| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting NOTCH3 in cholangiocarcinoma cell CCLP1 cell line (Study accession: SRP174604) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_3562_KD_NOTCH3_SRP174604 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM120B | transmembrane protein 120B | 20.0 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | 20.0 |
| SZT2 | seizure threshold 2 homolog (mouse) | 20.0 |
| ATP8B4 | ATPase, class I, type 8B, member 4 | 20.0 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | 20.0 |
| GGACT | gamma-glutamylamine cyclotransferase | 20.0 |
| DNAJC17 | DnaJ (Hsp40) homolog, subfamily C, member 17 | 20.0 |
| HDDC2 | HD domain containing 2 | 20.0 |
| BEST1 | bestrophin 1 | 19.5229 |
| CLDN5 | claudin 5 | 19.5229 |
| KRT8 | keratin 8, type II | 18.8239 |
| DEAF1 | DEAF1 transcription factor | 17.2111 |
| FKRP | fukutin related protein | 16.0852 |
| SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | 15.9512 |
| CLVS1 | clavesin 1 | 15.7883 |
| CARM1 | coactivator-associated arginine methyltransferase 1 | 15.3526 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 14.7544 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 14.6991 |
| SPRYD4 | SPRY domain containing 4 | 14.5297 |
| HOXA10 | homeobox A10 | 14.4329 |
| MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | 14.0743 |
| ZFAND1 | zinc finger, AN1-type domain 1 | 13.8008 |
| NME7 | NME/NM23 family member 7 | 13.6533 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 13.3074 |
| AFAP1 | actin filament associated protein 1 | 13.2802 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 13.1387 |
| SH3D19 | SH3 domain containing 19 | 12.9755 |
| PRR29 | proline rich 29 | 12.8799 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 12.8087 |
| EME2 | essential meiotic structure-specific endonuclease subunit 2 | 12.8023 |
| PCNXL4 | pecanex-like 4 (Drosophila) | 12.6064 |
| DAZAP2 | DAZ associated protein 2 | 12.5807 |
| DOK7 | docking protein 7 | 12.5709 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 12.0664 |
| RECQL4 | RecQ protein-like 4 | 12.017 |
| HEXB | hexosaminidase B (beta polypeptide) | 11.9523 |
| TMEM200B | transmembrane protein 200B | 11.8308 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | 11.5337 |
| LRRC24 | leucine rich repeat containing 24 | 11.432 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 10.9395 |
| HEATR1 | HEAT repeat containing 1 | 10.8741 |
| TTC7A | tetratricopeptide repeat domain 7A | 10.6611 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 10.5191 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | 10.4464 |
| PAQR3 | progestin and adipoQ receptor family member III | 9.96797 |
| AATK | apoptosis-associated tyrosine kinase | 9.94473 |
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 9.92608 |
| PINK1 | PTEN induced putative kinase 1 | 9.69206 |
| SUN2 | Sad1 and UNC84 domain containing 2 | 9.58785 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 9.486 |
| C12ORF73 | chromosome 12 open reading frame 73 | 9.3343 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 9.05933 |
| BOP1 | block of proliferation 1 | 8.76475 |
| FAM71E1 | family with sequence similarity 71, member E1 | 8.67475 |
| ANAPC10 | anaphase promoting complex subunit 10 | 8.63133 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 8.55829 |
| WRAP53 | WD repeat containing, antisense to TP53 | 8.4895 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 8.30335 |
| LYPD1 | LY6/PLAUR domain containing 1 | 8.24292 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 8.14333 |
| MESDC2 | mesoderm development candidate 2 | 8.12687 |
| METRN | meteorin, glial cell differentiation regulator | 7.8161 |
