| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KO perturbation targeting NFKBIA in ES-derived mesenchymal stem cells cell (Study accession: SRP149723) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_5574_KO_NFKBIA_SRP149723 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ESM1 | endothelial cell-specific molecule 1 | 20.0 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 20.0 |
| EPAS1 | endothelial PAS domain protein 1 | 20.0 |
| CCL2 | chemokine (C-C motif) ligand 2 | 20.0 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 20.0 |
| CTGF | connective tissue growth factor | 20.0 |
| OXTR | oxytocin receptor | 20.0 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 20.0 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 20.0 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 20.0 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 20.0 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 20.0 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 20.0 |
| BIRC3 | baculoviral IAP repeat containing 3 | 20.0 |
| JAG1 | jagged 1 | 20.0 |
| VCAM1 | vascular cell adhesion molecule 1 | 20.0 |
| CLDN11 | claudin 11 | 20.0 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 20.0 |
| THBS1 | thrombospondin 1 | 20.0 |
| MMP1 | matrix metallopeptidase 1 | 20.0 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 20.0 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 20.0 |
| LIPG | lipase, endothelial | 20.0 |
| CSRP1 | cysteine and glycine-rich protein 1 | 20.0 |
| ICAM1 | intercellular adhesion molecule 1 | 20.0 |
| IL1B | interleukin 1, beta | 20.0 |
| PITX3 | paired-like homeodomain 3 | 18.4685 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 18.1549 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 17.9355 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 17.7282 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 17.3526 |
| FOXO1 | forkhead box O1 | 16.5206 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 16.158 |
| RUNX3 | runt-related transcription factor 3 | 16.1129 |
| CLDN1 | claudin 1 | 15.6067 |
| LITAF | lipopolysaccharide-induced TNF factor | 15.3394 |
| BIRC2 | baculoviral IAP repeat containing 2 | 15.213 |
| MEIS1 | Meis homeobox 1 | 15.1397 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 14.3399 |
| BAMBI | BMP and activin membrane-bound inhibitor | 14.3228 |
| PCDH17 | protocadherin 17 | 13.5316 |
| HHIP | hedgehog interacting protein | 13.3888 |
| CD69 | CD69 molecule | 12.544 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 12.2209 |
| SMAD3 | SMAD family member 3 | 11.3835 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 11.133 |
| RNF150 | ring finger protein 150 | 10.9332 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 10.653 |
| COL4A1 | collagen, type IV, alpha 1 | 10.3336 |
| TLE3 | transducin-like enhancer of split 3 | 10.3336 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 10.098 |
| PLK2 | polo-like kinase 2 | 9.69902 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 9.67823 |
| CRYAB | crystallin, alpha B | 9.63933 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 9.39041 |
| CD274 | CD274 molecule | 9.38261 |
| TSLP | thymic stromal lymphopoietin | 9.1083 |
| EDN1 | endothelin 1 | 9.00316 |
| SRGN | serglycin | 9.00307 |
| GDF15 | growth differentiation factor 15 | 8.99328 |
| GATA2 | GATA binding protein 2 | 8.91918 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | 8.61861 |
| KIAA1462 | KIAA1462 | 8.59863 |
| HDAC9 | histone deacetylase 9 | 8.52547 |
| COL4A2 | collagen, type IV, alpha 2 | 8.42077 |
| C8ORF4 | chromosome 8 open reading frame 4 | 8.42077 |
| COL6A3 | collagen, type VI, alpha 3 | 8.2602 |
| PVR | poliovirus receptor | 8.25564 |
| HBEGF | heparin-binding EGF-like growth factor | 8.21464 |
| PCDHB5 | protocadherin beta 5 | 8.19002 |
| SAMD4A | sterile alpha motif domain containing 4A | 8.14334 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 8.00773 |
| NAV3 | neuron navigator 3 | 7.83215 |
| LAMC2 | laminin, gamma 2 | 7.70733 |
| DSC2 | desmocollin 2 | 7.69996 |
| SLC38A1 | solute carrier family 38, member 1 | 7.64628 |
| TRIM55 | tripartite motif containing 55 | 7.5998 |
| C15ORF52 | chromosome 15 open reading frame 52 | 7.5409 |
| CD83 | CD83 molecule | 7.49201 |
| IL1A | interleukin 1, alpha | 7.47645 |
| EFNA1 | ephrin-A1 | 7.43447 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 7.39982 |
| TMEM132A | transmembrane protein 132A | 7.33533 |
| DUSP1 | dual specificity phosphatase 1 | 7.31504 |
| SLC12A7 | solute carrier family 12 (potassium/chloride transporter), member 7 | 7.25989 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 7.23133 |
| FAM177A1 | family with sequence similarity 177, member A1 | 7.0945 |
| FOXL1 | forkhead box L1 | 6.9954 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 6.92703 |
| DTX4 | deltex 4, E3 ubiquitin ligase | 6.75498 |
| FAM107B | family with sequence similarity 107, member B | 6.68187 |
| CITED4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | 6.40727 |
| TXNRD1 | thioredoxin reductase 1 | 6.40055 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 6.33508 |
| BPGM | 2,3-bisphosphoglycerate mutase | 6.22844 |
| CTSZ | cathepsin Z | 6.16516 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 6.08642 |
| AMOTL2 | angiomotin like 2 | 6.07614 |
| ATP13A3 | ATPase type 13A3 | 6.07533 |
