Perturb_523_KD_PKR/BRF1_SRP382324 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting PKR/BRF1 in A549 cell line (Study accession: SRP382324) (PerturbAtlas)
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Genes

161 genes differentially expressed following the Perturb_523_KD_PKR/BRF1_SRP382324 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
MXRA8 matrix-remodelling associated 8 11.7995
VTI1B vesicle transport through interaction with t-SNAREs 1B 7.14625
LDLRAD2 low density lipoprotein receptor class A domain containing 2 6.88284
SNRPA small nuclear ribonucleoprotein polypeptide A 6.33992
TMEM63A transmembrane protein 63A 5.8755
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 5.22706
MMP24-AS1 MMP24 antisense RNA 1 4.86388
MED16 mediator complex subunit 16 4.85234
THBS1 thrombospondin 1 4.73283
PAQR3 progestin and adipoQ receptor family member III 4.70859
BBIP1 BBSome interacting protein 1 4.23288
NME7 NME/NM23 family member 7 4.13475
TNC tenascin C 3.79021
HRNR hornerin 3.69381
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.68357
ZNF575 zinc finger protein 575 3.68357
TSC2 tuberous sclerosis 2 3.59996
ACBD6 acyl-CoA binding domain containing 6 3.51422
FBXO44 F-box protein 44 3.01083
IQGAP2 IQ motif containing GTPase activating protein 2 2.97688
NUP62 nucleoporin 62kDa 2.76022
TMEM258 transmembrane protein 258 2.68051
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 2.57122
TMEM92 transmembrane protein 92 2.5128
TCF19 transcription factor 19 2.45691
TRABD2A TraB domain containing 2A 2.28624
YPEL4 yippee-like 4 (Drosophila) 2.21453
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.2116
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 2.20588
ANKRD11 ankyrin repeat domain 11 2.1688
HOOK2 hook microtubule-tethering protein 2 2.11452
STRADB STE20-related kinase adaptor beta 2.10278
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.10278
PROB1 proline-rich basic protein 1 2.07054
C12ORF73 chromosome 12 open reading frame 73 2.04026
GAS6 growth arrest-specific 6 2.03805
ASIC5 acid sensing (proton gated) ion channel family member 5 2.03805
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.01004
CRACR2B calcium release activated channel regulator 2B 1.96317
HBP1 HMG-box transcription factor 1 1.92805
C20ORF144 chromosome 20 open reading frame 144 1.9246
C22ORF15 chromosome 22 open reading frame 15 1.8961
PDGFRL platelet-derived growth factor receptor-like 1.88307
PDAP1 PDGFA associated protein 1 1.8456
C12ORF45 chromosome 12 open reading frame 45 1.84201
AGK acylglycerol kinase 1.78467
ARSD arylsulfatase D 1.77275
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 1.75719
WISP2 WNT1 inducible signaling pathway protein 2 1.67687
FAM71E1 family with sequence similarity 71, member E1 1.67687
CPLX2 complexin 2 1.67687
TPSG1 tryptase gamma 1 1.67461
C5ORF45 chromosome 5 open reading frame 45 1.67236
NKX6-2 NK6 homeobox 2 1.62844
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 1.62617
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 1.59707
ADGRG5 adhesion G protein-coupled receptor G5 1.58918
GULP1 GULP, engulfment adaptor PTB domain containing 1 1.57645
C9ORF50 chromosome 9 open reading frame 50 1.575
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 1.52373
SLC26A1 solute carrier family 26 (anion exchanger), member 1 1.51796
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.45155
VSIG10L V-set and immunoglobulin domain containing 10 like 1.44141
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.42638
TCP1 t-complex 1 1.41453
ITGB1BP1 integrin beta 1 binding protein 1 1.40775
CNIH3 cornichon family AMPA receptor auxiliary protein 3 1.39793
FSIP1 fibrous sheath interacting protein 1 1.3698
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 1.34658
C12ORF43 chromosome 12 open reading frame 43 1.33616
FADS1 fatty acid desaturase 1 1.336
POLRMT polymerase (RNA) mitochondrial (DNA directed) 1.32889