| NDRG4 | NDRG family member 4 | 7.63392 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 7.60849 |
| RHOB | ras homolog family member B | 7.5117 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 7.31562 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 7.11312 |
| BRD7 | bromodomain containing 7 | 7.09754 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 6.96563 |
| JMJD8 | jumonji domain containing 8 | 6.95201 |
| ZNF575 | zinc finger protein 575 | 6.88356 |
| CCDC78 | coiled-coil domain containing 78 | 6.82516 |
| PRRT3 | proline-rich transmembrane protein 3 | 6.7598 |
| SPTB | spectrin, beta, erythrocytic | 6.72614 |
| SOX9 | SRY (sex determining region Y)-box 9 | 6.64685 |
| CSNK1D | casein kinase 1, delta | 6.62306 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 6.4922 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 6.39287 |
| MARVELD3 | MARVEL domain containing 3 | 6.33287 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | 6.27851 |
| C11ORF48 | 6.21236 | |
| TCP1 | t-complex 1 | 6.15876 |
| RRBP1 | ribosome binding protein 1 | 6.05849 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 5.95804 |
| BMP8A | bone morphogenetic protein 8a | 5.88309 |
| FLNA | filamin A, alpha | 5.87044 |
| OTUD4 | OTU deubiquitinase 4 | 5.76651 |
| ZNHIT2 | zinc finger, HIT-type containing 2 | 5.70054 |
| MMP24-AS1 | MMP24 antisense RNA 1 | 5.56337 |
| PLEC | plectin | 5.48977 |
| TUBGCP2 | tubulin, gamma complex associated protein 2 | 5.45956 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 5.42775 |
| FAT1 | FAT atypical cadherin 1 | 5.39863 |
| MED11 | mediator complex subunit 11 | 5.37785 |
| SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | 5.26425 |
| PLK1 | polo-like kinase 1 | 5.25164 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 5.07636 |
| USP34 | ubiquitin specific peptidase 34 | 5.03676 |
| FTH1 | ferritin, heavy polypeptide 1 | 5.01649 |
| SLC5A10 | solute carrier family 5 (sodium/sugar cotransporter), member 10 | 4.93303 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -20.0 |
| SMIM19 | small integral membrane protein 19 | -19.1549 |
| HOXB3 | homeobox B3 | -17.6676 |
| APC2 | adenomatosis polyposis coli 2 | -17.6108 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -17.2782 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -16.8713 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -16.8351 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -15.1889 |
| FAS | Fas cell surface death receptor | -15.1069 |
| SSC4D | scavenger receptor cysteine rich family, 4 domains | -14.4329 |
| EDN1 | endothelin 1 | -13.0804 |
| SLFNL1 | schlafen-like 1 | -12.9886 |
| FAM134C | family with sequence similarity 134, member C | -12.9799 |
| PLD4 | phospholipase D family, member 4 | -12.9639 |
| SH3D21 | SH3 domain containing 21 | -12.4733 |
| SH3PXD2A | SH3 and PX domains 2A | -12.3014 |
| VIM | vimentin | -12.0262 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -11.0513 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -10.457 |
| RINT1 | RAD50 interactor 1 | -10.3585 |
| SIAE | sialic acid acetylesterase | -9.96183 |
| MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | -9.89459 |
| PQBP1 | polyglutamine binding protein 1 | -9.82714 |
| CARD9 | caspase recruitment domain family, member 9 | -9.48467 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -9.39882 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | -9.1666 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -8.65483 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -8.35266 |
| SPDYE3 | speedy/RINGO cell cycle regulator family member E3 | -8.35217 |
| FLNC | filamin C, gamma | -8.32757 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -8.31444 |
| CD3EAP | CD3e molecule, epsilon associated protein | -8.15191 |
