| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting CNOT1 in cervical cancer cell HeLa cell line (Study accession: SRP337789) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_3522_KD_CNOT1_SRP337789 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | 20.0 |
| CCDC18 | coiled-coil domain containing 18 | 20.0 |
| RBBP4 | retinoblastoma binding protein 4 | 20.0 |
| DNM2 | dynamin 2 | 20.0 |
| ARSG | arylsulfatase G | 20.0 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | 20.0 |
| BRD9 | bromodomain containing 9 | 20.0 |
| GLOD4 | glyoxalase domain containing 4 | 20.0 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 20.0 |
| CENPP | centromere protein P | 20.0 |
| TMEM184A | transmembrane protein 184A | 20.0 |
| TMEM120B | transmembrane protein 120B | 20.0 |
| THEM5 | thioesterase superfamily member 5 | 20.0 |
| SRRD | SRR1 domain containing | 20.0 |
| TRPM3 | transient receptor potential cation channel, subfamily M, member 3 | 20.0 |
| CEP72 | centrosomal protein 72kDa | 20.0 |
| TMC5 | transmembrane channel-like 5 | 20.0 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 19.699 |
| CDON | cell adhesion associated, oncogene regulated | 18.9586 |
| C1ORF122 | chromosome 1 open reading frame 122 | 18.7447 |
| HOOK2 | hook microtubule-tethering protein 2 | 18.301 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 18.1487 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | 17.7959 |
| CUL4A | cullin 4A | 17.3768 |
| SPAG1 | sperm associated antigen 1 | 17.1979 |
| OAZ3 | ornithine decarboxylase antizyme 3 | 17.1739 |
| TUBB6 | tubulin, beta 6 class V | 17.118 |
| ZFC3H1 | zinc finger, C3H1-type containing | 16.329 |
| FMNL1 | formin-like 1 | 15.8173 |
| CIRBP | cold inducible RNA binding protein | 15.3571 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | 15.0829 |
| UFSP2 | UFM1-specific peptidase 2 | 14.5831 |
| ZACN | zinc activated ligand-gated ion channel | 14.5479 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 14.4191 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 14.3214 |
| LAMA5 | laminin, alpha 5 | 13.949 |
| MEA1 | male-enhanced antigen 1 | 13.8531 |
| CRYZ | crystallin, zeta (quinone reductase) | 13.8355 |
| PAQR3 | progestin and adipoQ receptor family member III | 13.5489 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 13.5362 |
| FKBP15 | FK506 binding protein 15, 133kDa | 13.4075 |
| C15ORF40 | chromosome 15 open reading frame 40 | 13.2609 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | 13.2496 |
| FUZ | fuzzy planar cell polarity protein | 13.1448 |
| RNASEH2C | ribonuclease H2, subunit C | 12.9862 |
| C6ORF120 | chromosome 6 open reading frame 120 | 12.9661 |
| TXNDC17 | thioredoxin domain containing 17 | 12.6649 |
| NDUFC1 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | 12.62 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 12.305 |
| TMEM50B | transmembrane protein 50B | 12.2604 |
| PCID2 | PCI domain containing 2 | 11.7717 |
| FAS | Fas cell surface death receptor | 11.6475 |
| DEGS2 | delta(4)-desaturase, sphingolipid 2 | 11.4208 |
| CFL1 | cofilin 1 (non-muscle) | 11.1764 |
| NRDE2 | NRDE-2, necessary for RNA interference, domain containing | 10.61 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 10.5547 |
| ARL10 | ADP-ribosylation factor-like 10 | 10.4668 |
| DENND2A | DENN/MADD domain containing 2A | 10.4609 |
| TP53I13 | tumor protein p53 inducible protein 13 | 10.3515 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 10.3195 |
| ELMOD3 | ELMO/CED-12 domain containing 3 | 10.3039 |
| EME1 | essential meiotic structure-specific endonuclease 1 | 10.0909 |
| MTCL1 | microtubule crosslinking factor 1 | 10.0552 |
| SLC5A10 | solute carrier family 5 (sodium/sugar cotransporter), member 10 | 9.79248 |
| TVP23A | trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) | 9.79064 |
