| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting NUF2 in clear cell renal cell carcinoma cell 769-P cell line (Study accession: SRP352847) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_3689_KD_NUF2_SRP352847 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHST14 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 | 20.0 |
| TPM4 | tropomyosin 4 | 20.0 |
| PERP | PERP, TP53 apoptosis effector | 20.0 |
| CDK14 | cyclin-dependent kinase 14 | 20.0 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 20.0 |
| TM4SF1 | transmembrane 4 L six family member 1 | 20.0 |
| MESDC2 | mesoderm development candidate 2 | 20.0 |
| ZNF664 | zinc finger protein 664 | 20.0 |
| HABP4 | hyaluronan binding protein 4 | 20.0 |
| ZDHHC16 | zinc finger, DHHC-type containing 16 | 20.0 |
| SETD7 | SET domain containing (lysine methyltransferase) 7 | 20.0 |
| PMP22 | peripheral myelin protein 22 | 20.0 |
| GANAB | glucosidase, alpha; neutral AB | 20.0 |
| THBS1 | thrombospondin 1 | 20.0 |
| TUFT1 | tuftelin 1 | 20.0 |
| ZW10 | zw10 kinetochore protein | 19.699 |
| ATRNL1 | attractin-like 1 | 19.1549 |
| CARD11 | caspase recruitment domain family, member 11 | 18.4559 |
| GLE1 | GLE1 RNA export mediator | 17.4989 |
| MRFAP1 | Morf4 family associated protein 1 | 17.3045 |
| ITGB4 | integrin, beta 4 | 17.2062 |
| OGFR | opioid growth factor receptor | 17.1409 |
| ADAM15 | ADAM metallopeptidase domain 15 | 15.1971 |
| REEP5 | receptor accessory protein 5 | 15.0546 |
| PADI3 | peptidyl arginine deiminase, type III | 14.761 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 14.6609 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 14.6123 |
| SDC2 | syndecan 2 | 14.4575 |
| FAM32A | family with sequence similarity 32, member A | 14.425 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 14.3946 |
| ENSA | endosulfine alpha | 14.1718 |
| BICD2 | bicaudal D homolog 2 (Drosophila) | 13.932 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 13.8587 |
| STX12 | syntaxin 12 | 13.8445 |
| KIF3C | kinesin family member 3C | 13.5598 |
| IFI16 | interferon, gamma-inducible protein 16 | 13.3794 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | 13.1982 |
| PRSS23 | protease, serine, 23 | 12.996 |
| MSRB3 | methionine sulfoxide reductase B3 | 12.7795 |
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | 12.7795 |
| GLI2 | GLI family zinc finger 2 | 12.7746 |
| R3HCC1 | R3H domain and coiled-coil containing 1 | 12.6744 |
| PRDX4 | peroxiredoxin 4 | 12.626 |
| MLF2 | myeloid leukemia factor 2 | 12.5319 |
| COL6A3 | collagen, type VI, alpha 3 | 12.384 |
| DOCK4 | dedicator of cytokinesis 4 | 12.081 |
| WBSCR16 | Williams-Beuren syndrome chromosome region 16 | 11.9842 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 11.8581 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 11.8581 |
| PCNXL3 | pecanex-like 3 (Drosophila) | 11.6832 |
| WBP4 | WW domain binding protein 4 | 11.4572 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 11.3423 |
| AES | amino-terminal enhancer of split | 11.328 |
| DLG5 | discs, large homolog 5 (Drosophila) | 11.328 |
| RNF182 | ring finger protein 182 | 11.328 |
| PLA2G12A | phospholipase A2, group XIIA | 11.2622 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | 11.1928 |
| STX2 | syntaxin 2 | 11.1389 |
| EIF3F | eukaryotic translation initiation factor 3, subunit F | 10.9823 |
| ERO1L | ERO1-like (S. cerevisiae) | 10.9498 |
| ECE1 | endothelin converting enzyme 1 | 10.9375 |
| C9ORF78 | chromosome 9 open reading frame 78 | 10.8869 |
| DENND5A | DENN/MADD domain containing 5A | 10.8396 |
| EXTL3 | exostosin-like glycosyltransferase 3 | 10.6594 |
| KIF1C | kinesin family member 1C | 10.4454 |