| RAPSN | receptor-associated protein of the synapse | -8.03012 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -7.96734 |
| PCBP2 | poly(rC) binding protein 2 | -7.74711 |
| MAP7D1 | MAP7 domain containing 1 | -7.69538 |
| GBX2 | gastrulation brain homeobox 2 | -7.66457 |
| CTXN2 | cortexin 2 | -7.59183 |
| ERCC1 | excision repair cross-complementation group 1 | -7.46526 |
| SLC24A5 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 | -7.46526 |
| MRPL34 | mitochondrial ribosomal protein L34 | -7.39757 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -7.35751 |
| LOC122455342 | testis-specific serine/proline-rich protein | -7.30378 |
| HMOX1 | heme oxygenase 1 | -7.03933 |
| TRIM37 | tripartite motif containing 37 | -6.84074 |
| GLIPR1 | GLI pathogenesis-related 1 | -6.7995 |
| ACKR2 | atypical chemokine receptor 2 | -6.74119 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -6.64685 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | -6.64669 |
| FAHD1 | fumarylacetoacetate hydrolase domain containing 1 | -6.60424 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -6.27437 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | -6.20667 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -6.16217 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -6.16032 |
| EFCAB5 | EF-hand calcium binding domain 5 | -6.07108 |
| TMEM50B | transmembrane protein 50B | -5.96951 |
| NKX6-2 | NK6 homeobox 2 | -5.96616 |
| PCGF1 | polycomb group ring finger 1 | -5.88645 |
| ZNF497 | zinc finger protein 497 | -5.87345 |
| BTD | biotinidase | -5.86999 |
| PLTP | phospholipid transfer protein | -5.77411 |
| TTN | titin | -5.73649 |
| HYI | hydroxypyruvate isomerase (putative) | -5.5877 |
| ISYNA1 | inositol-3-phosphate synthase 1 | -5.5125 |
| CCDC85A | coiled-coil domain containing 85A | -5.37208 |
| RPL36 | ribosomal protein L36 | -5.35484 |
| PGF | placental growth factor | -5.18366 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | -5.17378 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | -5.16795 |
| ARSG | arylsulfatase G | -5.07497 |
| CNOT7 | CCR4-NOT transcription complex, subunit 7 | -5.03301 |
| BRD9 | bromodomain containing 9 | -4.93145 |
| DPP3 | dipeptidyl-peptidase 3 | -4.87468 |
| MFSD6 | major facilitator superfamily domain containing 6 | -4.84906 |
| CFAP126 | cilia and flagella associated protein 126 | -4.808 |
| OGFRL1 | opioid growth factor receptor-like 1 | -4.80084 |
| CCDC103 | coiled-coil domain containing 103 | -4.79472 |
| SGCE | sarcoglycan, epsilon | -4.79012 |
| TRIO | trio Rho guanine nucleotide exchange factor | -4.76514 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -4.72063 |
| ZNF529 | zinc finger protein 529 | -4.62323 |
| TMPRSS9 | transmembrane protease, serine 9 | -4.60735 |
| PDAP1 | PDGFA associated protein 1 | -4.60562 |
| FGFR1 | fibroblast growth factor receptor 1 | -4.60175 |
| RANGRF | RAN guanine nucleotide release factor | -4.50603 |
| C19ORF71 | chromosome 19 open reading frame 71 | -4.50603 |
| GLRX2 | glutaredoxin 2 | -4.47236 |
| ABHD14A | abhydrolase domain containing 14A | -4.47042 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | -4.45519 |
| LONP1 | lon peptidase 1, mitochondrial | -4.43431 |
| STRADB | STE20-related kinase adaptor beta | -4.41806 |
| C22ORF23 | chromosome 22 open reading frame 23 | -4.40866 |
| PCDHA10 | protocadherin alpha 10 | -4.37986 |
| MFSD12 | major facilitator superfamily domain containing 12 | -4.37029 |
| C14ORF79 | chromosome 14 open reading frame 79 | -4.32696 |
| NEK8 | NIMA-related kinase 8 | -4.31376 |
| PLIN4 | perilipin 4 | -4.26681 |
| CLDN10 | claudin 10 | -4.26396 |
| CNTD1 | cyclin N-terminal domain containing 1 | -4.20233 |
| CDH23 | cadherin-related 23 | -4.19993 |