| NCAPH2 | non-SMC condensin II complex, subunit H2 | 9.52958 |
| SLC35A5 | solute carrier family 35, member A5 | 9.46426 |
| TTI2 | TELO2 interacting protein 2 | 9.43912 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 9.43609 |
| NR1H3 | nuclear receptor subfamily 1, group H, member 3 | 9.31826 |
| MAPK15 | mitogen-activated protein kinase 15 | 9.27783 |
| COG8 | component of oligomeric golgi complex 8 | 9.17141 |
| ZFAND1 | zinc finger, AN1-type domain 1 | 9.13093 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 9.06649 |
| TCP1 | t-complex 1 | 9.00785 |
| TRIM14 | tripartite motif containing 14 | 8.90068 |
| TMEM79 | transmembrane protein 79 | 8.82841 |
| EML2 | echinoderm microtubule associated protein like 2 | 8.608 |
| TRRAP | transformation/transcription domain-associated protein | 8.59691 |
| TFIP11 | tuftelin interacting protein 11 | 8.59691 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 8.54211 |
| CCDC42B | coiled-coil domain containing 42B | 8.50441 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 8.44519 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | 8.43083 |
| ACTR3C | ARP3 actin-related protein 3 homolog C (yeast) | 8.42083 |
| KAT5 | K(lysine) acetyltransferase 5 | 8.31401 |
| ICAM3 | intercellular adhesion molecule 3 | 8.31179 |
| PDZD7 | PDZ domain containing 7 | 8.3017 |
| FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 8.1685 |
| COG5 | component of oligomeric golgi complex 5 | 8.1005 |
| CYB561D2 | cytochrome b561 family, member D2 | 7.97831 |
| C18ORF8 | chromosome 18 open reading frame 8 | 7.96375 |
| P4HA3 | prolyl 4-hydroxylase, alpha polypeptide III | 7.95423 |
| CARM1 | coactivator-associated arginine methyltransferase 1 | 7.84469 |
| FAM222B | family with sequence similarity 222, member B | 7.84325 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B | 7.73826 |
| NR2C2AP | nuclear receptor 2C2-associated protein | 7.67774 |
| SARM1 | sterile alpha and TIR motif containing 1 | 7.64599 |
| BCCIP | BRCA2 and CDKN1A interacting protein | 7.47366 |
| STS | steroid sulfatase (microsomal), isozyme S | 7.44678 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LRRC75A | leucine rich repeat containing 75A | -20.0 |
| MAP3K15 | mitogen-activated protein kinase kinase kinase 15 | -20.0 |
| STK24 | serine/threonine kinase 24 | -20.0 |
| SH3PXD2A | SH3 and PX domains 2A | -20.0 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -20.0 |
| SETD6 | SET domain containing 6 | -20.0 |
| KRT8 | keratin 8, type II | -18.6576 |
| SYT15 | synaptotagmin XV | -16.9076 |
| EPB41L4A | erythrocyte membrane protein band 4.1 like 4A | -15.8134 |
| LDLRAD2 | low density lipoprotein receptor class A domain containing 2 | -14.7165 |
| PKD2L2 | polycystic kidney disease 2-like 2 | -14.6369 |
| MCMDC2 | minichromosome maintenance domain containing 2 | -14.0051 |
| DDTL | D-dopachrome tautomerase-like | -13.9404 |
| RNPEP | arginyl aminopeptidase (aminopeptidase B) | -13.011 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -12.4701 |
| SPRN | shadow of prion protein homolog (zebrafish) | -11.7906 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -11.3245 |
| CLU | clusterin | -11.1776 |
| HIST1H4I | histone cluster 1, H4i | -11.0078 |
| BRD7 | bromodomain containing 7 | -10.7464 |
| LINC00094 | long intergenic non-protein coding RNA 94 | -10.6584 |
| PZP | pregnancy-zone protein | -10.5533 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | -10.2372 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -9.89069 |
| ADRM1 | adhesion regulating molecule 1 | -9.87198 |
| USP34 | ubiquitin specific peptidase 34 | -9.31826 |
| FAM57A | family with sequence similarity 57, member A | -9.0967 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | -9.00475 |
| BEST1 | bestrophin 1 | -8.8817 |
| SRPK3 | SRSF protein kinase 3 | -8.62631 |
