Perturb_46_OE_ERG/MYC_SRP069177 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description OE perturbation targeting ERG/MYC in 17 Day Differentiated iPrECs cell (Study accession: SRP069177) (PerturbAtlas)
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Genes

148 genes differentially expressed following the Perturb_46_OE_ERG/MYC_SRP069177 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
NECAB1 N-terminal EF-hand calcium binding protein 1 4.39182
TSC22D3 TSC22 domain family, member 3 4.12934
ITFG2 integrin alpha FG-GAP repeat containing 2 3.87771
EXOSC9 exosome component 9 3.86391
REP15 RAB15 effector protein 3.85614
MRPS18C mitochondrial ribosomal protein S18C 3.61256
RPS2 ribosomal protein S2 3.3072
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 3.22748
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 3.22131
ZBTB10 zinc finger and BTB domain containing 10 3.10909
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.90339
NQO2 NAD(P)H dehydrogenase, quinone 2 2.79911
COL7A1 collagen, type VII, alpha 1 2.66842
NT5DC4 5'-nucleotidase domain containing 4 2.66842
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.47213
FAS Fas cell surface death receptor 2.45204
TMEM120B transmembrane protein 120B 2.41256
CA11 carbonic anhydrase XI 2.3524
SYNPO synaptopodin 2.34235
KRT8 keratin 8, type II 2.33069
KIAA0895 KIAA0895 2.32892
ADAD2 adenosine deaminase domain containing 2 2.3184
CLCC1 chloride channel CLIC-like 1 2.25197
TREH trehalase (brush-border membrane glycoprotein) 2.22434
NCAPD2 non-SMC condensin I complex, subunit D2 2.18913
ERI2 ERI1 exoribonuclease family member 2 2.09413
CSF1R colony stimulating factor 1 receptor 2.08874
EYS eyes shut homolog (Drosophila) 2.05258
ENG endoglin 2.02708
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.01929
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 1.95638
AKAP12 A kinase (PRKA) anchor protein 12 1.94321
DNAH11 dynein, axonemal, heavy chain 11 1.93094
NES nestin 1.85611
GLUL glutamate-ammonia ligase 1.85611
FAM69B family with sequence similarity 69, member B 1.80123
PMEPA1 prostate transmembrane protein, androgen induced 1 1.78718
IRF1 interferon regulatory factor 1 1.76238
RPL12 ribosomal protein L12 1.75326
ARF4 ADP-ribosylation factor 4 1.71489
SKP1 S-phase kinase-associated protein 1 1.70137
CFAP70 cilia and flagella associated protein 70 1.68024
DLG4 discs, large homolog 4 (Drosophila) 1.67399
LCORL ligand dependent nuclear receptor corepressor-like 1.66493
CCDC66 coiled-coil domain containing 66 1.62749
ABHD14A abhydrolase domain containing 14A 1.58898
STRADA STE20-related kinase adaptor alpha 1.57086
EML2 echinoderm microtubule associated protein like 2 1.55793
TOP2A topoisomerase (DNA) II alpha 170kDa 1.55769
BBS1 Bardet-Biedl syndrome 1 1.55491
RELL1 RELT-like 1 1.54456
GPN3 GPN-loop GTPase 3 1.53784
TKFC triokinase/FMN cyclase 1.5335
NUP153 nucleoporin 153kDa 1.48498
FKRP fukutin related protein 1.47337
GRIP2 glutamate receptor interacting protein 2 1.4706
MAPK10 mitogen-activated protein kinase 10 1.45713
SARM1 sterile alpha and TIR motif containing 1 1.45023
CES4A carboxylesterase 4A 1.44317
RWDD2A RWD domain containing 2A 1.43561
CDC25B cell division cycle 25B 1.43425
ARHGAP33 Rho GTPase activating protein 33 1.3985
SIX5 SIX homeobox 5 1.36971
LRRC14 leucine rich repeat containing 14 1.36052
FANCD2OS FANCD2 opposite strand 1.36052
KHK ketohexokinase (fructokinase) 1.35538
PTMS parathymosin 1.3527
TIMP3 TIMP metallopeptidase inhibitor 3 1.3527
ACOT2 acyl-CoA thioesterase 2 1.32773
TRIM59 tripartite motif containing 59 1.30447

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -20.0
