Perturb_440_KD_PRMT5_SRP073189 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting PRMT5 in A549 cell line (Study accession: SRP073189) (PerturbAtlas)
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Genes

191 genes differentially expressed following the Perturb_440_KD_PRMT5_SRP073189 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
SLC19A1 solute carrier family 19 (folate transporter), member 1 20.0
FGF14 fibroblast growth factor 14 20.0
GPR39 G protein-coupled receptor 39 20.0
PAQR3 progestin and adipoQ receptor family member III 20.0
MXD3 MAX dimerization protein 3 20.0
CCDC18 coiled-coil domain containing 18 18.6383
NME7 NME/NM23 family member 7 11.9004
IQCK IQ motif containing K 7.75211
SZT2 seizure threshold 2 homolog (mouse) 7.73734
TGFB1 transforming growth factor, beta 1 7.06084
ITGB1BP1 integrin beta 1 binding protein 1 6.74362
SLFNL1 schlafen-like 1 6.45254
PTRH2 peptidyl-tRNA hydrolase 2 6.12755
BRD7 bromodomain containing 7 5.49706
TSPAN31 tetraspanin 31 5.26664
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) 5.09286
C11ORF68 chromosome 11 open reading frame 68 5.08184
KIAA0895 KIAA0895 4.58238
RFC5 replication factor C (activator 1) 5, 36.5kDa 4.50998
BMP6 bone morphogenetic protein 6 4.37205
LPCAT3 lysophosphatidylcholine acyltransferase 3 4.13524
TSPAN14 tetraspanin 14 3.7893
FAM69B family with sequence similarity 69, member B 3.64792
XYLT1 xylosyltransferase I 3.43743
TTI2 TELO2 interacting protein 2 3.31501
ABI2 abl-interactor 2 3.30615
YIPF2 Yip1 domain family, member 2 3.27273
COL6A1 collagen, type VI, alpha 1 3.22902
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 3.22902
CLTC clathrin, heavy chain (Hc) 3.22044
IL17D interleukin 17D 3.09615
CENPP centromere protein P 3.0657
WRAP53 WD repeat containing, antisense to TP53 3.00151
DFNA5 deafness, autosomal dominant 5 2.84853
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 2.82999
MFSD11 major facilitator superfamily domain containing 11 2.56133
DEGS2 delta(4)-desaturase, sphingolipid 2 2.49332
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.48444
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 2.48185
TRIM59 tripartite motif containing 59 2.42686
STK17A serine/threonine kinase 17a 2.34507
EPHA1 EPH receptor A1 2.33307
TUBA1C tubulin, alpha 1c 2.33277
ENO3 enolase 3 (beta, muscle) 2.32361
MFSD6 major facilitator superfamily domain containing 6 2.3091
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.19232
BEST1 bestrophin 1 2.15348
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.00374
TPSG1 tryptase gamma 1 1.96109
PREPL prolyl endopeptidase-like 1.9443
SLITRK5 SLIT and NTRK-like family, member 5 1.93779
SCAND1 SCAN domain containing 1 1.92278
MMP24-AS1 MMP24 antisense RNA 1 1.91274
C1ORF56 chromosome 1 open reading frame 56 1.90883
ALOX12B arachidonate 12-lipoxygenase, 12R type 1.88651
BOLA1 bolA family member 1 1.87125
CLDN2 claudin 2 1.85312
DLD dihydrolipoamide dehydrogenase 1.83881
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 1.83012
BRICD5 BRICHOS domain containing 5 1.82468
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 1.82025
PMPCB peptidase (mitochondrial processing) beta 1.82025
UNC45A unc-45 homolog A (C. elegans) 1.82025
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.81007
ZC3H14 zinc finger CCCH-type containing 14 1.79969
C16ORF62 chromosome 16 open reading frame 62 1.7339
HAGHL hydroxyacylglutathione hydrolase-like 1.71937
C1ORF54 chromosome 1 open reading frame 54 1.71898
TRRAP transformation/transcription domain-associated protein 1.70833
IFT80 intraflagellar transport 80 1.66936
CCDC97 coiled-coil domain containing 97 1.65117
ENOSF1 enolase superfamily member 1 1.63117
SPDYE3 speedy/RINGO cell cycle regulator family member E3 1.59493
DNASE1 deoxyribonuclease I 1.58414
BTD biotinidase 1.53356
ZSCAN32 zinc finger and SCAN domain containing 32 1.51504
COX20 COX20 cytochrome c oxidase assembly factor 1.50344
GLRX2 glutaredoxin 2 1.48512
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1.47894
CRACR2B calcium release activated channel regulator 2B 1.47031
COG1 component of oligomeric golgi complex 1 1.47031
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.4656
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 1.44541
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.44242
ANKRD37 ankyrin repeat domain 37 1.40938
LRRC75A leucine rich repeat containing 75A 1.40765
ZFP36L2 ZFP36 ring finger protein-like 2 1.38564
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.38564
SPAG17 sperm associated antigen 17 1.38564
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 1.33084
LYRM2 LYR motif containing 2 1.3182

