| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting TLR3/BRF1 in A549 cell line (Study accession: SRP382324) (PerturbAtlas) |
| Similar Terms | |
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200 genes differentially expressed following the Perturb_501_KD_TLR3/BRF1_SRP382324 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC2 | tuberous sclerosis 2 | 20.0 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 20.0 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | 20.0 |
| C5ORF45 | chromosome 5 open reading frame 45 | 20.0 |
| TMEM63A | transmembrane protein 63A | 20.0 |
| NME7 | NME/NM23 family member 7 | 20.0 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 20.0 |
| LDLRAD2 | low density lipoprotein receptor class A domain containing 2 | 20.0 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 20.0 |
| C12ORF73 | chromosome 12 open reading frame 73 | 20.0 |
| SNX22 | sorting nexin 22 | 20.0 |
| PDGFRL | platelet-derived growth factor receptor-like | 20.0 |
| PDAP1 | PDGFA associated protein 1 | 19.301 |
| WBSCR16 | Williams-Beuren syndrome chromosome region 16 | 18.585 |
| C12ORF45 | chromosome 12 open reading frame 45 | 16.743 |
| C12ORF43 | chromosome 12 open reading frame 43 | 16.5675 |
| BBIP1 | BBSome interacting protein 1 | 15.8257 |
| PAQR3 | progestin and adipoQ receptor family member III | 15.7516 |
| SNAP47 | synaptosomal-associated protein, 47kDa | 15.5403 |
| SPATA21 | spermatogenesis associated 21 | 15.1095 |
| GYG1 | glycogenin 1 | 14.6998 |
| FKRP | fukutin related protein | 14.3171 |
| KRT8 | keratin 8, type II | 14.2713 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 13.6075 |
| STRADB | STE20-related kinase adaptor beta | 13.3104 |
| KIF1B | kinesin family member 1B | 13.1122 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | 13.037 |
| FBXW8 | F-box and WD repeat domain containing 8 | 12.8758 |
| DOPEY1 | dopey family member 1 | 12.8196 |
| LHFPL5 | lipoma HMGIC fusion partner-like 5 | 12.7349 |
| MED16 | mediator complex subunit 16 | 12.6958 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 12.4519 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 12.0825 |
| RAPSN | receptor-associated protein of the synapse | 11.1789 |
| CD37 | CD37 molecule | 10.8157 |
| TMEM92 | transmembrane protein 92 | 10.7519 |
| CCDC42B | coiled-coil domain containing 42B | 10.4955 |
| ORAOV1 | oral cancer overexpressed 1 | 10.4509 |
| BMP6 | bone morphogenetic protein 6 | 10.2825 |
| BEST1 | bestrophin 1 | 10.2736 |
| FAM35A | family with sequence similarity 35, member A | 10.2503 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 10.05 |
| DLD | dihydrolipoamide dehydrogenase | 9.59979 |
| ADRM1 | adhesion regulating molecule 1 | 9.59008 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 9.32609 |
| MROH8 | maestro heat-like repeat family member 8 | 9.28028 |
| GPR137 | G protein-coupled receptor 137 | 8.89399 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 8.77994 |
| FUZ | fuzzy planar cell polarity protein | 8.6704 |
| STAG3 | stromal antigen 3 | 8.5815 |
| STAB1 | stabilin 1 | 8.54447 |
| TMEM258 | transmembrane protein 258 | 8.35384 |
| DNASE1 | deoxyribonuclease I | 8.24306 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | 8.03699 |
| SNX32 | sorting nexin 32 | 8.02258 |
| ITGA7 | integrin, alpha 7 | 8.01371 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 7.89677 |
| RNF123 | ring finger protein 123 | 7.859 |
| ENO3 | enolase 3 (beta, muscle) | 7.85204 |
| WDR90 | WD repeat domain 90 | 7.81244 |
| FADS1 | fatty acid desaturase 1 | 7.7971 |
| SLC39A9 | solute carrier family 39, member 9 | 7.69035 |
| HRNR | hornerin | 7.66852 |
| IL18BP | interleukin 18 binding protein | 7.58882 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 7.50647 |
| ADGRG5 | adhesion G protein-coupled receptor G5 | 7.49148 |