| RGS19 | regulator of G-protein signaling 19 | 10.3983 |
| ELFN2 | extracellular leucine-rich repeat and fibronectin type III domain containing 2 | 10.3091 |
| PRMT6 | protein arginine methyltransferase 6 | 10.2204 |
| PITX3 | paired-like homeodomain 3 | 10.0634 |
| RRBP1 | ribosome binding protein 1 | 9.99923 |
| FNBP1 | formin binding protein 1 | 9.97555 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 9.82798 |
| OSBPL5 | oxysterol binding protein-like 5 | 9.8257 |
| DENR | density-regulated protein | 9.74335 |
| TGFA | transforming growth factor, alpha | 9.68679 |
| KLHDC3 | kelch domain containing 3 | 9.64268 |
| MARVELD1 | MARVEL domain containing 1 | 9.57475 |
| C19ORF68 | chromosome 19 open reading frame 68 | 9.46066 |
| NUDCD3 | NudC domain containing 3 | 9.40466 |
| ADAM12 | ADAM metallopeptidase domain 12 | 9.37957 |
| TTC33 | tetratricopeptide repeat domain 33 | 9.32542 |
| MFN1 | mitofusin 1 | 9.23977 |
| FOXP4 | forkhead box P4 | 9.1987 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 9.15368 |
| KIF9 | kinesin family member 9 | 9.03898 |
| ZNF629 | zinc finger protein 629 | 9.03898 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 8.92121 |
| CDK16 | cyclin-dependent kinase 16 | 8.85601 |
| SP100 | SP100 nuclear antigen | 8.79118 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 8.75267 |
| TLK2 | tousled-like kinase 2 | 8.7412 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 | 8.73947 |
| TRIM22 | tripartite motif containing 22 | 8.72841 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | 8.65691 |
| TRAF3 | TNF receptor-associated factor 3 | 8.64723 |
| UNC45A | unc-45 homolog A (C. elegans) | 8.55285 |
| SAMD9L | sterile alpha motif domain containing 9-like | 8.39515 |
| SYNPO | synaptopodin | 8.39515 |
| TRIM5 | tripartite motif containing 5 | 8.39068 |
| DHX58 | DEXH (Asp-Glu-X-His) box polypeptide 58 | 8.37094 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RRAD | Ras-related associated with diabetes | -20.0 |
| HMGA2 | high mobility group AT-hook 2 | -20.0 |
| AGPAT9 | 1-acylglycerol-3-phosphate O-acyltransferase 9 | -20.0 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | -20.0 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -20.0 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -20.0 |
| ABHD2 | abhydrolase domain containing 2 | -20.0 |
| GGT1 | gamma-glutamyltransferase 1 | -18.4815 |
| RBM47 | RNA binding motif protein 47 | -18.3565 |
| SNN | stannin | -16.8778 |
| ARMT1 | acidic residue methyltransferase 1 | -16.618 |
| NEFL | neurofilament, light polypeptide | -15.7623 |
| SORBS1 | sorbin and SH3 domain containing 1 | -15.6929 |
| PRSS8 | protease, serine, 8 | -15.5665 |
| TMEM64 | transmembrane protein 64 | -14.6495 |
| MMD | monocyte to macrophage differentiation-associated | -14.3847 |
| TPRN | taperin | -13.9411 |
| TMEM185B | transmembrane protein 185B | -13.8587 |
| TMEM165 | transmembrane protein 165 | -13.3537 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -13.0322 |
| RHEB | Ras homolog enriched in brain | -12.7891 |
| NEB | nebulin | -12.3342 |
| NID1 | nidogen 1 | -12.313 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | -11.9511 |
| ORAI1 | ORAI calcium release-activated calcium modulator 1 | -11.5773 |
| IL6ST | interleukin 6 signal transducer | -11.4416 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -11.3463 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | -11.2246 |
| SLC25A45 | solute carrier family 25, member 45 | -11.1344 |
| HOOK1 | hook microtubule-tethering protein 1 | -11.1106 |
| METRNL | meteorin, glial cell differentiation regulator-like | -10.9957 |
| SPHK1 | sphingosine kinase 1 | -10.8106 |
| DAGLA | diacylglycerol lipase, alpha | -10.6317 |