| TSC2 | tuberous sclerosis 2 | -8.55693 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -8.52612 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -8.27589 |
| SH3D19 | SH3 domain containing 19 | -8.21171 |
| STK17A | serine/threonine kinase 17a | -8.13851 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -8.11832 |
| MTERF4 | mitochondrial transcription termination factor 4 | -8.04409 |
| CLCC1 | chloride channel CLIC-like 1 | -7.98254 |
| CDIP1 | cell death-inducing p53 target 1 | -7.89376 |
| KIF7 | kinesin family member 7 | -7.72886 |
| ATG7 | autophagy related 7 | -7.72792 |
| PKM | pyruvate kinase, muscle | -7.67212 |
| SGCE | sarcoglycan, epsilon | -7.62791 |
| UBXN6 | UBX domain protein 6 | -7.61858 |
| DNHD1 | dynein heavy chain domain 1 | -7.61737 |
| F8 | coagulation factor VIII, procoagulant component | -7.57102 |
| C16ORF62 | chromosome 16 open reading frame 62 | -7.55527 |
| TPT1 | tumor protein, translationally-controlled 1 | -7.54455 |
| RPL3 | ribosomal protein L3 | -7.21957 |
| CD37 | CD37 molecule | -7.21074 |
| AHNAK | AHNAK nucleoprotein | -7.10687 |
| LYRM5 | LYR motif containing 5 | -7.01282 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | -6.89378 |
| SMPD4 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) | -6.89378 |
| CCDC78 | coiled-coil domain containing 78 | -6.74266 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -6.69511 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -6.69036 |
| CTNS | cystinosin, lysosomal cystine transporter | -6.68057 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -6.52465 |
| GSE1 | Gse1 coiled-coil protein | -6.47323 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | -6.37662 |
| PTMA | prothymosin, alpha | -6.37403 |
| HOXA10 | homeobox A10 | -6.33332 |
| HMHA1 | histocompatibility (minor) HA-1 | -6.16356 |
| SMPD3 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | -6.05925 |
| HPS3 | Hermansky-Pudlak syndrome 3 | -6.03666 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | -6.01803 |
| TPPP | tubulin polymerization promoting protein | -5.98126 |
| STAB1 | stabilin 1 | -5.87035 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -5.80375 |
| CRMP1 | collapsin response mediator protein 1 | -5.73707 |
| C12ORF73 | chromosome 12 open reading frame 73 | -5.67655 |
| CEP295 | centrosomal protein 295kDa | -5.67204 |
| GNAS | GNAS complex locus | -5.53373 |
| APP | amyloid beta (A4) precursor protein | -5.53102 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | -5.39161 |
| RPS14 | ribosomal protein S14 | -5.37146 |
| WDR38 | WD repeat domain 38 | -5.11315 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -5.03904 |
| MPI | mannose phosphate isomerase | -5.03779 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -4.9926 |
| C9ORF172 | chromosome 9 open reading frame 172 | -4.94142 |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | -4.92563 |
| ABCB9 | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | -4.78681 |
| MTIF3 | mitochondrial translational initiation factor 3 | -4.69721 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -4.65921 |
| RPL11 | ribosomal protein L11 | -4.6582 |
| RABL6 | RAB, member RAS oncogene family-like 6 | -4.63936 |
| CEMP1 | cementum protein 1 | -4.51832 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -4.51094 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -4.50795 |
| ZNF132 | zinc finger protein 132 | -4.48053 |
| RPS2 | ribosomal protein S2 | -4.45409 |
| AIMP2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | -4.44762 |
| ACBD6 | acyl-CoA binding domain containing 6 | -4.44253 |
| NNAT | neuronatin | -4.42782 |
| RAB26 | RAB26, member RAS oncogene family | -4.40329 |
| BTBD2 | BTB (POZ) domain containing 2 | -4.3939 |
| NARFL | nuclear prelamin A recognition factor-like | -4.37677 |
| GDF9 | growth differentiation factor 9 | -4.37121 |