| MTBP | MDM2 binding protein | 7.3476 |
| GTPBP6 | GTP binding protein 6 (putative) | 6.92659 |
| TCHP | trichoplein, keratin filament binding | 6.89225 |
| THBS1 | thrombospondin 1 | 6.85999 |
| SAMD14 | sterile alpha motif domain containing 14 | 6.49042 |
| RRBP1 | ribosome binding protein 1 | 6.4882 |
| SCTR | secretin receptor | 6.44886 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 6.32339 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | 5.98823 |
| CLVS1 | clavesin 1 | 5.92386 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 5.90981 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | 5.78475 |
| MXRA8 | matrix-remodelling associated 8 | 5.75934 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | 5.73789 |
| ACBD6 | acyl-CoA binding domain containing 6 | 5.66932 |
| ZNF575 | zinc finger protein 575 | 5.64717 |
| GRIP2 | glutamate receptor interacting protein 2 | 5.6226 |
| EME2 | essential meiotic structure-specific endonuclease subunit 2 | 5.59387 |
| POLRMT | polymerase (RNA) mitochondrial (DNA directed) | 5.56277 |
| CIITA | class II, major histocompatibility complex, transactivator | 5.55109 |
| ZACN | zinc activated ligand-gated ion channel | 5.35304 |
| NUP88 | nucleoporin 88kDa | 5.34142 |
| CCDC159 | coiled-coil domain containing 159 | 5.09251 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 5.06799 |
| CDC42SE1 | CDC42 small effector 1 | 5.0676 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 4.85307 |
| TPSG1 | tryptase gamma 1 | 4.77591 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 4.75653 |
| STAC3 | SH3 and cysteine rich domain 3 | 4.68154 |
| CIDEB | cell death-inducing DFFA-like effector b | 4.63659 |
| SSR4 | signal sequence receptor, delta | 4.61515 |
| KCNAB1 | potassium channel, voltage gated subfamily A regulatory beta subunit 1 | 4.33181 |
| TP53I13 | tumor protein p53 inducible protein 13 | 4.21705 |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 4.17309 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -20.0 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -20.0 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -19.5229 |
| FAS | Fas cell surface death receptor | -19.0 |
| CCDC85B | coiled-coil domain containing 85B | -15.1691 |
| FAM65A | family with sequence similarity 65, member A | -13.7658 |
| TTC31 | tetratricopeptide repeat domain 31 | -12.8807 |
| TUBA1C | tubulin, alpha 1c | -12.8705 |
| COA3 | cytochrome c oxidase assembly factor 3 | -12.6881 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | -12.0457 |
| C22ORF23 | chromosome 22 open reading frame 23 | -11.8758 |
| TATDN1 | TatD DNase domain containing 1 | -11.6948 |
| SPTB | spectrin, beta, erythrocytic | -11.1029 |
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | -9.41828 |
| C15ORF40 | chromosome 15 open reading frame 40 | -9.41828 |
| C17ORF70 | chromosome 17 open reading frame 70 | -9.4129 |
| THRA | thyroid hormone receptor, alpha | -9.36153 |
| XYLT2 | xylosyltransferase II | -9.2479 |
| PPP2R3B | protein phosphatase 2, regulatory subunit B'', beta | -9.13304 |
| LOC100130705 | uncharacterized LOC100130705 | -8.88622 |
| HIF1AN | hypoxia inducible factor 1, alpha subunit inhibitor | -8.85214 |
| C11ORF68 | chromosome 11 open reading frame 68 | -8.80922 |
| ATP5S | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) | -7.63355 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | -7.52438 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -7.46887 |
| HIP1R | huntingtin interacting protein 1 related | -7.30329 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -7.26096 |
| ENOSF1 | enolase superfamily member 1 | -7.13312 |
| UNK | unkempt family zinc finger | -6.94611 |
| CHMP1B | charged multivesicular body protein 1B | -6.84481 |
| DENND3 | DENN/MADD domain containing 3 | -6.78378 |
