Perturb_4383_KO_PRMT5_SRP149386 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KO perturbation targeting PRMT5 in diffuse large B-cell lymphoma TMD8 cell line (Study accession: SRP149386) (PerturbAtlas)
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Genes

74 genes differentially expressed following the Perturb_4383_KO_PRMT5_SRP149386 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
ACAT2 acetyl-CoA acetyltransferase 2 6.08565
DDTL D-dopachrome tautomerase-like 4.44477
EFCAB10 EF-hand calcium binding domain 10 4.0754
CRLF1 cytokine receptor-like factor 1 3.66679
CCDC73 coiled-coil domain containing 73 3.3997
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 3.33731
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 3.33731
SRR serine racemase 3.02055
PRR33 proline rich 33 2.94046
FAM69B family with sequence similarity 69, member B 2.86962
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.86962
DLEC1 deleted in lung and esophageal cancer 1 2.75867
MCMDC2 minichromosome maintenance domain containing 2 2.70595
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.48977
ENOSF1 enolase superfamily member 1 2.4734
PMPCB peptidase (mitochondrial processing) beta 2.4629
SNX22 sorting nexin 22 2.39687
CDC42SE1 CDC42 small effector 1 2.36049
INTS8 integrator complex subunit 8 2.30519
ACSBG1 acyl-CoA synthetase bubblegum family member 1 2.28233
IL16 interleukin 16 2.21807
HIST1H2BN histone cluster 1, H2bn 2.06009
RFXANK regulatory factor X-associated ankyrin-containing protein 2.06009
PGM3 phosphoglucomutase 3 1.99543
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 1.99316
HIST1H4I histone cluster 1, H4i 1.98487
GLRX5 glutaredoxin 5 1.95604
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.95604
CCNE2 cyclin E2 1.95598
METTL5 methyltransferase like 5 1.95598
FANCI Fanconi anemia, complementation group I 1.93985
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 1.92784
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 1.90766
CEBPZOS CEBPZ opposite strand 1.90649
NELFCD negative elongation factor complex member C/D 1.88773
SETD6 SET domain containing 6 1.83968
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 1.77765
ZNF593OS ZNF593 opposite strand 1.69968
COX20 COX20 cytochrome c oxidase assembly factor 1.62862
LGALS8 lectin, galactoside-binding, soluble, 8 1.62862
WDR55 WD repeat domain 55 1.60576
NFE2L3 nuclear factor, erythroid 2-like 3 1.49923
GLRX2 glutaredoxin 2 1.48838
CPM carboxypeptidase M 1.46708
AHNAK2 AHNAK nucleoprotein 2 1.43847
PPAP2A phosphatidic acid phosphatase type 2A 1.3996
CAPN12 calpain 12 1.3996
SH3D19 SH3 domain containing 19 1.3996
PIAS3 protein inhibitor of activated STAT, 3 1.38085
OPN3 opsin 3 1.35656
DND1 DND microRNA-mediated repression inhibitor 1 1.34624
FBXO11 F-box protein 11 1.34146
ASB6 ankyrin repeat and SOCS box containing 6 1.33642

decreased expression

Symbol Name Standardized Value
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -3.47008
AFG3L2 AFG3-like AAA ATPase 2 -3.26504
ACTB actin, beta -3.17498
FAM35A family with sequence similarity 35, member A -2.50906
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -2.48977
FMNL3 formin-like 3 -2.48977
PTRH2 peptidyl-tRNA hydrolase 2 -2.30519
JMJD4 jumonji domain containing 4 -2.25021
TCTN1 tectonic family member 1 -2.10086
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.06009
BCL7A B-cell CLL/lymphoma 7A -1.97151
POLR1C polymerase (RNA) I polypeptide C, 30kDa -1.95604
ZBTB45 zinc finger and BTB domain containing 45 -1.92784
CCDC176 coiled-coil domain containing 176 -1.9178
NUP62 nucleoporin 62kDa -1.83968
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -1.69718
SARM1 sterile alpha and TIR motif containing 1 -1.43382
TGFB1 transforming growth factor, beta 1 -1.41383
TKFC triokinase/FMN cyclase -1.38085
ATF5 activating transcription factor 5 -1.37925
POU2F2 POU class 2 homeobox 2 -1.34146