Perturb_5893_KD_CBX3_SRP271175 Gene Set

Dataset PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations
Category transcriptomics
Type gene perturbation
Description KD perturbation targeting CBX3 in fibroblasts BJ cell line (Study accession: SRP271175) (PerturbAtlas)
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Genes

200 genes differentially expressed following the Perturb_5893_KD_CBX3_SRP271175 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

increased expression

Symbol Name Standardized Value
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 18.3872
DSC2 desmocollin 2 17.767
KLHL4 kelch-like family member 4 17.767
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 12.2625
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 11.7395
NUP205 nucleoporin 205kDa 10.7933
C7ORF60 chromosome 7 open reading frame 60 10.6558
SEC24B SEC24 family member B 10.3377
ANLN anillin, actin binding protein 10.3377
CAND1 cullin-associated and neddylation-dissociated 1 10.0326
RB1 retinoblastoma 1 9.93004
SCRN1 secernin 1 9.45954
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 9.37446
IDE insulin-degrading enzyme 9.21285
KIAA1468 KIAA1468 8.72222
IGSF1 immunoglobulin superfamily, member 1 8.39892
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 8.2197
CLTC clathrin, heavy chain (Hc) 8.2197
FAR1 fatty acyl CoA reductase 1 8.13883
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 7.99105
SSFA2 sperm specific antigen 2 7.84189
GABPA GA binding protein transcription factor, alpha subunit 60kDa 7.61356
YES1 YES proto-oncogene 1, Src family tyrosine kinase 7.60105
MMP7 matrix metallopeptidase 7 7.58031
KIAA1429 KIAA1429 7.58031
IPO11 importin 11 7.58031
BTBD3 BTB (POZ) domain containing 3 7.58031
ITGAV integrin, alpha V 7.58031
TTC37 tetratricopeptide repeat domain 37 7.51861
TLR4 toll-like receptor 4 7.50162
DDHD2 DDHD domain containing 2 7.40862
TMEM194A transmembrane protein 194A 7.36754
FEM1B fem-1 homolog b (C. elegans) 6.95666
ANKRD28 ankyrin repeat domain 28 6.95666
PKP2 plakophilin 2 6.95666
LHFPL2 lipoma HMGIC fusion partner-like 2 6.95666
CAPN7 calpain 7 6.87317
SOCS5 suppressor of cytokine signaling 5 6.79817
ZZZ3 zinc finger, ZZ-type containing 3 6.79817
MED23 mediator complex subunit 23 6.60576
DPY19L4 dpy-19-like 4 (C. elegans) 6.5194
RNMT RNA (guanine-7-) methyltransferase 6.39276
NUP160 nucleoporin 160kDa 6.37362
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 6.37362
PGM2L1 phosphoglucomutase 2-like 1 6.31613
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 6.15974
DCX doublecortin 6.12806
C1ORF116 chromosome 1 open reading frame 116 6.11363
WDFY1 WD repeat and FYVE domain containing 1 6.1082
ARHGAP19 Rho GTPase activating protein 19 6.05834
MFAP3 microfibrillar-associated protein 3 6.04236
STK38L serine/threonine kinase 38 like 5.96537
THBD thrombomodulin 5.92852
MON2 MON2 homolog (S. cerevisiae) 5.84385
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 5.8149
USP28 ubiquitin specific peptidase 28 5.78871
GNA13 guanine nucleotide binding protein (G protein), alpha 13 5.78272
KIAA0368 KIAA0368 5.77002
STMN2 stathmin 2 5.76003
FEM1C fem-1 homolog c (C. elegans) 5.71988
ZNF25 zinc finger protein 25 5.71988
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 5.70321
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 5.70181
ZBTB33 zinc finger and BTB domain containing 33 5.6648
PHTF2 putative homeodomain transcription factor 2 5.65461
CNOT1 CCR4-NOT transcription complex, subunit 1 5.63656
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 5.60823
MPZL3 myelin protein zero-like 3 5.60315
JAK2 Janus kinase 2 5.55889
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 5.50419
STAG1 stromal antigen 1 5.4463
DENND4C DENN/MADD domain containing 4C 5.4403
FRMD6 FERM domain containing 6 5.42294
FAM91A1 family with sequence similarity 91, member A1 5.41492
OCRL oculocerebrorenal syndrome of Lowe 5.39929
ANAPC1 anaphase promoting complex subunit 1 5.39929
KIF11 kinesin family member 11 5.37791
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 5.36788
CGGBP1 CGG triplet repeat binding protein 1 5.36788
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 5.36788
MBTPS2 membrane-bound transcription factor peptidase, site 2 5.32315
SPIN1 spindlin 1 5.31284
AGTPBP1 ATP/GTP binding protein 1 5.31071
SPINK1 serine peptidase inhibitor, Kazal type 1 5.31071
CDK6 cyclin-dependent kinase 6 5.3096
OSBPL11 oxysterol binding protein-like 11 5.29312
ZBED9 zinc finger, BED-type containing 9 5.29312
CCL14 chemokine (C-C motif) ligand 14 5.29312
BCAT1 branched chain amino-acid transaminase 1, cytosolic 5.22776
CNST consortin, connexin sorting protein 5.22398
JAK1 Janus kinase 1 5.21728
SLC38A2 solute carrier family 38, member 2 5.18734
ZNF614 zinc finger protein 614 5.18592
CCNJ cyclin J 5.1181
TMEM67 transmembrane protein 67 5.06453
ATE1 arginyltransferase 1 5.06453
CLASP2 cytoplasmic linker associated protein 2 5.01853
KLHL9 kelch-like family member 9 4.95734
CCNT2 cyclin T2 4.94082
PM20D2 peptidase M20 domain containing 2 4.94082

