Perturb_2818_OE_SUFU_SRP346101 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting SUFU in breast cancer epithelial cells SKBR3 cell (Study accession: SRP346101) (PerturbAtlas)
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Genes

160 genes differentially expressed following the Perturb_2818_OE_SUFU_SRP346101 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
SUFU suppressor of fused homolog (Drosophila) 20.0
GSTP1 glutathione S-transferase pi 1 20.0
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 9.44158
PM20D1 peptidase M20 domain containing 1 6.42936
RCAN1 regulator of calcineurin 1 6.17178
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 5.99144
TXNRD1 thioredoxin reductase 1 4.56559
GLDC glycine dehydrogenase (decarboxylating) 4.02515
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 3.80791
ANXA6 annexin A6 3.6881
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.0157
VTCN1 V-set domain containing T cell activation inhibitor 1 2.76048
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 2.70721
NCEH1 neutral cholesterol ester hydrolase 1 2.53744
SECISBP2L SECIS binding protein 2-like 2.45596
GDI2 GDP dissociation inhibitor 2 2.38448
CTSZ cathepsin Z 2.34542
KIAA1109 KIAA1109 2.05223
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.04974
SPTSSB serine palmitoyltransferase, small subunit B 2.04974
GCC1 GRIP and coiled-coil domain containing 1 2.03883
L1CAM L1 cell adhesion molecule 2.03737
SHANK2 SH3 and multiple ankyrin repeat domains 2 2.03737
CA12 carbonic anhydrase XII 1.92272
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 1.91627
BCAS1 breast carcinoma amplified sequence 1 1.88321
GPM6B glycoprotein M6B 1.82407
GJA5 gap junction protein, alpha 5, 40kDa 1.81651
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 1.78456
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 1.77915
PEG10 paternally expressed 10 1.77162
SYT15 synaptotagmin XV 1.74713
ZNF331 zinc finger protein 331 1.74096
SEPT11 septin 11 1.71614
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.69532
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.68561
HSPA8 heat shock 70kDa protein 8 1.68561
SNX14 sorting nexin 14 1.67485
GPRIN2 G protein regulated inducer of neurite outgrowth 2 1.671
PPT1 palmitoyl-protein thioesterase 1 1.64621
SEC24D SEC24 family member D 1.64621
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 1.62503
SCARB2 scavenger receptor class B, member 2 1.61339
C20ORF194 chromosome 20 open reading frame 194 1.60738
TM4SF1 transmembrane 4 L six family member 1 1.60738
ATP13A3 ATPase type 13A3 1.51701
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.48255
XBP1 X-box binding protein 1 1.46803
HSPG2 heparan sulfate proteoglycan 2 1.44388
HIP1 huntingtin interacting protein 1 1.4436
SRP72 signal recognition particle 72kDa 1.44066
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 1.43282
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1.42935
ASPH aspartate beta-hydroxylase 1.3895
CCND1 cyclin D1 1.385
WDFY3 WD repeat and FYVE domain containing 3 1.38289
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.33882
ZNF800 zinc finger protein 800 1.31998
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 1.3191
ARFGEF3 ARFGEF family member 3 1.31128

decreased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 -20.0
COL5A2 collagen, type V, alpha 2 -20.0
EYA2 EYA transcriptional coactivator and phosphatase 2 -20.0
FN1 fibronectin 1 -20.0
THBS1 thrombospondin 1 -14.617
AQP3 aquaporin 3 (Gill blood group) -13.7451
ITGB6 integrin, beta 6 -11.9027
S100A4 S100 calcium binding protein A4 -9.17824
TMPRSS4 transmembrane protease, serine 4 -8.74118
TGFBR1 transforming growth factor, beta receptor 1 -8.65923
KRT15 keratin 15, type I -8.40774
PTK7 protein tyrosine kinase 7 (inactive) -7.95745
CTNND2 catenin (cadherin-associated protein), delta 2 -7.72534
GLYATL2 glycine-N-acyltransferase-like 2 -7.58951
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -7.2807
S100A6 S100 calcium binding protein A6 -7.1365