decreased expression

Symbol Name Standardized Value
FZD4 frizzled class receptor 4 -20.0
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -20.0
TMEM184A transmembrane protein 184A -20.0
KRT8 keratin 8, type II -20.0
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -20.0
STAG3 stromal antigen 3 -20.0
ORAOV1 oral cancer overexpressed 1 -20.0
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -20.0
HPS3 Hermansky-Pudlak syndrome 3 -20.0
DENND3 DENN/MADD domain containing 3 -15.7779
TMEM120B transmembrane protein 120B -15.4073
WBSCR16 Williams-Beuren syndrome chromosome region 16 -14.7751
SARM1 sterile alpha and TIR motif containing 1 -14.1334
CCDC152 coiled-coil domain containing 152 -13.3733
SLA2 Src-like-adaptor 2 -12.2819
TCP1 t-complex 1 -9.89882
LOC122455342 testis-specific serine/proline-rich protein -9.21722
CLU clusterin -9.01211
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -8.54532
AKAP12 A kinase (PRKA) anchor protein 12 -8.44807
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -8.29922
FMNL1 formin-like 1 -8.18077
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -7.84733
RBBP4 retinoblastoma binding protein 4 -7.17247
CXCR5 chemokine (C-X-C motif) receptor 5 -6.32512
ZBTB7C zinc finger and BTB domain containing 7C -6.10516
SPATA32 spermatogenesis associated 32 -5.25374
C5ORF45 chromosome 5 open reading frame 45 -5.2254
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -5.18828
EDN1 endothelin 1 -5.02047
PRSS54 protease, serine, 54 -4.83151
C1ORF167 chromosome 1 open reading frame 167 -4.80742
USP24 ubiquitin specific peptidase 24 -4.75519
HARBI1 harbinger transposase derived 1 -4.42811
SIK2 salt-inducible kinase 2 -4.2504
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -4.22102
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -4.13524
SNAI3 snail family zinc finger 3 -4.01574
EYA4 EYA transcriptional coactivator and phosphatase 4 -3.77009
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -3.70991
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -3.37663
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -3.37663
SGCE sarcoglycan, epsilon -3.26004
BCAS4 breast carcinoma amplified sequence 4 -3.22902
COG5 component of oligomeric golgi complex 5 -3.15755
FBXO22 F-box protein 22 -3.00434
AKR1C2 aldo-keto reductase family 1, member C2 -2.97245
RHOF ras homolog family member F (in filopodia) -2.82885
RAPSN receptor-associated protein of the synapse -2.79946
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.76743
SPTY2D1-AS1 SPTY2D1 antisense RNA 1 -2.75986
CDK4 cyclin-dependent kinase 4 -2.75352
PHF3 PHD finger protein 3 -2.72009
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.7072
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.66853
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -2.66618
MROH8 maestro heat-like repeat family member 8 -2.58337
EPN2 epsin 2 -2.58117
ATP8B4 ATPase, class I, type 8B, member 4 -2.56133
SH3D19 SH3 domain containing 19 -2.5568
FAM227B family with sequence similarity 227, member B -2.50077
FEN1 flap structure-specific endonuclease 1 -2.49826
ANXA1 annexin A1 -2.4181
PPP2R1B protein phosphatase 2, regulatory subunit A, beta -2.38117
NEMF nuclear export mediator factor -2.37965
PRSS23 protease, serine, 23 -2.3258
MRPL43 mitochondrial ribosomal protein L43 -2.32361
HEXB hexosaminidase B (beta polypeptide) -2.32017
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.23957
KRT10 keratin 10, type I -2.09473
SULF2 sulfatase 2 -2.01484
MTMR7 myotubularin related protein 7 -2.0147
CP ceruloplasmin (ferroxidase) -1.97367
CDC37 cell division cycle 37 -1.96109
CCND1 cyclin D1 -1.93445
DDIT3 DNA-damage-inducible transcript 3 -1.88308
APC2 adenomatosis polyposis coli 2 -1.86573
TMEM63A transmembrane protein 63A -1.85771
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -1.82025
ZFYVE16 zinc finger, FYVE domain containing 16 -1.81174
IGFBP4 insulin-like growth factor binding protein 4 -1.7846
MAT2A methionine adenosyltransferase II, alpha -1.77397
CFAP126 cilia and flagella associated protein 126 -1.75838
TMEM165 transmembrane protein 165 -1.72463
FAM161B family with sequence similarity 161, member B -1.67099
BBIP1 BBSome interacting protein 1 -1.66936
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -1.65701
FANCL Fanconi anemia, complementation group L -1.64355
MED16 mediator complex subunit 16 -1.62474
C12ORF29 chromosome 12 open reading frame 29 -1.61422
HEATR1 HEAT repeat containing 1 -1.59493
LYRM5 LYR motif containing 5 -1.56317
C14ORF166 chromosome 14 open reading frame 166 -1.55231
CNTD1 cyclin N-terminal domain containing 1 -1.52533
CDC14B cell division cycle 14B -1.50344
MSMP microseminoprotein, prostate associated -1.50344
ATG10 autophagy related 10 -1.50094
TRABD2A TraB domain containing 2A -1.4825
KCNK15 potassium channel, two pore domain subfamily K, member 15 -1.4656
ACSBG1 acyl-CoA synthetase bubblegum family member 1 -1.44692