decreased expression

Symbol Name Standardized Value
JUND jun D proto-oncogene -18.3872
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -10.3377
BST2 bone marrow stromal cell antigen 2 -10.1234
HIST1H1C histone cluster 1, H1c -9.97989
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -9.30445
ALDOA aldolase A, fructose-bisphosphate -9.05329
SOWAHC sosondowah ankyrin repeat domain family member C -7.51367
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -7.22147
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -6.95666
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -6.50927
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -6.49227
CSNK2B casein kinase 2, beta polypeptide -6.47206
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -6.4186
CD99 CD99 molecule -6.13978
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -6.11602
H2AFJ H2A histone family, member J -6.05834
C20ORF194 chromosome 20 open reading frame 194 -6.05834
MTA2 metastasis associated 1 family, member 2 -5.80534
HIST1H2BG histone cluster 1, H2bg -5.70156
TMSB10 thymosin beta 10 -5.59495
TPM2 tropomyosin 2 (beta) -5.56837
HIST2H2BE histone cluster 2, H2be -5.39929
TNRC6B trinucleotide repeat containing 6B -5.38115
APOD apolipoprotein D -5.29312
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa -5.26382
SMIM4 small integral membrane protein 4 -5.22374
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -5.22276
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -5.14684
SHOX2 short stature homeobox 2 -5.11375
DYNLRB1 dynein, light chain, roadblock-type 1 -5.09821
RRBP1 ribosome binding protein 1 -4.94082
INSR insulin receptor -4.78918
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -4.6875
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -4.65318
FTH1 ferritin, heavy polypeptide 1 -4.65318
HIST1H2BH histone cluster 1, H2bh -4.63628
TMEM91 transmembrane protein 91 -4.61834
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -4.56076
ANKRD11 ankyrin repeat domain 11 -4.55751
LMOD1 leiomodin 1 (smooth muscle) -4.5325
C11ORF31 chromosome 11 open reading frame 31 -4.51808
PKD2L1 polycystic kidney disease 2-like 1 -4.44936
MGST2 microsomal glutathione S-transferase 2 -4.44665
HIST1H2AK histone cluster 1, H2ak -4.33291
PCTP phosphatidylcholine transfer protein -4.31041
EDF1 endothelial differentiation-related factor 1 -4.27445
GSR glutathione reductase -4.24761
SERF2 small EDRK-rich factor 2 -4.23028
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -4.17503
GFER growth factor, augmenter of liver regeneration -4.08542
CD63 CD63 molecule -4.06709
IFITM1 interferon induced transmembrane protein 1 -4.0068
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -3.95968
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -3.94413
ABHD6 abhydrolase domain containing 6 -3.90725
PTMS parathymosin -3.89476
GALR2 galanin receptor 2 -3.79924
CDK11B cyclin-dependent kinase 11B -3.79924
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 -3.79063
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -3.71376
GLT8D2 glycosyltransferase 8 domain containing 2 -3.68921
SORD sorbitol dehydrogenase -3.66904
KIF13B kinesin family member 13B -3.66512
MT1H metallothionein 1H -3.64856
MAB21L3 mab-21-like 3 (C. elegans) -3.64525
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -3.64525
S100A1 S100 calcium binding protein A1 -3.61972
C9ORF135 chromosome 9 open reading frame 135 -3.6186
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -3.61813
ZMAT2 zinc finger, matrin-type 2 -3.61813
METTL7A methyltransferase like 7A -3.61813
HIST1H2BK histone cluster 1, H2bk -3.61254
COX17 COX17 cytochrome c oxidase copper chaperone -3.59837
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -3.59326
METTL7B methyltransferase like 7B -3.57294
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -3.5639
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -3.53332
MPHOSPH8 M-phase phosphoprotein 8 -3.49226
TCEAL6 transcription elongation factor A (SII)-like 6 -3.48911
NR2F1 nuclear receptor subfamily 2, group F, member 1 -3.46084
RPL41 ribosomal protein L41 -3.41723
SYT6 synaptotagmin VI -3.41581
THY1 Thy-1 cell surface antigen -3.41525
APOE apolipoprotein E -3.41052
IFITM2 interferon induced transmembrane protein 2 -3.36608
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -3.36608
BMP4 bone morphogenetic protein 4 -3.32421
CLUAP1 clusterin associated protein 1 -3.29412
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -3.29003
PLAC9 placenta-specific 9 -3.28861
SAFB2 scaffold attachment factor B2 -3.26516
VTN vitronectin -3.25691
ZC3H13 zinc finger CCCH-type containing 13 -3.25481
PRRX2 paired related homeobox 2 -3.23619
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -3.2261
IFI6 interferon, alpha-inducible protein 6 -3.2261
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 -3.14562
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -3.12635
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -3.12075
PROCA1 protein interacting with cyclin A1 -3.11239