| C14ORF79 | chromosome 14 open reading frame 79 | -6.75042 |
| NARFL | nuclear prelamin A recognition factor-like | -6.67203 |
| MAN1B1 | mannosidase, alpha, class 1B, member 1 | -6.56564 |
| NGEF | neuronal guanine nucleotide exchange factor | -6.53992 |
| FXR2 | fragile X mental retardation, autosomal homolog 2 | -6.49042 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -6.35901 |
| SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | -6.34502 |
| RHOBTB2 | Rho-related BTB domain containing 2 | -6.29781 |
| SVIL | supervillin | -6.14747 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -6.00003 |
| ZNF862 | zinc finger protein 862 | -5.93447 |
| WDR24 | WD repeat domain 24 | -5.8685 |
| FBLIM1 | filamin binding LIM protein 1 | -5.84138 |
| RNF213 | ring finger protein 213 | -5.76421 |
| LRRN2 | leucine rich repeat neuronal 2 | -5.73789 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -5.70106 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -5.51149 |
| DENND1C | DENN/MADD domain containing 1C | -5.3499 |
| TMEM180 | transmembrane protein 180 | -5.33025 |
| ARRDC1 | arrestin domain containing 1 | -5.25326 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -5.15628 |
| NTPCR | nucleoside-triphosphatase, cancer-related | -5.00517 |
| EIF3G | eukaryotic translation initiation factor 3, subunit G | -4.79486 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | -4.79274 |
| PLLP | plasmolipin | -4.58341 |
| C1ORF159 | chromosome 1 open reading frame 159 | -4.57622 |
| KCTD19 | potassium channel tetramerization domain containing 19 | -4.51433 |
| TMEM80 | transmembrane protein 80 | -4.49752 |
| HAS3 | hyaluronan synthase 3 | -4.48797 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -4.46665 |
| FTSJ3 | FtsJ homolog 3 (E. coli) | -4.44835 |
| ZNF655 | zinc finger protein 655 | -4.41957 |
| LRRC75A | leucine rich repeat containing 75A | -4.40834 |
| MZF1 | myeloid zinc finger 1 | -4.39727 |
| PRPH | peripherin | -4.36933 |
| DYM | dymeclin | -4.278 |
| NLRC3 | NLR family, CARD domain containing 3 | -4.24695 |
| ACOT13 | acyl-CoA thioesterase 13 | -4.24659 |
| CCNB2 | cyclin B2 | -4.21539 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -4.09618 |
| SH2D2A | SH2 domain containing 2A | -4.08867 |
| FBLN1 | fibulin 1 | -4.08751 |
| ORC1 | origin recognition complex, subunit 1 | -3.99815 |
| CLMP | CXADR-like membrane protein | -3.99328 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -3.99328 |
| AATK | apoptosis-associated tyrosine kinase | -3.96795 |
| ACOT2 | acyl-CoA thioesterase 2 | -3.95924 |
| MARS | methionyl-tRNA synthetase | -3.95727 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | -3.91236 |
| LINC00514 | long intergenic non-protein coding RNA 514 | -3.84421 |
| LSAMP | limbic system-associated membrane protein | -3.77897 |
| SBF2 | SET binding factor 2 | -3.69397 |
| PCGF1 | polycomb group ring finger 1 | -3.64945 |
| PRRT2 | proline-rich transmembrane protein 2 | -3.63869 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -3.60744 |
| SIAE | sialic acid acetylesterase | -3.56914 |
| IDI2 | isopentenyl-diphosphate delta isomerase 2 | -3.54071 |
| BRSK2 | BR serine/threonine kinase 2 | -3.51731 |
| MCMDC2 | minichromosome maintenance domain containing 2 | -3.51731 |
| LNX1 | ligand of numb-protein X 1, E3 ubiquitin protein ligase | -3.48178 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | -3.44408 |
| IL12RB2 | interleukin 12 receptor, beta 2 | -3.41184 |
| DNAH10 | dynein, axonemal, heavy chain 10 | -3.41184 |
| TTN | titin | -3.39154 |
| DGKQ | diacylglycerol kinase, theta 110kDa | -3.38796 |
| HN1 | hematological and neurological expressed 1 | -3.37847 |
| JUN | jun proto-oncogene | -3.34152 |
| RASGRP4 | RAS guanyl releasing protein 4 | -3.33093 |
| KIF22 | kinesin family member 22 | -3.31562 |