| SLIT2 | slit homolog 2 (Drosophila) | 5.93995 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -20.0 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -20.0 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -20.0 |
| ARHGAP29 | Rho GTPase activating protein 29 | -20.0 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -20.0 |
| FBLN2 | fibulin 2 | -20.0 |
| HAS2 | hyaluronan synthase 2 | -20.0 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -20.0 |
| S100A6 | S100 calcium binding protein A6 | -20.0 |
| FN1 | fibronectin 1 | -20.0 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -20.0 |
| VEGFA | vascular endothelial growth factor A | -20.0 |
| ANPEP | alanyl (membrane) aminopeptidase | -20.0 |
| TRH | thyrotropin-releasing hormone | -20.0 |
| COL1A2 | collagen, type I, alpha 2 | -20.0 |
| CRABP2 | cellular retinoic acid binding protein 2 | -20.0 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -20.0 |
| COL1A1 | collagen, type I, alpha 1 | -20.0 |
| PLXNA4 | plexin A4 | -20.0 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -20.0 |
| SYT11 | synaptotagmin XI | -20.0 |
| HTRA1 | HtrA serine peptidase 1 | -20.0 |
| THBS2 | thrombospondin 2 | -20.0 |
| LTBP2 | latent transforming growth factor beta binding protein 2 | -20.0 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -19.0458 |
| CDCP1 | CUB domain containing protein 1 | -18.585 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -18.1549 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -18.1487 |
| IRS1 | insulin receptor substrate 1 | -17.3188 |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | -16.9957 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -16.4987 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 | -16.4621 |
| COLEC12 | collectin sub-family member 12 | -15.8352 |
| NES | nestin | -15.1325 |
| ADAM12 | ADAM metallopeptidase domain 12 | -14.8984 |
| PCOLCE | procollagen C-endopeptidase enhancer | -14.0469 |
| PAX8 | paired box 8 | -13.8589 |
| THBD | thrombomodulin | -13.6746 |
| COL5A2 | collagen, type V, alpha 2 | -13.5608 |
| COL5A1 | collagen, type V, alpha 1 | -13.3084 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -13.207 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -12.5093 |
| ITGA10 | integrin, alpha 10 | -12.1673 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -12.0859 |
| PEX5L | peroxisomal biogenesis factor 5-like | -12.0457 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -11.4605 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | -11.1812 |
| PRRX1 | paired related homeobox 1 | -11.0218 |
| PCDHGB4 | protocadherin gamma subfamily B, 4 | -10.3919 |
| FZD1 | frizzled class receptor 1 | -10.3442 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -10.1706 |
| ITGA7 | integrin, alpha 7 | -10.1706 |
| NDRG1 | N-myc downstream regulated 1 | -10.0659 |
| PRDM8 | PR domain containing 8 | -9.70858 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -9.64228 |
| DCHS1 | dachsous cadherin-related 1 | -9.35501 |
| DUSP4 | dual specificity phosphatase 4 | -9.2676 |
| TENM2 | teneurin transmembrane protein 2 | -9.19566 |
| COL16A1 | collagen, type XVI, alpha 1 | -9.19441 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -9.1097 |
| SH2B3 | SH2B adaptor protein 3 | -9.00316 |
| WWTR1 | WW domain containing transcription regulator 1 | -8.72527 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -8.62506 |
| CEL | carboxyl ester lipase | -8.47936 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 | -8.31179 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -8.28463 |
| HMOX1 | heme oxygenase 1 | -8.13702 |
| FAM20C | family with sequence similarity 20, member C | -7.96168 |
| ZFHX4 | zinc finger homeobox 4 | -7.95861 |
| MAP1B | microtubule-associated protein 1B | -7.92817 |
| SDC1 | syndecan 1 | -7.85112 |
| CEP170 | centrosomal protein 170kDa | -7.83813 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -7.67724 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -7.67588 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -7.25449 |
| CCDC80 | coiled-coil domain containing 80 | -7.20338 |
| DNM1 | dynamin 1 | -7.1322 |
| FHL1 | four and a half LIM domains 1 | -7.0702 |
| MMP2 | matrix metallopeptidase 2 | -6.88368 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -6.86011 |
| STC1 | stanniocalcin 1 | -6.65663 |
| TRPS1 | trichorhinophalangeal syndrome I | -6.59517 |
| PPP1R14A | protein phosphatase 1, regulatory (inhibitor) subunit 14A | -6.55156 |
| PSMG3 | proteasome (prosome, macropain) assembly chaperone 3 | -6.45359 |
| WNT5B | wingless-type MMTV integration site family, member 5B | -6.31342 |
| GMNN | geminin, DNA replication inhibitor | -6.0808 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -6.01555 |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | -5.9584 |
| PLD3 | phospholipase D family, member 3 | -5.90566 |
| CXXC5 | CXXC finger protein 5 | -5.86356 |
| TNRC18 | trinucleotide repeat containing 18 | -5.84659 |
| CTSB | cathepsin B | -5.58746 |
| LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | -5.57121 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -5.52066 |
| WDR72 | WD repeat domain 72 | -5.52007 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -5.46282 |
| ANGPTL4 | angiopoietin-like 4 | -5.4292 |
| SAMD11 | sterile alpha motif domain containing 11 | -5.33632 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -5.27171 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -5.20755 |
