Perturb_3609_KO_BCL7A_SRP127343 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting BCL7A in chronic myeloid leukemia cell HAP1 cell line (Study accession: SRP127343) (PerturbAtlas)
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Genes

43 genes differentially expressed following the Perturb_3609_KO_BCL7A_SRP127343 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
FAM166A family with sequence similarity 166, member A 20.0
LARP7 La ribonucleoprotein domain family, member 7 20.0
GLB1L3 galactosidase, beta 1-like 3 10.572
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 9.45358
SLC19A1 solute carrier family 19 (folate transporter), member 1 7.90244
KHK ketohexokinase (fructokinase) 7.89137
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 7.69011
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 6.41304
ZFAND1 zinc finger, AN1-type domain 1 6.29703
KLF4 Kruppel-like factor 4 (gut) 5.89637
ACAD8 acyl-CoA dehydrogenase family, member 8 5.73843
UNC45A unc-45 homolog A (C. elegans) 5.6661
MMP24-AS1 MMP24 antisense RNA 1 4.95426
PPP1R12B protein phosphatase 1, regulatory subunit 12B 4.90437
PCSK7 proprotein convertase subtilisin/kexin type 7 4.38664
AEBP1 AE binding protein 1 4.28038
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 3.82043
CXCR5 chemokine (C-X-C motif) receptor 5 3.4166
NT5C2 5'-nucleotidase, cytosolic II 3.10263
IL17D interleukin 17D 3.00233
EPB41 erythrocyte membrane protein band 4.1 2.98692
ADGRF3 adhesion G protein-coupled receptor F3 2.9427
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 2.79673
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 2.21812
CD37 CD37 molecule 2.12607
SMIM4 small integral membrane protein 4 1.89487
C9ORF173 chromosome 9 open reading frame 173 1.85746
DNM2 dynamin 2 1.69831
SRFBP1 serum response factor binding protein 1 1.59604
KCNK15 potassium channel, two pore domain subfamily K, member 15 1.58646
ZNF215 zinc finger protein 215 1.52526
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.49818
JMJD4 jumonji domain containing 4 1.33807

decreased expression

Symbol Name Standardized Value
SLC46A1 solute carrier family 46 (folate transporter), member 1 -20.0
HEATR1 HEAT repeat containing 1 -20.0
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -6.41304
HSPG2 heparan sulfate proteoglycan 2 -5.73843
HMGN5 high mobility group nucleosome binding domain 5 -3.30104
INTS8 integrator complex subunit 8 -2.14319
DXO decapping exoribonuclease -1.93879
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 -1.86968
TUBB1 tubulin, beta 1 class VI -1.63112
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -1.37359