| GSKIP | GSK3B interacting protein | -10.434 |
| DUSP5 | dual specificity phosphatase 5 | -10.4154 |
| YEATS4 | YEATS domain containing 4 | -9.95104 |
| SLC35D2 | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 | -9.90638 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -9.66653 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | -9.5905 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | -9.52774 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | -9.31613 |
| HES6 | hes family bHLH transcription factor 6 | -9.30914 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -9.28034 |
| GSR | glutathione reductase | -9.06807 |
| PAPLN | papilin, proteoglycan-like sulfated glycoprotein | -8.8512 |
| ISOC1 | isochorismatase domain containing 1 | -8.72894 |
| CCND1 | cyclin D1 | -8.58969 |
| MEGF9 | multiple EGF-like-domains 9 | -8.3907 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -8.33382 |
| PGM2 | phosphoglucomutase 2 | -8.28207 |
| SLC45A4 | solute carrier family 45, member 4 | -8.28138 |
| BTBD3 | BTB (POZ) domain containing 3 | -8.26495 |
| BMP2K | BMP2 inducible kinase | -8.19065 |
| NNT | nicotinamide nucleotide transhydrogenase | -8.18047 |
| ADCK3 | aarF domain containing kinase 3 | -8.17233 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -8.17233 |
| SNX25 | sorting nexin 25 | -8.06365 |
| STS | steroid sulfatase (microsomal), isozyme S | -8.03219 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -8.02287 |
| FOXN2 | forkhead box N2 | -8.00441 |
| LRRC1 | leucine rich repeat containing 1 | -7.93321 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -7.78752 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | -7.70995 |
| GXYLT1 | glucoside xylosyltransferase 1 | -7.64848 |
| TMED4 | transmembrane emp24 protein transport domain containing 4 | -7.64438 |
| RNF38 | ring finger protein 38 | -7.42632 |
| RHOB | ras homolog family member B | -7.4211 |
| TM4SF19 | transmembrane 4 L six family member 19 | -7.37223 |
| LMBR1L | limb development membrane protein 1-like | -7.27722 |
| LRRC75B | leucine rich repeat containing 75B | -7.27085 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -7.22427 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -7.22334 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -7.22273 |
| CUL4B | cullin 4B | -7.18762 |
| DEK | DEK proto-oncogene | -7.17878 |
| LAMP2 | lysosomal-associated membrane protein 2 | -7.16668 |
| ATP13A3 | ATPase type 13A3 | -7.13651 |
| MESDC1 | mesoderm development candidate 1 | -7.11894 |
| CD83 | CD83 molecule | -7.0671 |
| TRNP1 | TMF1-regulated nuclear protein 1 | -7.0671 |
| GPR180 | G protein-coupled receptor 180 | -6.98664 |
| TBC1D20 | TBC1 domain family, member 20 | -6.98322 |
| VIL1 | villin 1 | -6.94615 |
| PLSCR4 | phospholipid scramblase 4 | -6.91461 |
| DPP4 | dipeptidyl-peptidase 4 | -6.88336 |
| SIKE1 | suppressor of IKBKE 1 | -6.83087 |
| PAQR3 | progestin and adipoQ receptor family member III | -6.743 |
| WDR82 | WD repeat domain 82 | -6.73205 |
| ABCB9 | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | -6.63721 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -6.62353 |
| PHAX | phosphorylated adaptor for RNA export | -6.60452 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | -6.51992 |
| HEG1 | heart development protein with EGF-like domains 1 | -6.49534 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -6.4874 |
| ZNF697 | zinc finger protein 697 | -6.41077 |
| MTFR1 | mitochondrial fission regulator 1 | -6.36884 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -6.32069 |
| ATL2 | atlastin GTPase 2 | -6.31985 |
| EMX1 | empty spiracles homeobox 1 | -6.31162 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -6.30476 |