DTX4 deltex 4, E3 ubiquitin ligase -6.19081
PLTP phospholipid transfer protein -5.85223
PMEPA1 prostate transmembrane protein, androgen induced 1 -5.62949
ATP11A ATPase, class VI, type 11A -5.59336
KRT9 keratin 9, type I -5.19153
SLC44A4 solute carrier family 44, member 4 -5.00068
NPR3 natriuretic peptide receptor 3 -4.792
ZNF703 zinc finger protein 703 -4.69864
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -4.69853
MCF2L MCF.2 cell line derived transforming sequence-like -4.06433
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 -3.9951
TRIP6 thyroid hormone receptor interactor 6 -3.99127
BCL7A B-cell CLL/lymphoma 7A -3.96069
DDIT4 DNA-damage-inducible transcript 4 -3.893
CYBA cytochrome b-245, alpha polypeptide -3.80791
MARCKSL1 MARCKS-like 1 -3.75482
UNC5B unc-5 homolog B (C. elegans) -3.6935
EGR1 early growth response 1 -3.67174
LAMB1 laminin, beta 1 -3.66795
BMF Bcl2 modifying factor -3.51185
WNT5A wingless-type MMTV integration site family, member 5A -3.37604
GPC6 glypican 6 -3.35151
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.26665
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.18844
KRT81 keratin 81, type II -3.07733
ACTA1 actin, alpha 1, skeletal muscle -3.07733
LGALS1 lectin, galactoside-binding, soluble, 1 -3.0642
LAPTM4B lysosomal protein transmembrane 4 beta -2.96441
ADGRF1 adhesion G protein-coupled receptor F1 -2.74494
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.69889
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.60065
GATA3 GATA binding protein 3 -2.57922
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.50615
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.47738
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.474
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.45596
MT2A metallothionein 2A -2.43825
SAMD11 sterile alpha motif domain containing 11 -2.43692
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -2.43692
DLX1 distal-less homeobox 1 -2.43692
RPL21 ribosomal protein L21 -2.37906
CRABP2 cellular retinoic acid binding protein 2 -2.35664
HMGB1 high mobility group box 1 -2.33268
COL5A1 collagen, type V, alpha 1 -2.32646
PTMS parathymosin -2.26221
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -2.23492
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -2.23492
SOX4 SRY (sex determining region Y)-box 4 -2.1898
SYT8 synaptotagmin VIII -2.06693
NRK Nik related kinase -2.05949
MYL9 myosin, light chain 9, regulatory -2.05223
PRSS23 protease, serine, 23 -2.03909
PFKP phosphofructokinase, platelet -2.03737
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.02635
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.01092
OLFM4 olfactomedin 4 -2.0107
FREM2 FRAS1 related extracellular matrix protein 2 -1.99366
AIF1L allograft inflammatory factor 1-like -1.99366
NBL1 neuroblastoma 1, DAN family BMP antagonist -1.98052
KCTD12 potassium channel tetramerization domain containing 12 -1.96081
DCLK2 doublecortin-like kinase 2 -1.94839
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -1.94251
HSPB1 heat shock 27kDa protein 1 -1.94251
MUC1 mucin 1, cell surface associated -1.92708
ACTN4 actinin, alpha 4 -1.92708
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -1.86797
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -1.85981
RASAL1 RAS protein activator like 1 (GAP1 like) -1.8432
MXRA5 matrix-remodelling associated 5 -1.8432
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.83609
IVL involucrin -1.80047
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -1.79134
BMP7 bone morphogenetic protein 7 -1.78228
GPRC5B G protein-coupled receptor, class C, group 5, member B -1.77915
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -1.77895
ERF Ets2 repressor factor -1.77599
ITM2B integral membrane protein 2B -1.68381
TJP3 tight junction protein 3 -1.6735
FBXO32 F-box protein 32 -1.61366
NVL nuclear VCP-like -1.61339
ZHX2 zinc fingers and homeoboxes 2 -1.60738
UNC5A unc-5 homolog A (C. elegans) -1.60738
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -1.58873
PKP1 plakophilin 1 -1.5767