PSORS1C1 psoriasis susceptibility 1 candidate 1 -13.6271
KRT16 keratin 16, type I -11.1772
DMKN dermokine -8.4357
KRT6B keratin 6B, type II -8.23345
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -8.09765
CALML3 calmodulin-like 3 -6.67489
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -5.78054
NDRG1 N-myc downstream regulated 1 -5.14417
ZC3H14 zinc finger CCCH-type containing 14 -5.14417
SDC1 syndecan 1 -5.03278
EVA1B eva-1 homolog B (C. elegans) -4.37508
DSC2 desmocollin 2 -4.22748
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -4.00554
MAPK15 mitogen-activated protein kinase 15 -3.79082
PNKD paroxysmal nonkinesigenic dyskinesia -3.73152
ANXA1 annexin A1 -3.73152
DSG3 desmoglein 3 -3.57721
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -3.50344
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -3.26494
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -3.24915
KRT6A keratin 6A, type II -3.23365
TMBIM1 transmembrane BAX inhibitor motif containing 1 -3.10909
CRABP2 cellular retinoic acid binding protein 2 -3.04424
PKP1 plakophilin 1 -2.94773
KRT10 keratin 10, type I -2.82278
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.77561
TBC1D20 TBC1 domain family, member 20 -2.74391
GPNMB glycoprotein (transmembrane) nmb -2.66842
SGSM2 small G protein signaling modulator 2 -2.62301
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.56414
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.49948
PYGB phosphorylase, glycogen; brain -2.46709
ZFP41 ZFP41 zinc finger protein -2.32892
TRAF3IP3 TRAF3 interacting protein 3 -2.32027
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.32027
DQX1 DEAQ box RNA-dependent ATPase 1 -2.28712
TMEM41A transmembrane protein 41A -2.28639
HLA-F major histocompatibility complex, class I, F -2.25168
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -2.23914
CTSV cathepsin V -2.22355
TACC2 transforming, acidic coiled-coil containing protein 2 -2.20431
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.08874
LIPM lipase, family member M -2.08106
DSP desmoplakin -2.07259
GRID1 glutamate receptor, ionotropic, delta 1 -2.02708
CGNL1 cingulin-like 1 -1.97885
FRMD4B FERM domain containing 4B -1.97144
TM4SF1 transmembrane 4 L six family member 1 -1.96892
MXRA8 matrix-remodelling associated 8 -1.95558
ITGA6 integrin, alpha 6 -1.89565
SAT1 spermidine/spermine N1-acetyltransferase 1 -1.86956
NELL1 NEL-like 1 (chicken) -1.80146
TTPAL tocopherol (alpha) transfer protein-like -1.80146
PERP PERP, TP53 apoptosis effector -1.77847
SPAG4 sperm associated antigen 4 -1.75484
UPP1 uridine phosphorylase 1 -1.73316
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -1.71489
KANK1 KN motif and ankyrin repeat domains 1 -1.69032
KRT5 keratin 5, type II -1.68795
TGFBR1 transforming growth factor, beta receptor 1 -1.67787
BARX2 BARX homeobox 2 -1.66988
ANKH ANKH inorganic pyrophosphate transport regulator -1.63074
C1ORF74 chromosome 1 open reading frame 74 -1.60498
GLTP glycolipid transfer protein -1.5949
CSTB cystatin B (stefin B) -1.58064
ADAMTSL4 ADAMTS-like 4 -1.58064
DSTN destrin (actin depolymerizing factor) -1.54183
CENPP centromere protein P -1.54106
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.49113
PARD6G par-6 family cell polarity regulator gamma -1.46072
DUOXA2 dual oxidase maturation factor 2 -1.41852
PCSK7 proprotein convertase subtilisin/kexin type 7 -1.36052
CCDC85B coiled-coil domain containing 85B -1.36052
BICD2 bicaudal D homolog 2 (Drosophila) -1.36052
DHDDS dehydrodolichyl diphosphate synthase -1.35162
FUS FUS RNA binding protein -1.34435
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 -1.32504