decreased expression

Symbol Name Standardized Value
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -12.2352
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) -5.17935
DENND3 DENN/MADD domain containing 3 -5.17935
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -4.70859
ABI2 abl-interactor 2 -4.23288
HAS3 hyaluronan synthase 3 -3.80198
C17ORF70 chromosome 17 open reading frame 70 -3.49516
DNAH10 dynein, axonemal, heavy chain 10 -3.39831
C15ORF40 chromosome 15 open reading frame 40 -3.3444
CDH4 cadherin 4, type 1, R-cadherin (retinal) -3.20093
DYM dymeclin -2.94074
FXR2 fragile X mental retardation, autosomal homolog 2 -2.92873
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.88967
C19ORF54 chromosome 19 open reading frame 54 -2.86914
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 -2.77114
NGEF neuronal guanine nucleotide exchange factor -2.66388
PRPH peripherin -2.66117
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.64297
CORO1B coronin, actin binding protein, 1B -2.64271
C9ORF43 chromosome 9 open reading frame 43 -2.62735
IQCK IQ motif containing K -2.46944
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.44906
ZNF232 zinc finger protein 232 -2.4228
BSN bassoon presynaptic cytomatrix protein -2.4004
SOX15 SRY (sex determining region Y)-box 15 -2.4004
LRRC75A leucine rich repeat containing 75A -2.3895
SRRT serrate, RNA effector molecule -2.36424
ABR active BCR-related -2.33472
ARL10 ADP-ribosylation factor-like 10 -2.24757
PACS2 phosphofurin acidic cluster sorting protein 2 -2.19582
XYLT2 xylosyltransferase II -2.1688
BRSK2 BR serine/threonine kinase 2 -2.11219
CCNB2 cyclin B2 -2.10762
EIF3G eukaryotic translation initiation factor 3, subunit G -2.10762
PHF1 PHD finger protein 1 -2.10278
FBXL19 F-box and leucine-rich repeat protein 19 -2.05631
DYNLL1 dynein, light chain, LC8-type 1 -2.03432
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.03294
LRRN2 leucine rich repeat neuronal 2 -2.02109
TRIM41 tripartite motif containing 41 -1.97608
SLC46A1 solute carrier family 46 (folate transporter), member 1 -1.91503
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -1.91503
SH2D2A SH2 domain containing 2A -1.91001
MYRF myelin regulatory factor -1.89795
TMEM190 transmembrane protein 190 -1.88307
DPP3 dipeptidyl-peptidase 3 -1.88147
TMEM180 transmembrane protein 180 -1.8733
PLLP plasmolipin -1.82436
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.82436
MFSD7 major facilitator superfamily domain containing 7 -1.79
SLC38A10 solute carrier family 38, member 10 -1.78363
TMOD1 tropomodulin 1 -1.7639
FHOD1 formin homology 2 domain containing 1 -1.67839
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -1.67748
GDPGP1 GDP-D-glucose phosphorylase 1 -1.67748
PVRL3 poliovirus receptor-related 3 -1.67687
ZNF862 zinc finger protein 862 -1.67236
KRT18 keratin 18, type I -1.59707
TATDN1 TatD DNase domain containing 1 -1.56628
RNF39 ring finger protein 39 -1.56259
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -1.56259
TOP1MT topoisomerase (DNA) I, mitochondrial -1.53894
ZBTB17 zinc finger and BTB domain containing 17 -1.53317
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -1.50801
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase -1.50801
ZSCAN32 zinc finger and SCAN domain containing 32 -1.50185
TP53TG5 TP53 target 5 -1.50185
WDR59 WD repeat domain 59 -1.48577
SPTB spectrin, beta, erythrocytic -1.47136
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -1.46666
RNF213 ring finger protein 213 -1.45909
HSPB6 heat shock protein, alpha-crystallin-related, B6 -1.45155
LYRM2 LYR motif containing 2 -1.44426
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -1.44195
JAKMIP3 Janus kinase and microtubule interacting protein 3 -1.41592
SCAND1 SCAN domain containing 1 -1.41316
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 -1.40195
ANO9 anoctamin 9 -1.40195
ACOT2 acyl-CoA thioesterase 2 -1.40195
FGD1 FYVE, RhoGEF and PH domain containing 1 -1.39793
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -1.37403
RBBP4 retinoblastoma binding protein 4 -1.3698
UNK unkempt family zinc finger -1.3698
CCDC64B coiled-coil domain containing 64B -1.36152
MCMDC2 minichromosome maintenance domain containing 2 -1.34972
ERI2 ERI1 exoribonuclease family member 2 -1.34972
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B -1.34273
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -1.34186
NCAPH2 non-SMC condensin II complex, subunit H2 -1.32889