| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | Mut perturbation targeting SPOP in bronchial epithelial cell BEAS2B cell line (Study accession: SRP404927) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_2855_Mut_SPOP_SRP404927 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPOP | speckle-type POZ protein | 20.0 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 20.0 |
| IL7R | interleukin 7 receptor | 20.0 |
| C3 | complement component 3 | 20.0 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 17.153 |
| TGM2 | transglutaminase 2 | 13.3172 |
| VCAN | versican | 13.0889 |
| CADM3 | cell adhesion molecule 3 | 12.4088 |
| COLEC12 | collectin sub-family member 12 | 10.5306 |
| ITGA11 | integrin, alpha 11 | 10.1588 |
| SULF2 | sulfatase 2 | 9.57687 |
| CDHR1 | cadherin-related family member 1 | 9.38695 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | 9.27009 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 7.4113 |
| COL6A2 | collagen, type VI, alpha 2 | 7.28406 |
| NCAM1 | neural cell adhesion molecule 1 | 6.8145 |
| ARHGAP22 | Rho GTPase activating protein 22 | 6.72463 |
| C4B | complement component 4B (Chido blood group) | 6.61129 |
| COL12A1 | collagen, type XII, alpha 1 | 6.07988 |
| PRLR | prolactin receptor | 6.03761 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 6.00068 |
| TENM2 | teneurin transmembrane protein 2 | 5.85214 |
| FBXO32 | F-box protein 32 | 5.73929 |
| SP6 | Sp6 transcription factor | 5.48956 |
| ZNF467 | zinc finger protein 467 | 5.37933 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 5.3102 |
| KRT7 | keratin 7, type II | 5.31011 |
| PERP | PERP, TP53 apoptosis effector | 5.22434 |
| SARDH | sarcosine dehydrogenase | 5.20623 |
| SCARB1 | scavenger receptor class B, member 1 | 4.83765 |
| ITGB5 | integrin, beta 5 | 4.76473 |
| TMEM40 | transmembrane protein 40 | 4.74764 |
| ASS1 | argininosuccinate synthase 1 | 4.45019 |
| PDE10A | phosphodiesterase 10A | 4.41718 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 4.36178 |
| PODXL2 | podocalyxin-like 2 | 4.29222 |
| FAM83A | family with sequence similarity 83, member A | 4.18073 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 3.99324 |
| MGST1 | microsomal glutathione S-transferase 1 | 3.98098 |
| C1QTNF6 | C1q and tumor necrosis factor related protein 6 | 3.91275 |
| COL5A3 | collagen, type V, alpha 3 | 3.91204 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 3.78904 |
| FBXO2 | F-box protein 2 | 3.73163 |
| MDFIC | MyoD family inhibitor domain containing | 3.43954 |
| CARD11 | caspase recruitment domain family, member 11 | 3.28617 |
| PWWP2B | PWWP domain containing 2B | 3.26707 |
| CNN1 | calponin 1, basic, smooth muscle | 3.23149 |
| CRACR2A | calcium release activated channel regulator 2A | 3.11606 |
| LYNX1 | Ly6/neurotoxin 1 | 3.11218 |
| APBA2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | 3.05282 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.95455 |
| NOTCH3 | notch 3 | 2.89892 |
| BCL3 | B-cell CLL/lymphoma 3 | 2.89105 |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 2.84136 |
| COL1A2 | collagen, type I, alpha 2 | 2.827 |
| EPHB3 | EPH receptor B3 | 2.81664 |
| GLP2R | glucagon-like peptide 2 receptor | 2.7356 |
| NTN1 | netrin 1 | 2.67044 |
| FAM83H | family with sequence similarity 83, member H | 2.57983 |
| OLFML2B | olfactomedin-like 2B | 2.57983 |
| C1R | complement component 1, r subcomponent | 2.53574 |
| TSPAN9 | tetraspanin 9 | 2.52478 |
| SBK2 | SH3 domain binding kinase family, member 2 | 2.51922 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 2.50372 |
| SFRP1 | secreted frizzled-related protein 1 | 2.49497 |
| PSG5 | pregnancy specific beta-1-glycoprotein 5 | 2.49497 |
| FZD6 | frizzled class receptor 6 | 2.49441 |
| NUP210 | nucleoporin 210kDa | 2.45792 |
| DPYSL3 | dihydropyrimidinase-like 3 | 2.45635 |
| CLCA2 | chloride channel accessory 2 | 2.42944 |
| DPYSL4 | dihydropyrimidinase-like 4 | 2.35115 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | 2.35036 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 2.34334 |
| ZNF469 | zinc finger protein 469 | 2.32036 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 2.28056 |
| APOL6 | apolipoprotein L, 6 | 2.26289 |
| EFNA1 | ephrin-A1 | 2.26106 |
| PCDHB8 | protocadherin beta 8 | 2.25662 |
| KRT80 | keratin 80, type II | 2.24982 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 2.22006 |
| MVB12B | multivesicular body subunit 12B | 2.17273 |
| WNT5B | wingless-type MMTV integration site family, member 5B | 2.15508 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.11179 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 2.10793 |
| SCN4B | sodium channel, voltage gated, type IV beta subunit | 2.09417 |
| ZNF320 | zinc finger protein 320 | 1.93621 |
| MYL9 | myosin, light chain 9, regulatory | 1.82072 |
| LAPTM5 | lysosomal protein transmembrane 5 | 1.82072 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 1.79353 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 1.78892 |
| PLXNA2 | plexin A2 | 1.78724 |
| ZNF43 | zinc finger protein 43 | 1.77286 |
| ELAVL2 | ELAV like neuron-specific RNA binding protein 2 | 1.74524 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 | 1.72663 |
| SVIP | small VCP/p97-interacting protein | 1.72454 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 1.71438 |
