Perturb_3016_KD_SNHG1_SRP313438 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting SNHG1 in carboplatin resistance retinoblastoma cell line Weri-RB1/CRP cell line (Study accession: SRP313438) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_3016_KD_SNHG1_SRP313438 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
FGF2 fibroblast growth factor 2 (basic) 20.0
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 20.0
SNAP25 synaptosomal-associated protein, 25kDa 20.0
TOB1 transducer of ERBB2, 1 20.0
TFPI2 tissue factor pathway inhibitor 2 20.0
HEXIM1 hexamethylene bis-acetamide inducible 1 20.0
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 20.0
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 20.0
MUC5B mucin 5B, oligomeric mucus/gel-forming 20.0
LRRC59 leucine rich repeat containing 59 20.0
TUBB4B tubulin, beta 4B class IVb 20.0
CXCL5 chemokine (C-X-C motif) ligand 5 20.0
MKI67 marker of proliferation Ki-67 20.0
TACC2 transforming, acidic coiled-coil containing protein 2 20.0
HACD3 3-hydroxyacyl-CoA dehydratase 3 20.0
STEAP2 STEAP family member 2, metalloreductase 20.0
FNDC3A fibronectin type III domain containing 3A 20.0
TTC5 tetratricopeptide repeat domain 5 20.0
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 20.0
C1S complement component 1, s subcomponent 20.0
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 20.0
MAGED1 melanoma antigen family D1 20.0
TNS4 tensin 4 20.0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 20.0
CCL5 chemokine (C-C motif) ligand 5 20.0
MCM7 minichromosome maintenance complex component 7 20.0
MRC2 mannose receptor, C type 2 20.0
CCND1 cyclin D1 20.0
CCND3 cyclin D3 20.0
HSPA4 heat shock 70kDa protein 4 20.0
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 20.0
STMN1 stathmin 1 20.0
ELOVL5 ELOVL fatty acid elongase 5 20.0
ZC3HAV1 zinc finger CCCH-type, antiviral 1 20.0
AHCYL2 adenosylhomocysteinase-like 2 20.0
GRAMD1B GRAM domain containing 1B 20.0
CNTN1 contactin 1 20.0
FURIN furin (paired basic amino acid cleaving enzyme) 20.0
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 20.0
MCM4 minichromosome maintenance complex component 4 20.0
MYRF myelin regulatory factor 20.0
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 20.0
COL7A1 collagen, type VII, alpha 1 20.0
COL4A2 collagen, type IV, alpha 2 20.0
SMOC1 SPARC related modular calcium binding 1 20.0
NAMPT nicotinamide phosphoribosyltransferase 20.0
CLIP2 CAP-GLY domain containing linker protein 2 20.0
ADGRG1 adhesion G protein-coupled receptor G1 20.0
MARS methionyl-tRNA synthetase 20.0
VCAN versican 20.0
CALM1 calmodulin 1 (phosphorylase kinase, delta) 20.0
ANKRD52 ankyrin repeat domain 52 20.0
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 20.0
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 20.0
RANGAP1 Ran GTPase activating protein 1 20.0
CBX6 chromobox homolog 6 20.0
USB1 U6 snRNA biogenesis 1 20.0
FASN fatty acid synthase 20.0
HSPG2 heparan sulfate proteoglycan 2 20.0
LCN2 lipocalin 2 20.0
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 20.0
MYO15B myosin XVB 20.0
FANCI Fanconi anemia, complementation group I 20.0
STIP1 stress-induced phosphoprotein 1 20.0
PDK4 pyruvate dehydrogenase kinase, isozyme 4 20.0
GHITM growth hormone inducible transmembrane protein 20.0
PCNA proliferating cell nuclear antigen 20.0
ACACA acetyl-CoA carboxylase alpha 20.0
HLA-A major histocompatibility complex, class I, A 20.0
SLC25A39 solute carrier family 25, member 39 20.0
GPC1 glypican 1 20.0
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 20.0
CALU calumenin 20.0
RAB27B RAB27B, member RAS oncogene family 20.0
PCNXL3 pecanex-like 3 (Drosophila) 20.0
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 20.0
MEGF8 multiple EGF-like-domains 8 20.0
SAE1 SUMO1 activating enzyme subunit 1 20.0
ANXA1 annexin A1 20.0
PYGB phosphorylase, glycogen; brain 20.0
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 20.0
KIF1C kinesin family member 1C 20.0
PSAT1 phosphoserine aminotransferase 1 20.0
NOLC1 nucleolar and coiled-body phosphoprotein 1 20.0
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 20.0
RCN2 reticulocalbin 2, EF-hand calcium binding domain 20.0
WARS tryptophanyl-tRNA synthetase 20.0
IRF2BPL interferon regulatory factor 2 binding protein-like 20.0
PAPPA pregnancy-associated plasma protein A, pappalysin 1 20.0
PLAU plasminogen activator, urokinase 20.0
TXNIP thioredoxin interacting protein 20.0
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 20.0
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 20.0
RPA1 replication protein A1, 70kDa 20.0
SIGMAR1 sigma non-opioid intracellular receptor 1 20.0
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 20.0
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 20.0
