexin B3 2.51664
LOXL4 lysyl oxidase-like 4 2.40256
LAMA5 laminin, alpha 5 2.28347
ADGRG1 adhesion G protein-coupled receptor G1 2.25569
S100A4 S100 calcium binding protein A4 2.19263
ANO8 anoctamin 8 2.19263
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.19263
HSPG2 heparan sulfate proteoglycan 2 2.19263
F2RL3 coagulation factor II (thrombin) receptor-like 3 2.17947
CNTN1 contactin 1 2.11908
HSPA1A heat shock 70kDa protein 1A 2.10924
AREG amphiregulin 2.10856
COL6A3 collagen, type VI, alpha 3 2.10856
GLUL glutamate-ammonia ligase 2.10856
GPX3 glutathione peroxidase 3 2.09964
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.09964
PLXNB2 plexin B2 2.09964
MSLN mesothelin 2.09944
MMP14 matrix metallopeptidase 14 (membrane-inserted) 2.08785
IFI27 interferon, alpha-inducible protein 27 2.08785
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 2.05921
IFNLR1 interferon, lambda receptor 1 2.04466
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 2.04466
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 1.99601
GPR153 G protein-coupled receptor 153 1.9576
IRF7 interferon regulatory factor 7 1.9576
SREBF1 sterol regulatory element binding transcription factor 1 1.9576
LAMA3 laminin, alpha 3 1.9576
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 1.88272
RORA RAR-related orphan receptor A 1.88272
WNT7B wingless-type MMTV integration site family, member 7B 1.88272
ITGB4 integrin, beta 4 1.84497
TRIOBP TRIO and F-actin binding protein 1.83942
SBNO2 strawberry notch homolog 2 (Drosophila) 1.82271
MRC2 mannose receptor, C type 2 1.80479
CIITA class II, major histocompatibility complex, transactivator 1.80479
FAM83A family with sequence similarity 83, member A 1.7461
DMBT1 deleted in malignant brain tumors 1 1.74336
FN1 fibronectin 1 1.74336
ZNF467 zinc finger protein 467 1.73846
VNN1 vanin 1 1.73846
CXORF57 chromosome X open reading frame 57 1.73846
CRIP2 cysteine-rich protein 2 1.73096
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.73096
NDNF neuron-derived neurotrophic factor 1.7297
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.7297
AGRN agrin 1.7297
PLXNA1 plexin A1 1.694
GPRC5C G protein-coupled receptor, class C, group 5, member C 1.59877
CXCL3 chemokine (C-X-C motif) ligand 3 1.58822
HES4 hes family bHLH transcription factor 4 1.57896
BCL9L B-cell CLL/lymphoma 9-like 1.57896
SH3D21 SH3 domain containing 21 1.57748
RIN2 Ras and Rab interactor 2 1.56554
PPAP2C phosphatidic acid phosphatase type 2C 1.56554
DGAT2 diacylglycerol O-acyltransferase 2 1.56554
ZBTB7B zinc finger and BTB domain containing 7B 1.52415
TNS4 tensin 4 1.52293
PODXL2 podocalyxin-like 2 1.51568
GPRC5A G protein-coupled receptor, class C, group 5, member A 1.50446
NDRG1 N-myc downstream regulated 1 1.50249
IL6 interleukin 6 1.48859
SNX8 sorting nexin 8 1.47683
SORBS3 sorbin and SH3 domain containing 3 1.44834
EGR1 early growth response 1 1.43922
MAMDC4 MAM domain containing 4 1.42834
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.42834
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 1.42834
LPAR1 lysophosphatidic acid receptor 1 1.42707
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.39776
BCL3 B-cell CLL/lymphoma 3 1.39281
CERCAM cerebral endothelial cell adhesion molecule 1.3859
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 1.3859
KLF13 Kruppel-like factor 13 1.3859
CRLS1 cardiolipin synthase 1 1.3822
KCNIP3 Kv channel interacting protein 3, calsenilin 1.3822
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 1.38036
CCDC92 coiled-coil domain containing 92 1.38036
IQGAP3 IQ motif containing GTPase activating protein 3 1.38036

decreased expression

Symbol Name Standardized Value
ACTA1 actin, alpha 1, skeletal muscle -10.4633
MMP3 matrix metallopeptidase 3 -6.58939
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) -4.78489
NEXN nexilin (F actin binding protein) -4.33352
ITK IL2-inducible T-cell kinase -4.1003
ANKRD26 ankyrin repeat domain 26 -3.78591
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -3.16728
CPA3 carboxypeptidase A3 (mast cell) -2.93396
CD33 CD33 molecule -2.90929
PTPRR protein tyrosine phosphatase, receptor type, R -2.89551
TCF4 transcription factor 4 -2.75725
DMKN dermokine -2.70734
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.68058
CSPP1 centrosome and spindle pole associated protein 1 -2.61154
ZBTB20 zinc finger and BTB domain containing 20 -2.58361
EHD3 EH-domain containing 3 -2.56483
CST7 cystatin F (leukocystatin) -2.51016
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.45996
SAMD5 sterile alpha motif domain containing 5 -2.36388
NSRP1 nuclear speckle splicing regulatory protein 1 -2.27956
VGLL3 vestigial-like family member 3 -2.27626
FAM49A family with sequence similarity 49, member A -2.19263
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.17525
SYT15 synaptotagmin XV -2.09964
TNNC1 troponin C type 1 (slow) -2.0803
IGSF6 immunoglobulin superfamily, member 6 -2.04946
ANKRD30B ankyrin repeat domain 30B -2.00286
ONECUT2 one cut homeobox 2 -1.9576
NRXN3 neurexin 3 -1.9576
ANO2 anoctamin 2, calcium activated chloride channel -1.82271
MAP1A microtubule-associated protein 1A -1.77163
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -1.70752
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -1.70752
GPR132 G protein-coupled receptor 132 -1.66236
VCAN versican -1.66017
CCDC88A coiled-coil domain containing 88A -1.63188
STON2 stonin 2 -1.61931
ANKRD12 ankyrin repeat domain 12 -1.58873
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -1.58613
ANKRD11 ankyrin repeat domain 11 -1.58613
PPIG peptidylprolyl isomerase G (cyclophilin G) -1.58109
MAP9 microtubule-associated protein 9 -1.56554
MYL2 myosin, light chain 2, regulatory, cardiac, slow -1.55615
APOE apolipoprotein E -1.55131
NOV nephroblastoma overexpressed -1.51199
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -1.50446
ANKRD36C ankyrin repeat domain 36C -1.50249
GPNMB glycoprotein (transmembrane) nmb -1.46398
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -1.45415
PYGM phosphorylase, glycogen, muscle -1.44834
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -1.44834
SCIN scinderin -1.42707
AK5 adenylate kinase 5 -1.42707
CNPY2 canopy FGF signaling regulator 2 -1.41122
CCDC148 coiled-coil domain containing 148 -1.3859
ZC3H13 zinc finger CCCH-type containing 13 -1.3859
RBM25 RNA binding motif protein 25 -1.3822
CCDC102B coiled-coil domain containing 102B -1.38036
FAM217B family with sequence similarity 217, member B -1.35965
SCN2A sodium channel, voltage gated, type II alpha subunit -1.35965
NRCAM neuronal cell adhesion molecule -1.34219
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -1.3417
ABI3BP ABI family, member 3 (NESH) binding protein -1.3355
NAP1L3 nucleosome assembly protein 1-like 3 -1.33418
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -1.32898