| BMF | Bcl2 modifying factor | 1.68739 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 1.6824 |
| ZNF93 | zinc finger protein 93 | 1.66743 |
| SYPL2 | synaptophysin-like 2 | 1.6491 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -19.5229 |
| ANTXR2 | anthrax toxin receptor 2 | -11.8929 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -10.7981 |
| ITGB8 | integrin, beta 8 | -10.2186 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -10.1994 |
| LAMC2 | laminin, gamma 2 | -9.66676 |
| FBN1 | fibrillin 1 | -8.17744 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -7.61922 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -7.33275 |
| KLF2 | Kruppel-like factor 2 | -6.95873 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -6.94191 |
| FBN2 | fibrillin 2 | -6.89965 |
| ADAMTSL1 | ADAMTS-like 1 | -6.61129 |
| CD24 | CD24 molecule | -6.54197 |
| NPPB | natriuretic peptide B | -6.45622 |
| MPG | N-methylpurine-DNA glycosylase | -6.3132 |
| SORBS2 | sorbin and SH3 domain containing 2 | -6.3033 |
| FGF5 | fibroblast growth factor 5 | -6.07988 |
| FAT4 | FAT atypical cadherin 4 | -5.62118 |
| ITGA6 | integrin, alpha 6 | -5.60292 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -5.163 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -4.93887 |
| TMPRSS15 | transmembrane protease, serine 15 | -4.67017 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -4.3971 |
| MME | membrane metallo-endopeptidase | -4.32105 |
| PRKCA | protein kinase C, alpha | -4.15312 |
| EPAS1 | endothelial PAS domain protein 1 | -4.12466 |
| NGEF | neuronal guanine nucleotide exchange factor | -4.01342 |
| ADM | adrenomedullin | -3.91275 |
| AHNAK2 | AHNAK nucleoprotein 2 | -3.84644 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | -3.77639 |
| TJP1 | tight junction protein 1 | -3.69721 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -3.59982 |
| LOXL2 | lysyl oxidase-like 2 | -3.50939 |
| TUBB2B | tubulin, beta 2B class IIb | -3.37209 |
| DOCK4 | dedicator of cytokinesis 4 | -3.37209 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -3.30259 |
| FRMD6 | FERM domain containing 6 | -3.20768 |
| EMP1 | epithelial membrane protein 1 | -3.20768 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -3.18808 |
| DGKI | diacylglycerol kinase, iota | -3.0154 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -2.9564 |
| COL4A4 | collagen, type IV, alpha 4 | -2.95455 |
| SLC38A4 | solute carrier family 38, member 4 | -2.95455 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -2.95123 |
| TSPAN18 | tetraspanin 18 | -2.94039 |
| AHNAK | AHNAK nucleoprotein | -2.94039 |
| TMOD2 | tropomodulin 2 (neuronal) | -2.8912 |
| ZFHX4 | zinc finger homeobox 4 | -2.85493 |
| PLXNC1 | plexin C1 | -2.84405 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -2.83109 |
| IL17RD | interleukin 17 receptor D | -2.76423 |
| PRUNE2 | prune homolog 2 (Drosophila) | -2.7306 |
| NTM | neurotrimin | -2.71929 |
| NRXN3 | neurexin 3 | -2.67044 |
| RNMT | RNA (guanine-7-) methyltransferase | -2.66911 |
| SH3RF3 | SH3 domain containing ring finger 3 | -2.63471 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | -2.6214 |
| SCN5A | sodium channel, voltage gated, type V alpha subunit | -2.61212 |
| RRM2 | ribonucleotide reductase M2 | -2.61212 |
| TMEM2 | transmembrane protein 2 | -2.60812 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -2.54219 |
| RND3 | Rho family GTPase 3 | -2.49497 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -2.47798 |
| THBS2 | thrombospondin 2 | -2.45792 |
| SAMD5 | sterile alpha motif domain containing 5 | -2.45792 |
| ITGB4 | integrin, beta 4 | -2.45635 |
| RHOB | ras homolog family member B | -2.39927 |
| H1F0 | H1 histone family, member 0 | -2.35115 |
| ACKR3 | atypical chemokine receptor 3 | -2.34002 |
| NFIB | nuclear factor I/B | -2.30981 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -2.26029 |
| RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1 | -2.24982 |
| CYTH3 | cytohesin 3 | -2.19677 |
| CLMP | CXADR-like membrane protein | -2.17624 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -2.15508 |
| BCR | breakpoint cluster region | -2.11035 |
| FAM129A | family with sequence similarity 129, member A | -2.09446 |
| SDPR | serum deprivation response | -2.09286 |
| LAMA3 | laminin, alpha 3 | -2.04725 |
| DSC2 | desmocollin 2 | -2.03309 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -2.01912 |
| RAB8B | RAB8B, member RAS oncogene family | -2.00672 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -1.94339 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -1.92432 |
| GAA | glucosidase, alpha; acid | -1.9101 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -1.83097 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 | -1.81183 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -1.80379 |
| HSPG2 | heparan sulfate proteoglycan 2 | -1.78892 |
| PLXNA3 | plexin A3 | -1.78724 |
| RASEF | RAS and EF-hand domain containing | -1.78724 |
| BMP4 | bone morphogenetic protein 4 | -1.7747 |
| MGLL | monoglyceride lipase | -1.77286 |
| EGFR | epidermal growth factor receptor | -1.74794 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -1.71341 |
| CNTNAP1 | contactin associated protein 1 | -1.70244 |
| LOX | lysyl oxidase | -1.68988 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -1.67454 |
| TRPS1 | trichorhinophalangeal syndrome I | -1.66743 |