TMPO thymopoietin 20.0
PAQR5 progestin and adipoQ receptor family member V 20.0
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 20.0

decreased expression

Symbol Name Standardized Value
TBC1D22A TBC1 domain family, member 22A -20.0
EPC1 enhancer of polycomb homolog 1 (Drosophila) -20.0
ATXN1 ataxin 1 -20.0
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) -20.0
MUC1 mucin 1, cell surface associated -20.0
PLAGL1 pleiomorphic adenoma gene-like 1 -20.0
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -20.0
FAM210A family with sequence similarity 210, member A -20.0
IL4I1 interleukin 4 induced 1 -20.0
LOX lysyl oxidase -20.0
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -20.0
EPC2 enhancer of polycomb homolog 2 (Drosophila) -20.0
ATG14 autophagy related 14 -20.0
MATR3 matrin 3 -20.0
PER2 period circadian clock 2 -20.0
WDR54 WD repeat domain 54 -20.0
CA9 carbonic anhydrase IX -20.0
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -20.0
RBM7 RNA binding motif protein 7 -20.0
ALPK2 alpha-kinase 2 -20.0
LBH limb bud and heart development -20.0
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -20.0
CTGF connective tissue growth factor -20.0
AGTPBP1 ATP/GTP binding protein 1 -20.0
SEC61G Sec61 gamma subunit -20.0
NKX3-1 NK3 homeobox 1 -20.0
KAT6B K(lysine) acetyltransferase 6B -20.0
KDM4C lysine (K)-specific demethylase 4C -20.0
THBS1 thrombospondin 1 -20.0
HSPA6 heat shock 70kDa protein 6 (HSP70B') -20.0
TMEM47 transmembrane protein 47 -20.0
SH3D21 SH3 domain containing 21 -20.0
DUSP8 dual specificity phosphatase 8 -20.0
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -20.0
PHF11 PHD finger protein 11 -20.0
GBP2 guanylate binding protein 2, interferon-inducible -20.0
INSIG2 insulin induced gene 2 -20.0
OPN3 opsin 3 -20.0
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -20.0
AZI2 5-azacytidine induced 2 -20.0
SECTM1 secreted and transmembrane 1 -20.0
IDO1 indoleamine 2,3-dioxygenase 1 -20.0
SIM2 single-minded family bHLH transcription factor 2 -20.0
TLR3 toll-like receptor 3 -20.0
MOB3A MOB kinase activator 3A -20.0
RSRP1 arginine/serine-rich protein 1 -20.0
NR0B1 nuclear receptor subfamily 0, group B, member 1 -20.0
BARX1 BARX homeobox 1 -20.0
SPAG4 sperm associated antigen 4 -20.0
LOC128125822 uncharacterized LOC128125822 -20.0
UPK1A uroplakin 1A -20.0
SLC45A1 solute carrier family 45, member 1 -20.0
DRD1 dopamine receptor D1 -20.0
C11ORF96 chromosome 11 open reading frame 96 -20.0
DAPK3 death-associated protein kinase 3 -20.0
EDN2 endothelin 2 -20.0
C7ORF60 chromosome 7 open reading frame 60 -20.0
ZNF703 zinc finger protein 703 -20.0
RAB40C RAB40C, member RAS oncogene family -20.0
RFX1 regulatory factor X, 1 (influences HLA class II expression) -20.0
GAL3ST1 galactose-3-O-sulfotransferase 1 -20.0
SIAH2 siah E3 ubiquitin protein ligase 2 -20.0
SIAH1 siah E3 ubiquitin protein ligase 1 -20.0
PLA1A phospholipase A1 member A -20.0
FOXN3 forkhead box N3 -20.0
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -20.0
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -20.0
RIMKLA ribosomal modification protein rimK-like family member A -20.0
ATP10A ATPase, class V, type 10A -20.0
DOCK7 dedicator of cytokinesis 7 -20.0
THEMIS2 thymocyte selection associated family member 2 -20.0
GADD45B growth arrest and DNA-damage-inducible, beta -20.0
FBXO46 F-box protein 46 -20.0
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -20.0
C8ORF58 chromosome 8 open reading frame 58 -20.0
CLK4 CDC-like kinase 4 -20.0
TET2 tet methylcytosine dioxygenase 2 -20.0
ZFX zinc finger protein, X-linked -20.0
EYA2 EYA transcriptional coactivator and phosphatase 2 -20.0
TMEM184A transmembrane protein 184A -20.0
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) -20.0
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -20.0
PRDM1 PR domain containing 1, with ZNF domain -20.0
DPYSL4 dihydropyrimidinase-like 4 -20.0
CHML choroideremia-like (Rab escort protein 2) -20.0
BMP6 bone morphogenetic protein 6 -20.0
CLEC2B C-type lectin domain family 2, member B -20.0
NLRP6 NLR family, pyrin domain containing 6 -20.0
IL18BP interleukin 18 binding protein -20.0
HSF4 heat shock transcription factor 4 -20.0
ROR1 receptor tyrosine kinase-like orphan receptor 1 -20.0
FOSB FBJ murine osteosarcoma viral oncogene homolog B -20.0
IL1RAP interleukin 1 receptor accessory protein -20.0
TBC1D25 TBC1 domain family, member 25 -20.0
KCTD11 potassium channel tetramerization domain containing 11 -20.0
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -20.0
TMEM45A transmembrane protein 45A -20.0
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -20.0
POU5F1 POU class 5 homeobox 1 -20.0
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -20.0